Reynold A. Panettieri, Jr, M.D.

Description: Panettieri Photo.JPGRobert L. Mayock and David A. Cooper Professor of Medicine
Director, Airways Biology Initiative
Adjunct Professor, Wistar Institute
Deputy Director, Center of Excellence in Environmental Toxicology
University of Pennsylvania Medical Center
Pulmonary, Allergy, & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

tel.: (215) 573-9860
fax: (215) 746-1224
email: rap@mail.med.upenn.edu

Education: M.D., University of Pennsylvania, Philadelphia, PA

Residency: Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA

Dr. Panettieri directs the Airways Biology Initiative at the University of Pennsylvania. His interests are in the cellular and molecular mechanisms that regulate airway smooth muscle cell growth and the immunobiology of airway smooth muscle. Consequences of increases in airway smooth muscle growth promote the development of irreversible airflow obstruction and airway remodeling seen in subjects with chronic severe asthma. Dr. Panettieri's lab also focuses on cytosolic signaling pathways that mediate gene expression and alter myocyte function.

Dr. Panettieri also serves as the Deputy Director of the Center of Excellence in Environmental. He directs the human exposure chamber that defines the molecular mechanisms regulating ozone- and particulate matter-induced airway hyperresponsiveness.

In parallel with his basic science interests, Dr. Panettieri currently directs the comprehensive clinical program for the care of patients with asthma and is actively involved in clinical investigations focused on the management of asthma and COPD.

In addition to his research and clinical interests, Dr. Panettieri served as chairperson of the NIH Lung Cellular, Molecular, and Immunobiology Study Section, is a member of the NIH Distinguished Editorial Panel and is a member of the American Society for Clinical Investigation and Association of American Physicians.

Selected publications

  1. Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB. Beta-agonist-mediated relaxation of airway smooth muscle is PKA-dependent. J Biol Chem. 2014 Jun 27 [Epub ahead of print]
  2. Himes BE, Jiang X, Wagner P, Hu R, Wang Q, Klanderman B, Whitaker RM, Duan Q, Lasky-Su J, Nikolos C, Jester W, Johnson M, Panettieri RA Jr, Tantisira KG, Weiss ST, Lu Q. RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells. PLoS One. 2014 Jun 13;9(6):e99625. eCollection 2014.
  3. Damera G, Panettieri RA. Irreversible airway obstruction in asthma: What we lose, we lose early. Allergy Asthma Proc. 2014 Mar; 35(2):111-8.
  4. Balenga NA, Jester W, Jiang M, Panettieri RA Jr, Druey KM. Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. J Allergy Clin Immunol. 2014 Mar 22. [Epub ahead of print]
  5. Fitzgerald R, Desantiago B, Lee DY, Yang G, Kim JY, Brian Foster D, Chan-Li Y, Horton MR, Panettieri RA, Wang R, An SS. H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal KATP channel. Biochem Biophys Res Commun. 2014 Mar 7. [Epub ahead of print]
  6. Hu R, Pan W, Fedulov AV, Jester W, Jones MR, Weiss ST, Panettieri RA Jr, Tantisira K, Lu Q. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J. 2014 Feb 12. [Epub ahead of print]
  7. Kim WK, Jain D, Sanchez MD, Koziol-White CJ, Matthews K, Ge MQ, Haczku A, Panettieri RA Jr, Frieman MB, Lopez CB. Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation. Am J Respir Crit Care Med. 2014 Jan 13.
  8. Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri Jr RA, Liggett SB. Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2013 Nov 12.
  9. Columbo M, Wong B, Panettieri RA Jr, Rohr AS. The effect of multiple allergen immunotherapy on exhaled nitric oxide in adults with allergic rhinitis. Allergy Asthma Clin Immunol. 2013 Aug 19;9 (1):31.
  10. Columbo M, Wong B, Panettieri RA Jr, Rohr AS. Asthma in the elderly: The role of exhaled nitric oxide measurements. Respir Med. 2013 May; 107(5):785-7.
  11. Edelson JD, Makhlina M, Silvester KR, Vengurlekar SS, Chen X, Zhang J, Koziol-White CJ, Cooper PR, Hallam TJ, Hay DW, Panettieri RA Jr. In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-D-Ala-Gly-Arg-D-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pulm Pharmacol Ther. 2013 Apr;26(2):229-38. Epub 2012 Nov 12.
  12. Wang R, Mercaitis OP, Jia L, Panettieri RA, Tang DD. Raf-1, Actin Dynamics and Abl in Human Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2013 Feb;48 (2):172-8. Epub 2012 Oct 18.
  13. Jude JA, Dileepan M, Panettieri RA Jr, Walseth TF, Kannan MS. Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype. J Allergy (Cairo). 2012;2012:289468. Epub 2012 Nov 20.
  14. Bair AM, Turman MV, Vaine CA, Panettieri RA Jr, Soberman RJ. The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer. Mol Biol Cell. 2012 Nov;23(22):4456-64. Epub 2012 Sep 26.
  15. Gunst SJ, Panettieri RA Jr. Last Word on Point: Alterations in airway smooth muscle phenotype do cause airway hyperresponsiveness in asthma. J Appl Physiol. 2012 Sep;113(5):847. No abstract available. PMID: 22942224