Satish Sharma, Ph.D.

Description: Sharma picture.JPGResearch Specialist D
University of Pennsylvania Medical Center
Pulmonary, Allergy, & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

tel.: (215) 746-4097
fax: (215) 746-1224
email: shsatish@mail.med.upenn.edu

Education: Ph.D, Vallabhbhai Patel Chest Institute, University of Delhi, and Jamia Millia Islamia, New Delhi. India

Postdoctoral Fellowship: Thomas Jefferson University, Philadelphia, PA

Dr. Sharma joined the Airways Biology Initiative (ABI) in 2008 as a senior research scientist in Dr. Haczku's laboratory. His research interests in the Haczku lab have focused on investigating how inflammatory resolution is regulated after allergen induced airway changes. To this extent he has been studying the regulatory role of apoptosis in airway inflammation particularly in regards to the role played by Fas ligand. He has also been investigating the role of Resistin-Like Molecule (RELM)-Beta in chronic inflammation. His other studies have centered on studying the protective effects of surfactant protein D (SP-D).  He has been developing techniques to replace this protein by AAV2/9-SP-D and modified SP-D mRNA in SP-D knockout mice and he has started studies to investigate the effects of ozone exposure on bothexpression and function of SP-D in vitro and in vivo.  

Selected publications

  1. SK Sharma, FA. Almeida, S Kierstein, L Hortobagyi, T Lin, A Larkin, J Peterson, H Yagita, JG Zangrilli and A Haczku. Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma. Allergy. 2012 Mar; 67(3):328-35
  2. M Bailey , S Kierstein , SK Sharma , M Spaits , S Kinsey , O Tliba , Y Amrani , J Sheridan, RA Panettieri, Jr., A Haczku. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production. Journal of Immunology 2009; 182: 7888 - 7896.
  3. S Kierstein, K Krytska, SK Sharma, Y Amrani, M Salmon, R A Panettieri Jr, J Zangrilli, A Haczku. Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice. Allergy 2008, 63 (4) 438-446.
  4. SK Sharma, FA. Almeida, S Kierstein, L Hortobagyi, T Lin, A Larkin, J Peterson, H Yagita, JG Zangrilli and A Haczku. Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma. Allergy. 2012 Mar;67(3):328-35
  5. S.K. Sharma, M Fehrenbach, B Ducka, S Kierstein, C Koziol-White, G Wu, A Haczku. Chronic Inflammation Is Associated With Increased Resistin-Like Molecule (RELM)-Beta Expression In Surfactant Protein D (SP-D) Knockout Mice. (Manuscript in preparation).
  6. S K. Sharma, B Ducka, I Redai, A R Gupta, C Koziol-White, M Limberis, JM. Wilson, A Haczku. Rescue of lung innate immune cell abnormalities by SP-D replacement in SP-D-/- mice. (Manuscript in preparation).
  7. S.K. Sharma, M Fehrenbach, B Ducka, S Kierstein, C Koziol-White, G Wu, A Haczku. Chronic Inflammation Is Associated With Increased Resistin-Like Molecule (RELM)-Beta Expression In Surfactant Protein D (SP-D) Knockout Mice. Am J Respir Crit Care Med 183;2011:A2770