Anne Rentoumis Cappola, MD, ScM

faculty photo
Professor of Medicine
Department: Medicine

Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 746-6391
Fax: (215) 898-5408
Education:
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
M.D.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
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Description of Research Expertise

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism; Director of the CTSA-sponsored Center for Human Phenomic Science; and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Selected Publications

Segna D, Bauer DC, Feller M, Schneider C, Fink HA, Aubert CE, Collet TH, da Costa BR, Fischer K, Peeters RP, Cappola AR, Blum MR, van Dorland HA, Robbins J, Naylor K, Eastell R, Uitterlinden AG, Rivadeneira Ramierez F, Gogakos A, Gussekloo J, Williams GR, Schwartz A, Cauley JA, Aujesky DA, Bischoff-Ferrari HA, Rodondi N; Thyroid Studies Collaboration: Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 283(1): 56-72, Jan 2018.

Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC: An online survey of hypothyroid patients demonstrates prominent dissatisfaction. Thyroid In press 2018.

Sanders JL, Guo W, O’Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP, Cappola AR: Trajectories of IGF-I predict mortality in older adults: the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci In press 2018.

Gannon AW, Langer JE, Bellah R, Ratcliffe S, Pizza J, Mostoufi-Moab S, Cappola AR, Bauer AJ: Diagnostic accuracy of ultrasound with color flow Doppler in children with thyroid nodules. J Clin Endocrinol Metab In press 2018.

Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB: Association of biomarker and physiologic indices with mortality in older adults: Cardiovascular Health Study. J Gerontol Med Sci In press 2018.

Aneke-Nash CS, Xue X, Qi Q, Biggs ML, Cappola A, Kuller L, Pollak M, Psaty BM, Siscovick D, Mukamal K, Strickler HD, Kaplan RC: The association between IGF-1 and IGFPB-3 and incident diabetes in an older population of men and women in the Cardiovascular Health Study. J Clin Endocrinol Metab 102(12): 4541-4547, Dec 2017.

Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen W, Peeters RP, Luben R, Volzke H, Door M, Walksh JP, Bremner A, Iacoviello M, Macfarlane P, Heering J, Stott DJ, Westendorp R, Khaw KT, Magnani J, Aujesky D, Rodondi N for the Thyroid Studies Collaboration: Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation. Circulation 136(22): 2100-2116, Nov 2017.

Sofer T, Wong Q, Hartwig FP, Taylor K, Warren HR, Evangelou E, Cabrera CP, Levy D, Kramer H, Lange LA, Horta BL, COGENT-BP consortium (includes Cappola A), Kerr KF, Reiner AP, Franceschini N: Genome-wide association study of blood pressure traits by Hispanic/latino background: the Hispanic Community Health Study/Study of Latinos. Sci Rep 7(1): 10438, Sep 2017.

Aubert CE, Floriani C, Bauer DC, da Costa BR, Segna D, Blum MR, Collet TH, Fink HA, Cappola AR, Syrogiannouli L, Peeters RP, Åsvold BO, den Elzen WP, Luben RN, Bremner AP, Gogakos A, Eastell R, Kearney PM, Hoff M, Le Blanc E, Ceresini G, Rivadeneira F, Uitterlinden AG, Khaw KT, Langhammer A, Stott DJ, Westendorp RG, Ferrucci L, Williams GR, Gussekloo J, Walsh JP, Augjesky D, Rodondi N for the Thyroid Studies Collaboration: Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts. J Clin Endocrinol Metab 102(8): 2719-2728, Aug 2017.

Chaker L, Korevaar TIM, Rizopoulos D, Collet TH, Völzke H, Hofman A, Rodondi N, Cappola AR, Peeters RP, Franco OH: Defining optimal health range for thyroid function based on the risk of cardiovascular disease. J Clin Endocrinol Metab 102(8): 2853-2861, Aug 2017.

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Last updated: 04/18/2018
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