Sharon Xiangwen Xie, Ph.D.

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Associate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
Department of Biostatistics and Epidemiology
University of Pennsylvania
Perelman School of Medicine
607 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: (215) 573-3867
Fax: 215-573-4865
Education:
B.S.
Beijing Polytechnic University (Applied Mathematics), 1991.
M.S.
University of Texas (Statistics), 1993.
M.S.
University of Washington (Biostatistics), 1995.
Ph.D.
University of Washington (Biostatistics), 1997.
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Description of Research Expertise

Dr. Xie is currently principal investigator of the biostatistics and data management core for two NIH-funded neurodegenerative disease research centers: the Alzheimer's Disease Center and Morris K. Udall Parkinson's Disease Research Center of Excellence. Dr. Xie's current research goals are twofold. First, she continues to develop methods for measurement error problems, survival analysis, and receiver operating characteristic (ROC) analysis in response to methodological problems arising in her collaborative work in the research of neurodegenerative diseases (e.g. Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis), as well as other collaborative research. She has developed new methods to reduce the biases of relative risk estimators in Cox regression models in the presence of covariate measurement error. She has also proposed innovative methods to reduce bias in diagnostic evaluation measures for biomarkers with measurement error. Second, she continues to develop techniques and markers to better understand the progression of neurodegenerative diseases. As a primary example, Dr. Xie and colleagues examined the rate of decline in Alzheimer's disease measured by a dementia severity rating scale (DSRS). She found that the rate of decline was linear using this rating scale. This linearity has significant advantages for clinical trials. Treatment effects in a trial would be seen in the DSRS as a slowing of the linear rate of change during some or all stages of the disease. This is much easier than evaluating estimated treatment effects in a measure that does not change linearly.


Awards and Professional Recognition:

Dr. Xie was the recipient of the 1999 Young Investigator Award of Statistics in Epidemiology Section of the American Statistical Association, and the 2005 and 2011 recipient of the University of Pennsylvania Graduate Program in Biostatistics Teaching Award. She was an elected standing member of the National Institute of Aging Alzheimer's Disease Center Data Core Steering Committee during 2007 and 2010 (Chair during July 2008 and July 2009). Dr. Xie is currently an associate editor in Alzheimer's & Dementia.

Selected Publications

Xie, S.X., Wang, C.Y., Prentice, R.L: A risk set calibration method for failure time regression by using a covariate reliability sample. Journal of the Royal Statistical Society, Series B 63: 855-870, 2001.

Xie, S.X., Liao, D., Chinchilli, V.M: Measurement error reduction using weighted average method for repeated measurements from heterogeneous instruments. Environmetrics 12: 785-790, 2001.

Clark, C.M., Xie, S., Chittams, J., Ewbank, D., Peskind, E., Galasko, D., Morris, J.C., McKeel, D.W. Jr., Farlow, M., Weitlauf, S.L., Quinn, J., Kaye, J., Knopman, D., Arai, H., Doody, R.S., DeCarli, C., Leight, S., Lee, V.M.-Y., Trojanowski, J.Q: Cerebrospinal fluid tau and beta-amyloid: How well do these biomarkers reflect autopsy confirmed dementia diagnoses? Archives of Neurology 60: 1696-1702, 2003.

Brown, G.K., Ten Have, T., Henriques, G.R., Xie, S.X., Hollander, J.E., Beck, A.T: Cognitive therapy for the prevention of suicide attempts: A randomized controlled trial. Journal of the American Medical Association 294: 563-570, 2005.

Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E.B., Xie, S.X., Joyce, S., Li, C., Toleikis, P.M., Lee, V.M.-Y., Trojanowski, J.Q: Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Science 102: 227-231, 2005.

Xie, S.X., Forman, M.S., Farmer J., Moore, P., Wang, Y., Wang, X, Clark, C.M., Coslett, H.B., Chatterjee, A., Arnold, S.E., Rosen, H., Karlawish, J.H., Van Deerlin, V.M., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M: Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery & Psychiatry 79: 126-129, 2008.

Grossman, M., Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., Vesely, L., Berkowitz, R., Chatterjee, A., Coslett, H.B., Hurtig, H.I., Forman, M.S., Lee, V.M.-Y., Trojanowski, J.Q : Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology 70: 2036-2045, 2008.

Xie, S.X., Ewbank, D.C., Chittams, J., Karlawish, J.H.T., Arnold, S.E., Clark, C.M : Rate of decline in Alzheimer disease measured by a dementia severity rating scale. Alzheimer Disease & Associated Disorders 23: 268-274, 2009.

Trojanowski, J.Q., Arnold, S., Karlawish, J., Brunden, K., Cary, M., Davatzikos, C., Detre, J., Gaulton, G., Grossman, M., Hurtig, H., Jedrziewski, K., McCluskey, L., Naylor M, Polsky, D., Schellenberg, G.D., Siderowf, A., Shaw, L.M., Van Deerlin, V., Wang, L.-S., Werner, R, Xie, S.X., Lee, V.M-Y: Design of comprehensive Alzheimer's Disease Centers to address unmet national needs. Alzheimer's & Dementia 6: 150-155, 2010.

Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., Vesely, L., Khan, A, Chatterjee, A., Coslett, H.B., Hurtig, H.I., Liang, T.-W., Grossman M: Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's disease. Journal of the International Neuropsychological Society 16: 278-286, 2010.

Geser, F., Robinson, J.L., Malunda, J.A., Xie, S.X., Clark, C.M., Kwong, L.K., Moberg, P.J., Moore, E., Van Deerlin, V.M., Lee, V.M.-Y., Arnold, S.E., Trojanowski, J.Q: Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness. Archives of Neurology 67: 1238-1250, 2010.

Siderowf, A., Xie, S.X., Hurtig, H., Weintraub, D., Duda, J., Chen-Plotkin, A., Shaw, L.M., Van Deerlin, V., Trojanowski, J.Q., Clark, C: CSF Amyloid Beta 1-42 predicts cognitive decline in Parkinson's disease. Neurology 75: 1055-1061, 2010.

Xie, S.X., Baek, Y., Grossman, M., Arnold, S.E., Karlawish, J., Siderowf, A., Hurtig, H., Elman, L., McCluskey, L., Van Deerlin, V., Lee, V.M.-Y., Trojanowski, J.Q: Building an integrated neurodegenerative disease database at an academic health center. Alzheimer’s & Dementia 7(4): e84-e93, 2011.

Mao JJ, Palmer SC, Desai K, Li SQ, Armstrong K, Xie SX.: Development and validation of an instrument for measuring attitudes and beliefs about Complementary and Alternative Medicine (CAM) use among cancer patients. Evid Based Complement Alternat Med 2012.

Tan K, Libon DJ, Rascovsky K, Grossman M, Xie SX.: Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer's Disease. Alzheimer Dis Assoc Disord 27(4): 310-5, Oct-Dec 2013.

White MT, Xie SX.: Adjustment for measurement error in evaluating diagnostic biomarkers by using an internal reliability sample. Stat Med 32(27): 4709-25, Nov 2013.

Toledo JB, Xie SX, Trojanowski JQ, Shaw LM. : Longitudinal change in CSF Tau and Abeta biomarkers for up to 48 months in ADNI. Acta Neuropathol 126(5): 659-70, Nov 2013.

Mao JJ, Farrar JT, Bruner D, Zee J, Bowman M, Seluzicki C, DeMichele A, Xie SX. : Electro-acupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: A randomized trial. Cancer 2014 (in press).

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Last updated: 09/30/2014
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