Perelman School of Medicine at the University of Pennsylvania

Anesthesia Faculty Scholarship Newsletter

Newsletter Archives

2015 Summer

Research Highlights

Photo of Mark Neuman, MD

Mark Neuman, MD, Assistant Professor, was awarded an $11.9 million PCORI grant to evaluate anesthetic type on outcomes after hip fracture surgery in older adults. Find out how he became interested in research, what he’s working on now, how this research may impact our patients, and more…

Q: How did you become interested in research?

Mark: My first exposure to research came in medical school, through work I did with faculty at UCSF in international tobacco control policy. As an anesthesiologist, I've tried to apply the broad public health perspective that came from my experience in tobacco control research to studying the perioperative setting. Most of my work focuses on outcomes after hip fracture, a surgical condition that affects over 300,000 older adults in the US each year and 1.6 million individuals annually worldwide, with substantial associated morbidity, mortality and cost. Finding ways to improve outcomes for this group of patients through better perioperative care offers a genuine opportunity for anesthesiologists to impact public health on a large scale.

Q: What are you working on now?

Mark: In September, we will be starting work on a 1,600-patient, multicenter randomized controlled trial to compare outcomes at up to one year among patients aged 50 and older who receive spinal versus general anesthesia for hip fracture surgery. This project built on work I have done with colleagues here at Penn and elsewhere to look at this question using administrative data. Our new project, called the REGAIN Trial--Regional versus General Anesthesia for Promoting Independence after Hip Fracture--will be funded by the Patient Centered Outcomes Research Institute and will build on and go beyond this prior work. In contrast to our prior work, which was retrospective, REGAIN will compare outcomes after spinal versus general anesthesia through a prospective randomized trial; additionally, we'll be measuring a range of patient-centered outcomes, including measures of cognition, functional recovery, and pain, that have not been previously examined.

Q: What are some of the things you've learned in the process of developing this study?

Mark: A big learning point for me here was to understand just how many trade-offs are involved in designing a large-scale randomized trial. Our goal in putting REGAIN together has been to design a pragmatic study--in other words, a trial that approximates "real world" conditions to yield evidence that can be generalized to actual clinical practice. Doing this has involved a number of conscious design choices that required making tradeoffs between creating a study that would represent clinical practice, be tightly designed enough to answer our specific question, and actually be feasable to implement on a national scale.

Q: What impact do you envision this work having on clinical practice?

Mark: Our hope is that the REGAIN trial will yield meaningful insights that will help practicing anesthesiologists, patients and families to make better decisions about hip fracture care. At the same time, we also hope that REGAIN will be a starting point for other large-scale trials to produce better and better evidence about the effectiveness of different anesthesia regimens for hip fracture and other surgeries.

 

Education Highlights

Photo of David Eckmann, PhD, MD

David Eckmann, PhD, MD, has been teaching a unique undergraduate bioengineering class for the past 17 years, the last 11 as course director. Cumulatively, over 700 Penn junior and senior students in his BE400 course, “Clinical Preceptorship in Bioengineering,” have attended a series of 12 to 14 lectures given by Penn faculty who are internationally recognized clinical scientists, visited the Measey Simulation Suite and also engaged in an 11-week preceptorship, during which time they have served as engineering consultants to one of Penn’s practicing clinicians. The course introduces students to a wide variety of topics from deep brain stimulation to breast cancer imaging to the use of information systems within clinical medicine.

In addition to having to complete course assignments, such as papers, WIKIs and elevator presentations, students are paired up with a clinical preceptor from the Perelman School of Medicine, the School of Dental Medicine or the School of Veterinary Medicine. In addition to Dr. Eckmann, a number of other Department of Anesthesiology and Critical Care faculty, including Drs. Kofke, Mandel, Atkins, Kelz and Cereda, have served as preceptors. Their role is to challenge students to engage in an intellectual project that applies engineering principles to healthcare needs in order to improve and advance patient care.

“This course is designed to promote student insights into the role of bioengineering in the practice of clinical medicine,” Dr. Eckmann explains. “This course places students at the forefront  of biomedicine through their nascent engineering skillsets.” Dr. Eckmann adds that the preceptorship is not meant to be simply clinical shadowing. Instead, students are expected to engage fully and participate actively in problem-solving strategies. Results of work accomplished in the course have led to publications, intellectual property and, most importantly, have helped to highlight future career choices for hundreds of Penn undergrads.

 

Grants and Funding

Image of the NIH logoFY2015

Total Grants Submitted/amount :  42 / $39,946,472

Number Grants Funded/amount:   22 / $7,350,602

(UPENN only, not including CHOP)

 

 

UPENN Grant Proposals Submitted FY2015

Faculty Name

Type

Project Title

Sponsor

Total Cost

ARMSTEAD, WM

New

The Moody Project

UNIV OF TEXAS MEDICAL BRANCH

       102,647

ARMSTEAD, WM

Rev

Acute Intranasal GDNF Delivery as a Novel Therapy for Traumatic Brain Injury

UNIV OF TEXAS MEDICAL BRANCH

       240,000

ARMSTEAD, WM

Rev

tPA, NMDA receptor excitotoxicity, and outcome after stroke

NATIONAL INSTITUTES OF HEALTH

    3,104,505

ARMSTEAD, WM

New

tPA, NMDA receptor excitotoxicity, and outcome after stroke

American Heart Assoc (Affiliate)

       154,000

ARMSTEAD, WM

New

Vasoactive Agents and Cerebral Outcomes in Brain Injury

University of Washington

         63,648

ARMSTEAD, WM

Rev

Pressor Choice Influences Protection Of Autoregulation in Brain Injury

NATIONAL INSTITUTES OF HEALTH

    2,070,105

ASCH, DA

Rev

Training in Critical Care Health Policy Research

NATIONAL INSTITUTES OF HEALTH

    3,136,484

ASHBURN, MA

New

A Multicenter, Randomized, Double-Blinded,Placebo-Controlled Study Using a Bayesian Adaptive Design to Assess the Efficacy, Safety, Tolerability, and Serum Exposure of Multiple Doses of BG00010 (Neublastin) in Subjects with Painful Lumbar Radiculopathy

BIOGEN IDEC

       265,192

CEREDA, MF

New

An Imaging Approach to Measure and Contain Lung Injury

NATIONAL INSTITUTES OF HEALTH

    3,890,315

ECKENHOFF, RG

New

TORIE blood supplement

MOUNT SINAI SCHOOL OF MEDICINE

       291,490

ECKENHOFF, RG

New

Post-operative Cognitive Dysfunction (POCD) Nomenclature Workshop

BAXTER HEALTHCARE CORPORATION

           8,900

ECKENHOFF, RG

New

Anesthetic-induced myocardial depression: molecular mechanisms and reversal by nitroxyl

Johns Hopkins University

       201,897

ECKENHOFF, RG

New

The Impact Of Surgery-Induced Neuroinflammation On Tau Pathology And Function

Columbia University

       112,345

ECKMANN, DM

New

Smart Nanografted Infection-Responsive Catheters, Endotracheal Tubes & Implants

NATIONAL INSTITUTES OF HEALTH

    2,474,544

ECKMANN, DM

New

Inflammatory biomarkers of aortic valve disease; diagnosis and treatment

Children's Hospital of Philadelphia

    1,762,674

ECKMANN, DM

Resub

Inflammatory biomarkers of aortic valve disease; diagnosis and treatment

Children's Hospital of Philadelphia

       717,890

ECKMANN, DM

New

SpotKT: A High throughput particle based binding kinetics platform for diagnostics and nanomedicine

OPTOFLUIDICS, INC.

       148,189

ECKMANN, DM

New

NCval: Rapid binding assessment of nanocarriers designed for cancer chemotherapy

OPTOFLUIDICS, INC.

       148,189

ELKASSABANY, NM

CC

Risk Factors for Development of Chronic Pain After Total Knee Arthroplasty

Groff Foundation

         77,812

Kelz, MB

CC

Reconstructing Consciousness and Cognition, Phase 2

University of Michigan

       604,860

KOFKE, WA

New

Validation by PET of a Noninvasive  Neurometabolic and CBF Monitor in Humans

NATIONAL INSTITUTES OF HEALTH

    1,316,879

LAUDANSKI, K

New

Long-term decline in acquired immunity after cardiopulmonayr bypass

American Heart Assoc (Affiliate)

       231,000

LAUDANSKI, K

New

Long-term decline in acquired immunity after cardiopulmonary bypass

American Heart Assoc (National)

       308,000

LAUDANSKI, K

New

Protracted aberration of monocyte differentiation after cardiopulmonary bypass

NATIONAL INSTITUTES OF HEALTH

    1,239,100

LAUDANSKI, K

Resub

Long-term decline in acquired immunity after cardiopulmonary bypass

American Heart Assoc (Affiliate)

       231,000

LAUDANSKI, K

Rev

Long-term decline in acquired immunity aftercardiopulmonary bypass

American Heart Assoc (National)

       308,000

LAUDANSKI, K

Rev

Long - term acquired immunity deficit post severe stress

Foundation for Anesthesia Education and Research

       175,000

LAUDANSKI, K

Rev

Immuno-aberration due to the protracted M-CSF secretion  in patients undergoing cardiopulmonary bypass surgery

Society of Cardiovascular Anesthesiologists

         50,000

LIU, R

New

Salvinorin A for neonatal hypoxia/ischemia brain injury

CETAZAM, LLC

       142,878

LIU, R

Rev

Salvinorin A for cerebral vascular spasm and ischemia

CETAZAM, LLC

       142,878

LIU, R

New

Kappa opioid receptor and brain hypoxia/ischemia

NATIONAL INSTITUTES OF HEALTH

       440,000

LIU, R

Supp

Water soluble variants of the human mu opioid receptor

National Institute of General Medical Sciences/NIH/DHHS

         93,315

NEUMAN, MD

New

A PRACTICAL INTERVENTION TO IMPROVE PATIENT-CENTERED OUTCOMES AFTER HIP FRACTURES AMONG OLDER ADULTS (REGAIN TRIAL)

Patient Centered Outcomes Research Institute (PCORI)

  11,869,193

OCHROCH, EA

New

Genetic Susceptibility to Elevated Acute Pain and Development of Chronic Pain after Thoracic Surgery for Lung Cancer

National Institute on Drug Abuse/NIH/DHHS

    3,707,960

PATEL, PA

New

A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass; LEVO-CTS

Tenax Therapeutics

         98,038

PIZZINI, MD

New

Development of a Novel Device for Use in Nausea and Vomiting in Pediatric, Post-Operative, and Post-Chemotherapy Patients

Ablaze Development Corp.

         17,545

# Proposals

36

 

TOTAL

  39,946,472

New;     New proposals

Rev;       revised proposal

CC;         competing continuation/renewal

Supp;    Supplement

 

UPENN Grant Awards FY2015

PI

Sponsor

Title

Type

Total

ASCH, DA

NIH

Training in Critical Care Health Policy Research

New

521,256

ASHBURN, MA

GW PHARMACEUTICALS

A double blind, randomized, placebo-controlled, parallel group study of Sativex oromucosal spray (Sativex; Nabiximols) in relieving pain in patients with advanced cancer, who experience inadequate analgesia during optimized chronic opioid therapy

Ext.

48,109

ASHBURN, MA

GW PHARMACEUTICALS

A multicenter, non-comparative, open-label extension study to assess the long term safety of Sativex oromucosal spray (Sativex; Nabiximols) as adjunctive therapy in patients with uncontrolled persistent chronic cancer related pain

Ext.

23,134

ECKENHOFF, RG

NIH

Interaction of Inhaled Anesthetics with Macromolecules

NCR

1,714,870

ECKENHOFF, RG

NIH

Interaction of Inhaled Anesthetics with Macromolecules

NCR

1,710,408

ECKENHOFF, RG

BAXTER HEALTHCARE CORPORATION

The Fourth International Workshop on Perioperative Neurotoxicity in the Elderly

New

15,000

ECKENHOFF, RG

BAXTER HEALTHCARE CORPORATION

Post-Operative Cognitive Dysfunction (POCD) Nomenclature Workshop

New

8,900

ECKMANN, DM

NIH

Targeted Microcarrier Design and Optimization

NCR

478,139

ECKMANN, DM

NIH

Bridging multiple scales in modeling targeted drug nanocarrier delivery

NCR

524,210

ECKMANN, DM

OFFICE OF NAVAL RESEARCH

Coupling of Metabolic and Mechanical Function in Cell Physiology

Ext.

360,000

ELKASSABANY, NM

GROFF FOUNDATION

Risk Factors for Development of Chronic Pain After Total Knee Arthroplasty

New

49,281

KELZ, MB

NIH

Optoanesthesia

New

322,867

KOFKE, WA

NIH

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

NCR

578,213

KOFKE, WA

ORNIM MEDICAL

An Observational Study Evaluating the Ability of CerOx Monitor to Show Changes in Cerebral Blood Flow in Stroke Patients Undergoing Endovascular Recanalization

New

3,975

LANE-FALL, MB

ANESTHESIA PATIENT SAFETY FOUNDATION

Optimizing handoffs from operating room to intensive care unit

NCR

75,000

LIU, R

NIH

Water soluble variants of the human mu opioid receptor

New

316,894

LIU, R

NIH

Water soluble variants of the human mu opioid receptor

Suppl

93,315

MCKINSTRY-WU, AR

FOUNDATION FOR ANESTHESIA EDUCATION AND RESEARCH

Top-Down or Bottom-Up: Neuronal Mechanism of Alkylphenol Anesthesia

New

75,000

PATEL, PA

TENAX THERAPEUTICS

A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass; LEVO-CTS

Ext.

154

PATEL, PA

TENAX THERAPEUTICS

A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass; LEVO-CTS

New

4,224

WEI, H

NIH

Mechanisms of Anesthesia Mediated Neurotoxicity

NCR

324,894

TOTAL AWARDS:

        21

 

TOTAL 

7,350,602

New;      New Grant

NCR;      Non-Competing Renewal

Ext ;        Extension

 

Publications

As of today, over 100 peer reviewed publications from the Department, including CHOP, have been posted in PubMed since January 1, 2015.

Image of PubMed logo
 
 
See all publications…

 

Announcements and Awards

Press Releases 

April 2015: Roderic Eckenhoff, MD and the Department of Chemistry’s Jeffery Saven, PhD, studied the anesthetic drug ketamine and found that it binds to unique olfactory receptors.  Penn Medicine News Release

January 2015: Roderic Eckenhoff, MD and Andrew McKinstry-Wu, MD have made a discovery that could lead to the development of the first new general anesthetics in 40 years.  Penn Medicine News Release

January 2015: Mark Neuman, MD and Lee Fleisher, MD show that online marketing for transcatheter aortic valve replacement often omits the associated risks. Penn Medicine News Release

August 2014:  Mark Neuman, MD cautions that the rapid adoption of one or two studies as the basis for clinical practice, even if they are randomized controlled trials, can lead to misinformation and potential harm.  Penn Medicine News Release

August 2014: Joshua Atkins, MD, PhD and Jeffrey Mandel, MD led a team of researchers studying a new anesthesia procedure to help doctors safely and effectively evaluate sleep apnea patients for surgery.  Penn Medicine News Release

July 2014: David Eckmann, PhD, MD found that when delivered by a microscopic transporter called a nanocarrier, steroids can access the hard-to-reach lung endothelial cells that need it most and are successful at preventing inflammation in mice.  Penn Medicine News Release

 

Awards

Maurizio Cereda, MD was awarded the 2014-2015  Clinical Excellence and Critical Care Teaching Award by the Trauma and Critical Care Medicine Fellows this year.  It was presented at the Trauma  and CCM Fellowship Graduation.

Mark Neuman, MD, MSHP has been named the 2015 Recipient of the ASA Presidential Scholar Award.   This is the second time in the last 10 years during which a member of the Department has received this prestigious honor

Kryzstof Laudanski, MD, PhD won the top Kosaka  Award, including a cash prize, for the best abstract for Basic Science Research at the IARS annual meeting in March 2015. The Kosaka Awards Session was in honor of the anniversary of 25 years of collaboration between the JSCA and IARS is supported by the Japan Society for Clinical Anesthesia (JSCA) and the International Anesthesia Research Society (IARS).

Faculty awards at the 2015 resident graduation:

Leadership Positions 

Bob Gaiser, MD  was elected chair of the Anesthesiology Resident Review Committee.  In this role, he will have a major influence on the manner in which anesthesiology training is performed and evaluated in the US.

Alan Jay Schwartz, MD became the Editor-in-Chief of Anesthesia & Analgesia: Case Reports. This is an outstanding recognition of Alan’s long-standing career as an anesthesia educator. Also on Anesthesia & Analgesia's editorial board is Jeff Feldman, MD.

Mark Neuman, MD was appointed Associate Editor for Anesthesiology, to accompany associate editors, Ron Litman, DO and Alan Jay Schwartz, MD

W. Andrew Kofke, MD became President-Elect and William Armstead, PhD is a Director of the Society for Neuroscience in Anesthesia and Critical Care (SNACC).

 

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2015 Fall

Research Highlights

Photo of Andrew McKinstry-Wu, MD, Max Kelz, MD, PhD, and Alex Proekt, MD

The department has for decades been engaged in research on how general anesthetics interact with proteins to cause their dysfunction but, with the recruitment of Max Kelz, MD, PhD to the faculty a decade ago, the research focus grew to try to understand how this protein level work actually changed cellular behavior, and thereby network and organ level behavior; how did the myriad drug effects actually cause unconsciousness?  Max, drawing on his clinical experience with narcoleptic patients, wondered whether very specific areas of the brain that controlled arousal state, might also be specific network-level targets of general anesthetics. In other words, might general anesthetics “hijack” these centers to produce a less reversible form of sleep? Funded by two RO1s from the NIH, Max has indeed revealed that important contributions to the anesthetic state are made by interactions at specific deep brain centers, such as VLPO and MNPO, and that anesthetics differ amongst their ability to hijack these sites. The work is proceeding using a variety of sophisticated tools, such as stereotactic microinjection and optogenetics, to explore the full range of largely deep hypothalamic nuclei to map their contributions and pharmacologic differences.  Lab members contributing to this work include former graduate students Jason Moore and Hilary McCarren, and currently by Kaitlyn Maier and Sarah Reitz.

Another current NUG member, Andrew McKinstry-Wu, MD, worked with Max Kelz during his residency, became a post-doctoral fellow in the Kelz lab, and is now on the standing faculty.  His work, funded by a FAER Young Investigator Award, asked specifically whether the Locus Coeruleus (LC) might be a critical center for emergence from anesthesia. Co-opting a tool from the Eckenhoff lab, he is administering novel photo-active molecules systemically to mice and then using fiberoptics implanted in the LC to covalently lock these drugs to their molecular targets, in order to produce a very slowly reversible drug action. This has had dramatic effects, in some cases extending the normal 5 minutes of propofol-induced immobility to several hours after targeted illumination. Andrew states that this work also has the important benefit of actually identifying the molecular targets within the LC using high-resolution mass spectrometry in collaboration with the Eckenhoff Lab.

Most recently, Alex Proekt, MD, PhD, was recruited from Cornell to add entirely new expertise and approaches to the NUG. Alex’s focus is on neuroanesthesia with an interest in computational modeling of the EEG changes as a patient (or animal) proceeds through consciousness to unconsciousness and back again.  His NIH K-award examines the existence of metastable substates that are not necessarily followed obligatorily as the changes in states proceed.  These various substates may explain the differences patients exhibit as they emerge from anesthesia, or the persistent vegetative states or awareness-under anesthesia. He also has a strong laboratory component to his work, exploring the “bottom-up” nature of how deeper centers of the brain might control the entry into and emergence from the anesthetic state. 

In Summary, the PennAnesthesia NUG is a terrific example of the critical mass concept. The congregation of unique, but overlapping and complementary, skill sets and interests leads to much more than the sum of the parts. The group occupies about 1300 square feet of the Longnecker Labs on John Morgan 3 and serves as a hub for productive collaborations throughout PSOM, CHOP, HUP and UPENN in general; not unlike how the deep brain centers serve as a hub for the state of anesthesia.

Education Highlights

Photo of Josh Atkins, MD, PhD and Renyu Liu, MD, PhD

Penn Anesthesiology has been engaged with Chinese Anesthesiology for many years and is now established in China as one of the highest impact US academic anesthesiology programs.  The program really began with three Penn faculty.  Renyu Liu, MD, PhD was recruited by our previous chair, David Longnecker, MD, as a postdoctoral fellow with Roderic Eckenhoff, MD.  Shortly afterwards, Huafeng Wei, MD, PhD was recruited into the PennAnesthesia residency program and he used his connections in China to begin recruiting visiting scholars to his laboratory.  Josh Atkins, MD, PhD, also a product of our residency, has had a longstanding interest in Chinese culture and medicine and, together with Renyu Liu, formalized the relationship with Chinese anesthesiology in 2008 under the leadership of our current chair, Lee Fleisher, MD.  The goal of this Penn-China Anesthesiology Partnership is to promote the development of academic anesthesiology in China and to facilitate Penn Medicine’s engagement in Chinese healthcare.      

The Penn-China Anesthesiology Partnership, co-directed by Renyu and Josh, has been growing steadily and expanding in scope and impact.  Other Penn faculty members include Huafeng Wei and Jiabin Liu, MD, Ph.D. Regular activities include a special symposium during the Chinese Society of Anesthesiologists (CSA) Annual Meeting, an annual Quality, Safety, and Leadership Symposium at Penn, and a robust visiting scholar program for basic, translational and clinical research activities.  Many of the scholars who have been mentored by our faculty have produced outstanding scholarship and have risen to prominent leadership positions after returning to their academic departments in China.  The program has facilitated opportunities for our faculty members to speak at Chinese national and international meetings.    The Program has also promoted cross-school collaborations at Penn, specifically the Wharton School, the Leonard Davis Institute, and the School of Nursing, in the areas of hospital management, leadership training, and research.  For example, an interdisciplinary team, composed of Rosemary Polomano, PhD, RN (Nursing & Anesthesiology, Lead Investigator), Renyu and Josh, was recently awarded a grant from the Provost’s, Penn China Research & Engagement Fund, to expand Rosemary’s pioneering inter-professional pain training and research program to China.  

Activities of the Penn-China program have received robust and critical support from our Department (including CHOP), as well as financial support from industry. The impact of the growing Penn-China Anesthesia Partnership program has been recognized by Renyu’s appointment as one of the three Executive Counselors (overseas) for the CSA in 2011, and receipt of the CSA Outstanding Contribution Award in 2012 for the development of Chinese Anesthesiology.  Finally, Lee Fleisher, MD received an award from the CSA at their 2015 annual meeting to acknowledge his distinguished contributions to the advancement of anesthesiology in China.  This Penn-China Anesthesiology Partnership has, in fact, led the way for PennMedicine’s integration into Chinese Healthcare.     

Grants and Funding

Image of the NIH LogoJuly 1 - October 1, 2015 

Grant Proposals / amount:
            24 / $6,369,990 

Grants or Contracts Funded / amount:
            25 / $5,004,018  

(including UPENN and CHOP)

UPENN & CHOP Grant Proposals Submitted July 1 - October 1, 2015
PI Dept Sponsor Title Type 1 yr Total
Armstead, William  UPENN AHA tPA, NMDA receptor excitotoxicity, and outcome after stroke Rev $154,000
Armstead, William  UPENN Mallinckrodt Inhaled Nitric Oxide and Brain Outcomes After Pediatric Traumatic Brain Injury New $157,933
Atkins, Joshua UPENN Becton, Dickinson and Company The INtelliport SafeTy and Accurate documeNTation Study (INSTANTS): A prospective, observational, multi-center study of the safety and accuracy advantages provided by the BD Intelliport ® System New $171,318
Berg, Robert CHOP NIH -R01 The Impact of Nursing on In-Hospital Cardiac Arrest Patient Outcomes Rev $54,785
Berg, Robert CHOP NSF CPR Proposal / Villanova University (Nataraj) New $404,048
Bhatnagar, Seema CHOP NASA Biomarkers of Resiliency and Susceptibility to Stress in Space Flight CC  
Cohen, Akiva CHOP Dana Foundation Treatment of a Head Injury with Nutraceuticals (THIN) A Trial of Branched Chain Amino Acids in the Treatment of Sports-Related Concussion CC  
Cohen, Akiva CHOP US Army Blast Induced Thresholds for Neuronal Networks (BITNeT) CC  
Donoghue, Aaron CHOP AHA Creation and Validation of a CPR Report Card New $154,000
Du Pont-Thibodeau, Genevieve CHOP SCCM Society of Critical Care Medicine Vision Grant New $50,000
Eckmann, David UPENN DOD-USN-ONR Seahorse metabolic assessment of distressed cells New $166,670
Elkassabany, Nabil UPENN American Shoulder and Elbow Surgeons The effect of a single shot versus continuous perineural  ambulatory brachial plexus blocks on functional outcomes in patients with adhesive capsulitis undergoing arthroscopic capsular release New $20,000
Feldman, Jeffrey CHOP Draeger Medical, Inc Draeger Medical Project  New $5,500
Galvez, Jorge CHOP Microsoft HoloLens Augmented Reality Academic Research Proposal New $7,500
Lane-Fall, Meghan UPENN Robert Wood Johnson Foundation Improving Health Care Communication to Improve Quality and Outcomes: Context-sensitive Standardization of Operating Room to ICU Handoffs New $420,000
Lane-Fall, Meghan UPENN SCCM Characterizing patient-centered outcomes after life-threatening traumatic injury New $50,000
Liu, Renyu UPENN NIH - R21 Kappa opioid receptor and brain hypoxia/ischemia Rev $440,000
Nadkarni, Vinay CHOP NIH - R01 Coagulation & Fibrinolysis with Hyperglycemia in Criticall Ill Children CC  
Nadkarni, Vinay CHOP Zoll Medical Corp Pediatric RESuscitation Quality (pedRES-Q) Collaborative  CC  
Neuman, Mark UPENN Sunnybrook Research Institute Acute Pain Management and Long-term Opioid Use after Surgery New $1,506,605
Niles, Dana CHOP AHRQ - R18 Infant Simulation Program for In-hospital Resuscitation Education - Delivery Room CC  
Nishisaki, Akira CHOP AHA Nishisaki AHA Sub Award w Yale New $22,638
Valentino, Rita CHOP NIH - R01 Brain Noradrenergic Neurons, Peptides and Stress Rev $2,073,875
Valentino, Rita CHOP NIH - R01 Stress and Sexually Divergent Neuropathy in Alzheimer's Disease New $511,118
        TOTAL $6,369,990

UPENN & CHOP Grant Awards FY2015
PI Name Dept Sponsor Title Type 1 yr Total
Armstead, William UPENN Univ. of Texas Medical Branch The Moody Project New $60,616
Armstead, William UPENN NH - R01 Pressor Choice Influences Protection Of Autoregulation in Brain Injury Rev $362,043
Ashburn, Michael UPENN GW Pharmaceuticals A double blind, randomized, placebo-controlled, parallel group study of Sativex oromucosal spray (Sativex; Nabiximols) in relieving pain in patients with advanced cancer, who experience inadequate analgesia during optimized chronic opioid therapy Ext $16,636
Berg, Robert CHOP NIH - R01 Sepsis Induced Red Cell Dysfunction (SIRD) New $40,320
Berg, Robert CHOP NIH - R01 Life After Pediatric Sepsis Evaluation, LAPSE CC  
Bhatnagar, Seema CHOP NIH - R21 Orexins/hypocretins and resilience to stress CC  
Donoghue, Aaron CHOP NIH - N01 Duke University Sub New $5,000
Eckmann, David UPENN NIH -U01 Bridging multiple scales in modeling targeted drug nanocarrier delivery NCR $529,615
Eckmann, David UPENN Office of Naval Research Coupling of Metabolic and Mechanical Function in Cell Physiology Ext $70,000
Ganesh, Arjunan CHOP Iroko Pharmaceuticals LLC A Phase IIA, Open-label, Safety and Pharmacokinetic Study of Zorvolex® Capsules in Pediatric Subjects 6 to <17 Years of Age with Mild to Moderate Acute Postoperative Pain Following Elective Surgery New $80,660
Grafe, Laura CHOP NIH - F32 Orexins may contribute to sex difference in habituation to stress and cognitive function New $67,917
Kelz, Max UPENN NIH - R01 Optoanesthesia NCR $310,228
Kilbaugh, Todd CHOP Mallinckrodt Pharmaceuticals Mallinckrodt Pharmaceuticals Proposal New $186,878
Lane-Fall, Meghan UPENN UPENN McCabe Fund Patient-centered outcomes after severe trauma New $19,323
Lane-Fall, Meghan UPENN Penn Presbyterian Bach Fund  Patient-centered outcomes after severe trauma New $1,980
Maltese, Matthew CHOP FDA - P50 Philadelphia Pediatric Medical Device Consortium CC  
Maxwell, Lynne CHOP Janssen Research and Development, LLC An evaluation of the efficacy and safety of tapentadol oral solution in the treatment of post-operative acute pain requiring opioid treatment in pediatric subjects aged from birth to less than 18 years old New $71,285
Nadkarni, Vunay CHOP NIH - U01 HALF-PINT: Heart and Lung Failure-Pediatric Insulin Titration Trial CC  
Nadkarni, Vunay CHOP Nihon Kohden America Nadkarni Nihon Kohden Agreement APR2015 New $100,000
Neuman, Mark UPENN Patient Centered Outcomes Research Institute  A Practical Intervention to improve Patient-Centered Outcomes After Hip Fractures Among Older Adults (REGAIN Trial) New $2,384,685
Shinozaki, Koichiro CHOP Nihon Kohden America UPENN Subcontract for Shinozaki Fellowship New $36,523
Srinivasan, Vijay CHOP NIH - R44 In-Patient Pediatric Gastrojejunal Tube Cleaner Eliminating Surgical Intervention New $45,375
Srinivasan, Vijay CHOP NIH - U01 HALF-PINT:Heart and Lung Failure-Pediatric Insulin Titration Trial (Srinivasan) CC  
Topjian, Alexis CHOP NIH - K23 Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest CC  
Valentino, Rita CHOP NIH - R56 Central processing of bladder information CC  
Valentino, Rita CHOP NIH - R01 Development of Defensive Behavior and Social Stress Consequences CC  
Zuppa, Athena CHOP NIH - T32 Use of a novel therapeutic (DMFO) in the treatment of pts with high risk NB New $636,237
        TOTAL $5,025,321

Supp;  supplement                            CC;    competing continuation/renewal

Rev;    revised proposal                    NCR;  non-Competing Renewal

New;   new proposal/grant                Ext;    extension

 

Publications

Image of NIH logoClick here to view all UPENN & CHOP Anesthesia publications for 2015.
From July 1 — October 1, 49 peer reviewed publications from the Department,     
            including UPENN and CHOP, have been posted in PubMed.
Name Title Journal  date/Volume/pages
Cheng A, Hunt EA, Grant D, Lin Y, Grant V, Duff JP, White ML, Peterson DT, Zhong J, Gottesman R, Sudikoff S, Doan Q, Nadkarni VM,International Network for Simulation-based Pediatric Innovation, Research, Education (INSPIRE) CPR Investigators Variability in Quality of Chest Compressions Provided During Simulated Cardiac Arrest Across Nine Pediatric Institutions. Resuscitation 2015 Sep 25. pii: S0300-9572(15)00794-7
Cobb B, Liu R, Valentine E, Onuoha O. Breastfeeding after Anesthesia: A Review for Anesthesia Providers Regarding the Transfer of Medications into Breast Milk. Transl Perioper Pain Med.  2015;1(2):1-7
Goudra B, Singh PM, Gouda G, Borle A, Carlin A, Yadwad A. Propofol and non-propofol based sedation for outpatient colonoscopy-prospective comparison of depth of sedation using an EEG based SEDLine monitor. J Clin Monit Comput 2015 Sep 12. [Epub ahead of print]
Meng L, Li J, Lu Y, Sun D, Tao YX, Liu R, Luo JJ. Ketamine - A Multifaceted Drug. Transl Perioper Pain Med 2015;1(2):20-26
McGee WT, Raghunathan K, Adler AC Utility of Functional Hemodynamics and Echocardiography to Aid Diagnosis and Management of Shock. Shock 2015 Sep 8. [Epub ahead of print]
Kilbaugh TJ, Sutton RM, Karlsson M, Hansson MJ, Naim MY, Morgan RW, Bratinov G, Lampe JW, Nadkarni VM, Becker LB, Margulies SS, Berg RA. Persistently Altered Brain Mitochondrial Bioenergetics After Apparently Successful Resuscitation From Cardiac Arrest. J Am Heart Assoc 2015 Sep 14;4(9). pii: e002232
Kilbaugh TJ, Himebauch AS, Zaoutis T, Jobes D, Greeley WJ, Nicolson SC, Zuppa AF. A pilot and feasibility study of the plasma and tissue pharmacokinetics of cefazolin in an immature porcine model of pediatric cardiac surgery. Paediatr Anaesth 2015 Sep 15. [Epub ahead of print]
Weissman GE, Gabler NB, Brown SE, Halpern SD. Intensive care unit capacity strain and adherence to prophylaxis guidelines. J Crit Care 2015 Aug 22. [Epub ahead of print]
Lane-Fall MB, Gutsche JT The Challenge of Studying and Improving Perioperative Teamwork, and Yes, Another Checklist. Anesth Analg. 2015 Oct;121(4):852-3
Mandel JE, Atkins JH Hilbert-Huang Transform Yields Improved Minute Volume Estimates from Respiratory Inductance Plethysmography During Transitions to Paradoxical Breathing. Anesth Analg 2015 Sep 22. [Epub ahead of print]
Schwarz M, Rivera G, Hammond M, Silman Z, Jackson K, Kofke WA Acousto-Optic Cerebral Blood Flow Monitoring During Induction of Anesthesia in Humans. Neurocrit Care 2015 Sep 23. [Epub ahead of print]
Grimsrud KN, Sherwin CM, Constance JE, Tak C, Zuppa AF, Spigarelli MG, Mihalopoulos NL. Special population considerations and regulatory affairs for clinical research. Clin Res Regul Aff 2015;32(2):47-56
Hsu G, Taylor JA, Fiadjoe JE, Vincent AM, Pruitt EY, Bartlett SP, Stricker PA. Aminocaproic acid administration is associated with reduced perioperative blood loss and transfusion in pediatric craniofacial surgery. Acta Anaesthesiol Scand 2015 Sep 8 [Epub ahead of print]
Goudra B, Nuzat A, Singh PM, Gouda GB, Carlin A, Manjunath AK. Cardiac Arrests in Patients Undergoing Gastrointestinal Endoscopy: A Retrospective Analysis of 73,029 Procedures. Saudi J Gastroenterol 2015 Sep 8 [Epub ahead of print]
Meert KL, Keele L, Morrison W, Berg RA, Dalton H, Newth CJ, Harrison R, Wessel DL, Shanley T, Carcillo J, Clark A, Holubkov R, Jenkins TL, Doctor A, Dean JM, Pollack M End-of-Life Practices Among Tertiary Care PICUs in the United States: A Multicenter Study. Pediatr Crit Care Med 2015 Sep;16(7):e231-8
Brown CH 4th, Neuman MD Optimizing Perioperative Care for Older Adults. Anesthesiol Clin 2015 Sep;33(3) [Epub ahead of print]
Muhly WT, Gurnaney HG, Kraemer FW, Ganesh A, Maxwell LG. A retrospective comparison of ropivacaine and 2-chloroprocaine continuous thoracic epidural analgesia for management of postthoracotomy pain in infants. Paediatr Anaesth 2015 Aug 26
Andersen LW, Berg KM, Saindon BZ, Massaro JM, Raymond TT, Berg RA, Nadkarni VM, Donnino MW Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest. JAMA 2015 Aug 25;314(8):802-10
Guidi JL, Clark K, Upton MT, Faust H, Umscheid CA, Lane-Fall MB, Mikkelsen ME, Schweickert WD, Vanzandbergen CA, Betesh J, Tait G, Hanish A, Smith K, Feeley D, Fuchs BD. Clinician Perception of the Effectiveness of an Automated Early Warning and Response System for Sepsis in an Academic Medical Center. Ann Am Thorac Soc.  2015 Aug 19. [Epub ahead of print]
Gálvez JA, Rothman BS, Doyle CA, Morgan S, Simpao AF, Rehman MA A Narrative Review of Meaningful Use and Anesthesia Information Management Systems. Anesth Analg.  2015 Sep;121(3):693-706
Viswanath O, Simpao AF, Santhosh S. Atypical Presentation of a Pulmonary Embolism in the Perioperative Setting. A A Case Rep 2015 Aug 15;5(4):54-6.
Simpao AF, Lingappan AM, Ahumada LM, Rehman MA, Gálvez JA Perioperative Smartphone Apps and Devices for Patient-Centered Care. J Med Syst.  2015 Sep;39(9):310 
Raiten JM. A PIECE OF MY MIND. Lessons of the Gacaca. JAMA Aug 4;314(5):451-2
Goudra B, Singh PM Anesthesia for gastrointestinal endoscopy: A subspecialty in evolution? Saudi J Anaesth.  2015 Jul-Sep;9(3):237-8
Gutsche JT, Vernick WJ Invited Commentary. Ann Thorac Surg.  2015 Aug;100(2):464
Dexter F, Rosenberg H, Epstein RH, Semo JJ, Litman RS Implications of National Anesthesia Workload on the Staffing of a Call Center: The Malignant Hyperthermia Consultant Hotline. A A Case Rep.  2015 Aug 1;5(3):43-6
Bohman LE, Riley J, Milovanova TN, Sanborn MR, Thom SR, Armstead WM Microparticles Impair Hypotensive Cerebrovasodilation and Cause Hippocampal Neuronal Cell Injury after Traumatic Brain Injury. J Neurotrauma.  2015 Jul 31. [Epub ahead of print]
Ward CM, Hogan KJ, Eckenhoff RG. Potential Adverse Effects of Anesthesia in Children. JAMA.  2015 Jul 28;314(4):408-9
Neuman MD The Importance of Validation Studies in Perioperative Database Research. Anesthesiology.  2015 Aug;123(2):243-5
Schwartz AJ, Nussmeier NA, Shafer S. Experience = Education: Time for the Next Step. A A Case Rep.  2015 Jul 15;5(2):15-6.
Yehya N, Servaes S, Thomas NJ, Nadkarni VM, Srinivasan V. Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Med.  2015 Sep;41(9):1658-66
Gutsche JT, Riha H, Pate P, Atchley L, Valentine E, Shah R, Cisler ST, Weiss SJ, Silvay G, Augoustides JG Major themes for 2014 in cardiothoracic and vascular anaesthesia and intensive care. Heart Lung Vessel.  2015;7(2):101-9.
Srinivasan V. Tight Glucose Control With Insulin Following Pediatric Cardiac Surgery: Still "Muscling" on in Search of Answers! Pediatr Crit Care Med.  2015 Jul;16(6):587-8
Skowno J, Vutskits L, McGowan F, Kurth CD Staying away from the edge - cerebral oximetry guiding blood pressure management. Paediatr Anaesth.  2015 Jul;25(7):654-5
Pollack MM, Holubkov R, Funai T, Berger JT, Clark AE, Meert K, Berg RA, Carcillo J, Wessel DL, Moler F, Dalton H, Newth CJ, Shanley T, Harrison RE, Doctor A, Jenkins TL, Tamburro R, Dean JM Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment Crit Care Med.  2015 Aug;43(8):1699-709
Costarino AT, Dai D, Feng R, Feudtner C, Guevara JP. Gastric Acid Suppressant Prophylaxis in Pediatric Intensive Care: Current Practice as Reflected in a Large Administrative Database. Pediatr Crit Care Med.  2015 Sep;16(7):605-12
Marsillio LE, Ginsburg SL, Rosenbaum CH, Coffin SE, Naim MY, Priestley MA, Srinivasan V. Hyperglycemia at the Time of Acquiring Central Catheter-Associated Bloodstream Infections Is Associated With Mortality in Critically Ill Children. Pediatr Crit Care Med.   2015 Sep;16(7):621-8
Elkassabany N, Cai LF, Mehta S, Ahn J, Pieczynski L, Polomano RC, Picon S, Hogg R, Liu J. Does Regional Anesthesia Improve the Quality of Postoperative Pain Management and the Quality of Recovery in Patients Undergoing Operative Repair of Tibia and Ankle Fractures? J Orthop Trauma.  2015 Sep;29(9):404-9
Speck RM, Weisberg RW, Fleisher LA. Varying Goals and Approaches of Innovation Centers in Academic Health Systems: A Semistructured Qualitative Study. Acad Med.   2015 Aug;90(8):1132-6.
Wu Z, Yang B, Liu C, Liang G, Liu W, Pickup S, Meng Q, Tian Y, Li S, Eckenhoff MF, Wei H. Long-term Dantrolene Treatment Reduced Intraneuronal Amyloid in Aged Alzheimer Triple Transgenic Mice. Alzheimer Dis Assoc Disord.  2015 Jul-Sep;29(3):184-91. 
Goldhammer JE, Bakowitz MJ, Milas BL, Patel PA Intracardiac Thrombosis after Emergent Prothrombin Complex Concentrate Administration for Warfarin Reversal. Anesthesiology 2015 Aug;123(2):458. 
Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M,Eckmann DM, Davies PF, Muzykantov VR Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano.  2015 Jul 28;9(7):6785-93
Sarkar A, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Hydrodynamic interactions of deformable polymeric nanocarriers and the effect of crosslinking. Soft Matter.  2015 Jul 15;11(29):5955-69
The search routine may include a few false positives. Only papers which include in the author contact, "Anesthesiology and Critical Care" along with either: "Hospital of the University of Pennsylvania" or "Perelman School of Medicine " or "Children's Hospital of Philadelphia," will be included in this search.Disclaimer:

 

Announcements and Awards

 

Press Releases 

July 2015:  David M. Eckmann, PhD, MD and Bioengineering graduate student,  Judith Kandel, have devised a powerful new technique that enables the tracking of mitochondria as they move within a cell. Penn Medicine News Release

Awards and Honors

Lee Fleisher, MD, received a distinguished award on September 11th, 2015 from the Chinese Society of Anesthesiology at the opening ceremony of the annual meeting of the Chinese Society of Anesthesiology in Xi'An to recognize his outstanding contributions to the development and advancement of anesthesiology in China. Dr. Fleisher also delivered a speech during the opening ceremony after receiving the award.

William J. Greeley, MD, MBA, will receive the 2015 Myron Yaster Lifetime Achievement Award at the Annual Meeting of the Society for Pediatric Anesthesia on October 23rd in San Diego, CA to recognize Bill’s immeasurable contributions to the field of pediatric anesthesiology, as a “giant” in the specialty.  This award is the Society’s highest honor.

Meghan Lane-Fall, MD, was awarded the Harold Amos Medical Faculty Development Program of The Robert Wood Johnson Foundation in August, 2015. The Program was created to increase the number of faculty from historically disadvantaged backgrounds who can achieve senior rank in academic medicine or dentistry and who will encourage and foster the development of succeeding classes of such physicians and dentists.

Lynne Maxwell, MD, will receive the 2016 Robert M Smith Award from the American Academy of Pediatrics. The award recognizes an individual who has made outstanding contributions to the field of pediatric anesthesiology. 

Mark D. Neuman, MD, is the 2015 recipient of the Marjorie A. Bowman New Investigator Research Award, a PennMedicine Award of Excellence, which exemplifies our profession's highest values of scholarship and teaching, innovation, commitment to service, leadership, and dedication to patient care.

Rosemary Polomano, PhD, RN, FAAN, is a 2015 recipient of a grant from the Penn China Research & Engagement Fund. She, along with co-investigators, Renyu Liu, MD, PhD and Joshua Atkins, MD, PhD, will work with their Chinese colleagues to advance perioperative pain management and patient safety in China through interprofessional pain education and practice-based research.  

Vijay Srinivasan, MDhas been approved for FCCM designation by the Society of Critical Care Medicine with his convocation scheduled for the 2016 Congress.

Leadership Positions 

Rita Valentino, PhD, became the Editor-in-Chief of the new journal, Neurobiology of Stress, and Seema Bhatnagar, PhD is on the editorial board. This is a fully open access journal for translational and clinical research into stress and related disorders.

Promotions

Professor of Anesthesiology and Critical Care:

2015 Anesthesia Academic Evening

Department of Anesthesiology & Critical Care

presents

The Anesthesia Academic Evening

and

The 19th Annual James E. Eckenhoff Lecture

 

What is a Poor Outcome after Anesthesia and Surgery:

Quality of Recovery and Disability-Free Survival?

Professor Paul S. Myles

Director, Department of Anaesthesia and Perioperative Medicine

Alfred Hospital and Monash University

Melbourne, Australia

 

Thursday, October 29, 2015

5:00 P.M - Poster Session, First Floor - Smilow Commons

6:30 P.M. – Lecture, Rubenstein Auditorium - First Floor

7:30 P.M.  – Atrium, First Floor - Smilow Commons

 

Photo of Paul Myles, MDPaul Myles, MBBS, MPH, MD, FCARCSI, FANZCA, FRCA, is Chair of the Department of Anaesthesia and Perioperative Medicine at the Alfred Hospital in Melbourne, and at Monash University, Australia.  He is an Australian National Health and Medical Research Council Practitioner Fellow, a member of the Research Committee of the Australian and New Zealand College of Anaesthetists, and Fellow of the Australian Academy of Health and Medical Science.  Paul is an Editor of the British Journal of Anaesthesia, an Editorial Consultant for The Lancet, and an editorial board member of Anesthesiology and  Anaesthesia and Intensive Care.  The main focus of his research has been on patient quality of recovery,  avoidance of postoperative complications, and large multicenter trials in anesthesia.

 

PENN ASA & SNACC Schedule

PENN Anesthesiology & Critical Care

2015 Annual ASA and SNACC Meetings - San Diego, CA

October 22, 2015 - October 28, 2015

SNACC ANNUAL MEETING  - Manchester Grand Hyatt Hotel
Presenter
Date
Time
Location
Presentation
Kofke
 
10/22
8:00 pm -8:30 pm
Seaport FG
Speaker, Brain Monitoring with Near Infrared Technology
Kelz
 
10/23
8:00 am -8:45 am
Seaport FG
Moderator, Annual Maurice Albin Keynote Lecture
Kofke
 
 
10:45 am -12:00 pm 
Auditorium Lobby
Clinical Neuroscience II/ Morning Poster Session: Poster #41 Awake Craniotomy--a New  Airway Approach
Kelz
 
 
1:30 pm -4:45 pm
Seaport FG
Moderator, Mini Symposium 2 – The Unresponsive patient
Kofke
 
 
3:30 pm -4:45 pm 
Auditorium Lobby
Cerebral Ischemia / Clinical Neuroscience IV/ Afternoon Poster Session: Poster #79 Anesthetic Management of Acute Ischemic Stroke
Kofke
 
 
3:30 pm  - 4:45 pm  
Auditorium Lobby
Neuromonitoring III/ Afternoon Poster Session, Poster # 117  Acousto-Optic Cerebral Blood Flow Monitoring During Induction of Anesthesia in Humans
Armstead
 
 
3:30 pm - 4:45 pm
Auditorium Lobby
Basic Neuroscience II, Cerebral Protection Poster session,  Poster #73, Normalization of CPP by NE After TBI Protects Autoregulation and Limits Hippocampal Neuronal Cell Necrosis in Female But Not Male Piglets Via Block of ERK MAPK and IL6 Upregulation
ASA ANNUAL MEETING – San Diego Convention Center
Presenter
Date
Time
Location
Presentation
Gutsche
10/24
 
7:50 am - 8:50 am
Upper 20B-20C
Problem-Based Learning Discussions L102. Management of Severe ARDS in the ICU With ECMO
Neuman
 
7:50 am -  8:50 am
Upper 1A-1B
60 Minute Panel   PN100.
Regional Versus General Anesthesia - What Do We Know So Far?
Augoustides
 
9:00 am-
4:10 pm
Upper 30A-30B
Hands-on Workshop
802. Basic TEE Workshop
Wei, Qiao, Li
 
10:00 am -12:00 pm
Hall B2
MCCS  MCC01.
Medically Challenging Case Presentations
Goudra
 
10:30 am - 5:00 pm
Exhibit Hall C-G
Scientific and Educational Exhibits ScEdEx01. Scientific and Educational Exhibits
Elkassabany
 
 
10:45 am  11:45 am
Upper 20B-20C
Problem-Based Learning Discussions L121. Numb and Number: Should We Use Regional Anesthesia for Orthopedic Trauma?
Feldman
CHOP
 
1:00 pm - 3:00 pm
Upper 20D
Special Meetings and Events SPE03.
Anesthesia Patient Safety Foundation Workshop: From APSF Educational Videos to Your Practice: How to Make it Happen
Gaiser
 
1:10 pm - 3:10 pm
Mezzanine
16  16A-16B
120 Minute Panel  PN110.
A Guided Walk Through Clinical Conundrums in Obstetric Anesthesia
Gowri, Borle, Goudra, Sannegowda
 
1:00 pm - 3:00 pm
Hall B2-Area D
Poster Presentations PO01-1.
Ambulatory Anesthesia: New Agents, Outcomes, and Practice Changes in the Ambulatory and Geriatric Population
Weiss
 
1:10 pm - 2:10 pm
Upper 20B-20C
Problem-Based Learning Discussions L122.
Hold My Compass: Tools and Tips So That YOU Don't Get Lost in the EP Lab
Atkins
 
4:00 pm -5:00 pm
Upper 23A-23C
Speaker-Anesthetic Management of Sleep Endoscopy for OSA
 
Oct 24th,  7-10 pm,  41ST ANNUAL PENN ANESTHESIA ALUMNI RECEPTION
San Diego Marriott Gaslamp Quarter  Presidio Ballroom, 660 K Street

 

Presenter
Date
Time
Location
Presentation

Fiadjoe

CHOP

10/25

9:00 am - 12:00 pm

Upper 30D-30E

Hands-on Workshop 814. 

Pediatric Airway Workshop

Goudra

 

9:00 am - 4:00 pm

Exhibit Hall C-G

Scientific and Educational Exhibits ScEdEx02. Scientific and Educational Exhibits

Stricker

CHOP

 

9:00 am -12:00 pm

Upper 30D-30E

Hands-on Workshop 814.

 Pediatric Airway Workshop

Laudanski, Worthen,

Ivano,Frankivsk,

 

10:00 am -12:00 pm

Hall B2-Area  C

Poster Presentations PO06-2.

Critical Care

Gaiser

 

11:00 am -12:00 pm

Upper 6F

60 Minute Refresher Course Lecture 212. Evidence-Based Approach to Post-Dural Puncture Headaches

Goudra

 

11:00 am -12:00 pm

Upper 2

60 Minute Panel PN207.

Supraglottic Airway Devices in out of OR Locations

Gutsche

 

11:00 am -12:00 pm

Upper 20B-20C

Problem-Based Learning Discussions L226. Management of Severe ARDS in the ICU With ECMO

 

Feldman

CHOP

 

1:10 pm - 4:10 pm

Hall B1

Hands-on Workshop 825.  Hands-on Anesthesia Machine Workshop

Ganesh

CHOP

 

1:10 pm –

4:10 pm

Hall B1

Hands-on Workshop 822.

Ultrasound Guided Pediatric Regional Anesthesia Workshop

Wei,  Li,  Xie, Wu

 

1:00 pm –

 3:15 pm

Hall B2

MCCS MCC05.

Medically Challenging Case Presentations

Rackley

FAER 

Eckmann, Eckenhoff mentors

 

2:00 pm- 5 pm

Hall B1

Abstract.

 Mitochondrial Tracking of Propofol-Exposed Human Fibroblasts

Fleisher

 

2:20 pm - 3:20 pm

Upper 23A-23C

Point-Counterpoint

PC13. Is the Perioperative Surgical Home a Viable Option for Anesthesiology?

Roginski

VA

 

3:15 pm –

5:15 pm

Hall B2

Poster Presentations PO10-1.

Experimental Neurosciences: CNS Injury and POCD

Wei

 

3:15 pm –

5:15 pm

Hall B2

MCCS MCC06.

Medically Challenging Case Presentations

Elkassabany

 

4:00 pm - 5:00 pm

Upper 20B-20C

Problem-Based Learning Discussions 255.

Numb and Number: Should We Use Regional Anesthesia for Orthopedic Trauma?

Litman

CHOP

 

4:00 pm –

5:00 pm

Upper 23A-23C

Point-Counterpoint PC15.

 Succinylcholine for Emergency Use Only Does Not Require Onsite Dantrolene

Singh, Gouda, Yadvad, Basavana Goudra, Sannegowda,

 

4:00 pm - 5:30 pm

Upper 9

Oral Presentations OR01-2.

Ambulatory Anesthesia: A Close Look at the Surgical Home, Management and Outcomes of Complicated Patients

Weiss

 

4:00 pm -

5:00 pm

Upper 20B-20C

Problem-Based Learning Discussions L245.

 Hold My Compass: Tools and Tips So That YOU Don't Get Lost in the EP Lab

Presenter
Date
Time
Location
Presentation

Neuman

 10/26

8:00 am –

9:15 am

Hall H

Special Meetings and Events SPE16.

 Emery A. Rovenstine Lecture: Without Science There is Little    Art in Anesthesiology

Goudra

 

9:00 am - 1:00 pm

Exhibit Hall

C-G

Scientific and Educational Exhibits ScEdEx03.

Scientific and Educational Exhibits

Atkins

 

1:10 pm - 3:10 pm

Mezzanine   14A-14B

Speaker-The Impact of Neuromonitoring on Anesthetics and Outcome

Eckenhoff

 

1:15 pm - 2:45 pm

Upper 11A

Poster Discussions YI02.

Young Investigator: Basic Science

 

Elkassabany

 

1:10 pm –

4:10 pm

Hall B1

Hands-on Workshop 834A.

Peripheral Nerve Block Workshop: Ultrasound, Simulation and Stimulation

Gutsche

 

1:10 pm –

3:10 pm

Mezzanine 14A-14B

120 Minute Panel PN313.

Endovascular Thoracic Aortic Aneurysm Repair

Lockman

CHOP

 

1:10 pm –

2:10 pm

Upper 8

Clinical Forum CF11.

The Pediatric Checklist Manifesto-Utilization of Pediatric Checklists to Improve Care and Safety

Ochroch

 

1:10 pm - 3:10 pm

Mezzanine 14A-14B

120 Minute Panel PN313.

Endovascular Thoracic Aortic Aneurysm Repair

Wei

 

1:00 pm -

3:00 pm

Hall B2

MCCS MCC07.

Medically Challenging Case Presentations

Fleisher

 

2:10 pm -

4:10 pm

Hall H

Special Meetings and Events SPE21.

 FAER Academy of Research Mentors Workshop

Presenter
Date
Time
Location
Presentation

Elkassabany

10/27

 

 

9:00 am -12:00 pm

Hall B1

Hands-on Workshop

834B. Peripheral Nerve Block Workshop: Ultrasound, Simulation and Stimulation

Fleisher

 

10:00 am- 12:00 pm

Upper 24A-24C

Special Meetings and Events SPE24.

Aiming for a More Evidence-based Approach to Medical Practice – How to Get There Using Secondary Data for Outcomes Research

 

Royo, Falk, Mahmoud, Fleisher

 

10:00 am- 12:00 pm

Hall B2-Area A

Poster Presentations PO13-4.

Outcomes and Database Research

Litman

CHOP

 

10:00 am- 12:00 pm

Hall B2-Area A

Poster Presentations PO13-4.

Outcomes and Database Research

Goudra

 

11:00 am -12:00 pm

Upper 5A-5B

60 Minute Panels PN416.

 Anesthesia for GI Endoscopy

Elkassabany

 

1:00 pm - 4:00 pm

Upper 29A-29D

Hands-on Workshop

842. Ultrasound Guided Advanced Blocks

Elkassabany

 

1:00 pm –

4:00 pm

Hall B1

Hands-on Workshop

834C. Peripheral Nerve Block Workshop: Ultrasound, Simulation and Stimulation

Feldman

CHOP

 

1:00 pm –

4:00 pm

 

Upper 30A-30C

Seminar 844.

Controlling Inhaled Anesthetic Depth Without Waste: Master the Use of Low Fresh Gas Flow

Goudra

 

1:00 pm –

2:00 pm

Upper 23A-23C

Point-Counterpoint PC29.

MAC is More Dangerous Than GA -Reality or Myth?

Augoustides

 

1:00 pm-

3:00 pm

Mezzanine 14A-14B

120 Minute Panel

PN420. Cardiac Anesthesia Outside the Cardiac Operating Room

Lane-Fall,

Fleisher,  Collard, Gutsche, Pascual,

Peifer, Barry,

Beidas, Halpern

 

 

 

 

 

3:15 pm –

4:45 pm

Upper 9

Oral Presentations OR14-3.

Patient Safety and Practice Management

Ochroch

 

3:15 pm - 4:15 pm

Upper 8

Clinical Forum

CF20. The Thoracic Surgery Patient with Cardiovascular Disease

Wei

 

3:15 pm -

5:15 pm

Hall B2-Area C

Poster Presentations PO02-2.

Anesthetic Action and Biochemistry

Presenter
Date
Time
Location
Presentation

Elkassabany

10/28

7:45 am - 9:45 am

Upper 2

120 Minute Panel PN501.

Perioperative Management of Total Knee Arthroplasty (TKA) as a Model for the Surgical Home Initiative

Ellis

 

7:45 am –

8:45 am

Upper 6F

60 Minute Refresher Course Lecture504.

Wellness in Anesthesia Providers

Fleisher

 

7:45 am –

 9:15 am

Mezzanine 15A-15B

90 Minute Panels PN505.

Grading the Graders - How Do We Get to Better Performance Measures

Fiadjoe                   CHOP

 

7:45 am -

8:45 am

Upper 1A-1B

60 Minute Panel PN500.

The Pediatric Difficult Airway Managed by the Adult Anesthesiologist Versus the Pediatric Anesthesiologist

Ochroch

 

7:45 am- 8:45 am

Upper 6C

60 Minute Refresher Course Lecture

503. Innovations in Thoracic Anesthesiology

Mandel

 

9:00 am - 10:00 am

Upper 24A-24C

Point-Counterpoint PC37.

Can General Anesthesiologists Safely Provide Anesthesia in the Electrophysiology and Interventional Cardiology Laboratories?

Elkassabany

 

10:15am -11:45 am

Upper 6B

90 Minute Refresher Course Lecture 511.

Nerve Injury Following Regional Anesthesia: Anatomic Considerations, Mechanisms, Risk Factors and Prognosis

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2016 Winter

Research Highlights

Photo of Meghan Lane-Fall, MDMeghan Lane-Fall, MD, has come a long way since becoming the Department’s first Dripp’s Scholar.  After a critical care fellowship, she was a postdoctoral fellow in Penn’s Center for Healthcare Improvement in Patient Safety, funded by the Department’s T32 training grant in critical care health services research. She joined the standing faculty at Penn in 2013. Collaborating with investigators in anesthesiology, family medicine and anthropology, trauma, pulmonary critical care, sociology, general internal medicine, psychiatry, and physical medicine and rehabilitation, her research is focused on understanding and improving teamwork and communication in acute care. Within this area, she is particularly interested in improving healthcare transitions using mixed method and implementation science approaches. She leads a lab of twelve undergraduate and medical students and actively mentors Penn residents engaged in their own scholarly pursuits. She also serves as a research mentor for Penn nursing students and for the Leonard Davis Institute of Health Economics Summer Undergraduate Minority Research program. Meghan’s research group is working on two major projects:

1.     HATRICC: Handoffs and Transitions in Critical Care

The HATRICC project aims to improve operating room to intensive care unit handoffs by developing and evaluating the effectiveness of a standardized handoff process. Started in 2014, HATRICC is a hybrid effectiveness-implementation trial that is designed to answer two questions: (1) Is a standardized OR to ICU handoff process effective in improving information exchange? (2) What factors influence the implementation of a standardized OR to ICU handoff process? The study is taking place in surgical intensive care units at the Hospital of the University of Pennsylvania and at Penn Presbyterian Medical Center, but the HATRICC process has since been adopted in the Rhoads 2 Neurocritical Care Unit. HATRICC is funded by an Anesthesia Patient Safety Foundation Safety Scientist Career Development Award to Meghan Lane-Fall, mentored by Lee Fleisher. Meghan recently received a four-year career development award from the Robert Wood Johnson Harold Amos Medical Faculty Development Program to extend this work in the Christiana Care Health System in Delaware.

2.     PICS 1.0: Understanding patient-centered outcomes after critical illness

For patients experiencing critical illness, recovery does not end in the intensive care unit. Critical care survivors often experience a triad of physical impairment, cognitive impairment, and emotional problems known as “post-intensive care syndrome”, or PICS. The PICS 1.0 project is a pilot study designed to shed light on the trauma patient’s experience of PICS by interviewing critical illness survivors and their family members at multiple time points during the first year of their recovery process. These interviews will be paired with neurocognitive testing to characterize the nature and trajectory of cognitive dysfunction occurring after severe traumatic injury and critical illness. This project is funded by pilot awards from the Penn Presbyterian Bach Fund and the Perelman School of Medicine McCabe Fund, and will begin recruitment in January 2016.

 

Education Highlights

Photo of Penn Anesthesia Simulation ProgramDimitry Baranov, MD, started simulation training program in the PENN's Department of Anesthesiology and Critical Care back in 2007 based on firm conviction that experiential hands-on training is the best form of education to prepare residents for direct patient care in any clinical setting. Initially it was limited to teaching clinical skills in a simulated environment to CA-1 anesthesia residents, using partial task trainers and computer based simulation software purchased by the Department. With the opening of the Penn Medicine Simulation Center the Departmental Simulation Program expanded to incorporate human patient simulators based training in a realistic peri-operative style environment. It was made possible with a number of the anesthesia faculty participating as instructors in the annual simulation course for all levels of anesthesia residents. The curriculum is centered on important anesthesia emergencies which residents may not encounter during clinical rotations.

In recent years our Anesthesia Simulation Program has become a crucial part of the Penn multidisciplinary team simulation-based training for crisis management. Joshua Atkins, MD, PhD, played a particularly important leading role in initiating, organizing and developing in situ simulation training sessions for crisis management involving Perioperative Nursing, General Surgery, Otorhinolaryngology, Intensive Care, and Cardiology Departments combined with the Anesthesia team. These sessions are directed at improving teamwork and reducing communication errors during a clinical crisis. These program has helped to achieve better organizational preparedness in various perioperative settings and reveal procedural and equipment shortcomings that exist in our system and therefore allowed us to improve patient safety and potentially improve outcome in similar future emergencies. Team simulation efforts, led by collaborative efforts between Otorhinolaryngology and Anesthesiology have been an important component of system wide risk-reduction efforts.  In 2013, the team received honorable mention in the UPHS Quality & Patient Safety Awards for Development of an In Situ Simulation Training Program to Detect Unit Based System Errors.

Currently our Anesthesia simulation faculty team is working to develop a perioperative in situ multidisciplinary team training curriculum in collaboration with the departments of Surgery and Perioperative Nursing that will provide a consistent training for all anesthesia and surgical residents and nurses in order to improve patient safety and outcomes in perioperative emergencies, and stimulate better teamwork practices in our institution. This goal would be unattainable without the dedication and hard work by our anesthesia simulation faculty – Drs Joshua AtkinsJared FeinmanCaroline FosnotGaurav Malhotra and Elizabeth Valentine

 

Grants and Contracts

Image of NIH logoOctober 1 - December 31, 2015 

Grant Proposals / amount:
            36 / $1,604,565 

Grants or Contracts Funded / amount:
            22 / $3,718,531 

(including UPENN and CHOP)

 

UPENN & CHOP Grant Proposals Submitted Oct 1 — Dec 31, 2015

PI

Dept

Sponsor

Title

Type

1 yr Total

Ashburn, Michael

UPENN

Teva Pharmaceutical

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (4% and 8% w/w Ointment) in Patients with Postherpetic Neuralgia Phase 2 Study TV-45070-CNS-20013 IND 108802 Protocol Approval Date: 20 November 2014

New

48,431

Atkins, Joshua

UPENN

Covidien

A retrospective analysis of the Closed Claims Project database, Anesthesia Incident Reporting System and National Anesthesia Clinical Outcomes Registry, to investigate the burden of respiratory compromise and anesthesia?s role in its management

New

10,692

Badiola, Ignacio

UPENN

Innocoll, Inc.

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety the XaraColl? Bupivacaine Implant (300 mg Bupivacaine Hydrochloride) After Open Laparotomy Hernioplasty

CTA

62,938

Berg, Robert

CHOP

NIH - UG1

Pediatric Critical Care Research Network at Children's Hospital of Philadelphia

CC

260,064

Berg, Robert

CHOP

NIH - R21

Pulmonary Vasodilator Therapy During Resuscitation from Cardiac Arrest

New

 

Berg, Robert

CHOP

NIH -U01

CCDP Protocol Collaborative Pediatric Critical Care Research Network (CPCCRN)

CC

20,000

Berg, Robert

CHOP

NIH-U01

PHENOMS

CC

1,200

Berg, Robert

CHOP

NIH-U01

PICqCPR

CC

1,200

Berg, Robert

CHOP

NIH - R21

Optimizing Chest Compression during Infant and Child Cardiopulmonary Resuscitation

Rev

 

Berg, Robert

CHOP

NIH - R01

Sepsis Induced Red Cell Dysfunction (SIRD)

CC

 

Bhatnagar, Seema

CHOP

US Dept of Defense

Sleep deprivation disruptions of habituation to stress: testing the role of glucocorticoid and circadian inputs to the paraventricular thalamus

New

 

Bhatnagar, Seema

CHOP

US Dept of Defense

High School Apprenticeship Program (HSAP)/Undergraduate Research Apprenticeship Program (URAP) through the Army Research Office

New

 

Cohen, Akiva

CHOP

NIH - R35

Developing an Electrophysiological Foundation for Traumatic Brain Injury Assessment 

New

 

Donoghue, Aaron

CHOP

Zoll Foundation

The Videography In Pediatric Emergency Resuscitation (VIPER) Collaborative: Establishing a Multicenter Registry Examining Resuscitative Care in the Pediatric Emergency Department

CC

 

Eckenhoff, Roderic

UPENN

Columbia Univ.

The Impact Of Surgery-Induced Neuroinflammation On Tau Pathology And Function

Rev

21,386

Eckmann, David

UPENN

NIH - R01

Smart Nanografted Infection-Responsive Catheters, Endotracheal Tubes and Implants

Rev

488,746

Elkassabany, Nabil 

UPENN

American Society of Regional Anesthesia

The effect of regional anesthesia in patients with adhesive capsulitis undergoing shoulder arthroscopy for capsular release on functional outcomes: Single shot peripheral nerve block vs. continuous nerve catheter

New

75,030

Even-Shoshan, Orit

CHOP

NIH - K08

Understanding Variations in Hip Fracture Outcomes across the Continuum

of Care

CC

16,421

Fitzgerald, Julie

CHOP

NIH - U01

Age of Blood in Children in the Pediatric Intensive Care Units (ABC-PICU) 

CC

3,850

Kilbaugh, Todd

CHOP

NIH - U01

Approaches and Decisions for Acute Pediatric Traumatic Brain Injury

CC

5,250

Laudanski, Krzysztof

UPENN

NIH - K08

Epigenetic mediated long-term aberrations in myeloid cells after critical illness

New

291,520

Liu, Jiabin

UPENN

American Society of Regional Anesthesia

Use of Phentolamine for Reversal of Peripheral Nerve Blockade

New

83,466

Liu, Renyu

UPENN

 Neurokappa Therapeutics, LLC

Salvinorin A for neonatal hypoxia/ischemia brain injury

New

127,718

Nadkarni, Vinay

CHOP

NIH - U01

HALF-PINT: Heart and Lung Failure-Pediatric Insulin Titration Trial

CC

 

Nishisaki, Akira

CHOP

NIH - R21

Improving safety and quality of tracheal intubations in neonatal ICUs

New

 

Rehman, Mohamed

CHOP

UPENN

Where You Live Matters: Using Geographical and Socioeconomic Factors to Improve Perioperative Access, Efficiency and Outcomes

New

 

Srinivasan, Vijay

CHOP

NIH - R01

Coagulation and Fibrinolysis with Hyperglycemia

CC

10,000

Sutton, Robert

CHOP

NIH - R01

Improving Pediatric Cardiac Arrest Survival and Neurologic Outcome (PICASO)

New

 

Valentino, Rita

CHOP

NIH - R01

Development of Defensive Behavior and Social Stress Consequences

CC

 

Wang, Wei

CHOP

Patient-Centered Outcomes Research Institute 

Building Better Instrumental Variables for Patient-Centered Outcomes Research

Rev

 

Wolfe, Heather

CHOP

American Heart Association

In-hospital QCPR Leaderboard Study

CC

3,278

Yehya, Nadir

CHOP

American Lung Association

Angiopoietin 2 in Pediatric Acute Respiratory Distress Syndrome

CC

 

Zane, Nicole

CHOP

Thrasher Research Fund

Thrasher Award

CC

13,375

Zuppa, Athena

CHOP

NIH - R01

Effective delivery of hydrophobic active pharmaceutical ingredients to infants using casein-based liquid formulations

New

 

Zuppa, Athena

CHOP

NIH - U01

Pediatric Ecmo and Cefepime (CPCCRN)

CC

60,000

Zuppa, Athena

CHOP

NIH - R21

Urine Tenofovir Testing to Monitor and Promote Adherence to PrEP for HIV Prevention

New

 
       

TOTAL

1,604,565


UPENN & CHOP Grant Awarded Oct 1 — Dec 31, 2015

PI

Dept

Sponsor

Title

Type

1 yr Total

Atkins, Joshua

UPENN

Becton, Dickinson and Co.

The INtelliport SafeTy and Accurate documeNTation Study (INSTANTS): A prospective, observational, multi-center study of the safety and accuracy advantages provided by the BD Intelliport ? System

New

45,759

Badiola, Ignacio

UPENN

Innocoll, Inc.

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety the XaraColl? Bupivacaine Implant (300 mg Bupivacaine Hydrochloride) After Open Laparotomy Hernioplasty

New

14,720

Berg, Robert

CHOP

Innocoll, Inc.

Pediatric Critical Care Research Network at Children's Hospital of Philadelphia

CC

260,064

Berg, Robert

CHOP

NIH - U01

CCDP Protocol Collaborative Pediatric Critical Care Research Network (CPCCRN)

CC

20,000

Berg, Robert

CHOP

NIH - U01

PHENOMS

CC

1,200

Berg, Robert

CHOP

NIH - U01

PICqCPR

CC

1,200

Cohen, Akiva

CHOP

US Dept of the Army

Blast Induced Thresholds for Neuronal Networks (BITNeT)

CC

22,990

Donoghue, Aaron

CHOP

Zoll Foundation

The Videography In Pediatric Emergency Resuscitation (VIPER) Collaborative: Establishing a Multicenter Registry Examining Resuscitative Care in the Pediatric Emergency Department

CC

 

Even-Shoshan, Orit

CHOP

NIH - K08

Understanding Variations in Hip Fracture Outcomes across the Continuum
 of Care

CC

16,421

Feldman, Jeffrey

CHOP

Draeger Medical, Inc

Draeger Medical Project 

New

5,500

Fitzgerald, Julie

CHOP

NIH-U01

Age of Blood in Children in the Pediatric Intensive Care Units (ABC-PICU) 

CC

3,850

Kelz, Max

UPENN

Univ. of Michigan

Reconstructing Consciousness and Cognition, Phase 2

New

27,1487

Kilbaugh, Todd

CHOP

NIH-U01

Approaches and Decisions for Acute Pediatric Traumatic Brain Injury

CC

5,250

Nadkarni, Vinay

CHOP

NIH-R01

Coagulation & Fibrinolysis with Hyperglycemia in Criticall Ill Children

CC

6,968

Nadkarni, Vinay

CHOP

Zoll Medical Corp

Pediatric RESuscitation Quality (pedRES-Q) Collaborative 

CC

250,000

Neuman, Mark

UPENN

Patient-Centered Outcomes Research Institute 

A Practical Intervention to Improve Patient-Centered Outcomes after Hip Fractures Among Older Adults (Regain Trial) 

New

2,411,732

Niles, Dana

CHOP

Agency for Health Care Research and Quality (AHRQ) - R18

Infant Simulation Program for In-hospital Resuscitation Education - Delivery Room

CC

249,679

Srinivasan, Vijay

CHOP

NIH-R01

Coagulation and Fibrinolysis with Hyperglycemia

CC

10,000

Valentino, Rita

CHOP

NIH-R01

Opioid modulation of the coerueleo-cortical pathway

New

45,058

Wolfe, Heather

CHOP

American Heart Association

In-hospital QCPR Leaderboard Study

New

3,278

Zane, Nicole

CHOP

Thrasher Research Fund

Thrasher Award

New

13,375

Zuppa, Athena

CHOP

NIH - U01

Pediatric Ecmo and Cefepime (CPCCRN)

CC

60,000

       

TOTAL

3,718,531

Supp;    supplement                                                          CC;       competing continuation/renewal        

Rev;      revised proposal                                                   NCR;     non-Competing Renewal

New;     new proposal/grant                                               Ext;       extension

 

Publications

Image of PubMed logoClick here to view all UPENN & CHOP Anesthesia publications for 2015.

 

 

From October 1 — December 31, 2015, over 60 peer reviewed publications have been published from the Department, including UPENN and CHOP.

Name

Title

Journal

 Date/Volume/Pages

Lampe JW, Bratinov G, Weiland TR 3rd, Illindala U, Berg RA, Becker LB.

Volume infusion cooling increases end-tidal carbon dioxide and results in faster and deeper cooling during intra-cardiopulmonary resuscitation hypothermia induction.

Intensive Care Med Exp. 

2015 Dec;3(1):37. Epub 2015 Dec 29.

Frontera JA, Lewin Iii JJ, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, Del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL.

Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage : A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.

Neurocrit Care

2015 Dec 29. [Epub ahead of print]

Ramakrishna H, O'Hare M, Mookadam F, Gutsche JT, Shah R, Augoustides JG.

Sudden Cardiac Death and Disorders of the QT Interval: Anesthetic Implications and Focus on Perioperative Management.

J Cardiothorac Vasc Anesth. 

2015 Dec;29(6):1723-33. 

Heller JA, DeMaria S, Levine A, Heller BJ, Augoustides JG, Stone M, Silvay G, Goldberg A.

Cardiovascular and Pulmonary Impact of the Ebola Virus: A Review of Current Literature and Practices.

J Cardiothorac Vasc Anesth.

2015 Dec;29(6):1672-6. 

Ghadimi K, Gutsche JT, Setegne SL, Jackson KR, Augoustides JG, Ochroch EA, Bavaria JE, Cheung AT.

Severity and Duration of Metabolic Acidosis After Deep Hypothermic Circulatory Arrest for Thoracic Aortic Surgery.

J Cardiothorac Vasc Anesth

2015 Dec;29(6):1432-40. 

Gaiser R.

Anesthetic Considerations in the Obese Parturient.

Clin Obstet Gynecol.

2015 Dec 19. [Epub ahead of print]

Adams JA, Uryash A, Nadkarni V, Berg RA, Lopez JR.

Whole body periodic acceleration (pGz) preserves heart rate variability after cardiac arrest.

Resuscitation

2015 Dec 12;99:20-25.

Buttenheim AM, Fiks AG, Burson Ii RC, Wang E, Coffin SE, Metlay JP, Feemster KA.

A behavioral economics intervention to increase pertussis vaccination among infant caregivers: A randomized feasibility trial.

Vaccine.

2015 Dec 10. [Epub ahead of print]

Onuoha OC, Hatch MB, Miano TA, Fleisher LA.

The incidence of un-indicated preoperative testing in a tertiary academic ambulatory center: a retrospective cohort study.

Perioper Med (Lond). 

2015 Dec 15;4:14. 

Liu J, Elkassabany NM, Kamath AF, Nelson CL.

Reply to the Letter to the Editor: Low Albumin Levels, More Than Morbid Obesity, Are Associated With Complications After TKA.

Clin Orthop Relat Res. 

2015 Dec 15 [Epub ahead of print]

Nelson O, Quinn TD, Arriaga AF, Hepner DL, Lipsitz SR, Cooper Z, Gawande AA, Bader AM.

A Model for Better Leveraging the Point of Preoperative Assessment: Patients and Providers Look Beyond Operative Indications When Making Decisions.

A A Case Rep. 

2015 Dec 11. [Epub ahead of print]

Keele L, Meert KL, Berg RA, Dalton H, Newth CJ, Harrison R, Wessel DL, Shanley T, Carcillo J, Morrison W, Funai T, Holubkov R, Dean JM, Pollack M; Eunice KennedyShriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. 

Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed?

Pediatr Crit Care Med. 

2015 Dec 11. [Epub ahead of print]

Yehya N, Bhalla AK, Thomas NJ, Khemani RG.

Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome.

Pediatr Crit Care Med. 

2015 Dec 11. [Epub ahead of print]

Browning B, Page KE, Kuhn RL, DiLiberto MA, Deschenes J, Taillie E, Tomanio E, Holubkov R, Dean JM, Moler FW, Meert K, Pemberton VL.

Nurses' Attitudes Toward Clinical Research: Experience of the Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials.

Pediatr Crit Care Med.

2015 Dec 11. [Epub ahead of print]

Rassekh CH, Zhao J, Martin ND, Chalian AA, Atkins JH.

Tracheostomy Complications as a Trigger for an Airway Rapid Response: Analysis and Quality Improvement Considerations.

Otolaryngol Head Neck Surg. 

2015 Dec;153(6):921-6.  Epub 2015 Oct 30.

Murthy S, Hepner DL, Cooper Z, Bader AM, Neuman MD.

Controversies in anaesthesia for noncardiac surgery in older adults.

Br J Anaesth.

2015 Dec; 115 Suppl 2:ii15-ii25. 

Pryzbylkowski P, Ashburn MA.

The Pain Medical Home: A Patient-Centered Medical Home Model of Care for Patients with Chronic Pain.

Anesthesiol Clin.

2015 Dec;33(4):785-93. 

Fosnot CD, Fleisher LA, Keogh J.

Providing Value in Ambulatory Anesthesia in 2015.

Anesthesiol Clin.

2015 Dec;33(4):731-8. 

Atkins JH, Fleisher LA.

Value from the Patients' and Payers' Perspectives.

Anesthesiol Clin. 

2015 Dec;33(4):651-8. 

Cheng A, Hunt EA, Grant D, Lin Y, Grant V, Duff JP, White ML, Peterson DT, Zhong J, Gottesman R, Sudikoff S, Doan Q, Nadkarni VM; International Network for Simulation-based Pediatric Innovation, Research, and Education (INSPIRE) CPR Investigators.

Variability in Implementation of Interventions Aimed at Reducing Readmissions Among Patients With Heart Failure: A Survey of Teaching Hospitals.

Resuscitation 

2015 Dec;97:13-9. 

Fahy BG, Brull SJ, Schwartz AJ.

Anesthesiology Graduate Medical Education: Best Approaches for the Learner, Best Approaches for the Teacher.

Anesth Analg.

2015 Dec;121(6):1428-9. 

Srinivasan V.

Genetic Polymorphisms in the Somatotropic Axis and Critical Illness: "SNiPping" Away at a "Growing" Canvas!

Crit Care Med. 

2015 Dec;43(12):2695-6. 

Yuerek M, Rossano JW, Mascio CE, Shaddy RE.

Postoperative management of heart failure in pediatric patients.

Expert Rev Cardiovasc Ther. 

2015 Dec 1:1-15. [Epub ahead of print]

Madrigal VN, Carroll KW, Faerber JA, Walter JK, Morrison WE, Feudtner, C 

Parental Sources of Support and Guidance When Making Difficult Decisions in the Pediatric Intensive Care Unit.

J Pediatr.

2015 Dec 1. [Epub ahead of print]

Berg RA, Nadkarni VM, Clark AE, Moler F, Meert K, Harrison RE, Newth CJ, Sutton RM, Wessel DL, Berger JT, Carcillo J, Dalton H, Heidemann S, Shanley TP, Zuppa AF, Doctor A, Tamburro RF, Jenkins TL, Dean JM, Holubkov R, Pollack MM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs.

Crit Care Med.

2015 Dec 7. [Epub ahead of print]

Royo MB, Fleisher LA.

Chasing myocardial outcomes: perioperative myocardial infarction and cardiac troponin.

Can J Anaesth. 

2015 Dec 3. [Epub ahead of print]

Fleisher LA.

Value of Sequels: Is It Safe to Include Nitrous Oxide in Your Anesthetic?

Anesthesiology 

2015 Dec;123(6):1229-30.

Cooper Z, Sayal P, Abbett SK, Neuman MD, Rickerson EM, Bader AM.

A Conceptual Framework for Appropriateness in Surgical Care: Reviewing Past Approaches and Looking Ahead to Patient-centered Shared Decision Making.

Anesthesiology 

2015 Dec;123(6):1450-4. 

Rehder KJ, Giuliano JS Jr, Napolitano N, Turner DA, Nuthall G, Nadkarni VM, Nishisaki A; National Emergency Airway Registry for Children and Pediatric Acute Lung Injury and Sepsis Investigators.

Increased Occurrence of Tracheal Intubation-Associated Events During Nights and Weekends in the PICU.

Crit Care Med. 

2015 Dec;43(12):2668-74. 

Fosnot CD, Fleisher LA, Keogh J.

Providing Value in Ambulatory Anesthesia in 2015.

Curr Opin Anaesthesiol. 

2015 Dec;28(6):617-22. 

Reyes BA, Zitnik G, Foster C, Van Bockstaele EJ, Valentino RJ.

Social Stress Engages Neurochemically-Distinct Afferents to the Rat Locus Coeruleus Depending on Coping Strategy(1,2,3).

eNeuro. 

2015 Nov 26;2(6). 

Smith CJ, Xiong G, Elkind JA, Putnam B, Cohen AS.

Brain Injury Impairs Working Memory and Prefrontal Circuit Function.

Front Neurol. 

2015 Nov 13;6:240. 

Sivasankar C, Stiefel M, Miano TA, Kositratna G, Yandrawatthana S, Hurst R, Kofke WA.

Anesthetic variation and potential impact of anesthetics used during endovascular management of acute ischemic stroke.

J Neurointerv Surg.

2015 Nov 27. [Epub ahead of print]

Resnick B, Beaupre L, McGilton KS, Galik E, Liu W, Neuman MD, Gruber-Baldini AL, Orwig D, Magaziner J.

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review.

J Am Med Dir Assoc. 

2015 Nov 20. [Epub ahead of print] 

Goudra B, Nuzat A, Singh PM, Gouda GB, Carlin A, Manjunath AK.

Cardiac arrests in patients undergoing gastrointestinal endoscopy: A retrospective analysis of 73,029 procedures.

Saudi J Gastroenterol.

2015 Nov-Dec;21(6):400-11. 

Adhikary SD, Liu WM, Memtsoudis SG, Davis CM 3rd, Liu J.

Body Mass Index More Than 45 kg/m2 as a Cutoff Point Is Associated With Dramatically Increased Postoperative Complications in Total Knee Arthroplasty and Total Hip Arthroplasty.

J Arthroplasty. 

2015 Nov 10.  [Epub ahead of print]

Muhly WT, Gurnaney HG, Ganesh A.

Regional anesthesia for pediatric knee surgery: a review of the indications, procedures, outcomes, safety, and challenges.

Local Reg Anesth.

2015 Nov 5;8:85-91. 

Hadler RA, Neuman MD, Raper S, Fleisher LA.

Advance Directives and Operating: Room for Improvement?

A A Case Rep. 

2015 Nov 23. [Epub ahead of print]

Armstead WM Ph D, Riley J, Vavilala MS.

Norepinephrine Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis after Traumatic Brain Injury via Block of ERK MAPK and IL-6 in Juvenile Pigs.

J Neurotrauma. 

2015 Nov 23. [Epub ahead of print]

Lane-Fall MB, Collard ML, Turnbull AE, Halpern SD, Shea JA.

ICU Attending Handoff Practices: Results From a National Survey of Academic Intensivists.

Crit Care Med. 

2015 Nov 17. [Epub ahead of print]

Covarrubias M, Barber AF, Carnevale V, Treptow W, Eckenhoff RG

Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics.

Biophys J.

2015 Nov 17;109(10):2003-11. 

Vasilevskis EE, Kripalani S, Ong MK, Rosenthal JT, Longnecker DE, Harmon B, Hohmann SF, Wright K, Black JT.

Variability in Implementation of Interventions Aimed at Reducing Readmissions Among Patients With Heart Failure: A Survey of Teaching Hospitals.

Acad Med. 

2015 Nov 17;109(10):2003-11. 

Pieczynski LM, Raiten JM, Lane-Fall MB.

From Root Cause to Action Plan: How an Adverse Event Uncovered Deficiencies in Resident Knowledge of Sedation Policies and Practices.

A A Case Rep. 

2015 Nov 13. [Epub ahead of print]

Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS.

Neurotoxicity, general anesthesia in young children, and a survey of current pediatric anesthesia practice at US teaching institutions.

Paediatr Anaesth. 

2015 Nov 12.[Epub ahead of print]

Gardner B, Strus E, Meng QC, Coradetti T, Naidoo NN, Kelz MB, Williams JA.

Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol?

Anesthesiology

2015 Nov 9. [Epub ahead of print]

Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS.

Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury.

Mitochondrion

2015 Nov 5;26:19-25. [Epub ahead of print]

Lampe JW, Tai Y, Bratinov G, Weiland TR, Kaufman CL, Berg RA, Becker LB.

Developing a kinematic understanding of chest compressions: the impact of depth and release time on blood flow during cardiopulmonary resuscitation.

Biomed Eng Online.

2015 Nov 4;14(1):102. 

Su E, Kantor DB, Conlon T.

Looking for Tips on Central Venous Catheter Insertion? Try Ultrasound.

Pediatr Crit Care Med.

2015 Nov;16(9):891-3. 

Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E.

Diverse and Tissue Specific Mitochondrial Respiratory Response in A Mouse Model of Sepsis-Induced Multiple Organ Failure.

Shock.

2015 Nov 2. [Epub ahead of print]

Paterno R, Metheny H, Xiong G, Elkind J, Cohen AS.

Mild traumatic brain injury decreases broadband power in area CA1.

J Neurotrauma. 

2015 Nov 3. [Epub ahead of print] 

Irving SY, Seiple S, Nagle M, Falk S, Mascarenhas M, Srinivasan V.

Perceived Barriers To Anthropometric Measurements In Critically Ill Children.

Am J Crit Care. 

2015 Nov;24(6):e99-e107. 

Adler AC.

Medical Literature: Don't Believe Everything You Read.

Acad Med.

2015 Nov;90(11):1432. 

Neuman MD, Werner RM.

Marital Status and Postoperative Functional Recovery.

JAMA Surg. 

2015 Oct 28:1-3. [Epub ahead of print] 

Adler AC, Jablonka DH

Bedside Ultrasound: A Tool for Assessment of IV Functionality.

Anesthesiology 

2015 Oct 22. [Epub ahead of print] 

Neuman MD.

Understanding outcomes after neuraxial anaesthesia: time to turn the page.

Br J Anaesth.

2015 Oct 20. [Epub ahead of print] 

Hu YY, Parker SH, Lipsitz SR, Arriaga AF, Peyre SE, Corso KA, Roth EM, Yule SJ, Greenberg CC.

Surgeons' Leadership Styles and Team Behavior in the Operating Room.

J Am Coll Surg.

2015 Oct 17. [Epub ahead of print] 

Brunetti MA, Glatz AC, McCardle K, Mott AR, Ravishankar C, Gaynor JW.

Unplanned Readmission to the Pediatric Cardiac Intensive Care Unit: Prevalence, Outcomes, and Risk Factors.

World J Pediatr Congenit Heart Surg. 

2015 Oct;6(4):597-603. 

Yi P, Pryzbylkowski P.

Opioid Induced Hyperalgesia.

Pain Med. 

2015 Oct;16 Suppl 1:S32-6. 

Chen A, Ashburn MA

Cardiac Effects of Opioid Therapy.

Pain Med. 

2015 Oct;16 Suppl 1:S32-6. 

Myerson JW, Anselmo AC, Liu Y, Mitragotri S, Eckmann DM, Muzykantov VR.

Non-affinity factors modulating vascular targeting of nano- and microcarriers.

Adv Drug Deliv Rev.

2015 Oct 24 [Epub ahead of print] 

Lane-Fall MB, Gutsche JT.

The Challenge of Studying and Improving Perioperative Teamwork, and Yes, Another Checklist.

Anesth Analg. 

2015 Oct;121(4):852-3. 

Disclaimer: The search routine may include a few false positives. Only papers which include in the author contact, "Anesthesiology and Critical Care" along with either: "Hospital of the University of Pennsylvania" or "Perelman School of Medicine " or "Children's Hospital of Philadelphia," will be included in this search.

 

Announcements and Awards

Press Releases 

Mark Neuman, MD recently found that patients who are divorced, separated or widowed had an increased risk of dying or developing a new functional disability in the first two years following cardiac surgery than their married peers.  Penn Medicine News Release

David Eckmann, PhD, MD, is a collaborator on an NSF Partnership in Research and Education (PIRE) project for the development of Active Coating Technologies (ACTs) with the aim to transform the human habitat and our ability to respond to disasters. NSF Press Release

Awards

Rosemary Polomano, PhD, RN, FAAN,  and John Farrar, MD, PhD received Penn’s National Institutes of Health designation as a Center for Excellence in Pain Education (CoEPE). The CoEPE will act as hubs for the development, evaluation, and distribution of pain management curriculum resources for medical, dental, nursing, pharmacy and other schools to enhance and improve how health care professionals are taught about pain and its treatment.  

Mark Neuman, MD was awarded the Marjorie A. Bowman New Investigator Research Award at the 20th Annual Raymond and Ruth Perelman School of Medicine Awards of Excellence evening on November 18, 2015.  

Marc Royo, MD and team, including Elizabeth Valentine, MDRenyu Liu, MD, PhDOnyi Onuoha, MD, MPH,  Eric Greenblatt, MDJoseph Savino, MDLee Fleisher, MD, and anesthesia residents , Kathryn Hall, MD and Ronnie Zeidan, MD,  have been awarded an Innovation Accelerator Program Award to reimagine the preoperative evaluation processes to reduce cancellations and improve outcomes. 

Jeff E Mandel MD, presented modeling of human performance in drug administration at the FDA Workshop, Physiological Closed-Loop Controlled Devices, on October 13-15, 2015.

Leadership Positions 

W. Andrew Kofke, MD has been elected the 2015-2016 President of the Society of Neuroscience in Anesthesiology and Critical Care (SNACC).

John H. Keogh, MD, has accepted the position of Clinical Director of HUP Operating Rooms, effective January 11, 2016.

Elizabeth Valentine, MD, has been appointed as the Patient Safety Officer for the Department of Anesthesiology and Critical Care for the HUP campus.  

Promotions

Associate Professor of Anesthesiology and Critical Care:

 

Newsletter Naming Contest Results!

Image of winning envelopeThe newsletter naming award is shared by the Dos Equis (Eckmann & Eckenhoff),

two of the most interesting men in the world!

Close


2016 Spring

Spring 2016

This edition highlights UPENN and CHOP Faculty Scholarship for April 1 - June, 30, 2016                                           

Research Highlights

Photo of the Eckmann LabIn addition to being an attending anesthesiologist at HUP, Dr. David Eckmann is a PhD Bioengineer with expertise in biological fluid dynamics. His scientific research focus has been on interfacial phenomena in vascular medicine, including experimental and computational research techniques to address vascular endothelial targeting of drug nanocarriers, thin film surface coatings for vascular biomaterials and, most recently, cellular metabolic engineering. Dr. Eckmann has over 20 years of continuous extramural grant funding, including serving as the principle investigator on multiple NIH, NSF, Department of Defense (DoD) and NASA grants. This includes the recent awarding of a DoD infrastructure grant of approximately $170,000 to purchase new major cell metabolism analysis equipment for the lab.

Dr. Eckmann’s laboratory is in the John Morgan Building, and his lab group’s work is described on the lab webpage http://www.med.upenn.edu/eckmann-lab/ . Members of his lab group include postdocs, graduate students and technicians as well as faculty collaborators from several other departments in the Perelman School of Medicine and the School of Engineering and Applied Sciences, where he also holds a faculty appointment in Bioengineering. Dr. Eckmann is leading team science in multiple projects, including:

1.      Cell mechanics and cell bioenergetics: the Eckmann lab is studying how bioenergetic interactions bridging mitochondrial function and cellular maintenance of normal mechanical integrity occur via specific biochemical pathways in which appropriate signaling and normal cell health is preserved. They are attempting to identify critical “break points” in signaling that occur during environmental and toxic stress exposure and lead directly to alterations in either mitochondrial function or cell mechanics, with cell death or aberrant cellular function resulting from the loss of the normal interplay between cell mechanics and bioenergetics. This work relies on fluorescence microscopy techniques, atomic force microscopy methods, measures of mitochondrial function and energetic state.

2.      Targeted drug delivery and nanocarrier design: Dr. Eckmann and colleagues are using experimental and computational methods to optimize design parameters such that nanocarriers loaded with trackable cargoes and decorated with targeting molecules to endothelial determinants (e.g., ICAM-1 surface molecules) will: i) efficiently bind to endothelial cells, ii) enter endothelial endosomes and, iii) effectively unload their cargo in this compartment. Our methods include development of soft materials (e.g., nanogels) to have various drug loading and unloading characteristics, utilization of click-chemistry to decorate a variety of linkers and binding molecules for targeting to the nanocarrier surface, and cell-based and animal-based experiments to determine optimal parameters for targeting efficiency.

3.      Surface coatings for vascular and other implantable biomaterials: Dr. Eckmann works with materials scientists and chemists to develop ultrathin-film polymer constructs which, when grafted to the surface of vascular biomaterials (stents, grafts, implants) provide a “biomimetic” endothelial surface layer that reduces or eliminates thrombogenic and immunogenic responses of blood contact with the artificial surface. These polymer layers also can be chemically tuned to be bioresponsive for drug release for antimicrobial (i.e., anti-infection) drugs to prevent catheter-associated infections and ventilator-associated pneumonia and for elution of other drugs useful in biomaterial applications.

 

Education Highlights

Photo of the Penn Anesthesia CT Fellowship GroupThe Adult Cardiothoracic Anesthesiology Fellowship is a one-year clinical program designed to prepare graduates for leadership positions in the subspecialty practice of cardiothoracic anesthesiology. This fellowship is accredited by the Accreditation Council for Graduate Medical Education (ACGME) and provides state-of-the-art experience in a multidisciplinary academic environment. The clinical learning environment is designed to achieve competence in patient care, medical knowledge, practice-based learning and improvement, interpersonal and communication skills, professionalism, and systems-based practice in the field of cardiothoracic anesthesiology. The fellowship program offers 5 positions each academic year to qualified applicants. The current program director is Professor John Augoustides who has served in this capacity since 2014.

Clinical instruction is provided in the cardiothoracic operating rooms and intensive care unit under the supervision of faculty members. Fellows are assigned to provide comprehensive anesthetic and perioperative care that includes the performance and interpretation of the intraoperative echocardiographic examination.  The intraoperative experience in cardiothoracic anesthesiology is also supplemented with clinical experience of complex cardiac and thoracic surgical patients in the Cardiothoracic Surgical Intensive Care Unit. Their clinical ICU experience includes preoperative care and management of cardiogenic shock, ECMO and comprehensive care of the postoperative cardiac surgical patient. During the year, the fellow will prepare a case presentation for Department of Anesthesiology and Critical Care Grand Rounds, two case presentations for the Cardiology, CT Surgery, CT Anesthesiology Case Conference, and two literature review presentations for the Advanced Topics in Cardiothoracic Anesthesiology Fellow Conference.  The rigorous educational curriculum also prepares graduates for certification in Advanced Perioperative Transesophageal Echocardiography from the National Board of Echocardiography.

Scholarly activity, including laboratory or clinical research and publications, is encouraged.   Academic time and support is provided to fellows based on their career pathway and area of investigation.   In addition to the one-year clinical fellowship, the following three academic development tracks are also offered to qualified applicants:

1.     The combined Critical Care Medicine and Cardiothoracic Anesthesiology track is a two-year program for achieving board certification in both Adult Cardiothoracic Anesthesiology and Critical Care Medicine with an emphasis in Cardiothoracic Surgical Critical Care. Elective time is provided in order to pursue collaborative research with core faculty.

2.     The Instructor track is a two-year program designed for candidates seeking board certification in Adult Cardiothoracic Anesthesiology with the intention of pursuing an academic career as a clinical and/or collaborative investigator in the clinician-educator or academic clinician tracks. In the Instructor track, the candidate will be offered a faculty position as an Instructor in the division of cardiothoracic anesthesiology upon completion of the clinical requirements of the one-year fellowship. As an Instructor within the division, the candidate will be provided with sufficient academic time for research and educational projects.

3.     The Research Training Grant track is a three-year program designed for candidates seeking board certification in Adult Cardiothoracic Anesthesiology with the intention of pursuing an academic career as an independent investigator in the tenure-track. After fulfilling the clinical requirements of the fellowship, the candidate will devote two years of time pursuing basic or clinical research with an established investigator participating in the NIH-funded T-32 program at the University of Pennsylvania.

 

Grants and Contracts

Image of NIH logoJanuary 1 - March 31, 2016 

New Proposals / amount:
            41 / $7,342,440

New Awards / amount:
            8 / $1,233,792

(including UPENN and CHOP)

UPENN & CHOP Grant Proposals Jan 1 — Mar 31, 2016

PI

Dept

Sponsor

Title

Type

1 yr Total

Barr, Gordon

CHOP

NIH - R01

Adult neurobehavioral effects of using maternal presence as an analgesic in infants

Rev

$634,515

Berg, Robert

CHOP

NIH - U01

Inhaled Nitric Oxide in Pediatric Intensive Care

New

$1,000

Berg, Robert

CHOP

NIH - U01

Microbiome, Virome, and Host Responses Preceding Ventilator-Associated Pneumonia (VAP)

New

 

Bhatnagar, Seema

CHOP

NIH - R01

S1PR3 regulation of stress resilience

New

$582,515

Bhatnagar, Seema

CHOP

NASA

Biomarkers as Predictors of Physiological and Behavioral Responses to Sleep Loss and Intermittent Artificial Gravity
during 60-Days of Head-Down Tilted Bed Rest

New

$61,664

Bhatnagar, Seema

CHOP

NIH - R21

The gut microbiome and resilience to stress

New

$210,000

Bhatnagar, Seema

CHOP

NIH - R01

The Biological Embedding of Exposure to Violence

New

$23,139

Bhatnagar, Seema

CHOP

NIH - R01

Sex differences in orexins

Rev

$420,000

Blume, Shanon

CHOP

L'Oreal USA

L'Oreal Fellowship

New

$60,000

Cohen, Akiva

CHOP

NIH - R37

Injury-Induced Alterations in Limbic Functional Circuity

CC

$377,125

Donoghue, Aaron

CHOP

NIH - N01

Impact of personal protective equipment on pediatric procedures

New

$118,383

Donoghue, Aaron

CHOP

NIH - R21

Videography in emergency pediatric resuscitation collaborative

New

$241,124

Donoghue, Aaron

CHOP

NIH - R21

Impact of high frequency training on CPR performance in the pediatric emergency department

New

$210,000

Eckmann, David

UPENN

Children's Hospital of Philadelphia

Fabrication and Characterization of CD47 Modified Blood Conduits

New

$64,895

Feldman, Jeffrey

CHOP

Covidien

Alarms, Volumetric Capnography, Features Trend Visualization, and Capnography and Flow Feldman Consulting Services Agreement

New

$24,000

Fitzgerald, Julie

CHOP

NIH - U01

Age of Blood in Children in the Pediatric Intensive Care Units (ABC-PICU) 

CC

$3,850

Kelz, Max

UPENN

University of Miami

Zebrafish as a model for post-operative delirium

New

$40,868

Kofke, William 

UPENN

NIH - R01

Validation by PET of a Noninvasive  Neurometabolic and CBF Monitor in Humans

Rev

$648,181

Laudanski, Krzysztof

UPENN

American Heart Association

Epigenetic aberrations of monocyte function are responsible for unfavorable outcomes after cardiac

surgery

New

$77,000

Laudanski, Krzysztof

UPENN

Foundation for Anesthesia Education and Research (FAER)

Acquired aberration of PU.1 regulation are responsible for long-term immune dysfunction after sepsis in humanized mice

New

$75,000

Laudanski, Krzysztof

UPENN

International Anesthesia Research Society

Long-term decline in immunity after cardiopulmonary bypass

New

$75,000

Liu, Renyu

UPENN

NIH - R01

The role of kappa opioid receptor in neonatal brain hypoxia/ischemia

New

$402,500

Liu, Renyu

UPENN

NIH - R21

Kappa opioid receptor and brain hypoxia/ischemia

New

$241,500

Maxwell, Lynne

CHOP

Thrasher Research Fund

Neurocognitive Outcomes 5 Years After Infant Anesthesia: The GAS Trial

New

$2,944

Morrison, Wynne

CHOP

New York Academy of Medicine

Prospective Validation of the Pediatric Time of Death Predictor Scores After Terminal Withdrawal of Mechanical Ventilation

New

$4,000

Nadkarni, Vinay

CHOP

NIH - R21

Capnography to Improve Cardiopulmonary Resuscitation Quality among Children: A Training and Assessment Tool

New

$18,440

Nadkarni, Vinay

CHOP

NIH - R44

Risk Assessment Using Noninvasive Measurements in PostOp Pediatric Patients

CC

$160,002

Rehman, Mohamed

CHOP

NSF

PFI: BIC: A Clinical Decision Support System for Cardiac Arrest Prediction in Pediatric Intensive Care Units

New

$91,316

Valentino, Rita

CHOP

NIH - R01

Opioid Modulation of the Coeruleo-cortical Pathway

CC

$152,440

Valentino, Rita

CHOP

Alzheimer's Association 

Norepinephrine and regulation of amyloid beta

New

$35,000

Valentino, Rita

CHOP

NIH - R01

Stress, CRF and Locus Coeruleus-Cortical Network Activity

New

$420,000

Valentino, Rita

CHOP

NIH - R01

Sex Differences in CRF Regulation of Serotonin and Cognitive Consequences  

Rev

$671,692

Valentino, Rita

CHOP

NIH - R21

Optogenetic characterization of Corticotropin-releasing factor neurons of Barrington's Nucleus 

Rev

$126,000

Wei, Huafeng

UPENN

NIH - R01

Mechanism and Prevention of General Anesthetics Mediated Deterioration of Pathology and Cognitive dysfunction in Alzheimer?s Disease

New

$416,466

Weiss, Scott

CHOP

University of Pennsylvania

The Intestinal Microbiome in Pediatric Septic Shock: Feasibility, Clinical Relevance, and Association with Mitochondrial-Induced Immune Dysregulation

New

$39,041

Weiss, Scott

CHOP

NIH - K23

Mitochondrial Dysfunction in Pediatric Sepsis

CC

$181,155

Wolfe, Heather

CHOP

NIH - R01

Delirium in Critically-Ill Children – Understanding the Burden of Disease

New

$18,440

Zane, Nicole

CHOP

L'Oreal USA

Age-dependent Differences in Intestinal Metabolism Impact Bioavailability of Voriconazole

New

$60,000

Zuppa, Athena

CHOP

NIH

GM-CSF for Immunomodulation Following Trauma 

New

$1,710

Zuppa, Athena

CHOP

NIH - R01

Genetic Analysis of Pediatric Phenotypes of sedations (GAPPs)

Rev

$227,007

Zuppa, Athena

CHOP

NIH - T32

Use of a novel therapeutic (DMFO) in the treatment of pts with high risk NB

CC

$124,528

       

TOTAL

$7,342,440


UPENN & CHOP Grant Awards Jan 1 — Mar 31, 2016

PI

Dept

Sponsor

Title

Type

1 yr Total

Armstead, William

UPENN

University of Washington

Vasoactive Agents and Cerebral Outcomes in Brain Injury

New

$31,354

Berg, Robert

CHOP

NIH - U01

Inhaled Nitric Oxide in Pediatric Intensive Care

New

$1,000

Berg, Robert

CHOP

NIH - U01

Microbiome, Virome, and Host Responses Preceding Ventilator-Associated Pneumonia (VAP)

New

$1,200

Cohen, Akiva

CHOP

NIH - R21

Restoring Normal Output After Traumatic Brain Injury 

New

$252,000

Donoghue, Aaron

CHOP

NIH - N01

Impact of personal protective equipment on pediatric procedures

New

$118,383

Feldman, Jeffrey

CHOP

Covidien

Alarms, Volumetric Capnography, Features Trend Visualization, and Capnography and Flow Feldman Consulting Services Agreement

New

$24,000

Sutton, Robert

CHOP

NIH - R01

Improving Outcomes after Pediatric Cardiac Arrest

New

$804,145

Zuppa, Athena

CHOP

NIH

GM-CSF for Immunomodulation Following Trauma 

New

$1,710

       

TOTAL

$1,233,792

Supp;    supplement                                                          CC;       competing continuation/renewal        

Rev;      revised proposal                                                   NCR;     non-Competing Renewal

New;     new proposal/grant                                               Ext;       extension

 

Image of PubMedPublications

From January 1 - March 31, 2016, over 90 publications have been posted to PubMed, including UPENN and CHOP.  For the complete list click here and see all 2016 publications here.

From Jan 1 — Mar 31, 2016, over 90 peer reviewed publications have been published from the Department, including UPENN and CHOP.

Name

Title

Journal

 Date/Vol/Pages

Lyons MM, Bhatt NY, Kneeland-Szanto E, Keenan BT, Pechar J, Stearns B, Elkassabany NM, Memtsoudis SG, Pack AI, Gurubhagavatula I.

Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility.

Biomark Med. 

2016 Mar; 10(3):265-300. 

Litman RS.

The Use of Patient Registries to Detect Risk Factors of Anesthesia and Sedation Complications.

Pediatrics. 

2016 Mar; 137(3):1-2. 

Gurubhagavatula I, Nadkarni V, Winston F

Blind Spot: Are We Neglecting House Staff Driving Safety in the Era of Duty Hour Regulations? Driving Performance of Residents after Six Consecutive Overnight Work Shifts.

Anesthesiology

2016 Mar 30. [Epub ahead of print] 

Schwartz AJ.

Anesthetic Records: Lessons about Ethics and Education.

Anesthesiology

2016 Mar 30. [Epub ahead of print

Johnstone RE, Fleisher LA.

A 1966 Anesthetic Administered by Robert D. Dripps, M.D., Demonstrated His Experimental Style of Clinical Care.

Anesthesiology

2016 Mar 30. [Epub ahead of print]

Carvajal T, Villablanca-Spinetto P, Augoustides JG, Morozowich ST, Shamoum FE, Gutsche JT, Ramakrishna H.

Transcatheter Aortic Valve Replacement: Recent Evidence from Pivotal Trials.

J Cardiothorac Vasc Anesth

2016 Mar 22. [Epub ahead of print] 

Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ.

Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction.

J Bioenerg Biomembr

2016 Mar 28. [Epub ahead of print]

Elkassabany NM, Antosh S, Ahmed M, Nelson C, Israelite C, Badiola I, Cai LF, Williams R, Hughes C, Mariano ER, Liu J.

The Risk of Falls After Total Knee Arthroplasty with the Use of a Femoral Nerve Block Versus an Adductor Canal Block: A Double-Blinded Randomized Controlled Study.

Anesth Analg

2016 Mar 22. [Epub ahead of print]

Armstead WM, Riley J, Vavilala MS.

Norepinephrine Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis after Traumatic Brain Injury via Blockade of ERK MAPK and IL-6 in Juvenile Pigs.

J Neurotrauma. 

2016 Mar 22. 

Wu FX, He Y, Di HT, Sun YM, Pan RR, Yu WF, Liu R..

An Engineered Endomorphin-2 Gene for Morphine Withdrawal Syndrome.

PLoS One

2016 Mar 22; 11(3): e0149877

Pieczynski LM, Raiten JM, Lane-Fall MB.

From Root Cause to Action Plan: How an Adverse Event Uncovered Deficiencies in Resident Knowledge of Sedation Policies and Practices.

A A Case Rep. 

2016 Mar 15; 6(6):163-71. 

Ashburn MA, Fleisher LA.

Does assessment of patient satisfaction with pain care lead to patient harm?

Healthc (Amst). 

2016 Mar; 4(1):6-8. 

Silber JH, Satopää VA, Mukherjee N, Rockova V, Wang W, S Hill A, Even-Shoshan O, Rosenbaum PR, George EI.

Improving Medicare's Hospital Compare Mortality Model.

Health Serv Res. 

2016 Mar 14. [Epub ahead of print]

Wunsch H, Wijeysundera DN, Passarella MA, Neuman MD.

Opioids Prescribed After Low-Risk Surgical Procedures in the United States, 2004-2012.

JAMA

Mar 15. [Epub ahead of print] 

Moon RE, Martina SD, Peacher DF, Potter JF, Wester TE, Cherry AD, Natoli MJ, Otteni CE, Kernagis DN, White WD, Freiberger JJ.

Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.

Circulation. 

2016 Mar 8; 133(10):988-96. 

Sanders RC Jr, Nett ST, Davis KF, Parker MM, Bysani GK, Adu-Darko M, Bird GL, Cheifetz IM, Derbyshire AT, Emeriaud G, Giuliano JS Jr, Graciano AL, Hagiwara Y, Hefley G, Ikeyama T, Jarvis JD, Kamat P, Krishna AS, Lee A, Lee JH, Li S, Meyer K, Montgomery VL, Nagai Y, Pinto M, Rehder KJ, Saito O, Shenoi AN, Taekema HC, Tarquinio KM, Thompson AE, Turner DA, Nadkarni VM, Nishisaki A

Family Presence During Pediatric Tracheal Intubations.

JAMA Pediatr

2016 Mar 7; 170(3):e154627

Gurnaney HG, Fiadjoe JE, Levin LS, Chang B, Delvalle H, Gálvez J, Rehman MA.

Anesthetic management of the first pediatric bilateral hand transplant.

Can J Anaesth

2016 Mar 7. [Epub ahead of print]

Ambardekar AP, Singh D, Lockman JL, Rodgers DL, Hales RL, Gurnaney HG, Nathan A, Deutsch ES.

Pediatric anesthesiology fellow education: is a simulation-based boot camp feasible and valuable?

Paediatr Anaesth

2016 Mar 7.  [Epub ahead of print]

Kirschen MP, Topjian AA, Berg RA.

Neurologic outcome after cardiac arrest: What you see at hospital discharge may or may not be what you get.

Resuscitation

2016 Mar 5.  [Epub ahead of print]

Neuman MD.

How clinical registries can make a difference in hip fracture care.

Anaesthesia

2016 Mar 4.  [Epub ahead of print] 

 Smith AL, Hantsoo L, Malykhina AP, File DW, Valentino R, Wein AJ, Sammel MD, Epperson CN.

Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder.

Int Urogynecol J.

2016 Mar 4. [Epub ahead of print]

Speck RM, Neuman MD, Resnick KS, Mellers BA, Fleisher LA.

Anticipated regret in shared decision-making: a randomized experimental study.

Perioper Med (Lond).

2016 Mar 2;5:5. 

Viswanath O, Santhosh S, Simpao AF.

In Response.

A A Case Rep. 

2016 Mar 1; 6(5):138. 

Fleisher LA, Wiener-Kronish JP.

Ensuring the Future of the Specialty: What Is the Best Strategy to Ensure a Pipeline of Physician-scientists?

Anesthesiology

2016 Mar 1. [Epub ahead of print]

Resnick B, Beaupre L, McGilton KS, Galik E, Liu W, Neuman MD, Gruber-Baldini AL, Orwig D, Magaziner J.

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review.

J Am Med Dir Assoc. 

2016 Mar 1; 17(3):200-5. 

Resnick B, Beaupre L, McGilton KS, Galik E, Liu W, Neuman MD, Gruber-Baldini AL, Orwig D, Magaziner J.

Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review.

J Am Med Dir Assoc. 

2016 Mar 1; 17(3):200-5. 

Kinde MN, Bu W, Chen Q, Xu Y, Eckenhoff RG, Tang P.

Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.

Anesthesiology. 

2016 Mar; 124(3):664-73.

Armstead WM, Riley J, Vavilala MS.

Preferential Protection of Cerebral Autoregulation and Reduction of Hippocampal Necrosis With Norepinephrine After Traumatic Brain Injury in Female Piglets.

Pediatr Crit Care Med. 

2016 Mar; 17(3):e130-7. 

Fleisher LA.

Preoperative Assessment of the Patient with Cardiac Disease Undergoing Noncardiac Surgery.

Anesthesiol Clin. 

2016 Mar; 34(1):59-70. 

Tien M, Peacher DF, Franz AM, Jia SY, Habib AS.

Failure rate and complications associated with the use of spinal catheters for the management of inadvertent dural puncture in the parturient: a retrospective comparison with re-sited epidural catheters.

Curr Med Res Opin. 

2016 Mar 2:1-6. [Epub ahead of print]

Misfeldt AM, Kirsch RE, Goldberg DJ, Mascio CE, Naim MY, Zhang X, Mott AR, Ravishankar C, Rossano JW.

Outcomes of Single-Ventricle Patients Supported With Extracorporeal Membrane Oxygenation.

Pediatr Crit Care Med.

 2016 Mar; 17(3):194-202. 

Gálvez JA, Gralewski K, McAndrew C, Rehman MA, Chang B, Levin LS

Assessment and Planning for a Pediatric Bilateral Hand Transplant Using 3-Dimensional Modeling: Case Report.

J Hand Surg Am. 

2016 Mar; 41(3):341-3

Palmer CP, Metheny HE, Elkind JA, Cohen AS

Diminished amygdala activation and behavioral threat response following traumatic brain injury.

Exp Neurol. 

2016 Mar; 277:215-26. 

Gaiser R.

Anesthetic Considerations in the Obese Parturient.

Clin Obstet Gynecol. 

2016 Mar; 59(1):193-203. 

Browning B, Page KE, Kuhn RL, DiLiberto MA, Deschenes J, Taillie E, Tomanio E, Holubkov R, Dean JM, Moler FW, Meert K, Pemberton VL.

Nurses' Attitudes Toward Clinical Research: Experience of the Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials.

Pediatr Crit Care Med. 

2016 Mar; 17(3):e121-9

Saites V, Laudanski K.

Acute Hypotension After 50% Dextrose Injections.

A A Case Rep

2016 Feb 29. [Epub ahead of print]

Silber JH, Rosenbaum PR, Ross RN, Ludwig JM, Wang W, Niknam BA, Hill AS, Even-Shoshan O, Kelz RR, Fleisher LA.

Indirect Standardization Matching: Assessing Specific Advantage and Risk Synergy.

Health Serv Res. 

2016 Feb 29. [Epub ahead of print]

Kimball BA, Cohen AS, Gordon AR, Opiekun M, Martin T, Elkind J, Lundström JN, Beauchamp GK.

Brain Injury Alters Volatile Metabolome.

Chem Senses. 

2016 Feb 28.  [Epub ahead of print]

Work Group, Kouba DJ, LoPiccolo MC, Alam M, Bordeaux JS, Cohen B, Hanke CW, Jellinek N, Maibach HI, Tanner JW, Vashi N, Gross KG, Adamson T, Begolka WS, Moyano JV.

Guidelines for the use of local anesthesia in office-based dermatologic surgery.

J Am Acad Dermatol

2016 Feb 27.  [Epub ahead of print]

Stringer M, Rajeswaran L, Dithole K, Hoke L, Mampane P, Sebopelo S, Molefe M, Muecke MA, Rich VL, Polomano RC.

Bridging nursing practice and education through a strategic global partnership.

Int J Nurs Pract. 

2016 Feb; 22(1):43-52. 

Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM.

Multiscale Modeling in the Clinic: Drug Design and Development.

Ann Biomed Eng. 

2016 Feb 17. [Epub ahead of print]

Cereda M, Xin Y, Hamedani H, Clapp J, Kadlecek S, Meeder N, Zeng J, Profka H, Kavanagh BP, Rizi RR

Mild loss of lung aeration augments stretch in healthy lung regions.

J Appl Physiol 

2016 Feb 15; 120(4):444-54.

Hua M, Halpern SD, Gabler NB, Wunsch H.

Effect of ICU strain on timing of limitations in life-sustaining therapy and on death.

Intensive Care Med. 

2016 Feb 9. [Epub ahead of print]

Silvay G, Goldberg A, Gutsche JT, T Augoustides JG.

Same day admission for elective cardiac surgery: how to improve outcome with satisfaction and decrease expenses.

J Anesth. 

2016 Feb 4. [Epub ahead of print]

Wyler SC, Spencer WC, Green NH, Rood BD, Crawford L, Craige C, Gresch P, McMahon DG, Beck SG, Deneris E.

Pet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability.

J Neurosci

2016 Feb 3; 36(5):1758-74. .

Buttenheim AM, Fiks AG, Burson Ii RC, Wang E, Coffin SE, Metlay JP, Feemster KA.

A behavioral economics intervention to increase pertussis vaccination among infant caregivers: A randomized feasibility trial.

Vaccine. 

2016 Feb 3; 34(6):839-45. 

 Gálvez JA, Lin EE, Schwartz AJ, Simpao AF.

Ultrasound-guided Vascular Access: Visualizing the Tip of the Needle.

Anesthesiology.

2016 Feb 2. [Epub ahead of print] 

Grady ME, Composto RJ, Eckmann DM.

Cell elasticity with altered cytoskeletal architectures across multiple cell types.

J Mech Behav Biomed Mater. 

2016 Feb 1; 61:197-207. [Epub ahead of print]

Neuman MD, Werner RM.

Marital Status and Postoperative Functional Recovery.

JAMA Surg.

 2016 Feb 1; 151(2):194-6. 

Morrison JJ, Galgon RE, Jansen JO, Cannon JW, Rasmussen TE, Eliason JL.

A systematic review of the use of resuscitative endovascular balloon occlusion of the aorta in the management of hemorrhagic shock.

J Trauma Acute Care Surg. 

2016 Feb; 80(2):324-34. 

Raymond TT, Bonafide CP, Praestgaard A, Nadkarni VM, Berg RA, Parshuram CS, Hunt EA

Pediatric Medical Emergency Team Events and Outcomes: A Report of 3647 Events From the American Heart Association's Get With the Guidelines-Resuscitation Registry.

Hosp Pediatr. 

2016 Feb; 6(2):57-64

Frontera JA, Lewin Iii JJ, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, Del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL.

Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage : A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.

Neurocrit Care. 

2016 Feb; 24(1):6-46. 

Cooper SA, Desjardins PJ, Turk DC, Dworkin RH, Katz NP, Kehlet H, Ballantyne JC, Burke LB, Carragee E, Cowan P, Croll S, Dionne RA, Farrar JT, Gilron I, Gordon DB, Iyengar S, Jay GW, Kalso EA, Kerns RD, McDermott MP, Raja SN, Rappaport BA, Rauschkolb C, Royal MA, Segerdahl M, Stauffer JW, Todd KH, Vanhove GF, Wallace MS, West C, White RE, Wu C.

Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations.

Pain. 

2016 Feb; 157(2):288-301

Cohen M, Vaida A, Litman RS, Jenkins RH.

Error-Prone Abbreviations and Dose Expressions.

Anesth Analg. 

2016 Feb; 122(2):581

Jungquist CR, Correll DJ, Fleisher LA, Gross J, Gupta R, Pasero C, Stoelting R, Polomano R.

Avoiding Adverse Events Secondary to Opioid-Induced Respiratory Depression: Implications for Nurse Executives and Patient Safety.

J Nurs Adm.

 2016 Feb; 46(2):87-94. 

Liu J, Elkassabany NM, Kamath AF, Nelson CL.

Reply to the Letter to the Editor: Low Albumin Levels, More Than Morbid Obesity, Are Associated With Complications After TKA.

Clin Orthop Relat Res.  

2016 Feb; 474(2):602-3.

Keele L, Meert KL, Berg RA, Dalton H, Newth CJ, Harrison R, Wessel DL, Shanley T, Carcillo J, Morrison W, Funai T, Holubkov R, Dean JM, Pollack M

Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed?

Pediatr Crit Care Med. 

2016 Feb; 17(2):110-20. 

Yehya N, Bhalla AK, Thomas NJ, Khemani RG

Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome.

Pediatr Crit Care Med. 

2016 Feb; 17(2):101-9

Madrigal VN, Carroll KW, Faerber JA, Walter JK, Morrison WE, Feudtner C

Parental Sources of Support and Guidance When Making Difficult Decisions in the Pediatric Intensive Care Unit.

J Pediatr. 

2016 Feb; 169:221-226.e4. 

Adams JA, Uryash A, Nadkarni V, Berg RA, Lopez JR.

Whole body periodic acceleration (pGz) preserves heart rate variability after cardiac arrest.

Resuscitation. 

2016 Feb; 99:20-5.

Hsu G, Taylor JA, Fiadjoe JE, Vincent AM, Pruitt EY, Bartlett SP, Stricker PA.

Aminocaproic acid administration is associated with reduced perioperative blood loss and transfusion in pediatric craniofacial surgery.

Acta Anaesthesiol Scand. 

2016 Feb; 60(2):158-65. 

Royo MB, Fleisher LA.

Chasing myocardial outcomes: perioperative myocardial infarction and cardiac troponin.

Can J Anaesth. 

2016 Feb; 63(2):227-232. 

Gardner B, Strus E, Meng QC, Coradetti T, Naidoo NN, Kelz MB, Williams JA.

Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol?

Anesthesiology. 

2016 Feb; 124(2):404-16. 

Yuerek M, Rossano JW, Mascio CE, Shaddy RE.

Postoperative management of heart failure in pediatric patients.

Expert Rev Cardiovasc Ther. 

2016 Feb; 14(2):201-15. 

Hanlon LA, Huh JW, Raghupathi R.

Minocycline Transiently Reduces Microglia/Macrophage Activation but Exacerbates Cognitive Deficits Following Repetitive Traumatic Brain Injury in the Neonatal Rat.

J Neuropathol Exp Neurol. 

2016 Jan 29. [Epub ahead of print]

Silber JH, Rosenbaum PR, McHugh MD, Ludwig JM, Smith HL, Niknam BA, Even-Shoshan O, Fleisher LA, Kelz RR, Aiken LH.

Comparison of the Value of Nursing Work Environments in Hospitals Across Different Levels of Patient Risk.

JAMA Surg.

 2016 Jan 20. 

Bohman LE, Riley J, Milovanova TN, Sanborn MR, Thom SR, Armstead WM.

Microparticles Impair Hypotensive Cerebrovasodilation and Cause Hippocampal Neuronal Cell Injury after Traumatic Brain Injury.

J Neurotrauma. 

2016 Jan 15; 33(2):168-74. 

Pearson-Leary J, Osborne DM, McNay EC

Role of Glia in Stress-Induced Enhancement and Impairment of Memory.

Front Integr Neurosci. 

2016 Jan 11; 9:63.

Mohanty S, Rosenthal RA, Russell MM, Neuman MD, Ko CY, Esnaola NF

Optimal Perioperative Management of the Geriatric Patient: A Best Practices Guideline from the American College of Surgeons NSQIP and the American Geriatrics Society.

J Am Coll Surg

2016 Jan 4

Margulies S, Anderson G, Atif F, Badaut J, Clark R, Empey P, Guseva M, Hoane M, Huh J, Pauly J, Raghupathi R, Scheff S, Stein D, Tang H, Hicks M.

Combination Therapies for Traumatic Brain Injury: Retrospective Considerations.

J Neurotrauma. 

2016 Jan 1; 33(1):101-12. 

Patel MS, Asch DA, Troxel AB, Fletcher M, Osman-Koss R, Brady J, Wesby L, Hilbert V, Zhu J, Wang W, Volpp KG.

Premium-Based Financial Incentives Did Not Promote Workplace Weight Loss In A 2013-15 Study.

Health Aff (Millwood). 

2016 Jan 1;35(1):71-9

Hamedani H, Clapp JT, Kadlecek SJ, Emami K, Ishii M, Gefter WB, Xin Y, Cereda M, Shaghaghi H, Siddiqui S, Rossman MD, Rizi RR.

Regional Fractional Ventilation by Using Multibreath Wash-in <sup>3</sup>He MR Imaging.

Radiology 

2016 Jan 18:150495

McHugh MD, Rochman MF, Sloane DM, Berg RA, Mancini ME, Nadkarni VM, Merchant RM, Aiken LH

Better Nurse Staffing and Nurse Work Environments Associated With Increased Survival of In-Hospital Cardiac Arrest Patients.

Med Care.  

2016 Jan; 54(1):74-80.

Lane-Fall MB.

No Matter the Perspective, Anesthesia Handoffs Are Problematic.

Anesth Analg. 

2016 Jan; 122(1):7-9. 

Badiola IJ, Liu J, Neuman MD.

Deliberate Hypotension for Hip Arthroplasty: Still More Questions Than Answers.

Anesth Analg.  

2016 Jan; 122(1):15-6.

Ramakrishna H, Gutsche JT, Patel PA, Fernando R, Agoustides JG.

Options for Incidental Moderate Aortic Stenosis During Concomitant Valve Surgery: A Clinical Update for the Perioperative Echocardiographer.

J Cardiothorac Vasc Anesth.

 2016 Jan; 30(1):252-7. 

Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS.

Neurotoxicity, general anesthesia in young children, and a survey of current pediatric anesthesia practice at US teaching institutions.

Paediatr Anaesth. 

2016 Jan; 26(1):60-5. 

Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS.

Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury.

Mitochondrion. 

2016 Jan; 26:19-25

Cereda M, Xin Y, Meeder N, Zeng J, Jiang Y, Hamedani H, Profka H, Kadlecek S, Clapp J, Deshpande CG, Wu J, Gee JC, Kavanagh BP, Rizi RR.

Visualizing the Propagation of Acute Lung Injury.

Anesthesiology. 

2016 Jan; 124(1):121-31. 

Cocoros NM, Kleinman K, Priebe GP, Gray JE, Logan LK, Larsen G, Sammons J, Toltzis P, Miroshnik I, Horan K, Burton M, Sims S, Harper M, Coffin S, Sandora TJ, Hocevar SN, Checchia PA, Klompas M, Lee GM

Ventilator-Associated Events in Neonates and Children--A New Paradigm.

Crit Care Med. 

2016 Jan; 44(1):14-22. 

Kon AA, Davidson JE, Morrison W, Danis M, White DB

Shared Decision Making in ICUs: An American College of Critical Care Medicine and American Thoracic Society Policy Statement.

Crit Care Med. 

2016 Jan; 44(1):188-201

Pollack MM, Holubkov R, Funai T, Dean JM, Berger JT, Wessel DL, Meert K, Berg RA, Newth CJ, Harrison RE, Carcillo J, Dalton H, Shanley T, Jenkins TL, Tamburro R

The Pediatric Risk of Mortality Score: Update 2015.

Pediatr Crit Care Med. 

2016 Jan; 17(1):2-9. 

Neuman MD

Understanding outcomes after neuraxial anaesthesia: time to turn the page.

Br J Anaesth.

 2016 Jan; 116(1):15-7. 

Hu YY, Parker SH, Lipsitz SR, Arriaga AF, Peyre SE, Corso KA, Roth EM, Yule SJ, Greenberg CC

Surgeons' Leadership Styles and Team Behavior in the Operating Room.

J Am Coll Surg. 

2016 Jan; 222(1):41-51.

Kesner KL, Chaney MA, Dupont FW, Vernick W, Ramachandran S, Leff JD

CASE 2-2016 Complete Failure of Mechanical Mitral Valve Opening on Weaning From Cardiopulmonary Bypass.

J Cardiothorac Vasc Anesth. 

2016 Jan; 30(1):237-44. 

Mandel JE, Atkins JH

Hilbert-Huang Transform Yields Improved Minute Volume Estimates from Respiratory Inductance Plethysmography During Transitions to Paradoxical Breathing.

Anesth Analg. 

2016 Jan; 122(1):126-31.

Fabbro M, Goldhammer J, Augoustides JG, Patel PA, Frogel J, Ianchulev S, Cobey FC.

CASE 1-2016 Problem-Solving in Transcatheter Aortic Valve Replacement: Cardiovascular Collapse, Myocardial Stunning, and Mitral Regurgitation.

J Cardiothorac Vasc Anesth. 

2016 Jan; 30(1):229-36. 

Ramakrishna H, Gutsche JT, Evans AS, Patel PA, Weiner M, Morozowich ST, Gordon EK, Riha H, Shah R, Ghadimi K, Zhou E, Fernadno R, Yoon J, Wakim M, Atchley L, Weiss SJ, Stein E, Silvay G, Augoustides JG.

The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights From 2015.

J Cardiothorac Vasc Anesth. 

2016 Jan; 30(1):1-9. 

Liang X, Liu R, Chen C, Ji F, Li T.

Opioid System Modulates the Immune Function: A Review.

Transl Perioper Pain Med

2016; 1(1):5-13

Disclaimer: The search routine may include a few false positives. Only papers which include in the author contact, "Anesthesiology and Critical Care" along with either: "Hospital of the University of Pennsylvania" or "Perelman School of Medicine " or "Children's Hospital of Philadelphia," will be included in this search.

 

Announcements and Awards

Faculty Recognition

In the Press 

Mark Neuman, MD was highlighted in the March 25, 2016 issue of Penn News Today for his finding of  “a concerning trend” in an increase in physicians prescribing opioid painkillers for low-risk-surgery patients.  Penn Medicine News Release

Jack Gutsche, MD and Bill Vernick, MD were featured on  ABC Philadelphia Action News on January 19, 2016, for developing the Lung Rescue Program, which includes the use of a new, portable, ExtraCorporeal Membrane Oxygenation (ECMO) device, through money raised by the Palko family. ABC News clip.

Awards

Robert Berg , MD was chosen by American College of Chest Physicians to present the Roger C. Bone Memorial Lecture in Critical Care at the upcoming 2016 CHEST annual meeting.  An achievement well deserved by Bob for his many contributions to the fields of resuscitation science and critical care medicine.  

Lee Fleisher, MD, received the Lindback Award for Distinguished Teaching.  This award is given by the University of Pennsylvania and acknowledges his contributions to education at the medical school and beyond its walls. 

Jonathan Tan, MD and Ali Jalal, PhD won the 2016 Engineering Challenge from the Society for Technology in Anesthesia (STA). They designed an algorithm to detect EEG waveform changes based on anesthesiologists' perception of a change in pulse oximeter tone as a patient desaturates.  This is the third year in a row that the CHOP Biomedical Informatics (BMI) group has won the STA engineering challenge.  

William Vernick, MD and  Jacob Gutsche, MD received the 2016 Hospital Hero Award at the Penn Presbyterian Medical Center Gala in March, in recognition of their innovation and advances in Cardiovascular Medicine and Surgery.

Leadership Positions 

C. Dean Kurth, MD, will return to CHOP as the new Anesthesiologist-in-Chief and Chair of the Department of Anesthesiology and Critical Care Medicine, effective July 1, 2016.  Dean was a former CHOP resident in Pediatrics, fellow in Pediatric Anesthesiology, CHOP attending physician, and Penn faculty member from 1989-2002.  For the past 13 years, Dr. Kurth has been the Anesthesiologist-in-Chief and Anesthesia Department Chair at Cincinnati Children’s Hospital.  Bill Greeley, MD, who has admirably served in this role at CHOP for nearly 20 years will be stepping down as Department Chair and taking a much deserved sabbatical beginning July 1st.

Gaurav Malhotra, MD has been appointed as the Medical Director of the PACU at HUP.   Gaurav will be responsible for the clinical protocols and policies as well as our educational program for the residents.   

Promotions

Associate Professor of Anesthesiology and Critical Care:

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2016 Summer

Research Highlights

Photo of Mohamed Rehman, MDThe Section of Biomedical Informatics within the Anesthesiology Department at The Children’s Hospital of Philadelphia harnesses Big Data and analytics to improve the perioperative care of children. It is one of the largest anesthesia informatics groups in the country, consisting of a multi-disciplinary team of anesthesiologists (three of whom are board-certified in clinical informatics), intensivists, surgeons, pediatricians, data scientists and engineers. The section also has graduate and postgraduate fellows from Villanova University and the University of Pennsylvania.

Mohamed Rehman, MD, Professor, holds an endowed chair in Biomedical Informatics & Enterprenurial Sciences and leads the group both locally and nationally. The group has led the Society for Pediatric Anesthesia in forming a group of pediatric anesthesiology informaticians from around the country and guided the standardization of a pediatric pre-operative evaluation form that has been integrated in Epic.  We continue to advocate at the national level for incorporation of the standard pre-operative note in electronic health records.

The research interests of our group focus on clinical decision support as well as machine learning algorithms to understand physiologic data at a population level.  Over the last two years we have assisted in upgrading the anesthesia information management system from Compurecord to the Epic anesthesia platform, and seek ways to incorporate data-driven decision support into the Epic anesthesia platform. One example is the incorporation of pre-operative risk stratification for hemorrhage by recommending type and screen or blood product orders based on a patient’s age and planned surgical procedure.  The goal is to generate recommendations based on actual transfusion practice at our institution and to incorporate them into order sets that are available to all providers across the institution.

Photo of Anesthesia Section of Biomedical Informatics

Group Members

Research Interest

e-mail

Mohamed A. Rehman, MD

Electronic Health Record implementation, data visualization, operating room management, and liver transplant

rehman@email.chop.edu

Allan F. Simpao, MD, MBI

Population-level physiologic data, hemodynamic monitoring, cystic fibrosis, sickle cell disease, and neonatal anesthesia.

simpaoa@email.chop.edu

Jorge A. Galvez, MD

Clinical decision support, perioperative blood transfusion, blood management, data visualization, 3D printing, medical device innovation, and augmented reality/virtual reality.

galvezj@email.chop.edu

Arul M. Lingappan, MD

Cardiac anesthesia for non-cardiac surgery, pre-operative risk stratification, and pediatric sedation

lingappana1@email.chop.edu

Jonathan Tan, MD, MPH

Public health, improving access to at-risk populations, geographic information systems (GIS), and medical device innovation.

tanj1@email.chop.edu

Jack O. Wasey, MD (CHOP Pediatric Anesthesiology Fellow Class of 2016)

Perioperative risk stratification and is also a software developer (R Studio statistical packages) 

waseyj@email.chop.edu

Luis Ahumada MSCS - Principal Data Scientist

Big data analytics, natural language processing, data visualization, and machine learning.

ahumada@email.chop.edu

Ali Jalal, PhD (Post-Doctoral Fellow)

Machine learning, signal processing, physiological systems modeling, and population-level physiologic data.

jalalia@email.chop.edu

 

 

Education Highlights

Photo of Nabil Elkassabany, MDNabil Elkassabany, MD, MSCE, Assistant Professor, developed and heads the highly successful workshop, Annual Cadaver and Ultrasound Workshop for Regional Anesthesia and other Applications, which trains PENN residents, as well as residents in the greater Philadelphia area, in the art of regional anesthesia and the use of ultrasound for applications in anesthesiology.

The 6th Annual Cadaver and Ultrasound Workshop for Regional Anesthesia and other Applications was recently held at HUP in April, 2016. The course includes:

  • Review the anatomy of peripheral nerve blocks as demonstrated on fresh cadaver dissection
  • Review “sonoanatomy” of peripheral nerve blocks by scanning life models
  • Practice needle insertion in phantom models and cadaver specimen under ultrasound guidance
  • Review the basic principles of trans-thoracic echo (TTE) and Point of Care Ultrasound (POCUS)

 

Photo of the cadaver workshop

  •  
  • Every year, the workshop includes HUP faculty, as well as renowned guest faculty from around the country, and hosts a number of residents from training programs from around Philadelphia free of charge. Nabil attributes the growth of this program as a testament to the Department’s commitment to resident education, the advancement of the science and to the art of regional anesthesia and the use of ultrasound for applications in anesthesiology. He is especially grateful for the commitment of our faculty from the sections of regional and cardiac anesthesia who have made this event possible.

This year HUP faculty included: Moustafa Ahmed, MDIgnacio Badiola, MDLu Fan Cai, MDEmily Gordon, MDJiabin Liu, MD, PhDChristopher Mason, MDPrakash Patel, MDKenneth Richman, MDMitchell Weinstein, MD, and Andrew Wong, MD

Guest faculty included Carlo Franco, MD, Cook County Health & Hospital System, Chicago, IL,  Richelle Kruisselbrink, BMus, MD, FRCPC, Toronto Western Hospital, Toronto, Canada, Meera N. Gonzalez, MD, temple University, Philadelphia, PA, Hillenn Cruz Eng, MD, Penn State Hershey Medical Center, Hershey, PA, Hesham Elsharkawy, MD, Cleveland Clinic Foundation, Cleveland, OH, Eric Schwenk, MD, Thomas Jefferson University, Philadelphia, PA, and Yury Zasimovich, MD, University of Florida, Gainesville, FL.

 

2016 Anesthesia Cadaver Workshop

Above: Participants in this year's workshop!

 

Announcements and Awards

April 1 — June 30, 2016

In the Press 

Prakash Patel, MD, Assistant Professor, was part of a study highlighted in the  May 6, 2016 issue of Penn News Today, which found that  moderate sedation was more effective than general anesthesia for patients undergoing transcatheter aortic valve replacement (TAVR).  Penn Medicine News Release

Akiva Cohen, PhD, Associate Professor, was highlighted in the May 24, 2016 issue of Penn News Today for his work investigating whether a set of neurons could be a target to prevent cognitive damage after brain injury. CHOP News Release

Awards

Roderic Eckenhoff’s Pharmacology graduate student, Kellie Woll, PhDc, won the “Best of Meeting Abstract in Basic Science Research” at the 2016  Annual International Anesthesiology Research Society (IARS) meeting.

Several faculty were recognized at the 2016 resident graduation in June:

Leadership Positions 

Robert R. Gaiser, M.D., MSEd,  Professor of Anesthesiology and Critical Care, will be leaving Penn to accept a position as Professor and Chair of Anesthesiology at the University of Kentucky effective September 1, 2016. Bob joined the faculty in 1993 and rose to the Rank of Professor of Anesthesiology and Critical Care, Obstetrics and Gynecology and Nursing.  Since 2001, he has been Program Director for Anesthesiology and Critical Care and was appointed to the role of Vice-Chair for Education in 2004.  During his tenure, Bob has overseen a tremendous growth in our residency program and our fellowship programs. In addition, Bob has been recognized for his excellence in teaching, both locally and nationally.   Dr. Gaiser will be sorely missed at Penn but we are all happy that he has achieved a personal goal of leading an academic department.  

Promotions

Associate Professor of Anesthesiology and Critical Care:

 

PENN Alums Supporting Scholarship

A special shout-out to Penn Anesthesiology and Critical Care alumnus, Marvin J Noble, MD, of Dallas Texas, who recently contributed to the Harry Wollman Lectureship.   Marvin received his anesthesiology residency training at PENN from 1963-1965, and was on the faculty at University of Texas Southwestern Medical School.  Contributions to anesthesiology scholarship benefit not only the faculty but residents and fellows alike.  

Alums may be interested in donating to our special lectureships to support continued scholarship at PENN: 

James E Eckenhoff Lectureship

Josephine “Pina” Templeton Lectureship

Stephen J. Prevoznik Lectureship on Leadership

Brett Gutsche Lectureship on Obstetrical Anesthesia

Harry Wollman Lectureship

To donate online: 

go to our secure online giving page

To send a donation:

Lee A. Fleisher, MD

Department of Anesthesiology & Critical Care

University of Pennsylvania Health System

3400 Spruce Street

6 Dulles Building

Philadelphia, PA 19104

Office: (215) 662-3738

Please include your years at Penn and your current affiliations.

 

Image of NIH logoGrants and Contracts

April 1 - June 30, 2016 

New Proposals / amount:
            34 / $7,546,123

New Awards / amount:
            17 / $3,921,975

(including UPENN and CHOP)

 

UPENN & CHOP Grant Proposals April 1 — June 30, 2016

PI

Dept

Sponsor

Title

Type

1 yr Total

Armstead, William

UPENN

Univ of Washington

Vasoactive Agents and Cerebral Outcomes in Brain Injury

New

$32,294

Ashburn, Michael

UPENN

Media Rez, LLC

Virtual Reality for Mobile Pain Control

New

$19,518

Barr, Gordon

CHOP

CHOP, Foerderer grant

A mouse model of the effects of early life abuse on migraine

New

$49,910

Barr, Gordon

CHOP

NIH - R21

Effects of infant abuse and adolescence social stress on social behavior, fear and amygdala function

New

$252,000

Cereda, Maurizio

UPENN

Hill-ROM

Evaluation of a practice change to include The MetaNeb? System to reduce postoperative pulmonary complications

New

$71,998

Cohen, Akiva

CHOP

NIH - R37

Injury-Induced Alterations in Limbic Functional Circuity Supplement

New

$55,396

Corbett, Brian

CHOP

NIH - F32

Investigating Mechanisms of Stress Resilience Mediated by Sphingosine-1-Phosphate Receptor 3 in the Medial Prefrontal Cortex

New

$56,118

Eckenhoff, Roderic

UPENN

Baxter

Fifth International Workshop on Perioperative Neurotoxicicty in the Elderly

New

$5,000

Eckenhoff, Roderic

UPENN

NIH-PO1

Interaction of Inhaled Anesthetics with Macromolecules

Rev

$2,081,460

Eckmann, David

UPENN

NIH-UO1

Bridging multiple scales in modeling targeted drug nanocarrier delivery

Rev

$718,830

Han, Moonjoo

CHOP

CHOP, Center for Pediatric Clinical Effectiveness grant

Cytomegalovirus Reactivation in Pediatric Sepsis 

New

$10,000

Han, Moonjoo

CHOP

CHOP, Foerderer grant

Cytomegalovirus Reactivation in Pediatric Sepsis

New

$50,000

Himebauch, Adam

CHOP

CHOP, Foerderer grant

Attainment of Cefepime Therapeutic Targets in Pediatric Critical Illness

New

$50,000

Huh, Jimmy

CHOP

Pennsylvania Department of Health

Symptom-based treatments for concussions in high-school and college athletes

New

$39,989

Kelz, max

UPENN

NIH-RO1

Optoanesthesia

Rev

$403,734

Kilbaugh, Todd

CHOP

NeuroVive Pharmaceutical AB

NeuroSTAT in Pediatric Traumatic Brain Injury

New

$14,391

McGowan, Francis

CHOP

NIH - R43

Cardiac Monitor for VA ECMO Pediatric and Neonatal Patients

New

$41,735

McKinstry-Wu, Andrew

UPENN

NIH-KO8

Intersections of Sleep and Coma: Neural Pathways of Alpha-2 Adrenergic Hypnosis

New

$252,209

Nadkarni, Vinay

CHOP

American Heart Association (AHA)

PALS RQI Pilot - AHA

Con

$70,001

Nadkarni, Vinay

CHOP

NIH - R24

Simulation-based Pediatric Research Collaborative Network for Trauma (SPARC-Trauma)

Rev

$1,344,197

Nadkarni, Vinay

CHOP

Zoll Medical Corp

Pediatric RESuscitation Quality (pedRES-Q) Collaborative 

Con

$310,000

Nadkarni, Vinay

CHOP

NIH - U01

HALF-PINT: Heart and Lung Failure-Pediatric Insulin Titration Trial

Con

$65,402

Nadkarni, Vinay 

CHOP

NIH - R44

System for Targeted Estimation of Physiologic States

New

$116,918

Newuman, Mark

UPENN

Sunnybrook Research Institute

Acute Pain Management and Long-term Opiod Use after Surgery

Rev

$427,321

Proekt, Alex

UPENN

NIH-KO8

Neurophysiological Basis of General Anesthesia

CGI

$252,209

Rehman, Mohamed

CHOP

NIH - R21

Intelligent algorithms for detection of one-lung ventilation towards the development of a clinical decision support system

New

$89,040

Tan, Jonathan

CHOP

CHOP, Foerderer grant

Using Geographic and Socioeconomic Factors to Improve Perioperative Access

New

$50,000

Topjian, Alexis

CHOP

NIH - K23

Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest

Con

$161,547

Urban, Kimberly

CHOP

NIH - K99

Cognitive Consequences of Adolescent Psychostimulant Use and Social Stress

New

$88,380

Whitney, Jane

CHOP

CHOP, Center for Pediatric Clinical Effectiveness grant

Endothelial Biomarkers in Pediatric Sepsis and Acute Respiratory Distress Syndrome

New

$10,000

Whitney, JAne

CHOP

CHOP, Foerderer grant

Endothelial Biomarkers and Risk for ARDS in Pediatric Sepsis

New

$50,000

Yehya, Nadir

CHOP

NIH - R23

Clinical and Proteomic Characterization of Nucleosomes in Pediatric Acute Respiratory Distress Syndrome

New

$182,088

Yehya, Nadir

CHOP

NIH - R03

Soluble Receptor for Advanced Glycation End Products in Pediatric Acute Respiratory Distress Syndrome

New

$99,250

Zuppa, Athena

CHOP

NIH - R01

A Comparison of Buprenorphine Versus Morphine in the Treatment of the Neonatal Ab

New

$25,188

       

TOTAL

$7,546,123


UPENN & CHOP Grant Awards April 1 — June 30, 2016

PI

Dept

Sponsor

Title

Type

1 yr Total

Berg, Robert

CHOP

NIH - R01

The Impact of Nursing on In-Hospital Cardiac Arrest Patient Outcomes

Rev

$18,262

Bhatnagar, Seema

CHOP

NIH - R01

Sex differences in orexins

Rev

$420,000

Bhatnagar, Seema

CHOP

National Aeronautics and Space Administration

Biomarkers of Resiliency and Susceptibility to Stress in Space Flight

Con

$61,533

Bhatnagar, Seema

CHOP

US Department of Defense

High School Apprenticeship Program (HSAP)/Undergraduate Research Apprenticeship Program (URAP) through the Army Research Office

New

$8,845

Cereda, Maurizio

UPENN

Hill-ROM

Evaluation of a practice change to include The MetaNeb? System to reduce postoperative pulmonary complications

New

$42,642

Cohen, Akiva

CHOP

NIH - R37

Injury-Induced Alterations in Limbic Functional Circuity Supplement

New

$55,396

Eckenhoff, Roderic

UPENN

Baxter

Fifth International Workshop on Perioperative Neurotoxicicty in the Elderly

New

$5,000

Eckenhoff, Roderic

UPENN

NIH-PO1

Interaction of Inhaled Anesthetics with Macromolecules

NCR

$1,703,689

Eckmann, David

UPENN

NIH-T32

Physician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)

NCR

$306,809

Kilbaugh, Todd

CHOP

NeuroVive Pharmaceutical AB

NeuroSTAT in Pediatric Traumatic Brain Injury

New

$14,391

Lane-Fall, Meghan

UPENN

Robert Wood Johnson Foundation

Improving Health Care Communication to Improve Quality and Outcomes: Context-sensitive Standardization of Operating Room to ICU Handoffs

New

$105,000

Nadkarni, Vinay

CHOP

NIH - R44

Risk Assessment Using Noninvasive Measurements in PostOp Pediatric Patients

Con

$160,000

Nadkarni, Vinay

CHOP

Zoll Medical Corp

Pediatric RESuscitation Quality (pedRES-Q) Collaborative 

Con

$310,000

Newuman, Mark

UPENN

NIH-KO8

Understanding Variations in Hip Fracture Outcomes across the Continuum of Care

NCR

$128,358

Nishisaki, Akira

CHOP

Agency for Health Care Research and Quality (AHRQ)

Improving the Safety of Pediatric Tracheal Intubations in ICUs with Apneic Oxygenation and Video Laryngoscopes

New

$248,455

Valentino, Rita

CHOP

NIH - R01

Opioid Modulation of the Coeruleo-cortical Pathway

Con

$152,440

Weiss, Scott

CHOP

NIH - K23

Mitochondrial Dysfunction in Pediatric Sepsis

Con

$181,155

       

TOTAL

$3,921,975

New;    new                                                          CC;     competing continuation/renewal        

Rev;      revised                                                  NCR;     non-competing renewal

CGI;     change granting institution                     Con;    Continuation

 

Publications

Click here to view all UPENN & CHOP Anesthesia publications for 2016.


From April 1 — June 30, 2016, over 90 peer reviewed publications have been published from the Department, including UPENN and CHOP.

Authors

Title

Journal

 date/vol/pages

Himebauch AS, Kilbaugh TJ, Zuppa AF.

Pharmacotherapy during pediatric extracorporeal membrane oxygenation: a review.

Expert Opin Drug Metab Toxicol

2016 Jun 20. [Epub ahead of print]

Himebauch AS, Sankar WN, Flynn JM, Sisko MT, Moorthy GS, Gerber JS, Zuppa AF, Fox E, Dormans JP, Kilbaugh TJ.

Skeletal muscle and plasma concentrations of cefazolin during complex paediatric spinal surgery.

Br J Anaesth

2016 Jul;117(1):87-94.

Adler AC, Kodavatiganti R.

Kawasaki Disease With Giant Coronary Aneurysms Requiring a Ventricular Assist Device to Separate From Extracorporeal Membrane Oxygenation: Coronary Issues Can Be a Pediatric Problem Too!

A A Case Rep

2016 Jun 15. [Epub ahead of print]

Yuki K, Eckenhoff RG.

Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review.

Anesth Analg

2016 Jun 15. [Epub ahead of print]

Drum ET.

Pulse Oximeter: Disruptive Technology or Standard of Care?

A A Case Rep

Jun 15;6(12):370-2

Kirschen MP, Dori Y, Itkin M, Licht DJ, Ichord R, Vossough A.

Cerebral Lipiodol Embolism after Lymphatic Embolization for Plastic Bronchitis.

J Pediatr

2016 Jun 10. [Epub ahead of print]

King MR, Anderson TA, Sui J, He G, Poon KY, Coté CJ.

Age-related incidence of desaturation events and the cardiac responses on stroke index, cardiac index, and heart rate measured by continuous bioimpedance noninvasive cardiac output monitoring in infants and children undergoing general anesthesia.

J Clin Anesth

2016 32:181-8. 

Yehya N, Vogiatzi MG, Thomas NJ, Srinivasan V.

Cortisol Correlates with Severity of Illness and Poorly Reflects Adrenal Function in Pediatric Acute Respiratory Distress Syndrome.

J Pediatr

2016.05.02.  [Epub ahead of print]

Goudra BG, Singh PM, Jackson M, Sinha AC.

Epidural chloroprocaine bolus in emergency cesarean section-lessons learned from a near mishap.

J Anaesthesiol Clin Pharmacol

2016 32(2):263-5

Ohta K, Kurosawa H, Shiima Y, Ikeyama T, Scott J, Hayes S, Gould M, Buchanan N, Nadkarni V, Nishisaki A.

The Effectiveness of Remote Facilitation in Simulation-Based Pediatric Resuscitation Training for Medical Students.

Pediatr Emerg Care

2016 Jun 2. [Epub ahead of print]

Murthy S, Hepner DL, Cooper Z, Javedan H, Gleason LJ, Chi JH, Bader AM.

Leveraging the Preoperative Clinic to Engage Older Patients in Shared Decision Making About Complex Surgery: An Illustrative Case.

A A Case Rep

2016 Jun 1. [Epub ahead of print]

Lin EE, Moldenhauer JS, Tran KM, Cohen DE, Adzick NS.

Anesthetic Management of 65 Cases of Ex Utero Intrapartum Therapy: A 13-Year Single-Center Experience.

Anesth Analg

2016 Jun 1. [Epub ahead of print]

Tocco DB, Bassett RA, Fitzgerald J.

A 5-Year-Old Boy With an Acute Onset of Emesis, and Throat and Chest Pain, After Taking a Drink.

Pediatr Emerg Care

2016 32(6):419-21

Beamer M, Tummala SR, Gullotti D, Kopil K, Gorka S, Ted Abel, Bass CR, Morrison B 3rd, Cohen AS, Meaney DF.

Primary blast injury causes cognitive impairments and hippocampal circuit alterations.

Exp Neurol

2016  28;283      (Pt A):16-28

Karamyan A, Dünser MW, Wiebe DJ, Pilz G, Wipfler P, Chroust V, Novak HF, Hauer L, Trinka E, Sellner J.

Critical Illness in Patients with Multiple Sclerosis: A Matched Case-Control Study.

PLoS One

2016 11(5):e0155795

Yehya N, Thomas NJ.

Relevant Outcomes in Pediatric Acute Respiratory Distress Syndrome Studies.

Front Pediatr

2016 4:51.

Mao S, Xiong G, Zhang L, Dong H, Liu B, Cohen NA, Cohen AS.

Verification of the Cross Immunoreactivity of A60, a Mouse Monoclonal Antibody against Neuronal Nuclear Protein.

Front Neuroanat

2016 10:54.

Prin M, Itaye T, Clark S, Fernando RJ, Namboya F, Pollach G, Mkandawire N, Sobol J.

Critical Care in a Tertiary Hospital in Malawi.

World J Surg 

2016 May 26. [Epub ahead of print]

Naylor CH, Kybert NJ, Schneier C, Xi J, Romero G, Saven JG, Liu R, Johnson AT.

Scalable Production of Molybdenum Disulfide Based Biosensors.

ACS Nano

2016 Jun 15. [Epub ahead of print]

Ridley CH, Vallabhajosyula P, Bavaria JE, Patel PA, Gutsche JT, Shah R, Feinman JW, Weiss SJ, Augoustides JG.

The Sievers Classification of the Bicuspid Aortic Valve for the Perioperative Echocardiographer: The Importance of Valve Phenotype for Aortic Valve Repair in the Era of the Functional Aortic Annulus.

J Cardiothorac Vasc Anesth

2016 [Epub ahead of print]  

Ashburn MA.

The evolution of prescription drug monitoring programs.

Pharmacoepidemiol Drug Saf. 

2016 May 24. [Epub ahead of print] 

VanDerWerf J, Kumar MA.

Diagnosis and Management of Coagulopathy-Related Intracerebral Hemorrhage.

Semin Neurol

2016 36(3):274-87

Ishizuka M, Rangarajan V, Sawyer TL, Napolitano N, Boyer DL, Morrison WE, Lockman JL, Berg RA, Nadkarni VM, Nishisaki A

The Development of Tracheal Intubation Proficiency Outside the Operating Suite During Pediatric Critical Care Medicine Fellowship Training: A Retrospective Cohort Study Using Cumulative Sum Analysis.

Pediatr Crit Care Med

2016 May 20. [Epub ahead of print]

Li W, Sun H, Chen H, Yang X, Xiao L, Liu R, Shao L, Qiu Z.

Major Depressive Disorder and Kappa Opioid Receptor Antagonists.

Transl Perioper Pain Med.

2016;1(2):4-16

Goudra B, Singh PM, Gouda G, Sinha AC.

Peroral endoscopic myotomy-initial experience with anesthetic management of 24 procedures and systematic review.

Anesth Essays Res

2016 10(2):297-300

Fine PG, Ashburn MA.

Pain Management.

Anesthesiol Clin

2016 Jun;34(2)

Badiola IJ.

Can Chronic Pain Be Prevented?

Anesthesiol Clin

2016 34(2):303-15

Schleelein LE, Vincent AM, Jawad AF, Pruitt EY, Kreher GD, Rehman MA, Goebel TK, Cohen DE, Cook-Sather SD.

Pediatric perioperative adverse events requiring rapid response: a retrospective case-control study.

Paediatr Anaesth

2016 26(7):734-41

Hadler RA, Schiffman JM, Augoustides JG, Liu R, Chen L.

Hemiparesis after general anesthesia in a patient with migraine with unilateral motor symptoms.

J Clin Anesth

2016 31:142-4.

Clement RC, Soo AE, Kheir MM, Derman PB, Flynn DN, Levin LS, Fleisher LA.

What Incentives Are Created by Medicare Payments for Total Hip Arthroplasty?

J Arthroplasty

2016 Mar 17  [Epub ahead of print]

Ho JT, Feldman JM

High-Dose Desflurane for Tocolysis During Intrapartum Myelomeningocele Repair in a Patient with Post-Adriamycin Cardiomyopathy.

A A Case Rep

2016 May 13. [Epub ahead of print]

MacKnight BM, Maldonado Y, Augoustides JG, Cardenas RA, Patel PA, Ghadimi K, Gutsche JT, Ramakrishna H

Advances in Imaging for the Management of Acute Aortic Syndromes: Focus on Transesophageal Echocardiography and Type-A Aortic Dissection for the Perioperative Echocardiographer.

J Cardiothorac Vasc Anesth. 

2016 Jan 13.  [Epub ahead of print]

Meng T, Bu W, Ren X, Chen X, Yu J, Eckenhoff RG, Gao WD.

Molecular mechanism of anesthetic-induced depression of myocardial contraction.

FASEB J

2016 May 11. [Epub ahead of print]

Jiang X, Orton M, Feng R, Hossain E, Malhotra NR, Zager EL, Liu R.

Chronic Opioid Usage in Surgical Patients in a Large Academic Center.

Ann Surg 

2016 May 9. [Epub ahead of print]

Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA.

Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.

Ann Biomed Eng 

2016 May 2. [Epub ahead of print]

Strychowsky JE, Albert D, Chan K, Cheng A, Daniel SJ, De Alarcon A, Garabedian N, Hart C, Hartnick C, Inglis A, Jacobs I, Kleinman ME, Mehta NM, Nicollas R, Nuss R, Pransky S, Russell J, Rutter M, Schilder A, Thompson D, Triglia JM, Volk M, Ward B, Watters K, Wyatt M, Zalzal G, Zur K, Rahbar R.

International Pediatric Otolaryngology Group (IPOG) consensus recommendations: Routine peri-operative pediatric tracheotomy care.

Int J Pediatr Otorhinolaryngol

2016 86:250-5

Wood SK, Valentino RJ.

The brain norepinephrine system, stress and cardiovascular vulnerability.

Neurosci Biobehav Rev

2016 Apr 27.  [Epub ahead of print]

Yehya N, Thomas NJ, Margulies SS.

Circulating nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome.

Am J Physiol Lung Cell Mol Physiol

2016 310(11):L1177-84

Lee JH, Turner DA, Kamat P, Nett S, Shults J, Nadkarni VM, Nishisaki A; 

The number of tracheal intubation attempts matters! A prospective multi-institutional pediatric observational study.

BMC Pediatr

2016 16(1):58

Goudra B, Nuzat A, Singh PM, Borle A, Carlin A, Gouda G.

Association between Type of Sedation and the Adverse Events Associated with Gastrointestinal Endoscopy: An Analysis of 5 Years' Data from a Tertiary Center in the USA.

Clin Endosc

2016 Apr 29 [Epub ahead of print]

Giuliano JS Jr, Markovitz BP, Brierley J, Levin R, Williams G, Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL

Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs.

Pediatr Crit Care Med

2016 17(6):522-30.

Conlon TW, Ishizuka M, Himebauch AS, Cohen MS, Berg RA, Nishisaki A.

Hemodynamic Bedside Ultrasound Image Quality and Interpretation After Implementation of a Training Curriculum for Pediatric Critical Care Medicine Providers.

Pediatr Crit Care Med

2016 Apr 27. [Epub ahead of print]

Maltese MR, Margulies SS.

Biofidelic white matter heterogeneity decreases computational model predictions of white matter strains during rapid head rotations.

Comput Methods Biomech Biomed Engin

2016 28:1-12.  [Epub ahead of print]

Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, Srinivasan A, Dellit TH, Falck-Ytter YT, Fishman NO, Hamilton CW, Jenkins TC, Lipsett PA, Malani PN, May LS, Moran GJ, Neuhauser MM, Newland JG, Ohl CA, Samore MH, Seo SK, Trivedi KK.

Executive Summary: Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America.

Clin Infect Dis

2016 62(10):1197-202

Morgan RW, French B, Kilbaugh TJ, Naim MY, Wolfe H, Bratinov G, Shoap W, Hsieh TC, Nadkarni VM, Berg RA, Sutton RM.

A quantitative comparison of physiologic indicators of cardiopulmonary resuscitation quality: Diastolic blood pressure versus end-tidal carbon dioxide.

Resuscitation

2016 104:6-11

Yehya N, Thomas NJ, Meyer NJ, Christie JD, Berg RA, Margulies SS.

Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome.

Intensive Care Med

2016 42(7):1137-45

Wong JH, Selewski DT, Yu S, Leopold KE, Roberts KH, Donohue JE, Ohye RG, Charpie JR, Goldberg CS, DeWitt AG.

Severe Acute Kidney Injury Following Stage 1 Norwood Palliation: Effect on Outcomes and Risk of Severe Acute Kidney Injury at Subsequent Surgical Stages.

Pediatr Crit Care Med

2016 Apr 20. [Epub ahead of print]

Ward CG, Eckenhoff RG.

Neurocognitive Adverse Effects of Anesthesia in Adults and Children: Gaps in Knowledge.

Drug Saf

2016 39(7):613-26

Alqahtani MF, Smith CM, Weiss SL, Dawson S, Ralay Ranaivo H, Wainwright MS.

Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein.

PLoS One

2016 11(4):e0153645

Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, Srinivasan A, Dellit TH, Falck-Ytter YT, Fishman NO, Hamilton CW, Jenkins TC, Lipsett PA, Malani PN, May LS, Moran GJ, Neuhauser MM, Newland JG, Ohl CA, Samore MH, Seo SK, Trivedi KK.

Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America.

Clin Infect Dis

2016  62(10):e51-77

Lohrmann GM, Atwal D, Augoustides JG, Askar W, Patel PA, Ghadimi K, Makar G, Gutsche JT, Shamoun FE, Ramakrishna H.

Reversal Agents for the New Generation of Oral Anticoagulants: Implications for the Perioperative Physician.

J Cardiothorac Vasc Anesth

2016 30(3):823-30

Wong AK, Keeney LG, Chen L, Williams R, Liu J, Elkassabany NM

Effect of Local Anesthetic Concentration (0.2% vs 0.1% Ropivacaine) on Pulmonary Function, and Analgesia After Ultrasound-Guided Interscalene Brachial Plexus Block: A Randomized Controlled Study.

Pain Med

2016 Apr 13  [Epub ahead of print]

Goudra B, Singh PM.

Providing Deep Sedation for Advanced Endoscopic Procedures: The Esthetics of Endoscopic Anesthetics.

Dig Dis Sci

2016 61(6):1426-8

Sandsmark DK.

Clinical Outcomes after Traumatic Brain Injury.

Curr Neurol Neurosci Rep

2016 16(6):52

Ramchand P, Nyirjesy S, Frangos S, Doerfler S, Nawalinski K, Quattrone F, Ju C, Patel H, Driscoll N, Maloney-Wilensky E, Stein SC, Levine JM, Kasner SE, Kumar MA.

Thromboelastography Parameter Predicts Outcome After Subarachnoid Hemorrhage: An Exploratory Analysis.

World Neurosurg

2016 Apr 9. [Epub ahead of print]

Shiima Y, Berg RA, Bogner HR, Morales KH, Nadkarni VM, Nishisaki A

Cardiac Arrests Associated With Tracheal Intubations in PICUs: A Multicenter Cohort Study.

Crit Care Med 

2016 Apr 11. [Epub ahead of print]

Goudra B, Alvarez A, Singh PM.

Practical considerations in the development of a nonoperating room anesthesia practice.

Curr Opin Anaesthesiol

2016 Apr 6. [Epub ahead of print]

Clement RC, Kheir MM, Soo AE, Derman PB, Levin LS, Fleisher LA.

What Financial Incentives Will Be Created by Medicare Bundled Payments for Total Hip Arthroplasty?

J Arthroplasty

2016 Mar 3. [Epub ahead of print]

Singh PM, Borle A, Goudra BG.

Use of computer-assisted drug therapy outside the operating room.

Curr Opin Anaesthesiol

2016 Apr 6. [Epub ahead of print]

Goudra B, Singh PM, Borle A, Gouda G.

Effect of introduction of a new electronic anesthesia record (Epic) system on the safety and efficiency of patient care in a gastrointestinal endoscopy suite-comparison with historical cohort.

Saudi J Anaesth

2016 10(2):127-31

Mohanty S, Rosenthal RA, Russell MM, Neuman MD, Ko CY, Esnaola NF.

Optimal Perioperative Management of the Geriatric Patient: A Best Practices Guideline from the American College of Surgeons NSQIP and the American Geriatrics Society.

J Am Coll Surg

2016 222(5):930-47

Gillinov AM, Bagiella E, Moskowitz AJ, Raiten JM, Groh MA, Bowdish ME, Ailawadi G, Kirkwood KA, Perrault LP, Parides MK, Smith RL 2nd, Kern JA, Dussault G, Hackmann AE, Jeffries NO, Miller MA, Taddei-Peters WC, Rose EA, Weisel RD, Williams DL, Mangusan RF, Argenziano M, Moquete EG, O'Sullivan KL, Pellerin M, Shah KJ, Gammie JS, Mayer ML, Voisine P, Gelijns AC, O'Gara PT, Mack MJ; 

Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.

N Engl J Med

2016 374(20):1911-21

Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC.

Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.

J Intensive Care 

2016 4:24

Gurubhagavatula I, Nadkarni V, Winston F.

Blind Spot: Are We Neglecting House Staff Driving Safety in the Era of Duty Hour Regulations? Driving Performance of Residents after Six Consecutive Overnight Work Shifts.

Anesthesiology

2016 124(6):1210-2

Schwartz AJ.

Anesthetic Records: Lessons about Ethics and Education.

Anesthesiology

2016 124(6):1208-9

Johnstone RE, Fleisher LA.

A 1966 Anesthetic Administered by Robert D. Dripps, M.D., Demonstrated His Experimental Style of Clinical Care.

Anesthesiology

2016 124(6):1218-21

Carvajal T, Villablanca-Spinetto P, Augoustides JG, Morozowich ST, Shamoum FE, Gutsche JT, Ramakrishna H.

Transcatheter Aortic Valve Replacement: Recent Evidence from Pivotal Trials.

J Cardiothorac Vasc Anesth

2016 30(3):831-40

Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ.

Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction.

J Bioenerg Biomembr

2016 48(3):269-79

Adler AC, Greeley WJ, Conlin F, Feldman JM.

Perioperative Anesthesiology UltraSonographic Evaluation (PAUSE): A Guided Approach to Perioperative Bedside Ultrasound.

J Cardiothorac Vasc Anesth

2016 30(2):521-9

Elkassabany NM, Antosh S, Ahmed M, Nelson C, Israelite C, Badiola I, Cai LF, Williams R, Hughes C, Mariano ER, Liu J.

The Risk of Falls After Total Knee Arthroplasty with the Use of a Femoral Nerve Block Versus an Adductor Canal Block: A Double-Blinded Randomized Controlled Study.

Anesth Analg

2016 122(5):1696-703

Kovatsis PG, Fiadjoe JE.

'Those who cannot remember the past are condemned to repeat it'.

Paediatr Anaesth

2016 26(4):333-4

Gurnaney HG, Fiadjoe JE, Levin LS, Chang B, Delvalle H, Gálvez J, Rehman MA.

Anesthetic management of the first pediatric bilateral hand transplant.

Can J Anaesth 

2016 63(6):731-736

Ambardekar AP, Singh D, Lockman JL, Rodgers DL, Hales RL, Gurnaney HG, Nathan A, Deutsch ES.

Pediatric anesthesiology fellow education: is a simulation-based boot camp feasible and valuable?

Paediatr Anaesth

2016 26(5):481-7

Neuman MD.

How clinical registries can make a difference in hip fracture care.

Anaesthesia

2016 71(5):497-501

Silber JH, Satopää VA, Mukherjee N, Rockova V, Wang W, Hill AS, Even-Shoshan O, Rosenbaum PR, George EI.

Improving Medicare's Hospital Compare Mortality Model.

Health Serv Res

2016 51 Suppl 2:1229-47. 

Kirschen MP, Topjian AA, Berg RA.

Neurologic outcome after cardiac arrest: What you see at hospital discharge may or may not be what you get.

Resuscitation

2016 102:A1-2

Kouba DJ, LoPiccolo MC, Alam M, Bordeaux JS, Cohen B, Hanke CW, Jellinek N, Maibach HI, Tanner JW, Vashi N, Gross KG, Adamson T, Begolka WS, Moyano JV.

Guidelines for the use of local anesthesia in office-based dermatologic surgery.

J Am Acad Dermatol

2016 74(6):1201-19

Saites V, Laudanski K.

Acute Hypotension After 50% Dextrose Injections.

A A Case Rep 

2016 15;6(10):296-8

Fleisher LA, Wiener-Kronish JP.

Ensuring the Future of the Specialty: What Is the Best Strategy to Ensure a Pipeline of Physician-scientists?

Anesthesiology 

2016 124(5):996-7. 

Kimball BA, Cohen AS, Gordon AR, Opiekun M, Martin T, Elkind J, Lundström JN, Beauchamp GK.

Brain Injury Alters Volatile Metabolome.

Chem Senses

2016 41(5):407-14. 

Hua M, Halpern SD, Gabler NB, Wunsch H.

Effect of ICU strain on timing of limitations in life-sustaining therapy and on death.

Intensive Care Med

2016 42(6):987-94.

Silvay G, Goldberg A, Gutsche JT, T Augoustides JG.

Same day admission for elective cardiac surgery: how to improve outcome with satisfaction and decrease expenses.

J Anesth

2016 30(3):444-8. 

Lin EE, Chen AE, Panebianco N, Conlon T, Ju NR, Carlson D, Kopenitz J, Nishisaki A.

Effect of Inhalational Anesthetics and Positive-pressure Ventilation on Ultrasound Assessment of the Great Vessels: A Prospective Study at a Children's Hospital.

Anesthesiology

2016 124(4):870-7

Peberdy MA, Andersen LW, Abbate A, Thacker LR, Gaieski D, Abella BS, Grossestreuer AV, Rittenberger JC, Clore J, Ornato J, Cocchi MN, Callaway C, Donnino M;

Inflammatory markers following resuscitation from out-of-hospital cardiac arrest-A prospective multicenter observational study.

Resuscitation

2016 103:117-24. 

Hadler RA, Chawla S, Stewart BT, McCunn MC, Kushner AL.

Anesthesia Care Capacity at Health Facilities in 22 Low- and Middle-Income Countries.

World J Surg

2016 40(5):1025-33

Tien M, Peacher DF, Franz AM, Jia SY, Habib AS.

Failure rate and complications associated with the use of spinal catheters for the management of inadvertent dural puncture in the parturient: a retrospective comparison with re-sited epidural catheters.

Curr Med Res Opin

2016 32(5):841-6. 

Silber JH, Rosenbaum PR, McHugh MD, Ludwig JM, Smith HL, Niknam BA, Even-Shoshan O, Fleisher LA, Kelz RR, Aiken LH.

Comparison of the Value of Nursing Work Environments in Hospitals Across Different Levels of Patient Risk.

JAMA Surg

2016 151(6):527-36

Hamedani H, Clapp JT, Kadlecek SJ, Emami K, Ishii M, Gefter WB, Xin Y, Cereda M, Shaghaghi H, Siddiqui S, Rossman MD, Rizi RR.

Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging.

Radiology

2016 279(3):917-24

Gerstein NS, Panikkath PV, Carlson AP, Pollock DM, Tayler E, Augoustides JG.

CASE 4-2016: The Role of the Lumbar Drain in Thoracic Endovascular Aorta Repair: Exploring the Indications for Pre-Placement Neuraxial Imaging.

J Cardiothorac Vasc Anesth

2016 30(2):548-54. 

Shah R, Gutsche JT, Patel PA, Fabbro M, Ochroch EA, Valentine EA, Augoustides JG.

CASE 6-2016Cardiopulmonary Bypass as a Bridge to Clinical Recovery From Cardiovascular Collapse During Graft Reperfusion in Liver Transplantation.

J Cardiothorac Vasc Anesth

2016 30(3):809-15

Malhotra A, Ramakrishna H, Gutsche JT, Patel PA, Al-Ghofaily L, Feinman J, Yoon J, Augoustides JG.

Options for Incidental Mitral Regurgitation Found During Aortic Valve Surgery for Aortic Regurgitation: An Evidence-Based Clinical Update for the Perioperative Echocardiographer.

J Cardiothorac Vasc Anesth

2016 30(2):555-60

Nelson O, Quinn TD, Arriaga AF, Hepner DL, Lipsitz SR, Cooper Z, Gawande AA, Bader AM.

A Model for Better Leveraging the Point of Preoperative Assessment: Patients and Providers Look Beyond Operative Indications When Making Decisions.

A A Case Rep

2016 6(8):241-8

Adhikary SD, Liu WM, Memtsoudis SG, Davis CM 3rd, Liu J.

Body Mass Index More Than 45 kg/m(2) as a Cutoff Point Is Associated With Dramatically Increased Postoperative Complications in Total Knee Arthroplasty and Total Hip Arthroplasty.

J Arthroplasty

2016 31(4):749-53

Berg RA, Nadkarni VM, Clark AE, Moler F, Meert K, Harrison RE, Newth CJ, Sutton RM, Wessel DL, Berger JT, Carcillo J, Dalton H, Heidemann S, Shanley TP, Zuppa AF, Doctor A, Tamburro RF, Jenkins TL, Dean JM, Holubkov R, Pollack MM;

Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs.

Crit Care Med

2016 44(4):798-808

Lane-Fall MB, Collard ML, Turnbull AE, Halpern SD, Shea JA.

ICU Attending Handoff Practices: Results From a National Survey of Academic Intensivists.

Crit Care Med

2016 44(4):690-8

Vasilevskis EE, Kripalani S, Ong MK, Rosenthal JT, Longnecker DE, Harmon B, Hohmann SF, Wright K, Black JT.

Variability in Implementation of Interventions Aimed at Reducing Readmissions Among Patients With Heart Failure: A Survey of Teaching Hospitals.

Acad Med

2016 91(4):522-9

Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E.

DIVERSE AND TISSUE-SPECIFIC MITOCHONDRIAL RESPIRATORY RESPONSE IN A MOUSE MODEL OF SEPSIS-INDUCED MULTIPLE ORGAN FAILURE.

Shock

2016 45(4):404-10. 

Adler AC, Jablonka DH.

Bedside Ultrasound: A Tool for Assessment of IV Functionality.

Anesthesiology

2016 124(4):959. 

Schwarz M, Rivera G, Hammond M, Silman Z, Jackson K, Kofke WA.

Acousto-Optic Cerebral Blood Flow Monitoring During Induction of Anesthesia in Humans.

Neurocrit Care

2016 24(3):436-41

Disclaimer: The search routine may include a few false positives. Only papers which include in the author contact, "Anesthesiology and Critical Care" along with either: "Hospital of the University of Pennsylvania" or "Perelman School of Medicine " or "Children's Hospital of Philadelphia," will be included in this search.

 

 

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2016 Fall

This edition highlights UPENN and CHOP Faculty Scholarship for July 1 - September 30, 2016

Research Highlights

PennAnesthesia selected to lead the new ASA Patient Safety initiative on Brain Health.

Photo of Lee Fleisher, MD and Roderic Eckenhoff, MDThe ASA, under Dr. Dan Cole’s leadership, has elected to focus on perioperative brain health as their new patient safety initiative.  This follows decades of research on the topic, in both the ageing as well as the developing brain, and the familiar message that some patients have never been the same since their surgery.  Dr. Cole selected Lee Fleisher as overall lead on this project, with Rod Eckenhoff as chief scientific officer.  The initiative got underway with a “Brain Health Summit” on 15 September 2016 in Washington DC, with brief presentations from selected experts on the problem and potential mitigation, followed by breakout sessions on prioritizing next steps.  Importantly, the summit included a number of critical stakeholder organizations, such as Centers for Medicare and Medicaid Services (CMS), Agency for Health Research and Quality  (AHRQ),  American Association of Retired Persons (AAPR), American Geriatric Association (AGS), American College of Surgeons( ACS), American Nurses Association (ANA),  Institute for Healthcare Improvement (IHI), National Institute on Aging (NIA), and others.  Outcomes include a call for patient and provider education, better assessment of cognitive status perioperatively, and NIH-supported conferences to identify and prioritize future research directions.  Some of this will be discussed at an upcoming, “late-breaking” panel on Brain Health at the ASA Annual Meeting in Chicago on October 23rd.

 

Education Highlights

Transition in Educational Leadership.

Photos of Drs Baranov, Gordon, Kelz, and McKinstry-WuIn the Summer 2016 issue of  HapPENNing FAST, we announced that  Bob Gaiser, Vice Chair for Education here at Penn, was recruited to lead the Department of Anesthesiology at the University of Kentucky in Lexington, KY.   Dmitri Baranov and Emily Gordon, (top 2 photos) two very talented and committed  junior faculty members, immediately stepped up to the plate to lead the residency program.  Working with the Chief Residents, this dynamic duo is plotting significant and innovative changes and additions to the residency program.  Max Kelz, Director for Research Education (bottom left photo), is coordinating all aspects of the Dripps Scholarship, the FAER Medical Student Anesthesia Research Fellowship (MSARF), the research aspects of the PENN Medical Student Anesthesia Interest Group,  and the Department’s relationship with the MSTP (MD/PhD program), as well as various graduate groups.  The didactic medical student educational program will be taken over by Andrew McKinstry-Wu (bottom right photo).  Meanwhile, the department has initiated a search for a new Vice Chair for Education who will oversee all aspects of the Department’s broad educational program. 

 

Announcements and Awards

Faculty Recognition

In the Press 

David Eckmann, PhD, MD, Horatio C Wood Professor, Perelman School of Medicine, and his colleagues in the School of Engineering, were in the spotlight in Penn News Today, on  August 18, 2016, for their computer modelling of the design of nanocarriers for targeted drug delivery which may has important applications for precision medicine.   Penn Medicine News Release

Frank McGowan, MD and Lynne Maxwell, MD, both Professors at CHOP, were featured in the September 16, 2016 edition of Penn News Today for their involvement in the PANDA study that analyzed child cognitive development after early exposure to anesthesia, finding no impairment at 2 years of age.  CHOP News Release

Seema Bhatnagar, PhD, Associate Professor, CHOP,  and postdoc, Lara Grafe, PhD, were highlighted in Penn News Today, on September 20, 2016, for  their study of disparities between males and females in the brain’s response to stress due to orexin, a neuropeptide.  CHOP News Release

Awards

Lee A Fleisher, MD, the Robert E Dripps Professor and Chair, was awarded The Christian R. and Mary F. Lindback Award for Distinguished Teaching, one of the 2016 Penn Medicine Awards of ExcellenceLarry Jameson, MD, Dean, Perelman School of Medicine, said, “The distinguished awardees exemplify our profession's highest values of scholarship and teaching, innovation, commitment to service, leadership, and dedication to patient care. They epitomize the preeminence and impact we all strive to achieve.” 

Zahera Jabeen, PhD, and Samaneh Farokhirad, PhD,  postdoctoral fellows working with David Eckmann, PhD, MD,  received 1st and 2nd prize, respectively, for the poster session at the Penn Institute for Computational Science symposium, “Emerging Paradigms in Scientific Discovery.” 

Kellie Woll, PhDc, Pharmacology graduate student in Roderic Eckenhoff’s lab won the Best Oral Presentation Prize at the 32nd Annual Pharmacology Graduate Group Symposium held at the College of Physicians of Philadelphia. 

Renyu Liu, MD, PhD, won the "International Exchange Award” for his photograph during the Annual Chinese Society of Anesthesiology Meeting.  The winning photograph entitled, “Inheritance and Academic Exchanges,” featured 4 generations of anesthesiologists together in a Chinese operating room.

Photo of Dr Liu and Dr Fleisher Photo of 5 generations of Chinese Anesthesiologists in an OR

 

 

 

 

 

Left photo: Renyu Liu, MD, PhD and Lee A Fleisher, MD.   Right photo: Left to right: Dajin Sun, Lee Fleisher, Jie Xiao (trained in Renyu Liu's lab), and Yannan Hang (looking at the monitor). 

 

Leadership Positions 

Laura Schleelein, MD, Assistant Professor, CHOP, has been appointed the Medical Director of the Patient Safety team in the Office of Safety and Medical Operations (OSMO).

Anesthesia Happy Science Hour

November 2, 2016 from 5:00-8:00pm
Announcing the first recipient of the David E. Longnecker Endowed Chair
All are welcome for an evening of poster viewing and appetizers.

 

ASA & SNACC PENN Itinerary

Image of SNACC and ASA logosUPENN and CHOP Anesthesiology and Critical Care faculty members are presenting or moderating 50 sessions at the 2016 ASA and SNACC Annual Meetings in Chicago, October 21-26. For the PENN itinerary, click here: ASA/SNACC Itinerary

 

 

 

PENN Alums Supporting Faculty Scholarship

Photo of Drs David and Kathy GuarnieriPenn Anesthesiology and Critical Care alumnus, David Guarnieri , MD and his wife, Kathy Guarnieri , MD, generously established the Guarnieri Scholars Fund for the Department.  David is a graduate of PENN Perelman School of Medicine and of our PENN anesthesia residency and Kathy completed her pediatric anesthesia training at St. Christopher's Hospital for Children in Philadelphia.  Both are in a practice in Scottsdale, Arizona. They are great supporters of the Department and of the Perelman School of Medicine and truly understand the importance of creating future leaders in the field. To this end, they have established this fund to send one fellow or instructor to attend a meeting for career development in the areas of leadership, patient safety, quality improvement and/or value enhancement. The first recipient will be announced at the PENN Alumni Reception at the American Society of Anesthesiologists Annual Meeting in Chicago on October 22, 2016.

Alums may be interested in donating to the Anesthesiology and Critical Care Resident Mentorship Fund or our special lectureships to support continued scholarship at PENN

The Anesthesiology and Critical Care Resident Mentorship Fund supports the Future of Anesthesiology Program, which sets Penn Medicine’s residency program apart as a national leader in training. The program provides our residents with tools such as leadership training, coaching on difficult conversations, and other topics that are not typically available through the course of a residency program.  Philanthropy from our resident alumni is what created this program, and your support will allow Penn’s program to continue to be one of the nation’s leading anesthesiology and critical care training programs in the nation and to grow the future leaders of our discipline.

Special lectureships in the Department include:

  • James E Eckenhoff Lectureship 
  • Josephine “Pina” Templeton Lectureship
  • Stephen J. Prevoznik Lectureship on Leadership
  • Brett Gutsche Lectureship on Obstetrical Anesthesia
  • Harry Wollman Lectureship

Publications

Image of cover of Annals of Biomedical EngineeringA recent paper from the David Eckmann, PhD, MD, lab was featured on the cover of the Annals of Biomedical Engineering. Check out his paper and the other 90 publications from the Department from July1-Sept 30, 2016 here and see all 2016 publications here.

 

 

 

 

 

Grants and Contracts

July 1 - September 30, 2016 

New Proposals / amount: 31 / $4,408,701

New Awards / amount:  24 / $5,941,459

(UPENN and CHOP combined)    

 

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2017 Winter

Research Highlights

Cardiothoracic Surgical Trials Network

 

Photo of Jesse Raiten, MD

The goal of the Cardiothoracic Surgical Trials Network (CTSN) is to conduct high quality trials of surgical techniques, devices, and pharmaceutical products directed towards improving the care of patients with cardiovascular disease.  The group, coordinated by the International Center for Health Outcomes and Innovation Research at the Mount Sinai Medical Center in New York, is an international collaborative of medical centers from across the US, Canada and Europe.  Trials are funded by the NHLBI, NINDS, and the Canadian Institutes for Health Research.

Since it’s founding in 2007, the network has conducted several large scale trials on a variety of topics related to the care of cardiac surgical patients.  Jesse Raiten, MD became involved with the CTSN in 2013 when he participated in a trial designed to investigate rate control versus rhythm control for atrial fibrillation after cardiac surgery.  Atrial fibrillation is the most common complication following cardiac surgery and contributes heavily to patient morbidity.  CTSN enrolled more than 2000 patients in the US and Canada and randomized patients with postoperative AF to rhythm or rate control.  The primary outcome, which showed no difference, was patient days in the hospital during the first 60 days after randomization.  These results were presented as a Late Breaking Clinical Trial at the American College of Cardiology 2016 meeting, and the paper was published in the New England Journal of Medicine

Drs. Jared Feinman and Jesse Raiten were both involved in a recently concluded study to investigate a device to reduce risk of stroke after aortic valve replacement surgery.  This trial has been completed and is in the data analysis phase.  The group has almost completed enrolling patients in another large trial of stem cell implantation in patients receiving LVAD support devices.  Several other studies are also in the protocol development phase. From the cardiac surgery department, Dr Mike Acker is the PI and Mary Lou Mayer is the research coordinator for the CTSN at Penn. 

 

Education Highlights

The Growth of Non-operating Room Anesthesia (NORA) Service and Education at Penn Medicine

Graph of # of NORA cases/month

The number and variety of Non-Operating Room Anesthesia (NORA) cases have skyrocketed here at Penn to now constitute over one-third of all anesthesia cases done by our department, as shown in the graph from data collected by Dr. Jonathan Tanner. This is not unique to Penn; the same trend is occurring across this nation.  What is unique to Penn, is that we have recognized this trend early, and have taken a number of steps in preparing our specialty for the future.

Book cover image

 

 

First, there is little to no educational material dealing with this topic in the literature or in textbooks.  Thus, in recognition of this, and to standardize teaching and practice, Drs. Mark Weiss and Lee Fleisher wrote the first textbook on what has become a new sub-specialty, NORA (Figure 2).

Photo of Dr Mark Weiss

However, textbooks are only a start. Thus, recognizing the need to formalize education of our residents, Dr. Weiss and colleagues developed the first structured teaching curricula for NORA, as well.  In addition to those on NORA rotations, this program has greatly improved the care of patients when our call team residents are sent to take over these specialized cases after hours.  To further standardize the training of residents, and to make the program available outside of Penn, www.NORAlink.org was launched.  NORAlink is designed to unify the teaching of residents by introducing a national standardized curriculum.  Our department is offering a free partnership with other academic programs by sharing the educational program that we have already developed at UPenn to provide uniform goals and standardized teaching to residents across the nation.

The NORA rotation and NORAlink have been so well received, that Dr. Robert Gaiser, then chair of the Anesthesia Residency Review Committee (RRC), brought it to attention of the ACGME.  As a result, the NORA program developed here was instrumental in the decision to include NORA teaching a part of every ACGME program. It has now been mandated by the RRC in Program Requirement IV.A.6.i., which reads that residents must have at least two weeks of experience managing the anesthetic care of patients undergoing diagnostic or therapeutic procedures outside of the surgical suite.  This requirement began in July 2016.

Visit NORAlink!  It currently consists of:

  • A "Letter of Introduction" to residents explaining the NORA rotation.
  • A series of goals for the rotation, based on the teaching requirements of medical knowledge, patient care, practice-based learning, communication, systems based practice, and professionalism.
  • A series of introductory lectures didactically delivered by your faculty to each resident
  • A sectional library with articles covering various topics in NORA including site work, culture and teamwork, patient care, site specific cases and economic issues.  This library will be continually expanded as new papers are placed.
  • An expanding series of Video lessons by experts that cover various topics in the NORA Suite.  These videos have pre- and post-tests to measure results.
  • A Protocol Section which will answer some basic "how-to" questions.
  • Pertinent ASA guidelines to the Non-Operating suite.

If programs outside of Penn are interested,  we ask that they participate in our continued evaluation of the program through a series of timely surveys to both residents and program directors. Based on such feedback, we will continue to improve the program on a regular basis. We also ask these programs to commit to help building NORAlink by submitting relevant papers to increase the library, and work with us to develop a video on a NORA topic of their choice. These surveys, feedback, and improvements, together with outcome data, will be published in the future. 

Our goal is to provide your residents and faculty with a thorough, seamless, integrated NORA experience through a combination of hands-on learning, didactic lectures, and reading materials.  If you are interested in participating in NORALink, please contact Mark.

 

Announcements

In the Press 

Mark Neuman, MD, assistant professor, was highlighted in Penn News Today, on  November 15, 2016, featuring his study that showed out-of-hospital care for patients suffering from hip fracture had a greater impact on recovery, which can help inform policy.  Penn Medicine News Release

 

Awards

Photo of Dr Max Kelz and Dr David Longnecker

Max Kelz, MD, PhD, was invested as the first David E. Longnecker Associate Professor of Anesthesiology and Critical Care on 2 November 2016. David E Longnecker, MD, was chair of the Department of Anesthesiology and Critical Care at the University of Pennsylvania from 1988-2002. The celebration was accompanied by the Anesthesia Science Happy Hour and poster presentations.

 

 

 

Kathryn Hall, MD, clinical instructor, is the first recipient of the Guarnieri Scholars Award, announced at the Penn Anesthesia Alumni Reception during the 2016 ASA Annual Meeting in Chicago.

Martha Curley, PhD, RN, the Ellen and Robert Kapito Professor in Nursing Science at the University of Pennsylvania School of Nursing, with a joint appointment in Anesthesia and Critical Care, has been elected to the National Academy of Medicine (formerly the Institute of Medicine of the National Academies). Her research has set standards of care for critically-ill pediatric patients, has provided better tools to measure important phenomena of concern in pediatrics, and has illuminated relationship-based care when partnering with parents-of-critically-ill children. Other members of the Department previously elected to the National Academy of Medicine include, David longnecker, MD, Lee Fleisher, MD, and Charles Bosk, PhD

David Eckmann, PhD, MD's postdoctoral fellows,Zahera Jabeen, PhD, and Samaneh Farokhirad, PhD, received 1st and 2nd prize, respectively, for the poster session at the Penn Institute for Computational Science symposium “Emerging Paradigms in Scientific Discovery” on October 6, 2016. 

Roderic Eckenhoff, MD's graduate student, Kellie Woll, PhD candidate in the Department of  Pharmacology, won first place for her oral presentation in the Pharmacology Graduate Group Symposium, held on October 13, 2016, at the Philadelphia College of Physicians.

 

Leadership Positions 

Mark-Allen Pizzini, MD, associate professor, will become the new Chief of Anesthesiology & Critical Care at Presbyterian Hospital in January 2017, where he will also serve as the new Director of Perioperative Services.

 

Promotions:

Associate Professor

News:

Photo of Dr Lee Fleisher and Dr John BianRosa

John Joseph BianRosa, MD, JD, associate professor, retired in December 2016.  John served as Chief, Department of Anesthesiology and Critical Care, at Penn Presbyterian Medical Center for 8 years. John also trained at Penn for his anesthesia residency and fellowship.  We wish him clear skies ahead!

 

 

Jesse Raitten, MD, assistant professor, and Joshua Atkins, MD, PhD, associate professor, were featured speakers at the recent Penn Global Surgery Symposium on Multidisciplinary Approaches to Sustainable Global Surgery held on 2 December, 2016.

Patricia Kapur, MD, clinical professor, will be giving the 11th Annual Stephen J. Prevoznik lecture on Leadership, at the 6:30 am Grand Rounds on February 2, 2017. Pat is an outstanding leader in our specialty, including former Chair of the Department of Anesthesiology of the David Geffen School of Medicine, UCLA, Executive Vice President of UCLA Health, and CEO of the Faculty Practice Group (FPG), as well as, President of the American Board of Anesthesiology, President of the Foundation of Anesthesia Education and Research, and Chair of the Board of Trustees of the International Anesthesia Research Society.

The 9th Annual Brett Gutsche Lecture on Obstetrical Anesthesia, will be presented by Steven J. Ralston, MD, MPH, Chair, Department of Obstetrics and Gynecology at Pennsylvania Hospital, on April 6, 2017, at our 6:30 am Grand Rounds. Dr Ralston is an obstetrician, specializing in high risk pregnancy, with an interest in ethical issues around maternal autonomy, prenatal diagnosis, fetal therapy, and parental decision-making at periviable gestations.

Renyu Liu, MD, PhD, associate professor, in collaboration with Jing Zhao MD, PhD (a neurologist at Fudan University in China), initiated Stroke 1-2-0 as a rapid response program for stroke recognition and response in China, similar to the English program, FAST (Face, Arm, Speech, and Time). The day after it was published online in Lancet Neurol, last October, the program was officially endorsed by the Chinese Stroke Association on the 2016 World Stroke Day, followed by widespread media and television coverage throughout China.  The strategy to use Stroke 1-2-0, to improve stroke awareness, rapid recognition, and reduce prehospital delay, has been incorporated into the practice guidelines of the Chinese Stroke Association to be released in 2017.

Photo of Dr Renyu Liu and Dr Yongjun Wang

Photo of Dr Renyu LiuDr. Renyu Liu and Dr. Yongjun Wang (far left), the Executive Vice President of the Chinese Stroke Association, introducing Stroke 1-2-0 on the 2016 World Stroke Day. 

 

Co-authors, Dr. Jing Zhao (upper) and Dr. Renyu Liu (Lower) on China Central Television introducing Stroke 1-2-0.

 

Publications

Image of PubMed logo
Click here to view all UPENN & CHOP Anesthesia publications for 2016.
Click here to see  over 90 peer reviewed publications that have been published from the Department, including UPENN and CHOP from Oct 1 — Dec 31, 2016.

Disclaimer: The search routine may include a few false positives. Only papers which include in the author contact, "Anesthesiology and Critical Care" along with either: "Hospital of the University of Pennsylvania" or "Perelman School of Medicine " or "Children's Hospital of Philadelphia," will be included in this search

 

Grants and Contracts

Oct 1 - December 31, 2016 

New Proposals / amount:            31 / $6,178,107

New Awards / amount:            16 / $1,935,504

(including UPENN and CHOP)

For the proposals and awards list, click here.

 

Support PENN Anesthesia Scholarship

 

Photo of LOVE scuplture

Penn Anesthesia alums and others may be interested in donating to the Anesthesiology and Critical Care Resident Mentorship Fund or our special lectureships to support continued scholarship at PENN:

The Anesthesiology and Critical Care Resident Mentorship Fund supports the Future of Anesthesiology Program, which sets Penn Medicine’s residency program apart as a national leader in training. The program provides our residents with tools such as leadership training, coaching on difficult conversations, and other topics that are not typically available through the course of a residency program.  Philanthropy from our resident alumni is what created this program, and your support will allow Penn’s program to continue to be one of the nation’s leading anesthesiology and critical care training programs in the nation and to grow the future leaders of our discipline.

Special lectureships in the Department include:

  • James E Eckenhoff Lectureship 
  • Josephine “Pina” Templeton Lectureship
  • Stephen J. Prevoznik Lectureship on Leadership
  • Brett Gutsche Lectureship on Obstetrical Anesthesia
  • Harry Wollman Lectureship

To donate online: go to our secure online giving page

To send a donation:

Lee A. Fleisher, MD

Department of Anesthesiology & Critical Care

University of Pennsylvania Health System

3400 Spruce Street

6 Dulles Building

Philadelphia, PA 19104

Office: (215) 662-3738

Please include your interest in helping Penn Anesthesia! 

 

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