Glenn F. Rall

faculty photo
Department: Microbiology
Graduate Group Affiliations

Contact information
Fox Chase Cancer Center
Basic Science Division
333 Cottman Avenue
Philadelphia, PA 19111
Office: 215-728-3617
Fax: 215-728-2412
Education:
B.A. (Biology)
Lafayette College, Easton, PA, 1985.
PhD (Microbiology)
Vanderbilt University, 1990.
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Description of Research Expertise

Research Interests
Viral pathogenesis, neurovirology, neuroimmunology.

Key words: measles, neuron, CNS, immunology.

Research Description
The overall theme of our laboratory is to understand basic paradigms of viral infection of the CNS and the consequences of such an infection on the host. The major questions include:

1. how do viruses gain access to the CNS from the periphery?
2. how do neurotropic viruses replicate within the brain?
3. what role, if any, does the host immune response play in the control of such infections?
4. what host and viral factors (e.g., viral dose, host age, host immunocompetence) dictate the overall pathogenesis of such an infection?

To address these issues, we use a combination of transgenic mouse and primary cell culture models to study the virology and immunobiology of measles virus infection and lymphocytic choriomeningitis virus (LCMV) infection of neurons. By understanding the factors which contribute to CNS diseases caused by viruses, we will be in a more informed position to develop interventive therapeutic approaches to prevent or treat such infections.

Rotation Projects for 2006-2007
Basis of age-dependent susceptibility to CNS infection by measles virus in a transgenic mouse model.
Mechanisms of chemokine production by neurons following virus infection

Lab personnel:
Wes Rose, Postdoc
Virginia Young, Postdoctoral Fellow
Christine Matullo, Grad student (TJU)
Lisa Gechman, Sci Tech II
Jason Skipworth, Sci Tech I

Selected Publications

Patterson, C.E., Daley, J.K., Echols, L.A., Lane, T.E., Rall, G.F.: Measles virus infection induces chemokine synthesis by neurons. J. Immunol. 171: 3102-3109, 2003.

Rall, G.F.: Measles Virus 1998-2002: Progress and Controversy. Annual Reviews of Microbiology 57: 343-367, 2003.

Patterson, C.E., J. K. Daley, G. F. Rall.: Neuronal survival skills in the face of viral infection. J. Infectious Diseases 186: S215-S219, 2002.

Phillips, J.J., M. M. Chua, G. F. Rall, S. M. Weiss.: Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation and virus-induced immunopathology in the central nervous system. Virology 301: 109-120, 2002.

Evans, C. F., J. M. Redwine, C. E. Patterson, S. Askovic, G. F. Rall.: LCMV and the central nervous system; uncovering basic principles of CNS physiology and virus-induced disease. Curr. Top. Microbiol. Immunol. 263: 177-195, 2002.

Katz, R. M., J. G. Greger, K. Darby, P. Boimel, G. F. Rall, A. M. Skalka: Transduction of interphase cells by avian sarcoma virus. J. Virol. 76: 5422-5434, 2002.

Patterson, C. E., D. M. Lawrence, L. A. Echols, G. F. Rall: Immune-mediated protection from measles virus-induced CNS disease is noncytolytic and interferon gamma-dependent. J. Virol. 76: 4497-4506, 2002.

Manchester, M. and G. F. Rall: Transgenic mouse models for measles pathogenesis. Trends Microbiol. 9: 19-23, 2001.

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Last updated: 11/14/2014
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