Zachary T Schug, Ph.D.

faculty photo
Adjunct Assistant Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Room 533
Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104
Office: 6098207478
Lab: 2158983705
Education:
B.S. (Biology)
Saint Joseph's University, 2001.
Ph.D. (Molecular Cell Biology)
Thomas Jefferson University, 2007.
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Description of Research Expertise

Cancer Metabolism
Metabolomics
Lipidomics
Acetate Metabolism
Lipid Metabolism
Functional Genomics
Synthetic Lethality

Selected Publications

Schug Zachary T, Vande Voorde Johan, Gottlieb Eyal: The Nurture of Tumors Can Drive Their Metabolic Phenotype. Cell metabolism 23(3): 391-2, Mar 2016.

Peck Barrie, Schug Zachary T, Zhang Qifeng, Dankworth Beatrice, Jones Dylan T, Smethurst Elizabeth, Patel Rachana, Mason Susan, Jiang Ming, Saunders Rebecca, Howell Michael, Mitter Richard, Spencer-Dene Bradley, Stamp Gordon, McGarry Lynn, James Daniel, Shanks Emma, Aboagye Eric O, Critchlow Susan E, Leung Hing Y, Harris Adrian L, Wakelam Michael J O, Gottlieb Eyal, Schulze Almut: Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer & metabolism 4: 6, 2016.

Patella Francesca, Schug Zachary T, Persi Erez, Neilson Lisa J, Erami Zahra, Avanzato Daniele, Maione Federica, Hernandez-Fernaud Juan R, Mackay Gillian, Zheng Liang, Reid Steven, Frezza Christian, Giraudo Enrico, Fiorio Pla Alessandra, Anderson Kurt, Ruppin Eytan, Gottlieb Eyal, Zanivan Sara: Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular & cellular proteomics : MCP 14(3): 621-34, Mar 2015.

Schug Zachary T, Peck Barrie, Jones Dylan T, Zhang Qifeng, Grosskurth Shaun, Alam Israt S, Goodwin Louise M, Smethurst Elizabeth, Mason Susan, Blyth Karen, McGarry Lynn, James Daniel, Shanks Emma, Kalna Gabriela, Saunders Rebecca E, Jiang Ming, Howell Michael, Lassailly Francois, Thin May Zaw, Spencer-Dene Bradley, Stamp Gordon, van den Broek Niels J F, Mackay Gillian, Bulusu Vinay, Kamphorst Jurre J, Tardito Saverio, Strachan David, Harris Adrian L, Aboagye Eric O, Critchlow Susan E, Wakelam Michael J O, Schulze Almut, Gottlieb Eyal: Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer cell 27(1): 57-71, Jan 2015.

Witney Timothy H, Pisaneschi Federica, Alam Israt S, Trousil Sebastian, Kaliszczak Maciej, Twyman Frazer, Brickute Diana, Nguyen Quang-Dé, Schug Zachary, Gottlieb Eyal, Aboagye Eric O: Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 55(9): 1506-12, Sep 2014.

Schug Zachary T, Frezza Christian, Galbraith Laura C A, Gottlieb Eyal: The music of lipids: how lipid composition orchestrates cellular behaviour. Acta oncologica (Stockholm, Sweden) 51(3): 301-10, Mar 2012.

Schug Z T, Gonzalvez F, Houtkooper R H, Vaz F M, Gottlieb E: BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell death and differentiation 18(3): 538-48, Mar 2011.

Anyatonwu Georgia, Khan M Tariq, Schug Zachary T, da Fonseca Paula C A, Morris Edward P, Joseph Suresh K: Calcium-dependent conformational changes in inositol trisphosphate receptors. The Journal of biological chemistry 285(32): 25085-93, Aug 2010.

Schug Zachary T, Gottlieb Eyal: Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Biochimica et biophysica acta 1788(10): 2022-31, Oct 2009.

Gonzalvez Francois, Schug Zachary T, Houtkooper Riekelt H, MacKenzie Elaine D, Brooks David G, Wanders Ronald J A, Petit Patrice X, Vaz Frédéric M, Gottlieb Eyal: Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. The Journal of cell biology 183(4): 681-96, Nov 2008.

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Last updated: 04/28/2016
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