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Institute on Aging

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Visiting Scholars Series Archive

Joseph Pignolo, Sr. Award in Aging Research Lectureship

November 24, 2014

Smilow Center for Translational Research

2:30 - 4:00 PM

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About the Award

The Joseph A. Pignolo, Sr. Award in Aging Research will be given out as part of the Institute on Aging (IOA) Visiting Scholar series to annually recognize an outstanding contribution to the field of biogerontology. Created by geriatrician and gerontologist Robert J. Pignolo, M.D., Ph.D. in honor of his father. Award recipients will be invited to give a lecture highlighting their work in basic aging research and will receive a $2,000 prize to recognize their exceptional contributions.

2013 Recipient
Joseph A. Baur, PhD

The 2013 recipient was Joseph A. Baur, PhD, Assistant Professor of Physiology at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Baur spoke on November 20, 2013, in BRB 2/3 Auditorium. His lecture, " Promise and pitfalls of targeting mTOR signaling," began at 3:30pm. A reception recognizing Dr. Baur's award was held prior.

Dr. Baur's research focuses on understanding the basic mechanisms that lead to aging and how interventions such as caloric restriction (CR) are able to slow the process. He was the first to show that resveratrol, a small molecule with many effects, including activation of the sirtuin SIRT1, is able to improve insulin sensitivity and extend lifespan in obese mice. Dr. Baur and his lab are continuing to test the hypothesis that sirtuins play a critical role in mammalian CR, exploring potential upstream mechanisms that could regulate their activity, and downstream effects that could account for changes in health and longevity. Elucidating the mechanism(s) by which CR extends lifespan is expected to yield insights into the causes of aging and to highlight new therapeutic approaches to the prevention and treatment of age-related disease.

Dr. Baur was nominated for his Science (March 2012) paper, "Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity".

The lecture was held on November 20, 2013 at 3pm in BRB 2/3 Auditorium, 421 Curie Boulevard, on the University of Pennsylvania's campus.


Nominations for the award should be made to:

The Joseph A. Pignolo, Sr. Award in Aging Research
Nominations Committee
c/o Institute on Aging
3615 Chestnut Street, Room 210
Philadelphia, PA 19104-2676

The nominee shall be the first or last author of a paper or papers, published within the previous 2 years, describing an outstanding contribution to basic aging research. Two letters of nomination (or one letter of self-nomination plus an additional letter) describing the contribution and its relevance to basic aging principles, curriculum vitae, and copies of the paper or papers for which the award is being sought are required.

Nominations Committee

Joshua Dunaief, MD, PhD
F. Brad Johnson, MD, PhD
Robert J. Pignolo, MD, PhD, Chair
John Q. Trojanowski, MD, PhD

How to support the Joseph A. Pignolo, Sr. Award in Aging Research

Please direct inquiries to:

Michael Sofolarides
Director of Development
PENN Medicine Centers & Institutes
3535 Market Street, Suite 750
Philadelphia, PA 19104-3309
Tel: 215-573-0187

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Topic: Translational Research Efforts in Neurotherapeutics and Clinical Care
Jeffrey Cummings, MD
October 29, 2013

Vincent J. Cristofalo, PhD, Annual Lectureship
October 15, 2013


Topic: Mobility and Aging
Stephanie Studenski, MD, MPH
October 9, 2012

2012 Cristofalo Lectureship: Understanding Aging Through Conserved Longevity Pathways
Cristofalo Lecturer: Matt Kaeberlein, PhD
October 18, 2012

Physical Activity: The Trek to Healthy Brain Aging
Kirk Erickson, PhD
January 24, 2013

The Surprising Heterogeneity in the Hazards of Hospitalization: Diagnosis Matters
Theodore Iwashyna, MD, PhD
February 27, 2013

Aging, Redox Signaling, and the Development of Osteoarthritis
Richard Loeser, Jr., MD
March 12, 2013


2011 Cristofalo Lectureship
Cristofalo Lecturer: James W. Vaupel, PhD
September 12, 2011

Topic: Towards Novel Therapeutics for Alzheimer's Disease
Todd Golde, MD, PhD
November 29, 2011

Topic: Function Focused Care: Optimizing Function and Activity Among Older Adults
Barbara Resnick, PhD, RN, CRNP
January 12, 2012

Topic: Tracking the Health &Economic Implications of the U.S. Population's 'Brain Health': Findings from the Health and Retirement Study
Kenneth M. Langa, MD, PhD
January 26, 2012

Topic: Maintaining Mobility in Old Age: The Role of Physical Activity
Jack Guralnik, MD, PhD
March 20, 2012


Topic: PET Imaging of Amyloid Plaque in Alzheimer's Disease – Insights into Pathogenesis of Disease
Daniel M. Skovronsky, MD, PhD
September 16, 2010

Joseph A. Pignolo, Sr., Award in Aging Research
Richard A. Miller, MD, PhD
September 21, 2010

Topic: Can Simple Cells Model Complex Disease?
Susan L. Lindquist, PhD
January 25, 2011

Topic: The Oldest Old: 95 is the New 65
Claudia Kawas, MD
March 22, 2011

Topic: Sex, Stress and the Brain: Hormone Actions Above the Hypothalamus Via Novel Mechanisms
Bruce S. McEwen, PhD
May 6, 2011

A Conversation on Breaking the Treatment Barrier: Moving from Disease Modification to Prevention of Alzheimer's Disease
Russell Katz, MD, and Zaven Khachaturian, PhD
January 7, 2010

Topic: Clinical Trials for Parkinson's Disease
Karl D. Kieburtz, MD, MPH
January 14, 2010

Lecture: Drug Treatments for Dementia: Using the Past to Make Sense of the Present
Jesse F. Ballenger, PhD
February 4, 2010

Lecture: The Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) Study: An urban study of health, race, and socioeconomic status
Michele K. Evans, MD
March 3, 2010

Lecture: Central Role of Sarcopenia in Frailty
Luigi Ferrucci, MD, PhD
April 8, 2010

Sylvan M. Cohen Annual Retreat with Poster Session on Aging: Focus on Osteoporosis
Cohen Visiting Scholar: Clifford J. Rosen, MD
Penn Presenters: Robert J. Pignolo, MD, PhD: Biological Basis for Alternative Approaches to Osteoporosis Treatment; Mary Beth Leonard, MD, MSCE: Bone Structure, Muscle Function and Vitamin D in Adults with Chronic Kidney Disease
April 28, 2010


We Need to Do Something: An Alzheimer's Action Plan to Help Families Through Key Decisions
Lisa P. Gwyther, MSW
July 22, 2008

Dementia and Cognitive Impairment: New Complications of Diabetes?
Lenore J. Launer, PhD
October 30, 2008

Facing the End of Life as a Hospital Patient: Spiritual Care Needs and Opportunities
Christina M. Puchalski, MD
December 3, 2008

Topic TBA
Henry L. Paulson, MD, PhD
February 12, 2009

Lecture: The Path Toward a High Value Health Care System
L. Gregory Pawlson, MD, MPH
February 17, 2009

The Presymptomatic Diagnosis of Alzheimer's Disease Using Imaging and CSF Biomarkers
Mony J. De Leon, PhD
February 26, 2009

The Challenges and Opportunities of an Aging Society
John (Jack) W. Rowe, MD
April 1, 2009

Parkinson's Diseases: Looking Forward to Tomorrow's Therapies
Ted Dawson, MD, PhD
April 9, 2009

Genetic and Environmental Influences on Health and Mental Health in Older African Americans
Keith E. Whitfield, PhD
April 16, 2009

Selective autophagy and aging: Regulated cleaning and refueling
Ana Maria Cuervo, MD, PhD
April 30, 2009

Mixed Pathology and Neural Reserve: Implications for the Prevention of Alzheimer's Disease
David A. Bennett, MD
May 7, 2009


Experimental Therapeutics in Pre-Manifest Huntington's Disease
Ira Shoulson, MD
October 18, 2008

Measuring the Impact of State Policy Changes on Nursing Home Quality
Vincent Mor, MD, PhD
October 25, 2007

Opportunities for Translational Research
Evan C. Hadley, MD
November 7, 2007

Funding Opportunities from the Ellison Medical Foundation
Richard L. Sprott, PhD
March 18, 2008

Translational Research in Lewy Body Disorders Symposium
April 29, 2008

Of Birds and Man — Speculations on the Basal Ganglia
Anne B. Young, MD, PhD
May 1, 2008

IOA 2008 Sylvan M. Cohen Annual Retreat with Poster Session on Aging
Theme: Healthy Brain Aging
May 6, 2008

What's New in Mild Cognitive Impairment?
Ronald C. Petersen, MD, PhD
June 12, 2008

We Need to Do Something: An Alzheimer's Action Plan to Help Families Through Key Decisions
Lisa P. Gwyther, MSW
July 22, 2008


The Mature Mind: The Potential for Creative Expression and Psychological Growth with Aging
Gene Cohen, MD, PhD
September 21, 2006

Topic: Older adult morality and BMI
Gabriel M. Leung, MD, MPH
October 9, 2006

New Research Directions in Delirium
Sharon K. Inouye, MD, MPH
October 11, 2006

Funding mechanisms and opportunities at the NIA and NIH
Felipe Sierra, PhD
October 30, 2006

Novel body composition and biochemical markers of obesity-related risk for older person
Tamara B. Harris, MD, MS
February 21, 2007

Converging Lines of Evidence in Comparative Models of Aging – Exploring Human Animal Intersections
March 8, 2007

Penn Panel #1: Convergence of Medicine and Nursing Research
Panel Participants: Jerry Johnson, MD; Neville Strumpf, PhD, RN, FAAN; Deanna Grey-Miceli, DNSc, FAANP
March 22, 2007

Leadership, Politics and the New Aging: Implications for the Emerging Latino Majority
Fernando Torres-Gil, PhD
March 28, 2007

Prevention of Cognitive Impairment: Promising Directions in 2007
Kristine Yaffe, MD
April 11, 2007

Penn Panel #2: Convergence of Medicine and Nursing Research
Panel Participants: C. William Schwab, MD; Therese Richmond, PhD, FAAN, CRNP; Mary Ann Forciea, MD; Douglas J. Weibe, PhD
April 12, 2007

A Critical Perspective on Social Security Privatization
Carroll L. Estes, PhD
April 18, 2007

Sylvan M. Cohen 2008 Annual Retreat with Poster Session
The Convergence of Medicine and Nursing Research to Optimize Care for Older Adults
Rosemary A. Stevens, PhD, MPH
Penn Presenters: Neville Strumpf, PhD, RN; David Casarett, MD
May 8, 2007

Helping the Most Vulnerable: Emergency Preparedness, Older Adult and Health Disparities
Risa Lavizzo-Mourey, MD, MBA
June 7, 2007


Food for Thought: Dietary Modification of Brain Aging and Neurodegenerative Disorders
Mark Mattson, PhD
September 7, 2005

Alzheimer's Disease: The Care Trajectory as Developmental Processes
Geri R. Hall, PhD, ARNP, CS, FAAN
October 6, 2005

Deciphering Exceptional Longevity: What We've Learned from the New England Centenarian Study
Thomas Perls, MD, MPH
January 12, 2006

Windows of Opportunity for Improving Transitional Care: Time for a Plan
Eric Coleman, MD, MPH
February 2, 2006

Creativity in Dementia: Portraits of Artists
Bruce L. Miller, MD
March 1, 2006

Toward a New Paradigm for Gerontological Education, Practice, and Research: Multigenerational Health, Development and Equality
Nancy Hooymna, PhD
March 23, 2006

T cell replicative senescense and bone homeostatus: lessons from aging and HIV disease
Rita Effros, PhD
March 27, 2006

Race, The Life-Course, & Health Disparities
James S. Jackson, PhD
April 20, 2006

2006 Sylvan M. Cohen Annual Retreat with Poster Session
Vaccines for neurodegenerative diseases
Alzheimer's disease immunotherapy
Speakers: Dr. Richard Hodes; Dr. David Weiner; Edward Lee, MD, PhD


Translational Research in Nursing: Sleep, Body Temperature and Hemodialysis
Kathy P. Parker, RN, CS, PhD
September 30, 2004

The Mind in the Hand
Robert Storr, MFA
December 2, 2004

When I Get Older, Losing My Hair: The Family as Provider of Last Resort
Patricia G. Archbold, RN, DNSc, FAAN
February 3, 2005

The Arts & Science of Anti-Aging Therapies: Convergence of Theory and Practice
March 18-19, 2005

Medicare Matters: Healthcare, Aging, and the Social Contract
Christine Cassel, MD
April 7, 2005

The Brave New World of Healthcare
Governor Richard D. Lamm
May 3, 2005

Mild Cognitive Impairment: What Is It and Can We Treat It?
Leon J. Thal, MD
May 23, 2005

2005 Sylvan M. Cohen Annual Retreat with Poster Session
Majd Alwan, PhD; Stuart L. Fine, MD; Joshua L. Dunaief, MD, PhD

Cristofalo Annual Lectureship Archive

2013 Cristofalo Annual Lectureship

Shin-ichiro Imai, MD, PhD – Seventh Cristofalo Lecturer

October 15, 2013

BRB 2/3 Auditorium, 421 Curie Boulevard


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About the Lectureship

This endowed Lectureship is an annual tribute to Dr. Vincent Cristofalo, an expert in cellular aging, a cherished mentor, and the founder of the Institute on Aging at Penn (formerly the Center for the Study of Aging).

The seventh Vincent J. Cristofalo, PhD, Annual Lectureship will take place at 3:30pm on Tuesday, October 15, 2013 at the University of Pennsylvania. The lecture and reception will be held in BRB 2/3 Auditorium, 421 Curie Boulevard, University of Pennsylvania.

Dr. Shin-ichiro Imai will serve as the 2013 Cristofalo Lecturer and will present discussion on his research in "Towards Productive Aging: The Systemic Regulatory Network for Mammalian Aging and Longevity."

About the 2013 Cristofalo Lecturer

Shin-ichiro Imai, MD, PhD, is Professor of Developmental Biology and of Medicine at Washington University School of Medicine at St. Louis.

Dr. Imai and his lab are studying the fundamental mechanisms of aging and longevity in mammals, focusing on the physiological importance of the mammalian nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) for the regulation of metabolism and aging.

Giving to the Cristofalo Annual Lectureship Fund

If you would like to make a contribution to the Vincent J. Cristofalo, PhD, Annual Lectureship Fund, please contact:
Michael Sofolarides
Director of Development
Penn Medicine Centers & Institutes
3535 Market Street, Suite 750
Philadelphia, PA 19104-3309
Email: Tel: 215-573-0187

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2012 Cristofalo Annual Lectureship
Matt Kaeberlein, PhD
"Understanding Aging Through Conserved Longevity Pathways"
October 18, 2012

2011 Cristofalo Annual Lectureship
James W. Vaupel, PhD
"The Biodemography of Longevity"
September 12, 2011

2010 Cristofalo Annual Lectureship
Carol W. Greider, PhD
"Telomerase and the Consequences of Telomere Dysfunction"
October 19, 2010

2009 Cristofalo Annual Lectureship
David A. Sinclair, PhD
"Finding Genes and Medicines That Extend Healthy Lifespans"
November 12, 2009

2008 Cristofalo Annual Lectureship
Judith Campisi, PhD
"Cellular Senescence Links the Rival Demons of Cancer and Aging"
November 11, 2008

Inaugural Vincent J. Cristofalo, PhD, Annual Lectureship
Steven Austad, PhD
November 27, 2007

Sylvan M. Cohen Annual Retreat Archive

Sylvan M. Cohen Annual Retreat & Poster Session 2014

The Gender Gap in Aging & The 21st Century Longevity Revolution

May 14, 2014

Smilow Translational Research Center, 3400 Civic Center Boulevard


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The 2014 Sylvan M. Cohen Annual Retreat & Poster Session was held on May 14 in the Smilow Translational Research Center, attached to the Perelman Center for Advanced Medicine (3400 Civic Center Boulevard) here on Penn's campus.

The IOA partnered with the Penn Center for the Study of Sex and Gender in Behavioral Health and Medicine to present the 2014 retreat, with its focus on "The Gender Gap in Aging & The 21st Century Longevity Revolution."


Registration is required to attend and/or present a poster. Lunch is provided to those who register.


The day begins with lunch provided for all registered guest followed by the presentations from Penn Presenters and the Visiting Scholar. The event concludes with a reception and the annual Institute on Aging Poster Session.

The Speakers at the 2014 Annual Retreat

The Sylvan M. Cohen Visiting Scholar for the 2014 Annual Retreat was Susan M. Resnick, PhD, Chief, Laboratory of Behavioral Neuroscience, National Institute on Aging.

This year's Penn Presenters were C. Neill Epperson, MD, and Tracy L. Bale, PhD, both Co-Directors of the Penn Center for the Study of Sex and Gender in Behavioral Health and Medicine.

Video from the day's events can be accessed here:

The Poster Session

The annual Poster Session is open to all who wish to participate. Poster winners are selected from each category: Basic Science, Clinical Research, and Education & Community. Categories may be combined for judging depending on the number of posters submitted.

Poster Session Winners

Winners for the 2014 Poster Session are as follows:

  • Basic Science
    • First Place: "A Telephone-based Intervention for Chronic Pain in Older Adults Enrolled in a Behavioral Health Care Management Program" Presented by: J. Zimmerman
    • Second Place: "Penetrating Torso Injuries in an Elderly Population: An Urban Trauma Center’s Experience"  Presented by: Dane Scantling
  • Clinical Research
    • First Place: "Defining Kapβ2 as a Protein Disaggregase for ALS Disease Protein: FUS"    Presented by: Lin Guo
    • Second Place: "MMP-9 in Subsets of Spinal Motor Neurons Drives Loss of Fast Muscle Innervation in ALS"   Presented by: Krista Spiller

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       2013: Protecting the Genome in the Longevity Revolution: Cancer and Aging
       Sylvan M. Cohen Visiting Scholar: Norman E. Sharpless, MD
       May 22, 2013

  • Opening Remarks and Dr. Ned Sharpless' presentation (MP4 file)
  • Dr. Shelley Berger and Dr. Brad Johnson (MP4 File)
  • Dr. Eric Brown and Dr. Doug Wallace (MP4 File)


    2012: Behavioral Economics and Health for an Aging Population
    Sylvan M. Cohen Visiting Scholar: Troyen A. Brennan, MD, MPH
    May 15, 2012

    2011: New Prospects for Healthy Vision Across the Lifespan
    Sylvan M. Cohen Visiting Scholar: Paul A. Sieving, MD, PhD
    May 17, 2011

    2010: Structurally Sound: Bone Health and Aging
    Sylvan M. Cohen Visiting Scholar: Clifford J. Rosen, MD
    April 28, 2010

    2009: The Interface of the Aging Brain and Metabolic Disorders
    Sylvan M. Cohen Visiting Scholar: Bruce Yankner, MD, MPH
    May 12, 2009

    2008 Sylvan M. Cohen Annual Retreat with Poster Session on Aging
    Marcelle Morrison-Bogorad, PhD; Marilyn Albert, PhD; Carl Cotman, PhD; Hugh Hendrie, MB, ChB, DSc
    May 6, 2008

    2007 Sylvan M. Cohen Annual Retreat with Poster Session on Aging
    Rosemary A. Stevens, PhD, MPH
    May 8, 2007

    2006 Sylvan M. Cohen Annual Retreat with Poster Session on Aging
    Sylvan M. Cohen Visiting Scholar: Richard J. Hodes, MD
    May 4, 2006

    2005 Sylvan M. Cohen Annual Retreat with Poster Session on Aging
    Sylvan M. Cohen Visiting Scholar: Majd Alwan, PD
    June 8, 2005

    IOA's 25th Anniversary and Sylvan M. Cohen Annual Retreat 2004
    May 25, 2004