Single Nucleotide Polymorphisms in Human AKR Genes

as of February 18, 2007

Listed below are documented single nucleotide polymorphisms (SNPs) as found in the NCBI SNP database for the human AKRs. To date, these have all been discovered by large scale sequencing projects, although it is expected that in the future individual investigators will report their findings as the technology improves. The only SNPs listed below are those that are found in exons. In future updates, if a SNP is found to result in a change of protein activity or stability, those findings will be included in this table.

To learn more about the AKR SNP nomenclature, please check here.

  Exon Cluster ID Function Location AA change Date Nomenclature
AKR1A1              
  8 rs17849990 syn A558G E186 8/25/04 AKR1A1*1
  5 rs2229540 nonsyn A155G N52S 6/28/01 AKR1A1*2
  5 rs6690497 nonsyn G165C E55D 6/27/03 AKR1A1*3
AKR1B1              
  5 rs5060 syn G423A T141 6/29/99 AKR1B1*1A
  9 rs1803093 syn C864T T288 10/7/00 AKR1B1*1B
  7 rs3210035 syn C663A A221 4/26/02 AKR1B1*1C
  11 rs11544689 syn C936T F312 11/18/03 AKR1B1*1D
  2 rs17849987 syn A6T A2 8/25/04 AKR1B1*1E
  2 rs5054 nonsyn A43T I15F 6/29/99 AKR1B1*2
  3 rs5057 nonsyn C217G L73V 6/29/99 AKR1B1*3
  3 rs5056 nonsyn A125T H42L 6/29/99 AKR1B1*4
  7 rs5061 nonsyn G610A G204S 6/29/99 AKR1B1*5
  10 rs5062 nonsyn C863T T288I 6/29/99 AKR1B1*6
  4 rs4728325 nonsyn A268G K90E 2/12/03 AKR1B1*7
  6 rs11544687 nonsyn C521T P174L 11/18/03 AKR1B1*8
  5 rs17856148 nonsyn T424C W142R 8/25/04 AKR1B1*9
AKR1B10              
  3 rs1722883 syn T75C L25 11/3/00 AKR1B10*1A
  2 rs2005412 syn G9A T3 1/2/01 AKR1B10*1B
  8 rs2257306 syn G666A K222 9/20/01 AKR1B10*1C
  8 rs2257307 syn A672G E224 9/20/01 AKR1B10*1D
  8 rs2347382 syn A669T P223 9/20/01 AKR1B10*1E
  2 rs11545284 syn C21T L7 11/8/03 AKR1B10*1F
  11 rs17856271 syn G936A L312 8/25/04 AKR1B10*1G
  7 rs28545160 syn A576G T192 3/11/05 AKR1B10*1H
  4 rs2303312 nonsyn C259T P87S 9/5/01 AKR1B10*2
  10 rs3735042 nonsyn T857C M286T 7/24/02 AKR1B10*3
  11 rs4728329 nonsyn A937G N313D 2/12/03 AKR1B10*4
AKR1C1              
  4 rs15986 syn C342T Y114 8/23/99 AKR1C1*1A
  3 rs1138567 syn T103C L35 9/13/00 AKR1C1*1B
  6 rs7097713 syn G549A K183 6/29/03 AKR1C1*1C
  3 rs1138569 nonsyn A112G T38A 9/13/00 AKR1C1*2A
  3 rs1138570 nonsyn C113T T38I 9/13/00 AKR1C1*2B
  3 rs1138575 nonsyn G140A R47H 9/13/00 AKR1C1*3
AKR1C2              
  6 rs13933 nonsyn A259T S87C 8/23/99 AKR1C2*2
  8 rs11474 nonsyn T515A L172Q 8/23/99 AKR1C2*3
  8 rs10618 nonsyn A509G H170R 8/23/99 AKR1C2*4
  8 rs2518042 nonsyn A535G K179E 9/24/01 AKR1C2*5
  5 rs2854482 nonsyn T137A F46Y 9/26/01 AKR1C2*6
  6 rs2854486 nonsyn T332C V111A 9/26/01 AKR1C2*7
  5 rs3207905 nonsyn A140G H47R 4/26/02 AKR1C2*8
  5 rs3207898 nonsyn G112A V38I 4/26/02 AKR1C2*9
  5 rs3207901 nonsyn T113C V38A 4/26/02 AKR1C2*10
  10 rs28943580 nonsyn C772T R258C 5/19/05 AKR1C2*11
AKR1C3              
  3 rs7741 syn G90A P30 8/23/99 AKR1C3*1A
  4 rs12387 syn G312A K104 8/23/99 AKR1C3*1B
  6 rs1131124 syn G495A V165 9/13/00 AKR1C3*1C
  3 rs1804061 syn A117G K39 11/7/00 AKR1C3*1D
  6 rs1937839 syn G459A K153 1/3/01 AKR1C3*1E
  8 rs7342072 syn C705T L235 7/3/03 AKR1C3*1F
  6 rs17849485 syn C546T L182 8/25/04 AKR1C3*1G
  3 rs28943574 syn A231G E77 5/19/05 AKR1C3*1H
  1 rs12529 nonsyn C15G Q5H 8/23/99 AKR1C3*2
  6 rs1131132 nonsyn C525G M175I 9/13/00 AKR1C3*3
  3 rs1804062 nonsyn G106T E36term 11/7/00 AKR1C3*4
  9 rs1804059 nonsyn G879T M293I 11/7/00 AKR1C3*5
  4 rs4987102 nonsyn G316A A106T 2/14/03 AKR1C3*6
  3 rs11551177 nonsyn A230G E77G 11/18/03 AKR1C3*7
  9 rs11551178 nonsyn G883T A295S 11/18/03 AKR1C3*8
  5 rs28943579 nonsyn G434A C145Y 5/19/05 AKR1C3*9
  8 rs28943580 nonsyn C772T R258C 5/19/05 AKR1C3*10
AKR1C4              
  3 rs17306779 syn A105G V35 8/10/04 AKR1C4*1
  5 rs3829125 nonsyn C434G S145C 8/12/02 AKR1C4*2
  8 rs4880718 nonsyn A749G R250Q 2/12/03 AKR1C4*3
  5 rs11253043 nonsyn G404A G135E 11/17/03 AKR1C4*4
  10 rs17134592 nonsyn C931G L311V 8/10/04 AKR1C4*5
  6 rs17851824 nonsyn G509A C170Y 8/25/04 AKR1C4*6
AKR1D1              
  none            
AKR6A3              
  13 rs2280031 syn T1065C N355 9/5/01 KCNAB1*1A
  2 rs9812862 syn C234T S79 11/5/03 KCNAB1*1B
AKR6A5              
  7 rs11121193 syn C276T A92 11/14/03 KCNAB2*1A
  7 rs11542387 syn T255C D85 11/18/03 KCNAB2*1B
AKR6A9              
  none            
AKR7A2              
  6 rs2231202 syn C753T F251 7/19/01 AKR7A2*1A
  8 rs11550269 syn T1014G A338 11/18/03 AKR7A2*1B
  3 rs859208 nonsyn G471C Q157H 9/2/00 AKR7A2*2
  4 rs859210 nonsyn G538A E180K 9/2/00 AKR7A2*3
  3 rs1043657 nonsyn G424A T142A 9/13/00 AKR7A2*4
  5 rs2231200 nonsyn G592A G198S 7/19/01 AKR7A2*5
  6 rs2231203 nonsyn G764A S255N 7/19/01 AKR7A2*6
  8 rs2231206 nonsyn C935T A312V 7/19/01 AKR7A2*7
  3 rs6670759 nonsyn G403A V135M 6/27/03 AKR7A2*8
  2 rs12753516 nonsyn G249T E83D 3/18/04 AKR7A2*9
AKR7A3              
  3 rs1774079 syn C357T T119 11/3/00 AKR7A3*1A
  6 rs1738024 syn T645C N215 11/3/00 AKR7A3*1B
  8 rs2995181 syn T969C T323 10/15/01 AKR7A3*1C
  4 rs17852284 syn G501C V167 8/25/04 AKR7A3*1D
  8 rs17852953 syn C939T D313 8/25/04 AKR7A3*1E
  6 rs1738023 nonsyn A643G N215D 11/3/00 AKR7A3*2
  8 rs1738025 nonsyn A967G T323A 11/3/00 AKR7A3*3
  4 rs2231198 nonsyn G412A V138M 7/19/01 AKR7A3*4