Li-San Wang, Ph.D.
Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Penn Center for Bioinformatics
1424 Blockley Hall
423 Guardian Drive
University of Pennsylvania
Philadelphia, PA 19104
1424 Blockley Hall
423 Guardian Drive
University of Pennsylvania
Philadelphia, PA 19104
Office: +1(215) 7467015
Email:
lswang@mail.med.upenn.edu
lswang@mail.med.upenn.edu
Education:
B.S. (Electrical Engineering)
National Taiwan University, 1994.
M.S. (Electrical Engineering)
National Taiwan University, 1996.
Ph.D. (Computer Sciences)
University of Texas at Austin, 2003.
Permanent linkB.S. (Electrical Engineering)
National Taiwan University, 1994.
M.S. (Electrical Engineering)
National Taiwan University, 1996.
Ph.D. (Computer Sciences)
University of Texas at Austin, 2003.
Description of Research Expertise
My lab uses bioinformatic approaches to study Alzheimer's disease and other neurodegenerative disorders. We develop new algorithms or apply existing methods to study the following research questions.- Genomics and genetics of Alzheimer's disease and other neurodegenerative disorders using genome-wide association studies and whole-exome/whole-genome resequencing.
- Transcriptomic changes in Alzheimer's disease brains by RNA-seq experiments.
- Developing accurate multi-modal algorithms for reliable early diagnosis of Alzheimer's disease.
Selected Publications
Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma’ayan, Kaitlin E. Samocha, Aniko Sabo, Chiao-Feng Lin, Christine Stevens, Li-San Wang, Vladimir Makarov, Paz Polak, Seungtai Yoon, Jared Maguire, Emily L. Crawford, Nicholas G. Campbell, Evan T. Geller, Otto Valladares, Chad Schafer, Han Liu, Tuo Zhao, Guiqing Cai, Jayon Lihm, Ruth Dannenfelser, Omar Jabado, Zuleyma Peralta, Uma Nagaswamy, Donna Muzny, Jeffrey G. Reid, Irene Newsham, Yuanqing Wu, Lora Lewis, Yi Han, Benjamin F. Voight, Elaine Lim, Elizabeth Rossin, Andrew Kirby, Jason Flannick, Menachem Fromer, Khalid Shakir, Tim Fennell, Kiran Garimella, Eric Banks, Ryan Poplin, Stacey Gabriel, Mark DePristo, Jack R. Wimbish, Braden E. Boone, Shawn E. Levy, Catalina Betancur, Shamil Sunyaev, Eric Boerwinkle, Joseph D. Buxbaum, Edwin H. Cook, Bernie Devlin, Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe & Mark J. Daly: Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature April 2012 Notes: doi:10.1038/nature11011.Nan Liu, Michael Landreh, Kajia Cao, Masashi Abe, Gert-Jan Hendriks, Jason R. Kennerdell, Yongqing Zhu, Li-San Wang, Nancy M. Bonini: The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature Page: doi:10.1038/nature10793, January 2012.
Li, F., Zheng, Q., Ryvkin, P., Dragomir, I., Desai, Y., Aiyer, S., Valadares, O., Yang, J., Bambina, S., Sabin, L.R., Murray, J.I., Lamitina, T., Raj, A., Cherry, S., Wang, L.S.*, and Gregory, B.D.* (*: co-corresponding authors) : Global analysis of RNA secondary structure in two metazoans. Cell Reports 1(1): 69-82, January 2012.
Fan Li, Paul Ryvkin, Micah Childress, Otto Valladares, Brian D. Gregory and Li-San Wang: SAVoR: a server for sequencing annotation and visualization of RNA structures. Nucleic Acids Research (Web Server Issue) 2012 Notes: 10.1093/nar/gks310.
Günter U Höglinger, Nadine M Melhem, Dennis W Dickson, Patrick M A Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan de Silva, Irene Litvan, David E Riley, John C van Swieten, Peter Heutink, Zbigniew K Wszolek, Ryan J Uitti, Jana Vandrovcova, Howard I Hurtig, Rachel G Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, PSP Genetics Study Group, Laura B Cantwell, Mi Ryung Han, Allissa Dillman, Marcel P van der Brug, J Raphael Gibbs, Mark R Cookson, Dena G Hernandez, Andrew B Singleton, Matthew J Farrer, Chang-En Yu, Lawrence I Golbe, Tamas Revesz, John Hardy, Andrew J Lees, Bernie Devlin, Hakon Hakonarson, Ulrich Müller & Gerard D Schellenberg: Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics 43: 699–705, 2011.
Adam C Naj, Gyungah Jun, Gary W Beecham, Li-San Wang, Badri Narayan Vardarajan, Jacqueline Buros, Paul J Gallins, Joseph D Buxbaum, Gail P Jarvik, Paul K Crane, Eric B Larson, Thomas D Bird, Bradley F Boeve, Neill R Graff-Radford, Philip L De Jager, Denis Evans, Julie A Schneider, Minerva M Carrasquillo, Nilufer Ertekin-Taner, Steven G Younkin, Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Patricia Kramer, John Hardy, Matthew J Huentelman, Amanda J Myers, Michael M Barmada, F Yesim Demirci, Clinton T Baldwin, Robert C Green, Ekaterina Rogaeva, Peter St George-Hyslop, Steven E Arnold, Robert Barber, Thomas Beach, Eileen H Bigio, James D Bowen, Adam Boxer, James R Burke, Nigel J Cairns, Chris S Carlson, Regina M Carney, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, Carl W Cotman, Jeffrey L Cummings, Charles DeCarli, Steven T DeKosky, Ramon Diaz-Arrastia, Malcolm Dick, Dennis W Dickson, William G Ellis, Kelley M Faber, Kenneth B Fallon, Martin R Farlow, Steven Ferris, Matthew P Frosch, Douglas R Galasko, Mary Ganguli, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Sid Gilman, Bruno Giordani, Jonathan D Glass, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Elizabeth Head, Lawrence S Honig, Christine M Hulette, Bradley T Hyman, Gregory A Jicha, Lee-Way Jin, Nancy Johnson, Jason Karlawish, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Edward H Koo, Neil W Kowall, James J Lah, Allan I Levey, Andrew P Lieberman, Oscar L Lopez, Wendy J Mack, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Joseph E Parisi, Daniel P Perl, Elaine Peskind, Ronald C Petersen, Wayne W Poon, Joseph F Quinn, Ruchita A Rajbhandary, Murray Raskind, Barry Reisberg, John M Ringman, Erik D Roberson, Roger N Rosenberg, Mary Sano, Lon S Schneider, William Seeley, Michael L Shelanski, Michael A Slifer, Charles D Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Jennifer Williamson, Randall L Woltjer, Laura B Cantwell, Beth A Dombroski, Duane Beekly, Kathryn L Lunetta, Eden R Martin, M Ilyas Kamboh, Andrew J Saykin, Eric M Reiman, David A Bennett, John C Morris, Thomas J Montine, Alison M Goate, Deborah Blacker, Debby W Tsuang, Hakon Hakonarson, Walter A Kukull, Tatiana M Foroud, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer & Gerard D Schellenberg : Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics 43(5): 436-441, 2011.
Kajia Cao, Alice S. Chen-Plotkin, Joshua B. Plotkin, and Li-San Wang: Age-correlated gene expression in normal and neurodegenerative human brain tissues. PLoS ONE 5(9): e13098, 2010.
Erika L. Pearce, Matthew C. Walsh, Pedro J. Cejas, Gretchen M. Harms, Hao Shen, Li-San Wang, Russell G. Jones and Yongwon Choi: Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460: 103-7, 2009.
Li-San Wang*, Dubravka Hranilovic, Kai Wang, Ingrid Lindquist, Lindsay Yurcaba, Zorana-Bujas Petkovic, Nicole Gidaya, Branimir Jernej, Hakon Hakonarson, and Maja Bucan* (*: Co-corresponding authors): Genome-wide patterns of genetic variation in individuals with autism spectrum disorders from Croatia. BMC Medical Genetics 11, 2010.
Mingyao Li, Myredach Reilly, Daniel Rader, Li-San Wang: Correcting Population Stratification in Genetic Association Studies Using a Phylogenetic Approach. Bioinformatics 26(6): 798-806, 2010.
Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL 3rd, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, de Munain AL, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM.: Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics 42(3): 234-9, 2010.
Steve G. Hershman, Qijun Chen, Julia Y. Lee, Marina L. Kozak, Peng Yue, Li-San Wang, and F. Brad Johnson: Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae. Nucleic Acids Research 36(1): 144-156, 2008.
Jay E. Johnson, Kajia Cao, Paul Ryvkin, Li-San Wang, and F. Brad Johnson: Altered gene expression in the Werner and Bloom syndromes is associated with G-quadruplex forming potential. Nucleic Acids Research 38(4): 1114-1122, 2009 Notes: Li-San Wang and F. Brad Johnson are co-corresponding authors (contribute equally).
Wang, L.-S., Warnow, T.: Reconstructing Chromosomal Evolution. SIAM Journal on Computing 36: 99-131, 2006.
Hannenhalli, S., Wang, L.-S.: Enhanced position weight matrices using mixture models. Bioinformatics 21(Supp.1): i204-i212, 2005.
Moret, B.M.E., Wang, L.-S., Warnow, T., Wyman, S.: New Approaches for Reconstructing Phylogenies Based on Gene Order Bioinformatics 17(Supp.1): 165–173, 2001.