Joseph A. Pignolo, Sr. Award in Aging Research
About the Award
The Joseph A. Pignolo, Sr. Award in Aging Research will be given out as part of the Institute on Aging (IOA) Visiting Scholar series to annually recognize an outstanding contribution to the field of biogerontology. Created by geriatrician and gerontologist Robert J. Pignolo, M.D., Ph.D. in honor of his father. Award recipients will be invited to give a lecture highlighting their work in basic aging research and will receive a $2,000 prize to recognize their exceptional contributions.
The 2013 recipient is Joseph A. Baur, PhD, Assistant Professor of Physiology at the Perelman School of Medicine at the University of Pennsylvania.
Dr. Baur will speak on November 20, 2013, in BRB 2/3 Auditorium. His lecture, " Promise and pitfalls of targeting mTOR signaling," will begin at 3:30pm. A reception recognizing Dr. Baur's award will begin at 3pm.
Dr. Baur's research focuses on understanding the basic mechanisms that lead to aging and how interventions such as caloric restriction (CR) are able to slow the process. He was the first to show that resveratrol, a small molecule with many effects, including activation of the sirtuin SIRT1, is able to improve insulin sensitivity and extend lifespan in obese mice. Dr. Baur and his lab are continuing to test the hypothesis that sirtuins play a critical role in mammalian CR, exploring potential upstream mechanisms that could regulate their activity, and downstream effects that could account for changes in health and longevity. Elucidating the mechanism(s) by which CR extends lifespan is expected to yield insights into the causes of aging and to highlight new therapeutic approaches to the prevention and treatment of age-related disease.
Dr. Baur was nominated for his Science (March 2012) paper, "Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity."
The lecture will be held on November 20, 2013 at 3pm in BRB 2/3 Auditorium, 421 Curie Boulevard, on the University of Pennsylvania's campus. Those interested in attending the lecture should contact email@example.com.
The 2012 recipient is Darren A. Baker, PhD, Assistant Professor of Biochemistry and Molecular Biology, at the Mayo Clinic.
Dr. Baker's research focuses on the involvement of senescent cells in the processes of aging and cancer. He is looking closely at senescent cells in natural aging and the role of these cells in Alzheimer's and dementia. He has recently demonstrated the ability to significantly delay age-related pathologies and phenotypes, including cataract formation, by removing senescent cells. Dr. Baker was nominated for his Nature 2011 paper, "Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders."
The lecture will be held on September 27, 2012 at 3pm in BRB 2/3 Auditorium, 421 Curie Boulevard, on the University of Pennsylvania's campus. Those interested in attending the lecture should contact firstname.lastname@example.org.
The first prize was given to Richard A. Miller, MD, PhD, Professor of Pathology at the University of Michigan and Associate Director for Research at its Geriatrics Center. Dr. Miller is also a Research Scientist at the Ann Arbor DVA Medical Center.
Dr. Miller's work centers on the genetics and cell biology of aging in mice, with emphasis on the immune system. Major ongoing projects include studies of Aging and T lymphocyte activation, with particular emphasis on protein kinases and cytoskeletal pathways in the first few minutes after encounter with antigen, and modification of the T cell surface glycoproteins to improve function of T cells from old mice.
The lecture was held on September 22, 2010 at 3:30pm in Austrian Auditorium, Clinical Research Building (CRB), 415 Curie Boulevard, University of Pennsylvania campus.
Nominations for the award should be made to:
The Joseph A. Pignolo, Sr. Award in Aging Research
c/o Institute on Aging
3615 Chestnut Street
Philadelphia, PA 19104-2676
The nominee shall be the first or last author of a paper or papers, published within the previous 2 years, describing an outstanding contribution to basic aging research. Two letters of nomination (or one letter of self-nomination plus an additional letter) describing the contribution and its relevance to basic aging principles, curriculum vitae, and copies of the paper or papers for which the award is being sought should be submitted by March 1, 2010.
Joshua Dunaief, MD, PhD
F. Brad Johnson, MD, PhD
Robert J. Pignolo, MD, PhD, Chair
John Q. Trojanowski, MD, PhD
How to support the Joseph A. Pignolo, Sr. Award in Aging Research
Please direct inquiries to:
Irene I. Lukoff
Director of Development
PENN Medicine Centers & Institutes
3535 Market Street, Suite 750
Philadelphia, PA 19104-3309
Tel: 215-573-0187 Fax: 215-573-2800