Paul M. Titchenell, Ph.D.

faculty photo
Assistant Professor of Physiology
Department: Physiology

Contact information
Institute for Diabetes, Obesity, and Metabolism
Smilow Center for Translational Research
3400 Civic Center Blvd, Building 421
Room: 12-104
Philadelphia, PA 19104
Office: 215-573-1872
Lab: 215-573-1875
Education:
B.S. (Biochemistry and Molecular Biology)
Dickinson College, 2008.
Ph.D. (Physiology)
Pennsylvania State University, 2013.
Permanent link
 

Description of Research Expertise

Research Interests:
Molecular mechanisms of insulin signaling and insulin resistance

Keywords:
metabolism, insulin, diabetes, obesity, Akt

Research Details:
My research interests are focused on the regulation of metabolism by hormones and nutrients, with a particular emphasis on the master regulators of organismal metabolism, insulin and glucose. Alterations in insulin and glucose signaling underlie metabolic disease and lead to the development of deadly vascular and neuronal complications. Through the use of various techniques encompassing molecular biology, biochemistry, metabolomics, genome-wide transcriptional techniques and whole-animal physiology, the long-term goals of my research program are to decipher the underlying mechanisms driving metabolic deregulation during disease and identify new therapies that improve metabolic control.

Rotation Projects for 2017-2018
There are numerous potential projects that I would be pleased to discuss in person.

Lab personnel:
Matthew Gavin (Research Specialist)
Kahealani Uehara (BMB rotation graduate student)
Rebecca Gelfer (Undergraduate)
Brennan Rose (Undergraduate)

Selected Publications

Quinn William J, Wan Min, Shewale Swapnil V, Gelfer Rebecca, Rader Daniel J, Birnbaum Morris J, Titchenell Paul M: mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. The Journal of clinical investigation 127(11): 4207-4215, Nov 2017.

Titchenell Paul M, Lazar Mitchell A, Birnbaum Morris J: Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends in endocrinology and metabolism: TEM 28(7): 497-505, Apr 2017.

Papazyan Romeo, Sun Zheng, Kim Yong Hoon, Titchenell Paul M, Hill David A, Lu Wenyun, Damle Manashree, Wan Min, Zhang Yuxiang, Briggs Erika R, Rabinowitz Joshua D, Lazar Mitchell A: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell metabolism 24(6): 863-874, Dec 2016.

Jang Hagoon, Lee Gha Young, Selby Christopher P, Lee Gung, Jeon Yong Geun, Lee Jae Ho, Cheng Kenneth King Yip, Titchenell Paul, Birnbaum Morris J, Xu Aimin, Sancar Aziz, Kim Jae Bum: SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nature communications 7: 12180, Jul 2016.

Titchenell Paul M, Quinn William J, Lu Mingjian, Chu Qingwei, Lu Wenyun, Li Changhong, Chen Helen, Monks Bobby R, Chen Julia, Rabinowitz Joshua D, Birnbaum Morris J: Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell metabolism 23(6): 1154-66, Jun 2016.

Titchenell Paul M, Chu Qingwei, Monks Bobby R, Birnbaum Morris J: Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nature communications 6: 7078, May 2015.

Perry Rachel J, Camporez João-Paulo G, Kursawe Romy, Titchenell Paul M, Zhang Dongyan, Perry Curtis J, Jurczak Michael J, Abudukadier Abulizi, Han Myoung Sook, Zhang Xian-Man, Ruan Hai-Bin, Yang Xiaoyong, Caprio Sonia, Kaech Susan M, Sul Hei Sook, Birnbaum Morris J, Davis Roger J, Cline Gary W, Petersen Kitt Falk, Shulman Gerald I: Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160(4): 745-58, Feb 2015.

Cannon Corey E, Titchenell Paul M, Groff David N, El Ouaamari Abdelfattah, Kulkarni Rohit N, Birnbaum Morris J, Stoffers Doris A: The Polycomb protein, Bmi1, regulates insulin sensitivity. Molecular metabolism 3(8): 794-802, Nov 2014.

Patel Kashyap, Foretz Marc, Marion Allison, Campbell David G, Gourlay Robert, Boudaba Nadia, Tournier Emilie, Titchenell Paul, Peggie Mark, Deak Maria, Wan Min, Kaestner Klaus H, Göransson Olga, Viollet Benoit, Gray Nathanael S, Birnbaum Morris J, Sutherland Calum, Sakamoto Kei: The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature communications 5: 4535, Aug 2014.

Titchenell Paul M, Antonetti David A: Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy. Diabetes 62(6): 1808-15, Jun 2013.

back to top
Last updated: 12/01/2017
The Trustees of the University of Pennsylvania