Selected Publications

Noma K, Smalley KS, Lioni M, Naomoto Y, Tanaka N, El-Diery W, King AJ, Nakagawa H, and Herlyn M: The Essential Role of Fibroblasts in Esophageal Squamous Cell Carcinoma-Induced Angiogenesis. Gastroenterology March 2008.

Okawa T, Michaylira CZ, Nakagawa H, Andl CD, Stairs DB, Johnstone CN, Klein-Szanto AJP, El-Deiry WS, Cukierman E, Herlyn M, and Rustgi AK: The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes & Development 21(21): 2788-803, Nov 2007.

Hirt N, Steffen Heeg S, Queisser A, Doebele M, Hauss S, Kunert H, Egenter E, Quante M, Werder AV, Nakagawa H, Beijersbergen R, Blum HE, and Opitz OG: EGFR-overexpression induces telomerase reactivation and cell cycle progression as distinct steps in a cellular model of oral esophageal carcinogenesis. May 2007 Notes: Presented at Digestive Disease Week and the 108th annual meeting of the American Gastroenterological Association, Washington DC.

Okawa T, Oyama K, Takaoka M, Nakagawa H, Michaylira CZ, Andl CD, Stairs D, Rhoades B, Herlyn M, Rustgi AK: Functional analysis of murine esophageal stem cells. May 2007 Notes: Presented at Digestive Disease Week and the 108th annual meeting of the American Gastroenterological Association, Washington DC.

Takaoka M, Kim SH, Michaylira CZ, Stairs D, Okawa T, Andl CD, Johnstone CN, Rhoades B, Lee J, Klein-Szanto AJP, El-Deiry WS, Nakagawa H: Insulin-like growth factor binding protein-3 regulates esophageal tumor formation and growth through insulin-like growth factor-dependent and independent mechanisms. May 2007 Notes: Presented at Digestive Disease Week and the 108th annual meeting of the American Gastroenterological Association, Washington DC.

Queisser A, Doebele M, Werder AV, Egenter E, Heeg S, Hirt N, Kunert H, Hauss S, Harada H, Nakagawa H, Li S, Blackburn EH, Blum HE, and Opitz OG: Inhibition of telomerase by mutant template telomerase RNA and anti-telomerase siRNA induces ALT in immortalized human esophageal epithelial cells and in generated human squamous cancer cells. May 2007 Notes: Presented at Digestive Disease Week and the 108th annual meeting of the American Gastroenterological Association, Washington DC.

Kong J, Isariyawongse B, Ezaki T, Nakagawa H, Silberg D, Lynch JP: Proliferation and epigenetic changes in human esophageal keratinocytes are necessary for Cdx2 induction of intestinalization. May 2007 Notes: Presented at Digestive Disease Week and the 108th annual meeting of the American Gastroenterological Association, Washington DC.

Okawa T, Michaylira CZ, Andl CD, Nakagawa H, Takaoka M, Miller C, El-Deiry WS, Herlyn M, Rustgi AK: The combinatorial biological effects of EGFR overexpression, hTERT activation and p53 mutation result in malignant transformation with the induction of MMP-9 in a novel organotypic culture model. April 2007 Notes: Presented at the 98th Annual Meeting of American Association for Cancer Research, Los Angeles, CA.

Takaoka M, Kim SH, Lee J, Michaylira CZ, Stairs D, Okawa T, Andl CD, Johnstone CN, Rhoades B, Klein-Szanto AJP, El-Deiry WS, Haase V, Nakagawa H: Insulin-like growth factor binding protein-3, induced by hypoxia, determines esophageal cancer cell adaptation to the microenvironment. April 2007 Notes: Presented at the 98th Annual Meeting of American Association for Cancer Research, Los Angeles, CA.

Michaylira CZ, Okawa T, Mitchell S, Andl CD, Douglas BS, Miller CG, Nakagawa H, Herlyn M, El-Deiry W, Rustgi AK: Combined EGFR overexpression and p53 inactivation in esophageal epithelial cells leads to increased tumorigenic potential. February 2007 Notes: AACR Special Conference: Advances and Challenges in Aerodigestive Epithelial Cancer. Charleston, SC.