John H. Kempen, MD, MPH, MHS, PhD

faculty photo
Professor of Ophthalmology
Department: Ophthalmology
Graduate Group Affiliations

Contact information
Ocular Inflammation Service
Scheie Eye Institute
51 N. 39th St
Philadelphia, PA 19104
Education:
BS (Biological Sciences, with Departmental Honors)
Stanford University, 1988.
MD (Medicine)
School of Medicine, University of California, San Diego, 1992.
MPH (International Health)
School of Hygiene & Public Health, Johns Hopkins University, 1997.
MHS (Biostatistics)
School of Hygiene and Public Health, Johns Hopkins University, 1999.
PhD (Epidemiology)
Bloomberg School of Public Health, Johns Hopkins University, 2001.
Permanent link
 

Description of Research Expertise

Dr. Kempen is well-known nationally and internationally as an expert in ocular inflammatory diseases—such as uveitis, scleritis, and others—as well as ocular complications of AIDS. He is the Director of the Penn Ocular Inflammation Service, and Director of Ophthalmic Epidemiology at the Center for Preventive Ophthalmology and Biostatistics. As an expert epidemiologist, he holds a joint appointment in the Department of Biostatistics & Epidemiology, and the Penn Center for Clinical Epidemiology and Biostatistics.

Clinical Research
-Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study (funded by the National Eye Institute): Dr. Kempen is the national Principal Investigator for this study, the first NIH-sponsored multicenter clinical research study in the field of uveitis.
-Multicenter Uveitis Steroid Treatment (MUST) Trial (funded by the National Eye Institute): Dr. Kempen serves as International Vice-Chairman, as well as Director of the Penn Clinical Center enrolling patients in this study.
-Posurdex for Intermediate Uveitis, phase 3 Trial (funded by Allergan): Dr. Kempen directs the Penn clinical center for this study.
-Longitudinal Study of Ocular Complications of AIDS (funded by the National Eye Institute): Dr. Kempen is a co-investigator for this study.

Key words
Uveitis, iritis, pars planitis, panuveitis, sympathetic ophthalmia, choroiditis, retinitis, neuroretinitis, Vogt-Koyanagi-Harada disease, Fuchs’ heterochromic cyclitis, retinal vasculitis, serpiginous retinochoroiditis, birdshot chorioretinitis, immunosuppressive therapy for eye disease, scleritis, orbital inflammatory disease, ocular complications of AIDS, cytomegalovirus retinitis, acute retinal necrosis, infectious retinitis, toxoplasmic retinitis

Selected Publications

Kempen JH, Sugar EA, Varma R, Dunn JP, Heinemann MH, Jabs DA, Lyon AT, Lewis RA: Risk of Cataract Among Subjects with the Acquired Immune Deficiency Syndrome Free of Ocular Opportunistic Infections Ophthalmology Aug 2014

Levin MH, Pistilli M, Daniel E, Gangaputra SS, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Kempen JH: Incidence of Visual Improvement in Uveitis Cases with Visual Impairment Caused by Macular Edema. Ophthalmology Feb 2014

Mehta S, Linton MM, Kempen JH: Outcomes of Cataract Surgery in Patients with Uveitis: A Systematic Review and Meta-Analysis. Am J Ophthalmol Oct 2014.

CHRISTINA H. CHOE, GRANT A. MCARTHUR, IVOR CARO, JOHN H. KEMPEN, AND RAVI K. AMARAVADI: Ocular Toxicity in BRAF Mutant Cutaneous Melanoma Patients Treated With Vemurafenib. American Journal of Ophthalmology October 2014.

Hornbeak DM, Payal A, Pistilli M, Biswas J, Ganesh SK, Gupta V, Rathinam SR, Davis JL, Kempen JH: Interobserver Agreement in Clinical Grading of Vitreous Haze Using Alternative Grading Scales. Ophthalmology Aug 2014.

Eftekhari K, Ghodasra DH, Haynes K, Chen J, Kempen JH, Vanderbeek BL: Risk of retinal tear or detachment with oral fluoroquinolone use: a cohort study. Pharmacoepidemiol Drug Saf Jul 2014.

Sheppard JD, Toyos MM, Kempen JH, Kaur P, Foster CS. : Difluprednate 0.05% Versus Prednisolone Acetate 1% for Endogenous Anterior Uveitis: A Phase III, Multicenter, Randomized Study. Invest Ophthalmol Vis Sci May 2014.

Artornsombudh P, Pistilli M, Foster CS, Pujari SS, Gangaputra SS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Kempen JH: Factors predictive of remission of new-onset anterior uveitis Ophthalmology 121(3): 778-84, March 2014 Notes: doi: 10.1016/j.ophtha.2013.09.041. Epub 2013 Dec 15.

Baxter SL, Pistilli M, Pujari SS, Liesegang TL, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Kempen JH: Risk of choroidal neovascularization among the uveitides Am J Ophthalmol 156(3): 468-477, Sep 2013 Notes: *Corresponding author. Epub 2013 Jun 21.

Kempen JH, Sugar EA, Jaffe GJ, Acharya NR, Dunn JP, Elner SG, Lightman SL, Thorne JE, Vitale AT, Altaweel MM; Multicenter Uveitis Steroid Treatment (MUST)Trial Research Group: Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema. Ophthalmology 120(9): 1852-9, Sep 2013 Notes: *Corresponding author. doi:pii:S0161-6420(13)00115-2. 10.1016/j.ophtha.2013.01.069.

back to top
Last updated: 10/22/2014
The Trustees of the University of Pennsylvania