Despina Kontos, Ph.D.

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Assistant Professor of Radiology
Department: Radiology

Contact information
Computational Breast Imaging Group (CBIG)
University of Pennsylvania, Department of Radiology
Rm D702 Richards Bldg., 3700 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-4064
Lab: 215-746-4060
B.Eng. (Computer Engineering and Informatics )
University of Patras, Greece, 2000.
M.Sc. (Computer and Information Sciences )
Temple University, Philadelphia PA , 2003.
Ph.D. (Computer and Information Sciences )
Temple University, Philadelphia PA , 2006.
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Description of Research Expertise

Biomedical image analysis; Quantitative imaging biomarkers; Pattern recognition; Identification, characterization and validation of imaging biomarkers; Evaluation of genotype to phenotype associations via imaging; Integrated diagnostics; Risk prediction; Personalized screening, prognostication and treatment of breast cancer.

Selected Publications

B.M. Keller, J. Chen, D. Daye, E.F. Conant, D. Kontos: Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: Comparison of fully-automated area and volumetric density measures in a case-control study with digital mammography. Breast Cancer Reserch 17(1): 117; doi: 10.1186/s13058-015-0626-8. Aug 2015.

AM. McCarthy, D. Kontos, M. Synnestvedt, K. Tan, D.F. Heitjan, M. Schnall, E.F. Conant: Screening Outcomes Following Implementation of Digital Breast Tomosynthesis in a General-Population Screening Program. Journal of the National Cancer Institute (JNCI) 106(11): dju316. doi: 10.1093/jnci/dju316, Oct 2014.

S. Wu, S.P. Weinstein, M.J. Deleo, E.F. Conant, J. Chen, S.M. Domchek, D. Kontos : Quantitative assessment of Background Parenchymal Enhancement in breast MRI predicts response to Risk-Reducing Salpingo-Oophorectomy: Preliminary evaluation in a cohort of BRCA1/2 mutation carriers. Breast Cancer Research 17(67): doi: 10.1186/s13058-015-0577-0, May 2015.

Y. Ou, SP. Weinstein, E.F. Conant, S. Englander, X. Da, B. Gaonkar, M-K. Hsieh, M. Rosen, A. DeMichele, C. Davatzikos, D. Kontos: Deformable registration for quantifying longitudinal tumor changes during neoadjuvant chemotherapy. Magnetic Resonance in Medicine (MRM) 73(6): 2343-56, Jun 2015.

A.B. Ashraf, D. Daye, S. Gavenonis, C. Mies, M. Feldman, M. Rosen, D. Kontos: Identification of intrinsic radio-phenotypes for breast cancer tumors: Preliminary associations with gene expression profiles. Radiology 272(2): 374-84, Aug 2014.

A.M.McCarthy, B.Keller, D.Kontos, L.Boghossian, E.McGuire, M.Bristol, J.Chen, S.M.Domchek, K.Armstrong: The use of the Gail Model, body mass index (BMI), and SNPs, to predict breast cancer among women with abnormal (BI-RADS 4) mammograms. Breast Cancer Research 17(1): doi: 10.1186/s13058-014-0509-4, Jan 2015.

S.Wu, S.P. Weinstein, E.F. Conant, D. Kontos: Automated fibroglandular tissue segmentation and volumetric density estimation in breast MRI using an atlas-aided fuzzy C-means method Medical Physics 40(12): 122302, Dec 2013.

A. Ashraf, S. Gavenonis, D. Daye, C. Mies, M. Feldman, M.A. Rosen, and D. Kontos: A Multichannel Markov Random Field Framework for Tumor Segmentation with an Application to Classification of Gene Expression-based Breast Cancer Recurrence Risk. IEEE Transactions on Medical Imaging 32(4): 637-48, Apr 2013.

B.M. Keller, D.L. Nathan, Y. Wang, Y. Zheng, J.C. Gee, E.F. Conant, D. Kontos: Estimation of Breast Percent Density in Raw and Processed Full Field Digital Mammography Images via Adaptive Fuzzy C-means Clustering and Support Vector Machine Segmentation. Medical Physics 39(8): 4903-17, Aug 2012.

D. Kontos, L. Ikejimba, P.R. Bakic, A.B. Troxel,E.F. Conant, A.D.A. Maidment: Digital Breast Tomosynthesis Parenchymal Texture Analysis: Comparison with Digital Mammography and Implications for Cancer Risk Assessment. Radiology 261(1): 80-91, Oct 2011

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Last updated: 09/14/2015
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