Joel D. Mainland, PhD

faculty photo
Adjunct Assistant Professor of Neuroscience
Department: Neuroscience
Graduate Group Affiliations

Contact information
Monell Chemical Senses Center
3500 Market Street
Philadelphia, PA 19104
Education:
Bachelor (Neuroscience)
Columbia University, 2001.
PhD (Neuroscience)
University of California at Berkeley, 2006.
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Description of Research Expertise

Research Interests

Develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.

Keywords

olfactory receptor, psychophysics, coding, cell culture, human

Research Details

A fundamental problem in neuroscience is mapping the physical properties of a stimulus to perceptual characteristics. In vision, wavelength translates into color; in audition, frequency translates into pitch. By contrast, the mapping from chemical structure to olfactory percept is unknown. In other words, there is not a scientist or perfumer in the world who can view a novel molecular structure and predict how it will smell. My research goal is to develop a predictive model relating molecular structure and olfactory perception using a combined psychophysical and molecular approach.

Selected Publications

Mainland JD, Matsunami H. : RAMP-like proteins: RTP and REEP family of proteins. Receptor Activity Modifying Proteins. (In press) http://www.landesbioscience.com/curie/chapter/4528/ Spielman W and Parameswaran N, ed (eds.). February 2012.

Mainland Joel D, Matsunami Hiroaki: Taste perception: how sweet it is (to be transcribed by you). Current biology : CB 19(15): R655-6, Aug 2009.

Matsunami Hiroaki, Mainland Joel D, Dey Sandeepa: Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. Annals of the New York Academy of Sciences 1170: 153-6, Jul 2009.

Saito Harumi, Chi Qiuyi, Zhuang Hanyi, Matsunami Hiroaki, Mainland Joel D: Odor coding by a Mammalian receptor repertoire. Science signaling 2(60): ra9, 2009.

Mainland Joel, Sobel Noam: The sniff is part of the olfactory percept. Chemical senses 31(2): 181-96, Feb 2006.

Mainland Joel D, Johnson Bradley N, Khan Rehan, Ivry Richard B, Sobel Noam: Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril. The Journal of neuroscience : the official journal of the Society for Neuroscience 25(27): 6362-71, Jul 2005.

Zelano Christina, Bensafi Moustafa, Porter Jess, Mainland Joel, Johnson Brad, Bremner Elizabeth, Telles Christina, Khan Rehan, Sobel Noam: Attentional modulation in human primary olfactory cortex. Nature neuroscience 8(1): 114-20, Jan 2005.

Bensafi M, Zelano CM, Johnson BN, Mainland JD, Khan R, Sobel N: Olfaction: From Sniff to Percept. In: The cognitive neurosciences. The cognitive neurosciences, 3rd Edition Gazzaniga MS, ed (eds.). Camridge, MA: MIT Press, Page: 259-280, 2004.

Bensafi M, Brown W M, Tsutsui T, Mainland J D, Johnson B N, Bremner E A, Young N, Mauss I, Ray B, Gross J, Richards J, Stappen I, Levenson R W, Sobel N: Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans. Behavioral neuroscience 117(6): 1125-34, Dec 2003.

Bensafi Moustafa, Porter Jessica, Pouliot Sandra, Mainland Joel, Johnson Bradley, Zelano Christina, Young Natasha, Bremner Elizabeth, Aframian Danny, Khan Rehan, Sobel Noam: Olfactomotor activity during imagery mimics that during perception. Nature neuroscience 6(11): 1142-4, Nov 2003.

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Last updated: 07/13/2012
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