Christoph Seeger
Adjunct Assistant Professor of Microbiology
Department: Microbiology
Graduate Group Affiliations
Contact information
Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111
333 Cottman Avenue
Philadelphia, PA 19111
Office: (215) 728-4312
Fax: (215) 728-4329
Fax: (215) 728-4329
Email:
seeger@fccc.edu
seeger@fccc.edu
Education:
M.S. (Microbiology)
University of Basel, Switzerland, 1979.
Ph.D. (Virology)
University of Basel, Switzerland, 1982.
Permanent linkM.S. (Microbiology)
University of Basel, Switzerland, 1979.
Ph.D. (Virology)
University of Basel, Switzerland, 1982.
Description of Research Expertise
Research InterestsAnimal viruses, viral pathogenesis, innate immunity.
Key words: hepatitis virus, interferon.
Description of Research
Our laboratory focuses on the replication and pathogenesis of hepatitis B and C viruses (HBV, HCV). Both viruses cause chronic infections that can lead to the development of liver cirrhosis and liver cancer. We are investigating host-virus interactions that are important for the replication and maintenance of HBV and HCV genomes in infected hepatocytes. We are particularly interested in the cellular antiviral programs that impinge on the life cycles of these viruses. For our studies we are applying established molecular approaches in combination with genomics and bioinformatics. In addition, we are beginning investigations of the HCV-related West Nile and Dengue viruses, which will allow us to exploit information forthcoming from the mouse genome project for studies on host-virus interactions and pathogenesis in an established animal model.
Rotation Projects for 2006-2007
The subjects of rotation projects are the innate immune response against hepatitis C and West Nile viruses.
Lab personnel:
Jared Evans, Ph.D., Postdoctoral Fellow
David Li, M.Sc., Scientific Technician
Ji A. Sohn, B.S., Scientific Technician
Paul Gramlich, B.S., Scientific Techician
David Stiffler, Student
Selected Publications
Guo J.-T., Pryce M., Wang X., Barrasa M.I., Hu J. and Seeger, C.: Conditional replication of duck hepatitis B virus in hepatoma cells. J. Virology 76: 1885-1893, 2003.Guo J.-T., Zhu Q. and Seeger C. : Characterization of the interferon-alpha response against HCV in hepatoma cells. J. Virology 77: 10769-10779, 2003.
Zhu G., Guo J.-T. and Seeger C.: Replication of hepatitis C virus in non-hepatic epithelial cells and mouse hepatoma cells. J. Virology 77: 9204-9210, 2003.
Barrasa M.I., Guo J.-T., Saputelli J, Mason W.S. and Seeger C.: Does a cdc2 kinase-like recognition motif on the core protein of hepadnaviruses regulate assembly and disintegration of capsids? J. Virology 75: 2024-2028, 2001.
Guo J.-T., Bichko V.V. and Seeger C. : The effect of interferon on the hepatitis C virus replicon. J. Virology 75: 8516-8523, 2001.