Despina Kontos, Ph.D.

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Assistant Professor of Radiology
Department: Radiology

Contact information
Computational Breast Imaging Group (CBIG)
University of Pennsylvania, Department of Radiology
Rm D702 Richards Bldg., 3700 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-4064
Lab: 215-746-4060
Education:
B.Eng. (Computer Engineering and Informatics )
University of Patras, Greece, 2000.
M.Sc. (Computer and Information Sciences )
Temple University, Philadelphia PA , 2003.
Ph.D. (Computer and Information Sciences )
Temple University, Philadelphia PA , 2006.
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Description of Research Expertise

Biomedical image analysis; Quantitative imaging biomarkers; Pattern recognition; Identification, characterization and validation of imaging biomarkers; Evaluation of genotype to phenotype associations via imaging; Integrated diagnostics; Risk prediction; Personalized screening, prognostication and treatment of breast cancer.

Selected Publications

B.L. Sprague, E.F. Conant, T. Onega, M.P. Garcia, E.F. Beaber, S.D. Herschorn, C.D. Lehman, A.N.A. Tosteson, R. Lacson, M.D. Schnall, D. Kontos, J.S. Haas, D.L. Weaver, W.E. Barlow, on behalf of the PROSPR consortium: Variation in mammographic breast density assessments among radiologists in clinical practice: Findings from a multicenter observational study. Annals of Internal Medicine Page: doi:10.7326/M15-2934 Jul 2016 (Accepted, On-Line First ahead of Print).

L. Chen, S. Ray, B.M. Keller, S. Pertuz, E.S. McDonald, E.F. Conant, D. Kontos: The Impact of Acquisition Dose on Quantitative Breast Density Estimation with Digital Mammography: Results from ACRIN PA 4006. Radiology Page: 151749. [Epub ahead of print] Mar 2016.

A.M. McCarthy, B.M. Keller, L.M. Pantalone, M-K. Hsieh, M. Synnestvedt, E.F. Conant, K. Armstrong, D. Kontos: Racial differences in quantitative measures of area and volumetric breast density. Journal of the National Cancer Institute (JNCI) 108(10): djw104 doi: 10.1093/jnci/djw104, May 2016.

S. Pertuz, E. McDonald, S.P. Weinstein, E.F. Conant, D. Kontos: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging. Radiology 279(1): 65-74, Apr 2016.

B.M. Keller, J. Chen, D. Daye, E.F. Conant, D. Kontos: Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: Comparison of fully-automated area and volumetric density measures in a case-control study with digital mammography. Breast Cancer Research 17(1): 117; doi: 10.1186/s13058-015-0626-8. Aug 2015.

S. Wu, S.P. Weinstein, M.J. Deleo, E.F. Conant, J. Chen, S.M. Domchek, D. Kontos : Quantitative assessment of Background Parenchymal Enhancement in breast MRI predicts response to Risk-Reducing Salpingo-Oophorectomy: Preliminary evaluation in a cohort of BRCA1/2 mutation carriers. Breast Cancer Research 17(67): doi: 10.1186/s13058-015-0577-0, May 2015.

AM. McCarthy, D. Kontos, M. Synnestvedt, K. Tan, D.F. Heitjan, M. Schnall, E.F. Conant: Screening Outcomes Following Implementation of Digital Breast Tomosynthesis in a General-Population Screening Program. Journal of the National Cancer Institute (JNCI) 106(11): dju316, Oct 2014.

A.B. Ashraf, D. Daye, S. Gavenonis, C. Mies, M. Feldman, M. Rosen, D. Kontos: Identification of intrinsic radio-phenotypes for breast cancer tumors: Preliminary associations with gene expression profiles. Radiology 272(2): 374-84, Aug 2014.

S.Wu, S.P. Weinstein, E.F. Conant, D. Kontos: Automated fibroglandular tissue segmentation and volumetric density estimation in breast MRI using an atlas-aided fuzzy C-means method Medical Physics 40(12): 122302, Dec 2013.

A. Ashraf, S. Gavenonis, D. Daye, C. Mies, M. Feldman, M.A. Rosen, and D. Kontos: A Multichannel Markov Random Field Framework for Tumor Segmentation with an Application to Classification of Gene Expression-based Breast Cancer Recurrence Risk. IEEE Transactions on Medical Imaging 32(4): 637-48, Apr 2013.

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Last updated: 08/26/2016
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