Joseph Jude, B.V.Sc., Ph.D.

Cindy Koziol White.jpgPostdoctoral Fellow
University of Pennsylvania Medical Center
Pulmonary, Allergy, & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

tel.: (215) 746-2893
fax:
(215) 746-1224
email:
aantony@mail.med.upenn.edu

Education: Ph.D., University of Minnesota, St. Paul, MN
B.V.Sc., University of Peradeniya, Sri Lanka

Postdoctoral Fellowship:

University of Minnesota, St. Paul, MN

Airway smooth muscle (ASM) cells contribute to asthma pathology through their synthetic and mechanical (contractile) functions. Joseph is interested in the molecular and cellular signaling mechanisms of ASM cells in airway disorders such as asthma. His current research focus is on the mechanisms of airway hypersensitivity exacerbation by environmental pollutants like ozone. Ozone and other environmental pollutants are associated exacerbation of clinical signs in asthmatic patients.

Selected publications

  1. Jude JA, Dileepan M, Panettieri RA Jr, Walseth TF, Kannan MS. Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype. J Allergy (Cairo). 2012;2012:289468. Epub 2012 Nov 20.
  2. Joseph A. Jude, Mythili Dileepan, Subbaya Subramanian, Julian Solway, Reynold A. Panettieri, Timothy F.Walseth, Mathur S. Kannan. MiR-140-3p regulation of TNF-alpha-induced CD38 expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2012 Sep; 303(5):L460-468.
  3. Joseph A. Jude, Krishnaswamy G. Tirumurugaan, Bit Na Kang. Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan. Regulation of CD38 Expression in Human Airway Smooth Muscle Cells: Role of Class I Phosphatidylinositol 3 Kinases. Am J Respir Cell Mol. Biol. 2012 May 3 (Epub ahead of print).
  4. Joseph A. Jude, Reynold A. Panettieri Jr, Timothy F. Walseth and Mathur S. Kannan. TNF-alpha regulation of CD38 expression in human airway smooth muscle: Role of MAPK Kinases and NF-kB. Adv Exp Med Biol 2011. 691: 449-459.
  5. Joseph A. Jude, Julian Solway, Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan. Differential induction of CD38 expression by TNF-alpha in asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010, 299 (6): L879-890.
  6. Bit Na Kang, Joseph A. Jude*, Reynold A. Panettieri Jr, Timothy F. Walseth, Mathur S. Kannan. Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: Role of dual specificity phosphatase I. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L186-93 (*Co-first author)
  7. Alonso G.P. Guedes, Joseph A. Jude, Jaime Paulin, Hirohito Kita, Frances E. Lund, Mathur S. Kannan. Role of CD38 in TNF-alpha-induced airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L290-9.
  8. K.G. Tirumurugaan, J.A. Jude, B.N. Kang, R.A. Panettieri, T.F. Walseth, M.S. Kannan. TNF-alpha induced CD38 expression in human airway smooth muscle cells: role of MAP kinases and transcription factors NF-kappa B and AP-1. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1385-95.
  9. Joseph A. Jude, Mark E. Wylam, Timothy F. Walseth and Mathur S. Kannan. Calcium signaling in airway smooth muscle. Proc Am Thorac Soc (2008). 5 (1): 15-22.
  10. Joseph A. Jude, Timothy F. Walseth, Mathur S. Kannan. Role of cyclic ADP-ribose in calcium signaling in smooth muscle. In: New Frontiers in Smooth Muscle biology and Physiology 2007. Ed: Jean-Pierre Savineau. Transworld Research Network. pp 152-172.