Jonathan Chernoff, MD, PhD

faculty photo
Adjunct Professor of Pharmacology
Department: Systems Pharmacology and Translational Therapeutics

Contact information
Fox Chase Cancer Center
333 Cottman Avenue - Room W455
Philadelphia, PA 19111
Office: 215-728-5319
Fax: 215-728-3616
Lab: 215-728-5320
Education:
B.A. (Molecular Biophysics/Biochemistry)
Yale College, 1978.
M.D (Biochemistry)
Mount Sinai School of Medicine, 1984.
Ph.D. (Biochemistry)
Mount Sinai School of Medicine, 1984.
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Selected Publications

Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K.: Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation. Cell Rep 40(11): 111345, September 2022 Notes: 10.1016/j.celrep.2022.111345.

Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR.: Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. Mol Cancer Res. May 2022 Notes: 10.1158/1541-7786.MCR-21-0837.

Binder P, Nguyen B, Collins L, Zi M, Liu W, Christou F, Luo X, Hille SS, Frey N, Cartwright EJ, Chernoff J, Müller OJ, Guan K, Wang X.: Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart. Front Cardiovasc Med. March 2022 Notes: 10.3389/fcvm.2022.851419.

Saldivar-Cerón HI, Villamar-Cruz O, Wells CM, Oguz I, Spaggiari F, Chernoff J, Patiño-López G, Huerta-Yepez S, Montecillo-Aguado M, Rivera-Pazos CM, Loza-Mejía MA, Vivar-Sierra A, Briseño-Díaz P, Zentella-Dehesa A, Leon-Del-Rio A, López-Saavedra A, Padierna-Mota L, Ibarra-Sánchez MJ, Esparza-López J, Hernández-Rivas R, Arias-Romero LE.: p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II. Front Cell Dev Biol. January 2022 Notes: 10.3389/fcell.2021.759259.

Chernoff J.: The two-hit theory hits 50. Mol Biol Cell December 2021 Notes: 10.1091/mbc.E21-08-0407.

Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, Yates C, Clapp DW, Chernoff J, Park SJ.: PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). Hum Mol Genet August 2021 Notes: 10.1093/hmg/ddab106.

Uribe-Alvarez C, Guerrero-Rodríguez SL, Rhodes J, Cannon A, Chernoff J, Araiza-Olivera D: Targeting effector pathways in RAC1P29S-driven malignant melanoma. Small GTPases July 2021 Notes: doi: 10.1080/21541248.2020.1728469.

Uribe-Alvarez C, Lam Q, Baldwin DA, Chernoff J.: Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests. PLoS One May 2021 Notes: 10.1371/journal.pone.0250202.

Chernoff J.: 2020 in 20/20 hindsight. Mol Biol Cell May 2021 Notes: 10.1091/mbc.E21-01-0022.

Karchugina S, Benton D, Chernoff J.: Regulation of MST complexes and activity via SARAH domain modifications. Biochem Soc Trans April 2021 Notes: doi: 10.1042/BST20200559.

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Last updated: 10/03/2022
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