Steven L. Reiner, M.D.
Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Rm. 414 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104-6160
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: (215) 746-5536
Fax: (215) 746-5525
Fax: (215) 746-5525
Email:
sreiner@mail.med.upenn.edu
sreiner@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Immunology graduate group faculty webpage.
Parasitology graduate group faculty webpage.
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Immunology graduate group faculty webpage.
Parasitology graduate group faculty webpage.
Education
B.A. (Philosophy)
Haverford College, 1982.
M.D.
Duke University School of Medicine, 1985.
B.A. (Philosophy)
Haverford College, 1982.
M.D.
Duke University School of Medicine, 1985.
Post-Graduate Training
Fellow in Infectious Diseases, University of California, San Francisco, 1989-1990.
Research Fellowship, Sponsor: Richard M. Locksley, M.D., University of California, San Francisco, 1990-1994.
Internal Medicine Intern and Resident, The New York Hospital-Cornell University Medical College, 1986-1989.
Fellow in Infectious Diseases, University of California, San Francisco, 1989-1990.
Research Fellowship, Sponsor: Richard M. Locksley, M.D., University of California, San Francisco, 1990-1994.
Internal Medicine Intern and Resident, The New York Hospital-Cornell University Medical College, 1986-1989.
Certifications
American Board of Internal Medicine: Certified in Infectious Diseases, 1992.
American Board of Internal Medicine: Certified in Internal Medicine, 1989.
Permanent linkAmerican Board of Internal Medicine: Certified in Infectious Diseases, 1992.
American Board of Internal Medicine: Certified in Internal Medicine, 1989.
Description of Research Expertise
Research InterestsHost response to infectious diseases, lymphocyte differentiation, gene silencing, chromatin structure and DNA methylation.
Key words: chromatin, epigenetics, transcription, lymphocyte
Research Summary
The Reiner laboratory studies how lymphocytes make decisions during the course of an immune response, in particular, the decision of which type of effector cell a helper T cell becomes upon encounter with antigen. In vivo approaches utilize infectious disease model systems such as challenge with Leishmania major. In vitro studies examine the relationship between the cell cycle and cellular differentiation, as well as the mechanisms whereby chromatin structure and cytosine methylation regulate gene expression.¾ The molecular basis of many of the unique properties of lymphocytes, such as their "memory", can be understood by how genes are silenced and activated. In addition, the study of lymphocyte differentiation has implications for how the genome is regulated during evolution and how cells make decisions during many developmental stages.
Rotation Projects for 2006-2007
Characterize the mechanisms of action of novel transcriptional regulators of immune cell differentiation.
Lab personnel:
Arnob Banerjee - Postdoctoral fellow
John Chang - Postdoctoral fellow
Christopher Gasink – Postdoctoral fellow
Andrew Intlekofer – Graduate student
Ichiko Kinjo - Postdoctoral fellow
Sarah Longworth - Research specialist
John Northrup - Research specialist
Felix Schambach - Postdoctoral fellow
Jennifer Stundon – Research specialist
Naofumi Takemoto - Postdoctoral fellow
Selected Publications
Mullen, A.C., Hutchins, A.S., High, F.A., Lee, H.W., Sykes, K.J., Chodosh, L.A. and Reiner, S.L.: Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction. Nature Immunology 3: 652-658, 2002.Hutchins, A.S., Mullen, A.C., Lee, H.W., Sykes, K.J., High, F.A., Hendrich B.D., Bird, A.P. and Reiner, S.L.: Gene silencing quantitatively controls the function of a developmental trans-activator. Molecular Cell 10: 81-91, 2002.
Murphy K.M. and Reiner, S.L.: Decision making in the immune system: The lineage decisions of helper T cells. Nature Reviews Immunology 2: 933-944, 2002.
Mullen, A.C., High, F.A., Hutchins, A.S., Lee, H.W., Villarino, A.V., Livingston, D.M., Kung, A.L., Cereb, N., Yao,T-P., Yang, S.Y. and Reiner, S.L.: Role of T-bet in Commitment of TH1 cells before IL-12-dependent selection. Science 292: 1907-1910, 2001.
Doyle, A.M., Mullen, A.C., Villarino, A.V., Hutchins, A.S., High, F.A., Lee, H.W., Thompson, C.B. and Reiner, S.L.: Induction of CTLA-4 restricts clonal expansion of helper T cells. Journal of Experimental Medicine 194: 893-902, 2001.
Mullen, A.C., Hutchins, A.S., Villarino, A.V., Lee, H.W., High, F.A., Cereb, N., Yang, S.Y., Hua X. and Reiner, S.L.: Cell Cycle Controlling the Silencing and Functioning of Mammalian Activators. Current Biology 11: 1695-1699, 2001.
Reiner, S.L.: Helper T cell differentiation, inside and out. Current Opinion in Immunology 13: 351-355, 2001.
Finkelman, F. D., Morris, S.C., Orekhova, T., Mori, M., Donaldson, D., Reiner, S.L., Reilly, N.L., Schopf, L., and Urban, J.F., Jr.: Stat6 regulation of in vivo IL-4 responses. Journal of Immunology 164: 2303-2310, 2000.
Masteller, E.L., Chuang, E., Mullen, A.C., Reiner, S.L. and Thompson, C. B.: Structural analysis of CTLA-4 function in vivo. Journal of Immunology 164: 5319-5327, 2000.
Brown, C.R. and Reiner, S.L.: Bone-marrow chimeras reveal hemopoietic and nonhemopoietic control of resistance to experimental lyme arthritis. Journal of Immunology 165: 1446-1452, 2000.
