Jan S. Erikson, Ph.D
Wistar Institute Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
The Wistar Institute
Rm.276, 3601 Spruce St.
Philadelphia, PA 19104
Rm.276, 3601 Spruce St.
Philadelphia, PA 19104
Office: (215) 898-3823
Fax: (215) 573-9053
Fax: (215) 573-9053
Email:
jan@wistar.org
jan@wistar.org
Publications
Permanent link
Description of Research Expertise
Research InterestsB cell, T cell, and dendritic cell interactions that mediate tolerance and immunity
Lymphocyte trafficking
Modification of lymphocyte activation via mediators of innate immunity
Research Summary
Autoimmune diseases are characterized by the presence of specific autoantibodies that are generally absent from the functional repertoire of healthy animals . Our objectives have been to define the cellular and molecular interactions that influence autoantibody expression, first, by determining how healthy animals regulate autoantibody production, and second, by identifying the critical lesion(s) in these regulatory processes that lead to autoimmunity. Our focus has been on autoantibody producing B cells, on T cells that are required for B cell stimulation, and on dendritic cells, which are key initiators in adaptive immunity. More recent studies are directed at understanding the interplay of adaptive and innate immunity on lymphocyte regulation.
Selected Publications
The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models.: Fields, M.L., and Erikson, J. Current Opinion in Immunology 2003.Seo S.J., Mandik-Nayak, L., and Erikson J. : B Cell Anergy and Systemic Lupus Erythematosus. Current Directions in Autoimmunity. Nemazee, D. (eds.). Basel, Karger, 6: 1-20, 2003.
Seo, S., Fields, M.L., Buckler, J.L., Reed, A.J., Mandik-Nayak, L., Nish, S.A., Noelle, R.J., Turka, L.A., Finkelman, F.D., Caton, A., and Erikson, J.: The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity 16: 535-546, 2002.
Fields, M.L., Sokol, C., Eaton-Bassiri, A., Seo, S., Madaio, M., and Erikson, J.: Fas/FasL-deficiency results in altered localization of anti-dsDNA B cells and dendritic cells. Immunol. 167: 2370-2378, 2001.
Seo S.J., Buckler J., and Erikson J.: Novel roles for lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice. J. Immunol. 166: 3710-3723, 2001.
Eaton-Bassiri, A.S., Mandik-Nayak, L., Seo, S-J., Madaio, M.P., Cancro, M.P., and Erikson, J. : Alterations in splenic architecture and the localization of anti-dsDNA B cells in aged mice. Int. Immunol. 12: 915-926, 2000.
Mandik-Nayak, L., Nayak, S., Sokol, C., Eaton-Bassiri, A., Madaio, M.P., Caton, A.J., and Erikson, J.: The origin of anti-nuclear antibodies in bcl-2 transgenic mice. Int. Immunol. 12: 353-364, 2000.
Mandik-Nayak, L., Seo, S-J., Eaton-Bassiri, A., Allman, D., Hardy, R.R., and Erikson, J.: Functional consequences of the developmental arrest and follicular exclusion of anti-double-stranded DNA B cells. J. Immunol. 164: 1161-1168, 2000.
Mandik-Nayak, L., Seo, S-J., Sokol, C., Potts, K.M., Bui, A., and Erikson, J.: MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells. J. Exp. Med. 189: 1799-1814, 1999.