Peter F. Davies, Ph.D.

faculty photo
Robinette Foundation Professor of Cardiovascular Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Education:
BSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
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Description of Research Expertise

CVI Program Unit Administrator:
Biotechnology / Nanomedicine / Imaging

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics. Stent design.

Rotation Projects
Please discuss with Dr. Davies.

Lab Personnel:
Juan Jimenez PhD, Postdoctoral Fellow
Armen Karamanian MD, Graduate Student
Mete Civelek PhD, Postdoctoral Fellow
Yun Fang PhD, Postdoctoral Fellow
Jennifer Clark PhD, Postdoctoral Fellow
Technical Staff: Congzhu Shi PhD, Technical Staff

Selected Publications

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35, In Press 2015.

Karamanian, A., Jimenez, J.M.,Jiang Y-Z, Davies, P.F. : Loss of flow-sensitive endothelial Claudin-5 expression at atherosusceptibility sites in vivo. Circulation Research In preparation 2015.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Endothelial methylome: Differential DNA methylation in athero-susceptible aortic regions in vivo. BMC Genomics, In Review BMC Genomics In Press 2015.

Sweet DT, Jiménez JM, Chang J, Hess PR, Shepard D, Davies PF, Kahn ML.: Lymph flow regulates lymphatic remodeling and valve development through shear stress-induced Gata2 signaling. J. Clin Invest. In Revision 2015.

Jiang Y-Z, Zhang L-D, Manduchi E, Davies PF. : Oxidative stress induces DNA hypermethylation of endothelial HOXA5 promoter and gene suppression in vitro and maps to athero-susceptible endothelium in vivo. Circulation Research In preparation 2015.

Chacko A-M, Han J, Zern BJ, Mikitsch JL, Nayak M, Menon D, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. In Press 2015.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release In Press 2015.

Kwak, B., Back M., Bochaton-Piallat, M.L., Caligiuri, G., Daemen, M., Davies, P.F., Hoefer, I., Holvoet, P., Krams, R., Monaco, C., Virmani, R., Weber, C., Wentzel Y., Evans, P.: Biomechanical factors in atherosclerosis - Mechanisms and implications. European Heart Journal doi: 10.1093 eurheartj/ehu353 in press. European Society Cardiology, In Press, Sept 2014.

Jiang YZ, Jiménez JM, Ou K, McCormick ME, Zhang LD, Davies PF.: Hemodynamic disturbed flow induces differential DNA methylation of endothelial kruppel-like factor 4 promoter in vitro and in vivo. Circulation Research 115:((1)): 32-43, June 2014.

Davies PF, Manduchi E, Stoeckert CJ, Jimenez JM, Jiang, Y-Z : Emerging topic: Flow-related epigenetic regulation of endothelial phenotype through DNA methylation. Vascular Pharmacology 62: 88-93, March 2014.

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Last updated: 05/09/2015
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