Ashani Weeraratna, PhD

faculty photo
Wistar Institute Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
The Wistar Institute
Molecular and Cellular Oncogenesis Program
3601 Spruce Street, Rm 454
Philadelphia, PA 19104
Office: 215-495-7938
Fax: 215-495-6938
Education:
BA (Biology)
St. Mary’s College of Maryland, 1991.
PhD (Molecular and Cellular Oncology)
George Washington University, 1998.
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Selected Publications

Webster MR, Kamat C, Connis N, Zhao M, Weeraratna AT, Rudek MA, Hann CL, Freel Meyers CL. : Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines. Mol Cancer Ther 13(2): 297-306, 2014.

Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin N, Weeraratna A, O'Connell MP, Jernigan D, Fatatis A, Languino L, Bosari S, Altieri D. : Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J. Clin Investigation 123(7): 2907-20, 2013.

O’Connell MP, Marchbank K, Webster MR, Valiga AA, Kaur A, Vultur A, Li L, Herlyn M, Villanueva J, Liu Q, Yin X, Widura S, Nelson J, Ruiz N, Camilli TC, Indig FE, Flahery KT, Wargo JA, Frederick DT, Cooper ZA, Nair S, Amaravadi RK, Schuchter LM, Karakousis GC, Wei X, Xu X, Weeraratna AT : Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer Discovery. 30(12): 1378-93, 2013.

O'Connell MP, Weeraratna AT: Change is in the air: the hypoxic induction of phenotype switching in melanoma J Invest Dermatol 133(10): 2316-7, 2013.

Webster MR, Weeraratna AT. : A Wnt-er migration: the confusing role of beta-catenin in melanoma metastasis. Science Signaling 6(268), 2013.

Tavecchio M, Lisanti S, Lam A, Ghosh JC, Martin NM, O'Connell M, Weeraratna AT, Kossenkov AV, Showe LC, Altieri DC. Cyclophilin D Extramitochondrial : Signaling Controls Cell Cycle Progression and Chemokine-Directed Cell Motility. J Biol Chem 288(8): 5553-61, 2013.

Orlov NV, Weeraratna AT, Hewitt SM, Coletta CE, Delaney JD, Mark Eckley D, Shamir L, Goldberg IG : Automatic detection of melanoma progression by histological analysis of secondary sites. Cytometry 81(5): 364-73, 2012.

Weeraratna AT: RAF around the edges: The Paradox of BRAF Inhibitors. New England Journal of Medicine 366(3): 271-3, 2012.

Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P, Park BH: The growth response to androgen receptor signaling in ERalpha-negative human breast cells is dependent on p21 and mediated by MAPK activation. Breast Cancer Res 14(1): R27, 2012.

Sharma BK, Manglik V, O'Connell M, Weeraratna A, McCarron EC, Broussard JN, Divito KA, Simbulan-Rosenthal CM, Rosenthal DS, Zapas JL: Clonal dominance of CD133+ subset population as risk factor in tumor progression and disease recurrence of human cutaneous melanoma. Int. J. Oncol 41(5): 1570-6, 2012.

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Last updated: 08/25/2014
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