Benjamin Aaron Garcia, Ph.D.

faculty photo
Presidential Associate Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
9-124 Smilow Center for Translational Research
3400 Civic Center Boulevard
Department of Biochemistry and Biophysics
Perelman School of Medicine
University of Pennsylvania
Philadelpha, PA 19104
Office: 215-573-9423
Lab: 215-573-9422
Education:
B.S. (Chemistry )
University of California, Davis, 2000.
Ph.D. (Chemistry with High Distinction )
University of Virginia, Charlottesville, VA, 2005.
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Selected Publications

Baliban Richard C, Sakellari Dimitra, Li Zukui, Dimaggio Peter A, Garcia Benjamin A, Floudas Christodoulos A: Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples. Journal of clinical periodontology 39(3): 203-12, Mar 2012.

Green Erin M, Mas Gloria, Young Nicolas L, Garcia Benjamin A, Gozani Or: Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nature structural & molecular biology Feb 2012.

Green, E.M., Mas, G., Young, N.L., Garcia, B.A., Gozani, O.: Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nat Struct Mol Biol. 19(3): 361-363 2012.

Ratnakumar K, Duarte LF, Leroy G, Hasson D, Smeets D, Vardabasso C, Bönisch C, Zeng T, Xiang B, Zhang DY, Li H, Wang X, Hake SB, Schermelleh L, Garcia BA, Bernstein E. : ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression. Genes Dev. 26(5): 433-438, 2012.

Yu Y, Song C, Zhang Q, Dimaggio PA, Garcia BA, York A, Carey MF, Grunstein M. : Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA. Mol Cell. Epub ahead of print, 2012.

Kuo Alex J, Cheung Peggie, Chen Kaifu, Zee Barry M, Kioi Mitomu, Lauring Josh, Xi Yuanxin, Park Ben Ho, Shi Xiaobing, Garcia Benjamin A, Li Wei, Gozani Or: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Molecular cell 44(4): 609-20, Nov 2011.

Britton Laura-Mae P, Gonzales-Cope Michelle, Zee Barry M, Garcia Benjamin A: Breaking the histone code with quantitative mass spectrometry. Expert review of proteomics 8(5): 631-43, Oct 2011.

Korpal Manav, Ell Brian J, Buffa Francesca M, Ibrahim Toni, Blanco Mario A, Celià-Terrassa Toni, Mercatali Laura, Khan Zia, Goodarzi Hani, Hua Yuling, Wei Yong, Hu Guohong, Garcia Benjamin A, Ragoussis Jiannis, Amadori Dino, Harris Adrian L, Kang Yibin: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nature medicine 17(9): 1101-8, Sep 2011.

Vedadi Masoud, Barsyte-Lovejoy Dalia, Liu Feng, Rival-Gervier Sylvie, Allali-Hassani Abdellah, Labrie Viviane, Wigle Tim J, Dimaggio Peter A, Wasney Gregory A, Siarheyeva Alena, Dong Aiping, Tempel Wolfram, Wang Sun-Chong, Chen Xin, Chau Irene, Mangano Thomas J, Huang Xi-Ping, Simpson Catherine D, Pattenden Samantha G, Norris Jacqueline L, Kireev Dmitri B, Tripathy Ashutosh, Edwards Aled, Roth Bryan L, Janzen William P, Garcia Benjamin A, Petronis Arturas, Ellis James, Brown Peter J, Frye Stephen V, Arrowsmith Cheryl H, Jin Jian: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature chemical biology 7(8): 566-74, Aug 2011.

Yan Kailin, Cao Qiang, Reilly Christopher M, Young Nicolas L, Garcia Benjamin A, Mishra Nilamadhab: Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity. The Journal of biological chemistry 286(33): 28833-43, Aug 2011.

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Last updated: 05/23/2013
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