Alice S. Chen-Plotkin, MD

faculty photo
Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
150 Johnson Pavilion
Philadelphia, PA 19104
Office: 215-573-7193
Lab: 215-746-8191
Education:
AB (English)
Harvard-Radcliffe College, 1996.
MSc (Biology)
University of Oxford, 1998.
MD
Harvard Medical School, 2003.
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Description of Research Expertise

Genomics
Neurodegenerative Disease
Frontotemporal lobar dementia
Frontotemporal dementia
Parkinson's Disease

Selected Publications

Chen-Plotkin Alice S, Hu William T, Siderowf Andrew, et al.: Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Annals of neurology 69(4): 655-63, Apr 2011.

Chen-Plotkin Alice S, Martinez-Lage Maria, Sleiman Patrick M A, et al.: Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of neurology 68(4): 488-97, Apr 2011 Notes: First and corresponding author.

Vass Ryan, Ashbridge Emily, Geser Felix, Hu William T, Grossman Murray, Clay-Falcone Dana, Elman Lauren, McCluskey Leo, Lee Virginia M Y, Van Deerlin Vivianna M, Trojanowski John Q, Chen-Plotkin Alice S: Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta neuropathologica 121(3): 373-80, Mar 2011.

Elden Andrew C*, Kim Hyung-Jun*, Hart Michael P*, Chen-Plotkin Alice S*, et al.: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature 466(7310): 1069-75, Aug 2010 Notes: Co-first author with equal contribution.

Chen-Plotkin AS, Lee VM, Trojanowski JQ: TAR DNA-binding protein 43 in neurodegenerative disease. Nature Reviews Neurology 6(4): 211-20, Apr 2010.

Van Deerlin VM,* Sleiman PM,* Martinez-Lage M,* Chen-Plotkin A,* et al. : Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics 42(3): 234-9, Mar 2010 Notes: Co-first author with equal contribution.

Chen-Plotkin, Alice S. Xiao, Jiping. Geser, Felix. Martinez-Lage, Maria. Grossman, Murray. Unger, Travis. Wood, Elisabeth M. Van Deerlin, Vivianna M. Trojanowski, John Q. Lee, Virginia M-Y.: Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathologica 119(1): 111-22, Jan 2010.

Hu W T, Chen-Plotkin A, Grossman M, Arnold S E, Clark C M, Shaw L M, McCluskey L, Elman L, Hurtig H I, Siderowf A, Lee V M-Y, Soares H, Trojanowski J Q: Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology 75(23): 2079-86, Dec 2010.

Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM-Y: Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Human molecular genetics 17(10): 1349-62, May 2008.

Chen-Plotkin AS, Yuan W, Anderson C, McCarty Wood E, Hurtig HI, Clark CM, Miller BL, Lee VM-Y, Trojanowski JQ, Grossman M, Van Deerlin VM: Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology 70(7): 521-7, Feb 2008.

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Last updated: 10/23/2013
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