Cultured human airway fibroblast stained for α-Smooth Muscle Actin and S-100. Airways Biology Initiative's summer research students dissecting human lung and trachea. Confocal image of cultured human airway smooth cells stained for β2 Adrenergic Receptor. Cells were transfected with plasmids expressing TSC2 & Rho A, and stained for α-Smooth Muscle Actin. Basic science labs located 125 South 31st Street in the Translational Research Laboratories Building. Cultured human airway smooth muscle cells stained for α-Smooth Muscle Actin. Cultured human airway smooth cells stained for β2 Adrenergic Receptor and LAMP-1. Airways Biology Initiative's human exposure chamber located in the Andrew Mutch Building. Cells were transfected with plasmids expressing TSC1 and then they were stained E-cadherin.  250 μM thick precision cut lung slice of human small lung airway. Dr. Koziol-White isolating DNA and RNA.  Cultured human airway smooth cells stained for β2 Adrenergic Receptor & α-Smooth Muscle Actin. Cultured human airway fibroblasts stained for S-100. Dr. Jiang working in the Airways Biology Initiative's basic science research lab's tissue culture facility.  Cells were transfected with plasmids expressing TSC2 & Rho A & stained for  α-Smooth Muscle Actin.  Cultured human airway smooth cells stained for β2 Adrenergic Receptor and LAMP-1. Andrew Mutch Building located at 51 North 39th Street in the Presbyterian Hospital complex. Cultured human airway smooth muscle cells stained for Caldesmon. Inverted phase contrast microscopes in Airways Biology Initiative's basic science research labs. Confocal image of human small airway stained for I-Cam 1. Dr. Panettieri and Carter Oosterhouse from HGTV at the Build Smart Breathe Easier Jobsite. Cultured human airway smooth cells at 10X magnification. Cells were transfected with Rho A (red) and then stained for Caspase-3 (green).  Translational Research Laboratories Building located at 125 South 31st Street. Dr. Krymskaya accepting the LAM Foundation's career investigator award.

ABI History

The Airways Biology Initiative (ABI), which was founded in 2005, conducts basic research in immunology, physiology and molecular biology related to understanding the mechanisms that regulate airway function and leukocyte interactions in asthma, chronic obstructive pulmonary disease and adult bronchiectasis. The ABI also performs unique clinical studies utilizing state-of-the-art pulmonary function testing, airway imaging (computerized tomography, magnetic resonance imaging, µCT scans, and confocal bronchoscopy) and invasive techniques (bronchoscopy) to assess airway inflammation and bronchoconstriction. Additionally, the ABI provides one of the only Respiratory Phase II Clinical Research Unit in the United States for drug evaluation.

The ABI is renowned for establishing state-of-the-art clinical and research programs that translate discoveries into new therapeutics for patients with airways disease that also includes orphan diseases such as lymphangioleiomyomatosis and Birt-Hogg-Dube syndrome. Further, the ABI provides unique opportunities for undergraduate, graduate and postdoctoral research and clinical education and training.

The program is interdisciplinary by nature and multicentric using fundamental and clinical science expertise from the Departments of Medicine, Pediatrics, Radiology, Surgery, Pharmacology and Emergency Medicine in the Schools of Medicine and Nursing at the University of Pennsylvania Perelman School of Medicine as well as at the Wistar Institute. The ABI is staffed by eight faculty, 36 support members and state-of-the-art facilitie. The Center of Excellence in Environmental Toxicology Human Exposure Laboratory is also directed by the ABI at Penn Presbyterian Medical Center.

Clinical Studies for Subject Recruitment

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ABI Summer Research Program

Airways Biology Initiative (ABI) Summer Research Program, creating the next generation of great young scientists.  More information