Table 3: Three-Dimensional Structures of AKR Proteins.

as of September 3, 2008

AKR Res. Complex PDB
1A1 (Human ALR) 2.48 Å NADP 2ALR
1A2 (Porcine ALR) 2.40 Å NADP, tolrestat 1AE4
1A2 2.00 Å NADP 1CWN
1A2 1.85 Å NADP, fidarestat 2AO0
1A2 ---Y50F 2.20 Å NADP 1HQT
1B1 (human ADR) 1.65 Å NADP 1ADS
1B1 1.80 Å NADP, zopolrestat 1MAR
1B1 1.76 Å NADP, citrate 2ACS
1B1 1.76 Å NADP, cacodylate 2ACR
1B1 1.76 Å NADP, glucose-6-phosphate 2ACQ
1B1 2.80 Å NADP, fidarestat 1EF3
1B1 1.70 Å  NADP, IDD384 1EL3
1B1 2.50 Å NADP, zenarestat 1IEI
1B1 1.80 Å NADP, IDD552, pH 5 1T40
1B1 1.05 Å NADP, IDD552 1T41
1B1 0.66 Å NADP, IDD594 1US0
1B1 1.10 Å NADP, minalrestat 1PWL
1B1 0.92 Å NADP, fidarestat 1PWM
1B1 1.40 Å NADP, citrate 1X96
1B1 1.40 Å NADP, fidarestat stereoisomer 2R4S 1X97
1B1 1.30 Å NADP, fidarestat stereoisomer 2S4R 1X98
1B1 --- C298A 2.40 Å NADPH 1ABN
1B1 --- R268A 2.10 Å Apo 1XGD
1B1 --- Y48H 1.76 Å NADP, citrate 2ACU
1B1 --- W219Y/C298A 1.80 Å NADP, alrestatin 1AZ1
1B1 --- W219Y/C298A 2.90 Å NADP, citrate 1AZ2
1B1 --- L300P 1.00 Å NADP, fidarestat 2AGT
1B1 1.90 Å NADP, phenylacetic acid 2INE
1B1 --- W219Y/C298A 2.00 Å NADP, phenylacetic acid 2ISF
1B1 1.70 Å NADP, dichlorophenylacetic acid 2IS7
1B1 2.00 Å NADP, lipoic acid 2IQD
1B1 1.95 Å NADP, hexanoic acid 2IQ0
1B1 --- W219Y/C298A 2.00 Å NADP, dichlorophenylacetic acid 2IPW
1B1 1.95 Å NADP, hydroxyphenylacetic acid 2INZ
1B6 (porcine ADR) 3.00 Å ADPRP 1DLA
1B6 2.00 Å NADP 1AH4
1B6 2.30 Å NADP, tolrestat 1AH3
1B6 2.30 Å NADP, sorbinil 1AH0
1B6 2.20 Å NADP, IDD384 1EKO
1B8 (mouse FR-1) 1.70 Å NADP, zopolrestat 1FRB
1B9 (CHO AKR) 2.40 Å NADP 1C9W
1B10 1.25 Å NADP, tolrestat 1ZUA
1C1 1.59 Å NADP, 20a-hydroxyprogesterone 1MRQ
1C2 (human 3a-HSD type 3) 3.00 Å NADP, ursodeoxycholate 1IHI
1C2 1.25 Å NADP, testosterone IJ96
1C2 1.90 Å NADP, citrate, acetate 1XJB
1C3 (human 17b-HSD type 5) 1.69 Å NADP, PGD2 1RY0
1C3 1.69 Å NADP, rutin 1RY8
1C3 1.20 Å NADP, acetate 1S1P
1C3 2.00 Å NADP, acetate 1S1R
1C3 1.70 Å NADP, indomethacin 1S2A
1C3 1.80 Å NADP, flufenamic acid 1S2C
1C3 2.00 Å NADP, 4-androstenedione-3,17-dione 1XF0
1C3 1.30 Å NADP, EM1404 1ZQ5
1C3 2.40 Å NADP, PEG 2FGB
1C4 (human 3a-HSD type 1) 2.40 Å NADP 2FVL
1C5 (rabbit 20a-HSD type 3) 2.08 Å NADP, testosterone 1Q13
1C5 1.32 Å NADP 1Q5M
1C9 (rat 3a-HSD) 3.00 Å Apo 1RAL
1C9 2.70 Å NADP 1LWI
1C9 2.50 Å NADP + testosterone 1AFS
1D1 (human 5b-reductase) 1.90 Å NADP + cortisone 3CMF
1D1 1.79 Å NADP + glycerol 3BV7
1D1 2.03 Å NADP + progesterone 3COT
1D1 1.62 Å NADP + testosterone 3BUR
1D1 1.35 Å NADP + HEPES 3BUV
1D1 1.9 Å NADP + 5beta-pregnan-3,20-dione 3CAV
2B5 (Candida tenuis Xylose reductase) 2.20 Å Apo 1JEZ
2B5 2.10 Å NADP 1K8C
2B5 1.80 Å NAD 1MI3
2B5 ---- H114A 2.20 Å NADP 1R38
2B5 ---- K274R/N276D 2.20 Å NAD 1SM9
2B5 ---- K274R 2.40 Å NAD 1YE4
2B5 ---- K274R 2.30 Å NADP 1YE6
2B5 ---- N309D 2.40 Å NAD 1Z9A
3A1 (Sac. Gcy1p) 2.50 Å NADP in progress
4A2 (Chalcone Reductase) 1.70 Å NADP 1ZGD
5C (Corynebacterium 2,5-diketo-D-gluconate reductase) 1.90 Å Apo 1HW6
5C1 (Coryne. 2,5-DKG Reductase) 2.10 Å NADPH 1A80
5C (Thermotoga mariti) 2.40 Å NADP 1VP5
6A2 (Rat Shaker b-subunit) 2.80 Å NADP 1QRQ
6A2 2.90 Å NADP, K 2A79
6A5 (Human K channel b-subunit 2) 1.90 Å NADP, Cl 1ZSX
7A1 (rat aflatoxin aldehyde reductase) 1.38 Å NADP, citrate 1GVE
7A2 2.40 Å NADPH, citrate 2BP1
7A5 2.30 Å NADP, tartate 2C91
11A1 1.80 Å Apo 1PYF
11A1 2.35 Å NADP 1PZ0
11B1 2.20 Å NADP 1PZ1
11C1 1.25 Å Apo 1YNP
11C1 1.30 Å NADP 1YNQ
YDHF, from E coli 2.80 Å NADP 1OG6
YDHF, from E coli 2.57 Å Apo 1UR3
Tas Protein from E coli 1.60 Å NADP 1LQA
Hypothetical 35.2 kDa Protein 1.60 Å   1QWK

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