Jan Joseph Melenhorst, PhD

faculty photo
Adjunct Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
SPE South Tower, Rm. 9-105,
3400 Civic Center Boulevard, Blg. 421
Philadelphia, PA 19104-5156
Office: 215.573.6852
Lab: N/A
Education:
BSc (Biology, Geography, Associate Professor in Continuing Education)
Moller Institute, 1988.
MS (Medical Biology)
Nijmegen Katholic University, 1991.
PhD (Immunology)
Leiden University, 1998.
Permanent link
 

Description of Research Expertise

My expertise is in human T cell immunology and immunogene therapy, understanding and improving the anti-tumor efficacy of gene-engineered T cells for the treatment of cancers.

Selected Publications

Lissina A, McLaren JE, Ilander M, Andersson EI, Lewis CS, Clement M, Herman A, Ladell K, Llewellyn-Lacey S, Miners KL, Gostick E, Melenhorst JJ, Barrett AJ, Price DA, Mustjoki S, Wooldridge L.: Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Sci Rep 8(1): 2534, Feb 2018.

Marcucci KT, Jadlowsky JK, Hwang WT, Suhoski-Davis M, Gonzalez VE, Kulikovskaya I, Gupta M, Lacey SF, Plesa G, Chew A, Melenhorst JJ, Levine BL, June CH.: Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients. Mol Ther. 26(1): 269-279, Jan 2018.

Joseph A. Fraietta1,2,3, Simon F. Lacey1,2,3*, Elena J. Orlando4,*, Iulian Pruteanu-Malinici4, Mercy Gohil2, Stefan Lundh2, Alina C. Boesteanu2, Yan Wang2, Roddy S. O’Connor2, Wei-Ting Hwang5, Edward Pequignot2, David E. Ambrose2, Changfeng Zhang2, Nicholas Wilcox2, Felipe Bedoya2, Corin Dorfmeier2, Fang Chen2, Lifeng Tian2, Harit Parakandi2, Minnal Gupta2, Regina M. Young2, F. Brad Johnson1, Irina Kulikovskaya2, Li Liu2, Jun Xu2, Sadik H. Kassim4, Megan M. Suhoski-Davis2, Bruce L. Levine1,2, Noelle V. Frey2,6, Donald L. Siegel1,2,7, Alexander C. Huang3,8, E. John Wherry3,8, Hans Bitter4, Jennifer L. Brogdon4, David L. Porter1,6, Carl H. June1,2,3 and Jan J. Melenhorst1,2,3,‡: Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T cell Therapy of Chronic Lymphocytic Leukemia Nature Medicine (in production) 2018.

Marco Ruella, Jun Xu, David M. Barrett, Joseph A. Fraietta, Tyler Reich, David E. Ambrose, Michael Klichinsky, Olga Shestova, Prachi R. Patel, Irina Kulikovskaya, Farzana Nazimuddin, Vijay G. Bhoj, Elena Orlando, Hans Bitter, Shannon L. Maude, Bruce L. Levine, Christopher L. Nobles, Frederic D. Bushman, Regina M. Young, John Scholler, Saar I. Gill, Terry J. Fry, Carl H. June, Stephan A. Grupp, Simon F. Lacey, J. Joseph Melenhorst: Induction of Resistance to Chimeric Antigen Receptor (CAR) T Cell Therapy by Transduction of a Single Leukemic B Cell. Nature Med (submitted) 2018.

Gregory L. Beatty, Mark O'Hara, Simon F. Lacey, Drew A. Torigian, Farzana Nazimudin, Fang Chen, Irina Kulikovskaya, Michael C. Soulen, Maureen McGarvey, Anne Marie Nelson, Whitney L. Gladney, Bruce L. Levine, J. Joseph Melenhorst, Gabriela Plesa, and Carl H. June: Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. Gastroenterology (accepted) 2018.

Guedan S, Posey AD Jr., Shaw C, Wing A, Da T, Patel PR, McGettigan SE, Casado-Medrano V, Kawalekar OU, Uribe-Herranz M, Song D, Melenhorst JJ, Lacey SF, Scholler J, Keith B, Young RM, June CH.: Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. JCI Insight Epub ahead of print, 2018.

Joseph A. Fraietta, Christopher L. Nobles, Morgan A. Sammons, Stefan Lundh, Shannon A. Carty, Tyler Reich, Alexandria P. Cogdill, Jennifer J.D. Morrissette, Jamie E. DeNizio, Shantan Reddy, Young Hwang, Mercy Gohil, Irina Kulikovskaya, Farzana Nazimuddin, Minnal Gupta, Fang Chen, John K. Everett, Katherine A. Alexander, Enrique Lin-Shiao, Marvin H. Gee, Xiaojun Liu, Regina M. Young, David Ambrose, Yan Wang, Jun Xu, Martha S. Jordan, Katherine T. Marcucci, Bruce L. Levine, K. Christopher Garcia, Yangbing Zhao, Michael Kalos, David L. Porter, Rahul M. Kohli, Simon F. Lacey, Shelley L. Berger, Frederic D. Bushman, Carl H. June, and J. Joseph Melenhorst: Disruption of TET2 Promotes the Therapeutic Efficacy of CD19-targeted T-cells. Nature (in press) 2018.

Schuster SJ, Svoboda J, Chong EA, Nasta SD, Mato AR, Anak Ö, Brogdon JL, Pruteanu-Malinici I, Bhoj V, Landsburg D, Wasik M, Levine BL, Lacey SF, Melenhorst JJ, Porter DL, June CH.: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. N Engl J Med 377(26): 2545-2554, Dec 2017.

Obstfeld AE, Frey NV, Mansfield K, Lacey SF, June CH, Porter DL, Melenhorst JJ, Wasik MA.: Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy; clinicopathological insights. Blood 130(23): 2569-2572, Dec 2017.

Tchou J, Zhao Y, Levine BL, Zhang PJ, Davis MM, Melenhorst JJ, Kulikovskaya I, Brennan AL, Liu X, Lacey SF, Posey AD Jr, Williams AD, So A, Conejo-Garcia JR, Plesa G, Young RM, McGettigan S, Campbell J, Pierce RH, Matro JM, DeMichele AM, Clark AS, Cooper LJ, Schuchter LM, Vonderheide RH, June CH.: Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. Cancer Immunol Res. 5(12): 1152-1161, Dec 2017.

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Last updated: 03/15/2018
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