Lawrence E. Samelson, MD

faculty photo
Adjunct Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Laboratory of Cellular and Molecular Biology
Center for Cancer Research
National Cancer Institute
National Institutes of Health
Bldg. 37, Room 2066
37 Convent Dr., MSC 4256
Bethesda, MD 20892
Office: 301-496-9683
Fax: 301-496-8479
Education:
BA
University of Rochester, 1972.
MD
Yale University, 1977.
Permanent link
 

Description of Research Expertise

T cell antigen receptor structure, physiology and ontogeny
Lymphocyte activation and signal transduction
Receptors and signal transduction
Protein kinases and phosphatases
Immunodeficiency diseases and autoimmunity
Signal transduction and cancer

Selected Publications

Kortum Robert L, Balagopalan Lakshmi, Alexander Clayton P, Garcia Julie, Pinski John M, Merrill Robert K, Nguyen Phan H, Li Wenmei, Agarwal Isha, Akpan Itoro O, Sommers Connie L, Samelson Lawrence E: The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Science signaling 6(301): ra99, Nov 2013.

Coussens Nathan P, Hayashi Ryo, Brown Patrick H, Balagopalan Lakshmi, Balbo Andrea, Akpan Itoro, Houtman Jon C D, Barr Valarie A, Schuck Peter, Appella Ettore, Samelson Lawrence E: Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells. Molecular and cellular biology 33(21): 4140-51, Nov 2013.

Baltanás Fernando C, Pérez-Andrés Martín, Ginel-Picardo Alicia, Diaz David, Jimeno David, Liceras-Boillos Pilar, Kortum Robert L, Samelson Lawrence E, Orfao Alberto, Santos Eugenio: Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival. Molecular and cellular biology 33(22): 4562-78, Nov 2013.

Parker Joshua, Sherman Eilon, van de Raa Matthias, van der Meer Devaraj, Samelson Lawrence E, Losert Wolfgang: Automatic sorting of point pattern sets using Minkowski functionals. Physical review. E, Statistical, nonlinear, and soft matter physics 88(2): 022720, Aug 2013.

Kortum Robert L, Rouquette-Jazdanian Alexandre K, Samelson Lawrence E: Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. Trends in immunology 34(6): 259-68, Jun 2013.

Balagopalan Lakshmi, Barr Valarie A, Kortum Robert L, Park Anna K, Samelson Lawrence E: Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. Journal of immunology (Baltimore, Md. : 1950) 190(8): 3849-53, Apr 2013.

Sherman Eilon, Barr Valarie A, Samelson Lawrence E: Resolving multi-molecular protein interactions by photoactivated localization microscopy. Methods (San Diego, Calif.) 59(3): 261-9, Mar 2013.

Sherman Eilon, Barr Valarie, Samelson Lawrence E: Super-resolution characterization of TCR-dependent signaling clusters. Immunological reviews 251(1): 21-35, Jan 2013.

Kunii Naoki, Zhao Yangbing, Jiang Shuguang, Liu Xiaojun, Scholler John, Balagopalan Lakshmi, Samelson Lawrence E, Milone Michael C, June Carl H: Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation. Human gene therapy 24(1): 27-37, Jan 2013.

Kortum Robert L, Rouquette-Jazdanian Alexandre K, Miyaji Michihiko, Merrill Robert K, Markegard Evan, Pinski John M, Wesselink Amelia, Nath Nandan N, Alexander Clayton P, Li Wenmei, Kedei Noemi, Roose Jeroen P, Blumberg Peter M, Samelson Lawrence E, Sommers Connie L: A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. Journal of immunology (Baltimore, Md. : 1950) 190(1): 147-58, Jan 2013.

back to top
Last updated: 11/13/2014
The Trustees of the University of Pennsylvania