Neal John Sondheimer, M.D. Ph.D.

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
ARC1010
Division of Developmental and Behavioral Pediatrics
3615 Civic Center Boulevard
Philadelphia, PA 19104
Education:
A.B. (Biology)
Harvard University, 1994.
Ph.D. (Molecular Genetics and Cell Biology)
University Of Chicago, 2000.
M.D.
University of Chicago, 2002.
Postdoc (Genetics)
The University of Pennsylvania - Narayan Avadhani (mentor), 2009.
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Description of Research Expertise

Mitochondrial genetics, mitochondrial heteroplasmy, mitochondrial transcription, mitochondrial disease.

Selected Publications

Sondheimer, Neal; Soundararajan, Suganthi; Koutzaki, Sirma H.; Doyle, Alden M.: Kidney Transplantation From a Deceased Donor With Metachromatic Leukodystrophy. Transplantation 15(97): e42-4, Apr 2014 Notes: in press.

Neal Sondheimer, Ornella Zollo, Vivianna Van Deerlin and John Q. Trojanowski: Analysis of CSF mitochondrial DNA levels in Alzheimer disease. Annals of Neurology 75(3): 458-460, Mar 2014.

Gai Xiaowu, Ghezzi Daniele, Johnson Mark A, Biagosch Caroline A, Shamseldin Hanan E, Haack Tobias B, Reyes Aurelio, Tsukikawa Mai, Sheldon Claire A, Srinivasan Satish, Gorza Matteo, Kremer Laura S, Wieland Thomas, Strom Tim M, Polyak Erzsebet, Place Emily, Consugar Mark, Ostrovsky Julian, Vidoni Sara, Robinson Alan J, Wong Lee-Jun, Sondheimer Neal, Salih Mustafa A, Al-Jishi Emtethal, Raab Christopher P, Bean Charles, Furlan Francesca, Parini Rossella, Lamperti Costanza, Mayr Johannes A, Konstantopoulou Vassiliki, Huemer Martina, Pierce Eric A, Meitinger Thomas, Freisinger Peter, Sperl Wolfgang, Prokisch Holger, Alkuraya Fowzan S, Falk Marni J, Zeviani Massimo: Mutations in FBXL4, Encoding a Mitochondrial Protein, Cause Early-Onset Mitochondrial Encephalomyopathy. Am J Human Genet 93(3): 482-495, Sep 2013.

Clarke Colleen, Xiao Rui, Place Emily, Zhang Zhe, Sondheimer Neal, Bennett Michael, Yudkoff Marc, Falk Marni J: Mitochondrial respiratory chain disease discrimination by retrospective cohort analysis of blood metabolites. Molecular genetics and metabolism 110(1-2): 145-52, Sep-Oct 2013.

Spinale Joann M, Laskin Benjamin L, Sondheimer Neal, Swartz Sarah J, Goldstein Stuart L: High-dose continuous renal replacement therapy for neonatal hyperammonemia. Pediatric nephrology (Berlin, Germany) 28(6): 983-6, Jun 2013.

Vergano Samantha A, Crossette Jonathan M, Cusick Frederick C, Desai Bimal R, Deardorff Matthew A, Sondheimer Neal: Improving surveillance for hyperammonemia in the newborn. Molecular genetics and metabolism 110(1-2): 102-5, May 2013.

D'Aco Kristin E, Manno Megan, Clarke Colleen, Ganesh Jaya, Meyers Kevin E C, Sondheimer Neal: Mitochondrial tRNA(Phe) mutation as a cause of end-stage renal disease in childhood. Pediatric nephrology (Berlin, Germany) 28(3): 515-9, Mar 2013.

Schadt Eric E, Banerjee Onureena, Fang Gang, Feng Zhixing, Wong Wing H, Zhang Xuegong, Kislyuk Andrey, Clark Tyson A, Luong Khai, Keren-Paz Alona, Chess Andrew, Kumar Vipin, Chen-Plotkin Alice, Sondheimer Neal, Korlach Jonas, Kasarskis Andrew: Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases. Genome research 23(1): 129-41, Jan 2013.

Zollo Ornella, Tiranti Valeria, Sondheimer Neal: Transcriptional requirements of the distal heavy-strand promoter of mtDNA. Proceedings of the National Academy of Sciences of the United States of America 109(17): 6508-12, Apr 2012.

Grant S F A, Glessner J T, Bradfield J P, Zhao J, Tirone J E, Berkowitz R I, Hakonarson H, Sondheimer N: Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity. International journal of obesity 36(1): 80-3, Jan 2012.

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Last updated: 07/30/2014
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