Kim A. Sharp, Ph.D
Associate Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations
Contact information
805A Stellar Chance Labs
422 Curie Boulevard
Philadelphia, PA 19104-6059
422 Curie Boulevard
Philadelphia, PA 19104-6059
Office: (215) 573-3506
Fax: (215) 898-4217
Fax: (215) 898-4217
Email:
SHARPK@MAIL.MED.UPENN.EDU
SHARPK@MAIL.MED.UPENN.EDU
Publications
Education:
BSc.Hons. (Biophysics)
Leeds University, 1978.
Ph.D. (Chemistry)
University of British Columbia, 1985.
Permanent linkBSc.Hons. (Biophysics)
Leeds University, 1978.
Ph.D. (Chemistry)
University of British Columbia, 1985.
Description of Research Expertise
The goal of my research is to gain a detailed understanding at the molecular and physical chemical level of how proteins bind and recognize other proteins, drugs, ligands and nucleic acids. Theoretical and computational methods used include Poisson-Boltzmann electrostatics, Molecular and Brownian Dynamics, and Monte Carlo simulations.Current Research:
1. Calculation of protein-ligand binding energies and association kinetics
2. Simulation of proteins in reverse micelles
3. Simulation of viral genome packaging
4. Computational methods to describe and analyze protein shape.
Selected Publications
Kuntz, I. D., K. Chen, K. Sharp and P. Kollman.: “The maximal affinity of ligands.” PNAS 96: 9997-10002, 1999.Luo, H., Sharp, K. A.: "On the calculation of absolute binding free energies". PNAS 99: 10399-10404, 2002.
Gallagher, K., Sharp, K. A.: "A new angle on the hydrophobic effect". JACS 125: 9863-60, 2003.
Chin, K. Sharp, K A. Honig, B. Pyle, A M.: Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function. Nature Structural Biology 6(11): 1055-61, Nov 1999.
Brooijmans, N., Sharp, K. A., Kuntz, I. D.: "The stability of macromolecular complexes". Proteins 48: 645-653, 2002.
Daber, R., K. Sharp and M. Lewis: One is Not Enough. J. Mol. Biol. 392: 1133-1144, 2009.
Coleman, Ryan G. Sharp, Kim A.: Travel depth, a new shape descriptor for macromolecules: application to ligand binding. Journal of Molecular Biology 362(3): 441-58, Sep 22 2006.
Prabhu, Ninad V. Panda, Manoranjan. Yang, Qingyi. Sharp, Kim A.: Explicit ion, implicit water solvation for molecular dynamics of nucleic acids and highly charged molecules. Journal of Computational Chemistry 29(7): 1113-30, May 2008.