Sean Hennessy, PharmD, PhD

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Associate Professor of Epidemiology in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
University of Pennsylvania
423 Guardian Drive
803 Blockley Hall
Philadelphia, PA 19104-6021
Office: 215-898-9112
Fax: 215-573-5315
Education:
BS (Pharmacy)
Philadelphia College of Pharmacy and Science, 1989.
PharmD (Clinical Pharmacy)
Philadelphia College of Pharmacy and Science, 1990.
MSCE (Clinical Epidemiology)
University of Pennsylvania School of Medicine, 1996.
PhD (Epidemiology with Biostatistics minor)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Hennessy’s primary field of interest is pharmacoepidemiology, which is the study of the use and effects of medical products in populations. Within pharmacoepidemiology, he has a particular interest in studying the clinical importance of drug-drug interactions. Dr. Hennessy’s research has been funded by the Agency for Healthcare Research and Quality (AHRQ), the National Institutes of Health (NIH), the Food and Drug Administration (FDA), pharmaceutical companies, and private foundations. He is currently leading a NIH-funded study on the clinical importance of drug-drug interactions. He is also the principal investigator of Penn's Center in the FDA-funded Scientific Program to Support Epidemiology Investigations, and plays a leadership role in the FDA-funded Mini-Sentinel program. Dr. Hennessy is also Director of Penn's Center for Pharmacoepidemiology Research and Training (CPeRT), which is based in Penn's Center for Clinical Epidemiology and Biostatistics (CCEB).

In addition to his research, Dr. Hennessy teaches clinical epidemiology to medical and graduate students, and is active in promoting evidence based practice at Penn, directing its Ambulatory Drug Use and Effects Program, and serving on its Pharmacy and Therapeutics Committee. Dr. Hennessy’s clinical program has received two Quality and Safety Awards from the University of Pennsylvania Health System. Dr. Hennessy received the 2005 Young Alumnus Award from the University of the Sciences in Philadelphia, the 2007 Lean I Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics, and the 2013 Samuel Martin Health Evaluation Sciences Research Award from the Perelman School of Medicine.

Selected Publications

Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT, Levy MZ, Hennessy S: Antibiotic residues in milk from small dairy farms in rural Peru. Food Additives & Contaminants: Part A 31: 1001-08, 2014.

LoRe V III, Byrne DD, Newcomb CW, Carbonari DM, Nezamzadeh MS, Leidl KB, Herlim MX, Yang YX, Hennessy S, Kostman JR, Leonard MB, Localio R.: Prevalence of diagnosed chronic hepatitis b infection among U.S. Medicaid enrollees, 2000-2007. Annals of Epidemiology 24: 418-23, 2014

Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT, Levy MZ, Hennessy S: Comparison of two methods for collecting antibiotic use data on small dairy farms. Preventive Veterinary Medicine 1: 213-22, 2014

Flory JH, Small DS, Cassano PA, Brillon DJ, Mushlin AI, Hennessy S: Comparative effectiveness of oral diabetes drug combinations in reducing glycosylated hemoglobin. Journal of Comparative Effectiveness Research 3(1): 29-39, 2014.

Schelleman H, Han EX, Brensinger C, Quinney S, Bilker W, Flockhart D, Li L, Hennessy S: Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. British Journal of Clinical Pharmacology 78: 639-48, 2014.

Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT, Levy MZ, Hennessy S: The use of antibiotics on small dairy farms in rural Peru. Preventive Veterinary Medicine 113: 88-95, 2014.

Schelleman H, Bilker WB, Kimmel SE, Daniel GW, Newcomb C, Guevara JG, Cziraky MJ, Strom BL, Hennessy S: Methylphenidate and risk of serious cardiovascular events in adults. American Journal of Psychiatry 169: 178-85, 2012.

Mao JJ, Chung A, Benton A, Hill S, Ungar L, Leonard CE, Hennessy S, Holmes JH: Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiology and Drug Safety 22: 256-262, 2013.

Schelleman H, Bilker WB, Kimmel SE, Daniel GW, Newcome C, Guevara JP, Cziraky MJ, Strom BL, Hennessy S: Amphetamines, atomoxetine and the risk of serious cardiovascular events in adults. PLoS One 8: e52991, 2012.

Strom BL, Kimmel SE, Hennessy S: Textbook of Pharmacoepidemiology, 2nd edition. Pharmacoepidemiology. Sussex; John Wiley and Sons, 2013.

Leonard CE, Freeman CP, Newcomb C, Bilker WB, Kimmel SE, Strom BL, Hennessy S: Antipsychotics and the risks of sudden cardiac death and all-cause death: cohort studies in Medicaid and dually-eligible Medicaid-Medicare beneficiaries of five states. Journal of Clinical and Experimental Cardiology 10: 1-9, 2013

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Last updated: 11/25/2014
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