Jean D. Boyer, Ph.D.

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Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
705 Stellar-Chance Laboratories
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-573-9960
B.S. (Biochemical Engineering)
Rutgers University, 1984.
M.S. (Biochemical Engineering)
Rutgers University, 1986.
Ph.D. (Biochemical Engineering)
Rutgers University, 1990.
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Description of Research Expertise

The cellular immune response is an important component in halting viral replication and in viral clearance. Research in the Boyer laboratory is focused on chronic infections such as HPV, HCV and HIV-1. The laboratory is investigating the profile of the cellular immune response that can suppress viral replication. We have used in the past the primate model and found that antigen specific proliferation of CD8/CD4 lymphocytes can lead to suppressed SHIV89.6p replication. Studies further demonstrated the depletion of CD8 cells in SHIV89.6p infected primates resulted in disease progression. The research team then moved an improved SIV vaccine into a more stringent primate model. This later model included challenge with SIVmac239. Our studies demonstrated increased cellular immune responses. Higher levels of vaccine specific lymphocytes proliferation was observed. Higher numbers of vaccine specific effector cells able to secrete IFN-gamma were also observed. Yet, we did not observe better viral control. The laboratory completed a project that incorporated gene array analysis of vaccine specific T cells. We found, similar to our immunological assays, T cell proliferation was important. The laboratory has on-going projects to study the immune response to HPV, HIV and HCV vaccines and the correlation to viral suppression.

In addition, we have observed that higher levels of inflammatory molecules are present in those who are HIV-1 infected. In vitro studies of these inflammatory molecules demonstrated the ability to suppress T cell immune response. We have several projects on going to understand the mechanism by which chronic inflammation leads to immune suppression.

Selected Publications

Ramirez LA, Arango TA, Thompson E, Naji M, Tebas P, and Boyer JD: High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART. Journal of Leukocyte Biology 96, 2014.

Lorenzo Ramirez, Alexander Daniel, Ian Frank, Pablo Tebas, Jean Boyer: Seroprotection of HIV-Infected Subjects after H1N1 Vaccination is Directly Associated with Baseline frequency of Naïve and Inversely associated with Terminally Differentiated T-Cells. Journal of Infectious Diseases. in press, 210: 646-650, 2014.

Spyros A. Kalams, Scott D. Parker, Marnie Elizaga,4 Barbara Metch, Srilatha Edupuganti, John Hural, Stephen De Rosa, Donald K. Carter, Kyle Rybczyk, Ian Frank, Jonathan Fuchs, Beryl Koblin, Denny H. Kim,Patrice Joseph, Michael C. Keefer, Lindsey R. Baden, John Eldridge, Jean Boyer, Adam Sherwat, Massimo Cardinali, Mary Allen, Michael Pensiero, Chris Butler, Amir S. Khan, Jian Yan, Niranjan Y. Sardesai, James G. Kublin, David B. Weiner, for the NIAID HIV Vaccine Trials Network: Safety and Comparative Immunogenicity of an HIV-1 DNAVaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery. Journal of Infectious Diseases 208(3): 818, 2013.

Christina S. Chu, Jean D. Boyer, Abbas Jawad, Kenyetta Mcdonald, Wade T. Rogers, Eline T. Luning Prak, Kathleen E. Sullivan: Immunologic consequences of chemotherapy for ovarian cancer: Impaired responses to the influenza vaccine. Vaccine 31: 5435-5442, 2013.

Eisenberg RA, Jawad AF, Boyer J, Maurer K, McDonald K, Luning Prak ET and Sullivan KE: Rituximab-Treated Patients Have a Poor Response to Influenza Vaccination. Journal of Clinical Immunology 33(2): 388-396, 2013.

Noah McKittrick, Ian Frank, Jeffrey M. Jacobson, C. Jo White, Deborah Kim, Rosemarie Kappes, Carol DiGiorgio, Thomas Kenney, Jean Boyer, Pablo Tebas: Improved Immunogenicity With High-Dose Seasonal Influenza Vaccine in HIV-Infected Persons: A Single-Center, Parallel, Randomized Trial. Annals of Internal Medicine 158: 19-26, 2013.

Yin J, Vahey M, Dai A, Arango T, Yan J, Lewis MG, Amir Khan A, Niranjan Y. Sardesai NY, Weiss W, Kosimar J, and Boyer JD: Malaria Infection Reduces Vaccine Efficacy through Alteration of the Vaccine Induced Immune Response in Simian Immunodeficiency Virus - Rhesus Macaques Model. Journal of Infectious Diseases 206: 523-533, 2012.

Devon J. Shedlock, Kendra T. Talbott, Stephan J. Wu, Christine M. Wilson, Karuppiah Muthumani, Jean D. Boyer, Niranjan Y Sardesai, Sita Awasthi, David B. Weiner: Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice. Human vaccines & immunotherapeutics. Human vaccines and Immunotherapeutics 8(11): 1668-1681, 2012.

Bagarazzi ML, Yan J, Morrow MP, Shen X, Parker RL, Lee JC, Giffear M, Pankhong P, Khan AS, Broderick KE, Knott C, Lin F, Boyer JD, Draghia-Akli R,1 C. Jo White CJ,1 J. Joseph Kim JJ, Weiner DB, Sardesai NY: Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses. Science Translational Med 4: 155-168, 2012.

Grupp SA, Luning-Prak E, BoyerJD, et al: Adoptive Transfer of Autologous T Cells Improves T-cell Repertoire Diversity and Long-term B-cell Function in Pediatric Patients with Neuroblastoma. Clinical Cancer Research 18: 6732-6742, 2012.

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Last updated: 09/03/2014
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