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Kyong-Mi Chang, M.D.

Associate Professor of Medicine
Member, Abramson Cancer Center, University of Pennsylvania
Member, CAMB, Microbiology, Virology and Parasitology Program, University of Pennsylvania
Member, Center for AIDS Research, University of Pennsylvania
Co-Director, Immunology Program, NIH Center for Molecular Studies in Digestive & Liver Diseases, University of Pennsylvania
Associate Director, Penn Center for Viral Hepatitis, Hospital of University of Pennsylvania
Associate Chief of Staff for Research, Philadelphia VA Medical Center
Associate Dean for Research at the Philadelphia VA Medical Center, University of Pennsylvanina
Department: Medicine
Graduate Group Affiliations

Contact information
A424, Medical Research Building
Philadelphia VA Medical Center
University and Woodland Ave
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
The Medical College of Pennsylvania, 1987.
Post-Graduate Training
General Surgery Internship, St. Francis Hospital/University of Connecticut, 1987-1988.
Family Practice Internship, Underwood Memorial Hospital/Thomas Jefferson University, Philadelphia, PA, 1988-1989.
Internal Medicine Residency, The Medical College of Pennsylvania, Philadelphia, PA, 1989-1992.
Gastroenterology Fellowship, Division of Gastroenterology, University of California at San Diego, 1992-1995.
NRSA Research Fellow (UCSD GI Division), Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1993-1995.
Research Associate/Sr Research Associate, Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1995-1999.
Diplomate, National Board of Medical Examiners, 1988.
American Board of Internal Medicine, 1992.
Gastroenterology Board Certification, 1995.
Gastroenterology Board Recertification, 2005.
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Description of Research Expertise

- immune mechanisms of viral persistence and liver disease progression in patients infected with hepatitis C virus (HCV) and hepatitis B virus (HBV)
-high dimensional single cell immune analysis through Mass Cytometry using CyTOF2, examining 30-40 parameters at a single cell level.
-emerging expertise in genetic analysis of cardiometabolic diseases with extension to other organs (e.g. liver) using the VA Million Veterans Program (MVP) genetic and clinical databases

Selected Publications

Park J., DK Wong, AS Wahed, WM Lee, JJ. Feld JJ, N Terrault N, M Khalili, RK. Sterling, KV KowdleY, N Bzowej N, DT. Lau, WR Kim WR, C SmitH, RL Carithers, KW Torrey , JW Keith, DL Levine, D Traum, S Ho, ME Valiga, GS. Johnson, E Doo, ASF. Lok, and KM Chang. : HBV-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology 2015 (in press).

Khalili M, Lombardero M, Chung RT, Terrault NA, Ghany MG, Kim WR, Lau D, Lisker-Melman M, Sanyal A, Lok AS; HBRN. Collaborators (33) Roberts LR, Smith CI, Di Bisceglie AM, Brunt EM, Janssen HL, Wong DK, Juan J, Feld J, Yim C, Heathcote J, Lee WM, Perrillo R, Do S, Han SH, Tran TT, Cooper SL, Fontana RJ, Tsai N, Fried MW, Patel K, Evon D, Carithers RC, Shuhart M, Kowdley KV, Wang CC, Sterling RK, Liang TJ, Chang KM, Park JJ, Belle S, Wahed A, Cloonan Y, Kleiner D.: Diabetes and prediabetes in patients with hepatitis B residing in North America. Hepatology 62(5), November 2015 Notes: (cited among the collaborators).

Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, Murad MH: AASLD guidelines for treatment of chronic hepatitis B. Hepatology Epub, November 2015.

Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS: Present and future therapies of hepatitis B: From discovery to cure. Hepatology Page: [Epub] August 2015.

Ogdie A, Pang WG, Forde KA, Samir BD, Mulugeta L, Chang KM, Kaplan DE, Amorosa VK, Kostman JR, Reddy RK, Schumacher RH, Lo Re V 3rd.: Prevalence and risk factors for patient-reported joint pain among patients with HIV/Hepatitis C coinfection, Hepatitis C monoinfection, and HIV monoinfection. BMC Musculoskelet Disord 16(93), April 2015.

Ghany M, Perrillo R, Li R, Belle SH, Janssen HL, Terrault NA, Shuhart MC, Lau DT, Kim WR, Fried MW, Sterling RK, Di Bisceglie AM, Han SH, Ganova-Raeva LM, Chang KM, Suk-Fong Lok A : Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and HBV Genotype. Clin Gastroenterol Hepatol July 2014.

Cho HS, M Kikuchi, Y Li, N Nakamoto, V Amorosa, ME Valiga, KM Chang: Induction of multiple immune regulatory pathways with differential impact in HCV/HIV coinfection. Frontiers in Immunology July 2014.

Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, KM Chang: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J. Clin. Gastroenterol Jan 2014.

Hafkin JS, MK Osborn, AR Localio, VK Amorosa, JR Kostmay, JJ Stern, P De La Torre, K Mounzer, I Frank, R Gross, K-M Chang, V. LoRe III: Incidence and risk factors for incomplete HBV DNA suppression in HIV/HBV-co-infected patients initiating tenofovir-based therapy. J. Viral Hepatitis Jul 2013.

Gardiner D, J Lalezari, E Lawitz, M DiMicco, R Ghalib, KR Reddy, KM Chang, M Sulkowski, J Anderson, B He, F McPhee, D Grasela, M Selby, A Korman and I Lowy: A randomized double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection. PLOS One May 2013.

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Last updated: 11/22/2015
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