Ian A. Blair, Ph.D.
A.N. Richards Professor of Pharmacology
Director
Investigator
Member
Investigator
Scientific Director
Vice Chair
Scientific Director
Director, Program in Systems Biology, Institute for Translational Medicine and Therapeutics
Member, Institute for Translational Medicine and Therapeutics
Department: Pharmacology
Graduate Group Affiliations
Contact information
854 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
Center for Cancer Pharmacology
421 Curie Boulevard
Philadelphia, PA 19104-6160
University of Pennsylvania School of Medicine
Center for Cancer Pharmacology
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 573-9885
Fax: (215) 573-9889
Fax: (215) 573-9889
Email:
IAN@SPIRIT.GCRC.UPENN.EDU
IAN@SPIRIT.GCRC.UPENN.EDU
Publications
Education
Cambridge Grammar School for Boys, United Kingdom , 1960.
Prince of Wales School, Nairobi, Kenya, 1963.
B.Sc. ((Special) Chemistry, ARCS)
Imperial College of Science and Technology, University of London, United Kingdom, 1968.
Ph.D.
Imperial College of Science and Technology, University of London, United Kingdom, 1971.
MRSC (Organic Chemistry)
Adelaide University, Australia, 1972.
ARACI
Australian National University, 1977.
Cambridge Grammar School for Boys, United Kingdom , 1960.
Prince of Wales School, Nairobi, Kenya, 1963.
B.Sc. ((Special) Chemistry, ARCS)
Imperial College of Science and Technology, University of London, United Kingdom, 1968.
Ph.D.
Imperial College of Science and Technology, University of London, United Kingdom, 1971.
MRSC (Organic Chemistry)
Adelaide University, Australia, 1972.
ARACI
Australian National University, 1977.
Post-Graduate Training
Research Fellow in Reproductive Physiology and Biology, Obstetrics and Gynecology, Adelaide University, Australia, 1977-1979.
Postdoctoral Research Fellow, Organic Chemistry, Adelaide University, Australia, 1972-1975.
Research Fellow in Chemistry, Research School of Chemistry, Australian National University, 1975-1977.
Research Fellow in Reproductive Physiology and Biology, Obstetrics and Gynecology, Adelaide University, Australia, 1977-1979.
Postdoctoral Research Fellow, Organic Chemistry, Adelaide University, Australia, 1972-1975.
Research Fellow in Chemistry, Research School of Chemistry, Australian National University, 1975-1977.
Certifications
None, .
Permanent linkNone, .
Description of Research Expertise
Oxidative stress, carcinogenesis, and cardiovascular diseaseOxidative stress results in damage to lipids through the formation of lipid hydroperoxides. Our laboratory is involved in determining the factors that control lipid hydroperoxide-mediated damage to DNA, and proteins. We are also characterizing the lesions in these macromolecules using novel mass spectrometry methodology, determining how the lesions affect proliferation and apoptosis using model in vitro systems, and assessing how such processes can be prevented using novel pharmacological agents.
Selected Publications
Blair IA: DNA-adducts with lipid peroxidation products. J Biol Chem 2008 [Epub ahead of print]Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, Fitzgerald GA, Grosser T: Analysis of the zebrafish proteome during embryonic development Mol Cell Proteomics 2008 [Epub ahead of print]
Shultz CA, Palackal NT, Mangal D, Harvey RG, Blair IA, Penning TM: Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as Substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): Structural basis for stereochemical preference. Chem Res Toxicol 21: 668-677, 2008.
Ran C, Dai Q, Ruan Q, Penning TM, Blair IA, Harvey RG: Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. J Org Chem 73: 992-1003, 2008.
Xu D, Duan Y, Blair IA, Penning TM, Harvey RG: Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their (13)C-labeled analogues. Org Lett 10: 1059-1062, 2008.
Zhu P, Oe T, Blair IA: Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide Rapid Commun Mass Spectrom 22: 432-440, 2008.
Jian W, Lee SH, Mesaros C, Oe T, Elipe MV, Blair IA: A novel 4-oxo-2(E)-nonenal-derived endogenous thiadiazabicyclo glutathione adduct formed during cellular oxidative stress. Chem Res Toxicol 20: 1008-1018, 2007.
Ruan Q, Gelhaus SL, Penning TM, Harvey RG, Blair IA: Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells. Chem Res Toxicol 20: 424-431, 2007.
Pettinella C, Lee SH, Cipollone F, Blair IA: Targeted quantitative analysis of fatty acids in atherosclerotic plaques by high sensitivity liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 850: 168-176, 2007.
Lee SH and Blair IA: Targeted chiral lipidomics analysis by liquid chromatography electron capture atmospheric pressure chemical ionization mass spectrometry (LC-ECAPCI/MS) Methods Enzymol 433: 159-174, 2007.
