Ekaterina L. Grishchuk, Ph.D.
Associate Professor of Physiology
Department: Physiology
Graduate Group Affiliations
Contact information
Physiology Department
Perelman School of Medicine
University of Pennsylvania
415 Curie Blvd.
675A Clinical Research Building
Philadelphia, PA 19104
Perelman School of Medicine
University of Pennsylvania
415 Curie Blvd.
675A Clinical Research Building
Philadelphia, PA 19104
Office: (215) 746-8178
Fax: (215) 573-2273
Lab: (215) 746-8177
Fax: (215) 573-2273
Lab: (215) 746-8177
Publications
Education:
M.S. (Physics, specialization in Biophysics)
Moscow State University, Russia, 1990.
Ph.D. (Molecular, Cellular and Developmental Biology)
University of Colorado, Boulder, USA, 1997.
Permanent linkM.S. (Physics, specialization in Biophysics)
Moscow State University, Russia, 1990.
Ph.D. (Molecular, Cellular and Developmental Biology)
University of Colorado, Boulder, USA, 1997.
Description of Research Expertise
Mechanisms that drive and control chromosome motions in mitosisSelected Publications
Zaytsev Anatoly V, Dario Segura-Peña, Maxim Godzi, Abram Calderon, Edward R. Ballister, Rumen Stamatov, Alyssa M. Mayo, Laura Peterson, Ben E. Black, Fazly I. Ataullakhanov, Michael A. Lampson, Ekaterina L. Grishchuk : Bistability of a coupled Aurora B kinase-phosphatase system in cell division. eLife Jan 2016.Zaytsev Anatoly V, Mick Jeanne E, Maslennikov Evgeny, Nikashin Boris, DeLuca Jennifer G, Grishchuk Ekaterina L: Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity. Molecular Biology of the Cell 26(10): 1829-44, May 2015.
Barisic Marin, Sousa Ricardo S, Tripathy Suvranta K, Magiera Maria M, Zaytsev Anatoly V, Pereira Ana L, Janke Carsten, Grishchuk* Ekaterina L, Maiato* Helder: Microtubule detyrosination guides chromosomes during mitosis. Science 348(6236): 799-803, May 2015.
Zakharov Pavel, Gudimchuk Nikita, Voevodin Vladimir, Tikhonravov Alexander, Ataullakhanov Fazoil I, Grishchuk Ekaterina L : Molecular and mechanical causes of microtubule catastrophe and aging Biophysical Journal 109: 2574-91, Dec 2015.
Zaytsev Anatoly V, Sundin Lynsie, DeLuca Keith F, Grishchuk* Ekaterina L, DeLuca* Jennifer R: Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions. Journal of Cell Biology 206(1): 45-59, Jun 2014.
Gudimchuk Nikita, Vitre Benjamin, Kim Yumi, Kiyatkin Anatoly, Cleveland Don W, Ataullakhanov Fazly I, Grishchuk Ekaterina L : Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips Nature Cell Biology 15(9): 1079-88, Sep 2013.
Volkov Vladimir A, Zaytsev Anatoly V, Gudimchuk Nikita, Grissom Paula M, Gintsburg Anatoly L, Ataullakhanov Fazly I, McIntosh J Richard, Grishchuk Ekaterina L: Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules. Proceedings of the National Academy of Sciences of the United States of America 110(19): 7708-13, May 2013.
McIntosh J Richard, Grishchuk Ekaterina L, Morphew Mary K, Efremov Artem K, Zhudenkov Kirill, Volkov Vladimir A, Cheeseman Iain M, Desai Arshad, Mastronarde David N, Ataullakhanov Fazly I: Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell 135(2): 322-33, Oct 2008.
Grishchuk Ekaterina L, Efremov Artem K, Volkov Vladimir A, Spiridonov Ilia S, Gudimchuk Nikita, Westermann Stefan, Drubin David, Barnes Georjana, McIntosh J Richard, Ataullakhanov Fazly I: The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proceedings of the National Academy of Sciences of the United States of America 105(40): 15423-8, Oct 2008.
Grishchuk Ekaterina L, Molodtsov Maxim I, Ataullakhanov Fazly I, McIntosh J Richard: Force production by disassembling microtubules. Nature 438(7066): 384-8, Nov 2005.