Garret A. FitzGerald, M.D.
Robert L. McNeil, Jr., Professor in Translational Medicine and Therapeutics
Professor of Cardiovascular Medicine
Chairman, Department of Pharmacology
Elmer Bobst Professor of Pharmacology
Associate Dean for Translational Research
Director, Institute for Translational Medicine and Therapeutics
Department: Medicine
Graduate Group Affiliations
Contact information
Department of Pharmacology
153 Johnson Pavilion
3620 Hamilton Walk
Philadelphia, PA 19104-6084
153 Johnson Pavilion
3620 Hamilton Walk
Philadelphia, PA 19104-6084
Office: (215) 898-1185
Fax: (215) 573-9135
Fax: (215) 573-9135
Email:
garret@spirit.gcrc.upenn.edu
garret@spirit.gcrc.upenn.edu
Publications
Links
Search PubMed for articles
"Garret FitzGerald, Renaissance Man," Penn Medicine, pg 6-11, Spring 2001.
Faculty Profile, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine
Faculty Profile, Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine
Dr Garret A FitzGerald, University College Dublin Graduate, awarded RDS Boyle Medal, in association with The Irish Times
Faculty Profile, Penn Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Profile, Department of Pharmacology, University of Pennsylvania School of Medicine
Search PubMed for articles
"Garret FitzGerald, Renaissance Man," Penn Medicine, pg 6-11, Spring 2001.
Faculty Profile, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine
Faculty Profile, Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine
Dr Garret A FitzGerald, University College Dublin Graduate, awarded RDS Boyle Medal, in association with The Irish Times
Faculty Profile, Penn Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Profile, Department of Pharmacology, University of Pennsylvania School of Medicine
Education
MB, BCh (Honors, First Place)
University College, Dublin, Ireland, 1974.
Diploma (Statistics)
Trinity College, Dublin, Ireland, 1977.
M.Sc. (Statistics)
University of London, 1979.
M.D.
University College, Dublin, 1980.
D.Sc. (Hon Causa)
University of Edinburgh, UK, 2004.
D.Sc. (Hon Causa)
National University of Ireland (150th Anniversary), Dublin, Ireland, 2004.
M.D. (Hon Causa)
Johann Wolfganag Goethe University of Frankfurt, Germany, 2007.
MB, BCh (Honors, First Place)
University College, Dublin, Ireland, 1974.
Diploma (Statistics)
Trinity College, Dublin, Ireland, 1977.
M.Sc. (Statistics)
University of London, 1979.
M.D.
University College, Dublin, 1980.
D.Sc. (Hon Causa)
University of Edinburgh, UK, 2004.
D.Sc. (Hon Causa)
National University of Ireland (150th Anniversary), Dublin, Ireland, 2004.
M.D. (Hon Causa)
Johann Wolfganag Goethe University of Frankfurt, Germany, 2007.
Post-Graduate Training
Fellowship, Wellcome Clinical Research, 1977-1979.
Research Register in Endocrinology/Diabetes Mellitus (Dr. M.I. Drury), Mater Hospital, Dublin, Ireland, 1977-1977.
Research Fellow in Clinical Pharmacology (Professor C.T. Dollery), Royal Postgraduate Medical School, 1977-1979.
Research Fellow in Clinical Pharmacology, Department of Internal Medicine II (Professor W. Kaufmann) and Research Fellow in Neurology, Max Planck Institut fur Hirnforschung Cologne (Professor K.A. Hossman), University of Cologne, 1979-1980.
Fellowship in Medicine, Alexander von Humboldt Stiftung, Government of the German Federal Republic, 1979-1980.
Traveling Studentship in Medicine, National University of Ireland, 1977-1980.
Internship in Urology (Mr. F.A. Duff and Mr. D.G. Kelly), St. Vincent's Hospital, Dublin, Ireland, 1975-1975.
Senior House Officer in Endocrinology/Diabetes Mellitus (Dr. M.I. Drury), Mater Hospital, Dublin, Ireland, 1976-1977.
Fellow, Royal College of Physicians, Ireland, 1982-1982.
Fellow, American College of Physicians, 1984-1984.
Senior House Officer in Hematology and Oncology (Dr. L.G. O'Connell and Dr. J.J. Fennelly), St. Vincent's Hospital, Dublin, Ireland, 1975-1976.
Internship in Gastroenterology/Therapeutics (Professor O. FitzGerald), St. Vincent's Hospital, Dublin, Ireland, 1974-1974.
Research Fellow in Pharmacology (Professor John A. Oates), Vanderbilt University School of Medicine, Nashville, TN, 1980-1980.
Internship in General Surgery (Mr. J.P. McMullin), St. Vincent's Hospital, Dublin, Ireland, 1975-1975.
Fellowship, Wellcome Clinical Research, 1977-1979.
Research Register in Endocrinology/Diabetes Mellitus (Dr. M.I. Drury), Mater Hospital, Dublin, Ireland, 1977-1977.
Research Fellow in Clinical Pharmacology (Professor C.T. Dollery), Royal Postgraduate Medical School, 1977-1979.
Research Fellow in Clinical Pharmacology, Department of Internal Medicine II (Professor W. Kaufmann) and Research Fellow in Neurology, Max Planck Institut fur Hirnforschung Cologne (Professor K.A. Hossman), University of Cologne, 1979-1980.
Fellowship in Medicine, Alexander von Humboldt Stiftung, Government of the German Federal Republic, 1979-1980.
Traveling Studentship in Medicine, National University of Ireland, 1977-1980.
Internship in Urology (Mr. F.A. Duff and Mr. D.G. Kelly), St. Vincent's Hospital, Dublin, Ireland, 1975-1975.
Senior House Officer in Endocrinology/Diabetes Mellitus (Dr. M.I. Drury), Mater Hospital, Dublin, Ireland, 1976-1977.
Fellow, Royal College of Physicians, Ireland, 1982-1982.
Fellow, American College of Physicians, 1984-1984.
Senior House Officer in Hematology and Oncology (Dr. L.G. O'Connell and Dr. J.J. Fennelly), St. Vincent's Hospital, Dublin, Ireland, 1975-1976.
Internship in Gastroenterology/Therapeutics (Professor O. FitzGerald), St. Vincent's Hospital, Dublin, Ireland, 1974-1974.
Research Fellow in Pharmacology (Professor John A. Oates), Vanderbilt University School of Medicine, Nashville, TN, 1980-1980.
Internship in General Surgery (Mr. J.P. McMullin), St. Vincent's Hospital, Dublin, Ireland, 1975-1975.
Certifications
VQE, 1979.
FLEX, 1981.
ECFMG, 1974.
TOEFL, 1978.
Permanent linkVQE, 1979.
FLEX, 1981.
ECFMG, 1974.
TOEFL, 1978.
Description of Research Expertise
The Pharmacology of COX InhibitionA particular interest is to elucidate the cardiovascular biology of COXs and its implication for the use of aspirin, traditional NSAIDs and COX-2 inhibitors. Studies in mice and zebrafish complement studies of the genetic and environmental factors which modulate response to this interesting class of compounds.
Selected Publications
Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I: Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circulation Res 102: 607-614, 2008.Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Pure E, FitzGerald GA: Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117: 1302-1309, 2008.
Song W-L, Wang M, Ricciotti E, Fries S, Yu Y, Grosser T, Reilly M, Lawson JA, FitzGerald GA: Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283: 1179-1188, 2008.
Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD. Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA: Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling. Arterioscl Thromb VascBiol 28: 121-126, 2008.
FitzGerald GA: Translational therapeutics at the platelet vascular interface (Introduction). Arterioscl Thromb Vasc Biol 28: S3-S4, 2008.
FitzGerald GA: Translational therapeutics at the platelet vascular interface (Summary). Arterioscl Thromb Vasc Biol 28: S51-S52, 2008.
Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, FitzGerald GA: Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci USA 104: 3450-3455, 2007.
Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, FitzGerald GA, Grosser T: EBP, a program for protein identification using multiple tandem mass spectrometry datasets. Molec Cell Prot 6: 527-536, 2007.
Yu Y, Fan J, Hui Y, Rouzer CA, Marnett LJ, Klein-Szanto AJ, FitzGerald GA, Funk CD: Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem 282: 1498-1506, 2007.
FitzGerald GA: Clinical pharmacology or translational medicine and therapeutics: Reinvent or rebrand and expand? Clin Pharmacol Therap 81: 19-20, 2007.
