Foteini Mourkioti, PhD

faculty photo
Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Graduate Group Affiliations

Contact information
McKay Orthopaedic Research Laboratory
112A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
Education:
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
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Description of Research Expertise

Keywords: muscle disorders, telomeres, NF-kB signaling, muscle regeneration, stem cells, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

Tichy, E.D., Sidibe, D.K., Tierney, M.T., Stec, M.J., Sharifi-Sanjani, M., Hosalkar, H., Mubarak, S., Johnson, F.B., Sacco, A., Mourkioti, F.: Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles Stem Cell Reports Sept 2017 Notes: This paper was highlighted in Penn Medicine News at: https://www.pennmedicine.org/news/news-releases/2017/september/researchers-find-shortened-telomeres-linked-to-dysfunction-in-duchenne-muscular-dystrophy.

Sharifi-Sanjani. M., Oyster, N.M., Tichy, E.D., Bedi, K.C., Harel, O., Margulies, K.B., Mourkioti, F.: Cardiomyocyte-specific telomere shortening is a distinct signature of heart failure in humans Journal of American Heart Association 7(6): 1855-1870, Sept 2017 Notes: This work was highlighted in Penn Medicine News at: https://www.pennmedicine.org/news/news-releases/2017/september/penn-researchers-closer-to-uncovering-a-new-feature-in-heart-failure

Sharifi-Sanjani M, Meeker AK, Mourkioti F.: Evaluation of Telomere Length in Human Cardiac Tissues Using Cardiac Quantitative FISH. Nature Protocols 12: 1855-1870, Aug 2017 Notes: Published online 17 Aug 2017, doi:10.1038/nprot.2017.082.

Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D.: Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. Journal of Clinical Investigation 127(5): 1683-1688, May 2017 Notes: doi: 10.1172/JCI90338.

Tichy, E., Mourkioti, F.: A new method to genotype mdx4cv mice by PCR-RFLP analysis. Muscle & Nerve Jan 2017 Notes: doi: 10.1002/mus.25566. [Epub ahead of print]

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA.: Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metabolism 24(2): 269-82. Aug 2016.

Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM.: Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine 20(3): 255-64. Feb 2014.

Mourkioti Foteini, Kustan Jackie, Kraft Peggy, Day John W, Zhao Ming-Ming, Kost-Alimova Maria, Protopopov Alexei, DePinho Ronald A, Bernstein Daniel, Meeker Alan K, Blau Helen M: Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nature cell biology 15(8): 895-904, Aug 2013.

Sacco Alessandra*, Mourkioti Foteini*, Tran Rose, Choi Jinkuk, Llewellyn Michael, Kraft Peggy, Shkreli Marina, Delp Scott, Pomerantz Jason H, Artandi Steven E, Blau Helen M: Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell 143(7): 1059-71, Dec 2010 Notes: * notes equal contribution.

Kratsios Paschalis, Catela Catarina, Salimova Ekaterina, Huth Marion, Berno Valeria, Rosenthal Nadia, Mourkioti Foteini: Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circulation research 106(3): 559-72, Feb 2010.

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Last updated: 09/20/2017
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