Hildegund C.J. Ertl, MD

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Wistar Institute Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104
Office: (215) 898-3863
Fax: (215) 898-3953
Medical Microbiology Institute, Univ. of Goettingen, Goettingen, Germany, 1974.
Medical School, Georg August Univ., Goettingen, Germany, 1977.
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Description of Research Expertise

Research Interests
The laboratory focuses on pre-clinical development of vaccines to infectious diseases and cancer emphasizing basic immunological mechanisms that influence vaccine efficacy.

Key words: HIV Vaccine, HPV vaccines, Rabies Virus vaccines.

Description of Research
The laboratory explores DNA vaccines and viral recombinant vaccines based on E1-deleted adenoviral recombinants or adeno-associated viral recombinants to rabies virus, human papillomavirus type 16, and human immunodeficiency virus (HIV)-1.

Rotation Projects
1. Use of AAV as a vaccine carrier

2. Mechanisms of the persistence of adenoviral vectors in lymphocytes of vaccinated mice

3. Immune responses to oral immunization with an adenoviral vector vaccine to HIV-1

4. Effect of pre-existing T cell immunity on the efficacy of adenoviral vector vaccines to HIV-1

5. Interactions between adenoviral vectors and cells of the innate immune system

Lab personnel:
Hildegund Ertl, MD, PI
Jason Xiang, MD, Senior Scientist
Marcio Lasaro, PhD, Postdoctoral Fellow
Nia Tatsis, PhD, Associate Staff Scientist
Dongming Zhou, Associate Staff Scientist
Hua Li, PhD, Postdoctoral Fellow
Scott Hensley, Predoctoral Fellow
Wenny Lin, Predoctoral Fellow
Wynetta Giles-Davis, Research Technician
Yan Li, Research Technician
Ang Bian, Research Technician
Lauren DiMenna, Reasearch Technician
Christina Cole, Research Assistant
Colin Barth, Research Assistant

Selected Publications

Hensley, S.E., Giles-Davis, W., McCoy, K.C., Weninger, W., Ertl, H.C.: Dendritic Cell Maturation, but Not CD8 T Cell Induction, Is Dependent on Type I IFN Signaling during Vaccination with Adenovirus Vectors. J. Immunol. 175: 6032-6041, 2005.

Wlazlo, A.P., Deng, H., Giles-Davis, W., Ertl, H.C.J.: DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins. Cancer Gene Ther. 11: 457-464, 2004.

Reyes-Sandoval, A. Fitzgerald, J.C., Grant, R., Roy, S. Xiang, Z.Q. Li, Y., Gao, G.P., Wilson, J.M., and Ertl, H.C.J.: Human immunodeficiency virus type 1-specific immune responses in primates upon sequential immunization with adenoviral vaccine carriers of human and simian serotypes. J.Virol 78: 7392-7399, 2004.

Xiang, Z.Q. Li, Y., Gao, G.P., Wilson, J.M. and Ertl, H.C.J.: Mucosally delivered E1-deleted adenoviral vaccine carriers induce transgene product-specific antibody responses in neonatal mice. J. Immunol 171: 4287 4293, 2003.

Pinto, A.R., Fitzgerald, J.C., Giles-Davis, W., Gao, G.P., Wilson, J.M., and Ertl, H.C.J.: Induction of CD8+ T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers. J. Immunol. 171: 6774-6779, 2003.

Ertl, H.C.: Technology evaluation: ALVAC-CEA/B7.1, Aventis Pasteur/Therion. Curr. Opin. Mol. Ther 4: 601-605, 2003.

Vinner, L., Wee, EG, Patel, S., Corbet, S., Gao, GP, Nielsen, C., Wilson, J.M., Ertl, H.C.J., Hanke, T., Fomsgaard , A: Immunogenicity in Mamu-A*01 rhesus macaques of a CCR5-tropic human immunodeficiency virus type 1 envelope from the primary isolate (Bx08) after synthetic DNA prime and recombinant adenovirus 5 boost J. Gen. Virol 84: 203-213, 2003.

Z. Q. Xiang, G. P. Gao, Y. Li, J. M. Wilson, and H. CJ. Ertl: T Helper cell-independent antibody responses to the transgene product of the E1-deleted adenoviral vaccine require NK1.1 T cells. Virology 305: 397-405, 2003.

Fitzgerald, J., Gao, G.P., Reyes-Sandoval, A., Pavlakis, G.N., Xiang, Z.Q., Wlazlo, A.P., Giles-Davis, W., Wilson, J., and Ertl, H.C.J.: A simian replication-defective adenoviral recombinant vaccine to HIV-1 gag. J. Immunol. 170: 1416-1422, 2003.

Jackson, A.C., Mary J. Warrell, M.J., Rupprecht, C.E., C. J. Ertl, H.C., Dietzschold, B., O'Reilly, M., Leach, R.P., Fu, Z.F., Wunner, W.H., Bleck, T.P., and Wilde, H.: Management of rabies in humans Clin. Infect. Dis. 36: 60-63, 2003.

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Last updated: 03/18/2013
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