Laurence A. Turka, M.D.
C. Mahlon Kline Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Renal Electrolyte & Hypertension Division
700 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
700 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Office: (215) 898-1018
Fax: (215) 573-2880
Fax: (215) 573-2880
Email:
turka@mail.med.upenn.edu
turka@mail.med.upenn.edu
Publications
Education
B.A. (Biochemistry, Summa Cum Laude)
Colgate University, Hamilton, N.Y., 1978.
M.D.
Yale University, 1982.
B.A. (Biochemistry, Summa Cum Laude)
Colgate University, Hamilton, N.Y., 1978.
M.D.
Yale University, 1982.
Post-Graduate Training
Intern in Medicine , Yale-New Haven Hospital, New Haven, CT, 1982-1983.
Fellowship,Nephrology, Brigham and Women's Hospital and Harvard Medical School, 1985-1988.
Resident in Medicine, Yale-New Haven Hospital, 1983-1985.
Intern in Medicine , Yale-New Haven Hospital, New Haven, CT, 1982-1983.
Fellowship,Nephrology, Brigham and Women's Hospital and Harvard Medical School, 1985-1988.
Resident in Medicine, Yale-New Haven Hospital, 1983-1985.
Certifications
American Board of Internal Medicine, 1985.
American Board of Internal Medicine, Nephrology, 1988.
Permanent linkAmerican Board of Internal Medicine, 1985.
American Board of Internal Medicine, Nephrology, 1988.
Description of Research Expertise
Research InterestsT cell tolerance, Transplantation immunology.
Research Summary
Broadly speaking, our laboratory is interested in defining cellular and biochemical mechanisms of peripheral tolerance. A subset of the lab has a particular interest in mechanisms and application to the setting of transplantation tolerance. One focus of particular interest is the role of T cell costimulatory signals through CD28:B7 family interactions as well as those of the TNF:TNFR family. These studies utilize T cell receptor transgenic mice for in vivo models of immune responses, as well as skin, heart, islet, and bone-marrow transplantation models. Emphasis is placed on the use of flow cytometry to track antigen-reactive T cells in vivo, quantitative analyses of effector function such as cytokine production and survival, requirements for the development of memory vs. regulatory cells, and signal transduction in regulatory and tolerized T cells.
Selected Publications
Gelman AE., Turka LA.: Autoimmunity heats up.[comment] Nature Medicine 9(12): 1465-6, Dec 2003.Sandner SE., Salama AD., Houser SL., Palmer E., Turka LA., Sayegh MH.: New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. American Journal of Transplantation 3(10): 1242-50, Oct 2003.
Adler SH., Chiffoleau E., Xu L., Dalton NM., Burg JM., Wells AD., Wolfe MS., Turka LA., Pear WS.: Notch signaling augments T cell responsiveness by enhancing CD25 expression. Journal of Immunology 171(6): 2896-903, Sep 15 2003.
Kobayashi T., Walsh PT., Walsh MC., Speirs KM., Chiffoleau E., King CG., Hancock WW., Caamano JH., Hunter CA., Scott P., Turka LA., Choi Y.: TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19(3): 353-63, Sep 2003.
Chung JB., Wells AD., Adler S., Jacob A., Turka LA., Monroe JG.: Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. Journal of Immunology 171(4): 1758-67, Aug 15 2003.
Sayegh MH., Wu Z., Hancock WW., Langmuir PB., Mata M., Sandner S., Kishimoto K., Sho M., Palmer E., Mitchell RN., Turka LA.: Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. American Journal of Transplantation 3(4): 381-9, Apr 2003.
Wells AD., Liu QH., Hondowicz B., Zhang J., Turka LA., Freedman BD.: Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. Journal of Immunology 170(8): 4127-33, Apr 15 2003.
Lechler RI., Garden OA., Turka LA.: The complementary roles of deletion and regulation in transplantation tolerance. [Review] [145 refs] Nature Reviews Immunology: 3(2):147-58, 2003 Feb. Apr 15 2003.
Kreisel D., Krupnick AS., Balsara KR., Riha M., Gelman AE., Popma SH., Szeto WY., Turka LA., Rosengard BR.: Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. Journal of Immunology 169(11): 6154-61, Dec 1 2002.
Liu QH., Fleischmann BK., Hondowicz B., Maier CC., Turka LA., Yui K., Kotlikoff MI., Wells AD., Freedman BD.: Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. Journal of Experimental Medicine 196(7): 897-909, Oct 7 2002.
