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Kyong-Mi Chang, MD

Associate Professor of Medicine
Member, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine
Co-Director, Immunology Program, NIH Center for Molecular Studies in Digestive & Liver Diseases, University of Pennsylvania Perelman School of Medicine
Associate Director, Penn Center for Viral Hepatitis, Hospital of University of Pennsylvania
Member, Samaha Award Review Committee, CMC VAMC
Associate Chief of Staff for Research, Philadelphia Corporal Michael J. Crescenz VA Medical Center (CMCVAMC)
Associate Dean for Research at the Philadelphia CMC VAMC, University of Pennsylvanina Perelman School of Medicine
Member, Penn Institute for Immunology
Department: Medicine
Graduate Group Affiliations

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
Post-Graduate Training
General Surgery Internship, St. Francis Hospital/University of Connecticut, 1987-1988.
Family Practice Internship, Underwood Memorial Hospital/Thomas Jefferson University, Philadelphia, PA, 1988-1989.
Internal Medicine Residency, The Medical College of Pennsylvania, Philadelphia, PA, 1989-1992.
Gastroenterology Fellowship, Division of Gastroenterology, University of California at San Diego, 1992-1995.
NRSA Research Fellow (UCSD GI Division), Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1993-1995.
Research Associate/Sr Research Associate, Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1995-1999.
Certifications
Diplomate, National Board of Medical Examiners, 1988.
American Board of Internal Medicine, 1992.
Gastroenterology Board Certification, 1995.
Gastroenterology Board Recertification, 2016.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Selected Publications

Gowda C, Sheikh U, Maier A, Chang KM, Kaplan DE, LoRe V, Amorosa VK: Identifying barriers and potential strategies to improve HCC surveillance for HBV-infected Veterans. Federal Practitioner in press, (in press) 2017.

Ojiro K, Qu X, Cho HS, Park J, Vuidepot A, Lissin N, Molloy PE, Bennett A, Jakobsen BK, Kaplan DE, Riley JL, Chang KM: Modulation of HCV-specific CD8 effector T-cell function with antiviral effect in infectious hepatitis C virus co-culture model. Journal of Virology (in press) 2017.

Bengsch B, Ohtani T, Herati RS, Bovenschene N, Chang KM, Wherry EJ: Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. Journal of Immunological Methods (in press) 2017.

Klarin D, Small A, Huang J, Lynch J, Arya S, Assimes T, Natarajan P, Saleheen D, Kathiresan S, Rader DJ, Concato J, Gaziano M, Cho K, Wilson P, Chang KM, O'Donnel C, Tsao P and Damrauer SM on behalf of the VA Million Veteran Program: Genetic evidence suggests a significant overlap in the pathogenesis of peripheral artery and coronary artery disease (Oral Presentation). Society for Vascular Surgery Vascular Research Initiative Conference 2017.

Chang, KM, Liu M: Chronic hepatitis B: Immune pathogenesis and emerging immunotherapeutics. Current Opinion in Pharmacology 30: 93-105, October 2016.

Liu M, Chang KM, Kaplan DE: CXCR3-high/CD81-low B cells in Early Acute HCV Infection Correlates with Severity of Liver Inflammation (Poster). Hepatology, Special Issue: 67th Annual Meeting of the AASLD Abstracts 64(S1): 746A, October 2016.

Wang YJ, Golson ML, Schug J. Traum D, Liu C, Vivek K, Dorrel C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.: Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metabolism 24(4): 616-626, October 2016.

Bengsch, B, Chang KM, : Evolution in our understanding of hepatitis B virus virology and immunology. Clin Liver Dis. 2016 Paul Martin (eds.). Elsevier, 20(3), August 2016.

Cozen ML, Ryan JC, Shen H, Cheung R, Kaplan DE, Pocha C, Brau N, Aytaman A, Schmidt WN, Pedrosa M, Anand BS, Chang KM, Morgan T, Monto A. : Improved Survival Among all Interferon-α-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders. Dig Dis Sci 61(6): 1744-1756, June 2016.

Park J., DK Wong, AS Wahed, WM Lee, JJ. Feld JJ, N Terrault N, M Khalili, RK. Sterling, KV KowdleY, N Bzowej N, DT. Lau, WR Kim WR, C SmitH, RL Carithers, KW Torrey , JW Keith, DL Levine, D Traum, S Ho, ME Valiga, GS. Johnson, E Doo, ASF. Lok, and KM Chang. : HBV-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology 150(3): 684-695, March 2016.

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Last updated: 06/02/2017
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