Vickas V. Patel, M.D., Ph.D.

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Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
11-106 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 573-8990
Fax: (215) 573-2094
S.B.E.E. (Electrical Engineering, cum laude)
Massachusetts Institute of Technology, 1987.
Ph.D. (Biophysics and Physiology)
University of Colorado School of Medicine, 1994.
M.D. (Medicine, with honors)
University of Colorado School of Medicine, 1995.
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Description of Research Expertise

The research in our laboratory is focused on elucidating molecular mechanisms of cardiac arrhythmias and conduction disease. We are using genetically engineered mouse models of human arrhythmogenic disorders to investigate the mechanisms underlying these disorderss at the level of the whole heart, the cardiomyocyte and molecule. This integrative approach is accomplished by using the murine in vivo electrophysiology technique in combination with the whole-cell patch clamp technique and employing standard molecular and biochemical approaches. Specifically, our lab has several areas of interest with active research projects investigating:

1) The role and contribution to atrial arrhythmogenesis of a newly identified melanocyte-like cell population in the mouse and human pulmonary veins.

2) The transcriptional regulation of cardiac conduction system development and function in mouse models engineered with conduction system deletion of T-box and GATA transcription factors using inducible Mink-Cre and Hcn4-Cre transgenic mice.

2) Investigate the contribution of HDACs to atrial fibrosis and atrial fibrillation in genetically engineered mice using a novel, inducible ANP-Cre transgenic mouse.

Lab Members:
Kurt Schinger, M.D., Ph.D. - EP Research Fellow
Hayoung Wang, Ph.D. - Post-doctoral Fellow
Fang Liu, Ph.D. - Research Specialist
Nataliya Peternko, M.S. - Research Speacialist
Terry Dean, M.D., Ph.D. - Post-doctoral Fellow
Neil Patel - Penn Undergraduate Student
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Last updated: 12/06/2013
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