Charles S. Abrams, M.D.
Associate Professor of Medicine
Co-Director & Scientific Director
Department: Medicine
Graduate Group Affiliations
Contact information
912 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 573-3288
Fax: (215) 573-7400
Fax: (215) 573-7400
Email:
abrams@mail.med.upenn.edu
abrams@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Biochemistry & Molecular Biophysics graduate group faculty webpage.
Cell and Molecular Biology graduate group faculty webpage.
Hematology / Oncology Faculty
Search PubMed for articles
Biochemistry & Molecular Biophysics graduate group faculty webpage.
Cell and Molecular Biology graduate group faculty webpage.
Hematology / Oncology Faculty
Education
B.E.S. (Bioengineering)
The Johns Hopkins University, 1980.
M.D. (Medicine)
Yale University School of Medicine, 1984.
B.E.S. (Bioengineering)
The Johns Hopkins University, 1980.
M.D. (Medicine)
Yale University School of Medicine, 1984.
Post-Graduate Training
Fellowship, Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia , 1987-1991.
Intern in Medicine, Temple University Hospital, Philadelphia, 1984-1985.
Resident in Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1985-1987.
Fellowship, Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia , 1987-1991.
Intern in Medicine, Temple University Hospital, Philadelphia, 1984-1985.
Resident in Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1985-1987.
Certifications
American Board of Internal Medicine, Hematology Subspecialty, 1990.
American Board of Internal Medicine, Oncology Subspecialty, 1989.
American Board of Internal Medicine, 1987.
American Board of Internal Medicine, Recertification in Hematology Subspecialty , 2005.
Permanent linkAmerican Board of Internal Medicine, Hematology Subspecialty, 1990.
American Board of Internal Medicine, Oncology Subspecialty, 1989.
American Board of Internal Medicine, 1987.
American Board of Internal Medicine, Recertification in Hematology Subspecialty , 2005.
Description of Research Expertise
Research InterestsPhospholipid signaling in platelet and T-cells.
Key words: Pleckstrin, PH domains, cytoskeleton.
Description of Research
Inappropriate platelet activation contributes to vascular diseases including stroke and myocardial ischemia. Our laboratory is focused on phospholipid signaling in platelets and its contribution to inappropriate platelet activation. Ongoing projects are directed at understanding the roles of pleckstrin and lipid kinases in platelets. Pleckstrin (p47) was once solely known as an early marker of platelet activation; more recently it has been noted to contain the prototypic Pleckstrin Homology motif. Over the past half dozen years, work derived from our laboratory has demonstrated that pleckstrin plays a dominant role in the reorganization of the platelet, and lymphocyte, cytoskeleton. Furthermore, our laboratory has established these effects are regulated by pleckstrin phosphorylation, require critical lipid-binding residues contained with the amino-terminal Pleckstrin Homology domain, and have implicated an effector for this process to be the small GTP-binding protein, Rac. Additional work from our laboratory has helped define the role of phospholipid kinases in the pathway that is initiated by G-protein coupled receptors and ultimately leads to actin reorganization. Our studies use molecular and cellular biologic techniques to examine blood cell biology, and involve expression mutagenesis, single cell microinjection, genetic library screening, and murine homologous gene targeting ("gene knock-out").
Rotation projects for 2006-2007
pleckstrin2 and actin assembly
PIP5K Ig and focal adhesions
Lab personnel:
Andrew Louden - Postdoctoral Fellow
Feng Wang - Postdoctoral Fellow
Seun-Ah Yang - Postdoctoral Fellow
Tami Bach - Postdoctoral Fellow
Michael Hu - Technician
Lurong Lian - Technician
Qing Chen - Undergraduate Student
Selected Publications
Draznin, J., Wang, Y., Lian, L., Wu, D., Abrams, C.S: ADP-mediated platelet activation requires both and phospholipase Cβ and phosphatidylinositol 3 Kinase γ National Meeting of the American Society of Hematology 2002.Yang, S.-A., Carpenter, C., Abrams, C.S: TRAP-Induces PIP5KI Translocation to Filamentous Actin During Platelet Activation. National Meeting of the American Society of Hematology 2002.
Bach, T.L., Huang, M., Wu, D., Zigmond, S.H., Abrams, C.S.: Loss of Function Mutations of PI3Kγ or PLCβ2/β3 Impair T-cell Migration to SDF. National Meeting of the American Society of Hematology 2002.
Abrams, C.S., Kazanietz, M.G: Platelet signaling: Protein Kinase C. Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics. Gresele et al (eds.). Page: 281-289, 2002.
Aasland, R., Abrams, C.S., Ampe, C., Ball, L.J., Bedford, M.T., Cesareni, G., Gimona, M., Hurley, J.H., Jarchau, T., Lehto, V.-P., Lemmon, M.A., Linding, R., Mayer, B.J., Nagai, M., Sudol, M., Walter, U., Winder, S.J: Normalization of Nomenclature for Peptide Motifs as Ligands of Modular Protein Domains. FEBS Letters 513(1): 141-144, 2002.
Abrams, C.S., Lemmon, M.A: Pleckstrin Homology domains and the cytoskeleton. FEBS Letters 513(1): 71-76, 2002.
Abrams, C.S., Cines, D.B: Platelet Glycoprotein IIb/IIIa Inhibitors and Thrombocytopenia: Possible link between platelet activation, autoimmunity and thrombosis. Thrombosis & Haemostasis 88: 888-889, 2002.
Cieslik, K., Abrams, C.S., and Wu, K.K: Upregulation of endothelial nitric oxide synthase promoter by a PI3kγ/JAK2/MEK1-dependent pathway. Journal of Biological Chemistry 276: 1211-1219, 2001.
Chatah, N.H., Abrams, C.S: G-protein coupled receptors regulate the membrane association of PIP5K Iα through a pathway dependent on both Rac and Rho. Journal of Biological Chemistry 276: 34059-34065, 2001.
Chatah, N.H., Abrams, C.S: G-protein coupled receptors regulate the membrane association of PIP5K Iα through a pathway dependent on both Rac and Rho. Meeting of the International Society of Thrombosis & Haemostasis 2001.
