Theresa M. Busch, Ph.D.

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Research Associate Professor of Radiation Oncology
Department: Radiation Oncology
Graduate Group Affiliations

Contact information
Radiation Biology Division
Department of Radiation Oncology
University of Pennsylvania
Smilow Center for Translational Research, Room 8-126
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5156
Office: 215-573-3168
Education:
B.S. (Biophysics)
University of Scranton, 1993.
Ph.D. (Biophysics)
University of New York at Buffalo, Roswell Park Cancer Institute Division, Buffalo, NY, 1998.
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Description of Research Expertise

RESEARCH INTERESTS:
Our primary research focus is the investigation of photodynamic therapy (PDT) for the treatment of solid malignancies. In PDT, diseased tissue is illuminated by specific wavelengths of visible light after the delivery of a photosensitizer to that tissue. The light-excited photosensitizer interacts with oxygen to produce reactive oxygen species that damage the tissue and its associated stroma, including the supporting vascular network.

Our research centers on the study of biophysical limitations of treatment response to PDT. This includes the study of heterogeneities in the distributions of oxygen, photosensitizing drug, and light. Our studies have found that PDT can create widespread, severe hypoxia during illumination, even in tumor cells immediately adjacent to perfused blood vessels. Furthermore, noninvasive monitoring has shown PDT effect on tumor oxygenation and blood flow during the illumination period to be predictive of an animal’s long-term response to therapy. Such findings are extremely relevant to clinical PDT applications, where significant heterogeneity in hypoxia and photosensitizer distributions among the tumors of PDT patients will contribute to variable therapeutic outcomes. Indeed, we have documented a relationship between biochemical (PSA) response to PDT in prostate cancer patients and levels of photosensitizer drug and light energy in their prostates. Ultimately, in order to improve the clinical therapeutic index and efficacy of PDT, we aim to alter the microenvironment of tumors undergoing treatment as guided by noninvasive monitoring of their response.

Selected Publications

Ghosh G, Minnis M, Ghogare AA, Abramova I, Cengel KA, Busch TM, Greer A: Photoactive fluoropolymer surfaces that release sensitizer drug molecules. Journal of Physical Chemistry-B 119(10): 4155-64, Mar 2015.

Zhu TC, Kim MM, Liang X, Finlay JC, Busch TM: In–vivo singlet oxygen threshold doses for PDT. Photonics and Lasers in Medicine 4(1): 59-71, Feb 2015.

Hana SW, Mesquitab RC, Busch TM, Putt ME: A method for choosing the smoothing parameter in a semi-parametric model for detecting change-points in blood flow. Journal of Applied Statistics 41(1): 26-45, Apr 2014 Notes: Manuscript ID: 830085.

Pietrofesa R, Turowski J, Tyagi S, Dukes F, Arguiri E, Busch TM, Gallagher-Colombo SM, Solomides CC, Cengel KA, Christofidou-Solomidou M: Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer 13(1): 179, Apr 2013.

Edmonds C, Hagan S, Gallagher-Colombo SM, Busch TM, Cengel KA: Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer. Cancer Biology & Therapy 13(14): 1463-70, Dec 2012.

Gallagher-Colombo SM, Maas AL, Yuan M, Busch TM: Photodynamic therapy-induced angiogenic signaling: consequences and solutions to improve therapeutic response. Israel Journal of Chemistry 52(8-9): 681-90, Sep 2012.

Maas AL, Carter SL, Wileyto EP, Miller J, Yuan M, Yu G, Durham D, Busch TM: Tumor vascular microenvironment determines responsiveness to photodynamic therapy. Cancer Research 72(8): 2079-88, Apr 2012.

Mesquita RC, Han SW, Miller J, Schenkel SS, Pole A, Esipova TV, Vinogradov SA, Putt ME, Yodh AG, Busch TM: Tumor blood flow differs between mouse strains: consequences for vasoresponse to photodynamic therapy. PloS ONE 7(5): e37322, 2012.

Marotta DE, Cao W, Wileyto EP, Li H, Corbin I, Rickter E, Glickson JD, Chance B, Zheng G, Busch TM: Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo. Nanomedicine 6(3): 475-87, Apr. 2011

Esipova TV, Karagodov A, Miller J, Wilson DF, Busch TM, Vinogradov SA: Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging. Analytical Chemistry 83(22): 8756-65, Nov 2011.

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Last updated: 05/18/2015
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