Brenda Elaine Porter, MD, PhD
Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations
Contact information
502C Abramson Research Building
The Children's Hospital of Philadelphia
34th and Civic Center Blvd
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
34th and Civic Center Blvd
Philadelphia, PA 19104
Office: 267 426-5210
Fax: 215 590-3779
Fax: 215 590-3779
Email:
porterb@mail.med.upenn.edu
porterb@mail.med.upenn.edu
Education:
A.B. (Biochemistry)
Washington University , 1987.
Ph.D. (Neuroscience)
Washington University , 1995.
M.D.
Washington University, 1995.
Permanent linkA.B. (Biochemistry)
Washington University , 1987.
Ph.D. (Neuroscience)
Washington University , 1995.
M.D.
Washington University, 1995.
Description of Research Expertise
My lab is interested in understanding changes in the brain that cause epilepsy. We have focused on changes in transcription and translation that contribute to the development of epilepsy. We hope to identify gene targets that we can manipulate to prevent the development of epilepsy or revert an epileptic brain back to a pre-epileptic state.Selected Publications
Xinjian Zhu1, Xiao Han, Julie A. Blendy and Brenda E. Porter: Decreased CREB levels suppress epilepsy. Neurobiology of Disease 45: 253-263, January 2012.Paciorkowskia,A.R. Porter, B.E.: MEF2C haploinsufficiency syndrome: A severe neurodevelopmental disorder with variable epilepsy. Journal of Pediatric Epilepsy 2012 Notes: in press.
Risbud, M.R., Lee, C.,Porter, B.E.: Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus. Brain Research 1424: 53-59, November 2011.
Gonzalez, X.O.,Venneti, S.Biegel,J.A., Rorke-Adams, L.B., Porter, B.E.: Ganglioglioma arising from dysplastic cortex. Epilepsia 52: e106-108, September 2011.
Campen,C. and Porter, B.E.: Subependymal Giant Cell Astrocytoma (SEGA) Treatment Update. Current Treatment Options in Neurology 13: 380-385, August 2011.
Gupta*,J.R., Marsh*,E.D. Nieh,H-A. Porter,B.E. and Litt,B.: High-frequency oscillations identify the seizure onset zone in some pediatric epilepsy patients. IEEE Engineering in Medicine and Biology Society Page: 3095-3098, August 2011.
Ross John R, Ramakrishnan Hariharasubramanian, Porter Brenda E, Robinson Michael B: Group I mGluR-Regulated Translation of the Neuronal Glutamate Transporter, Excitatory Amino Acid Carrier 1 (EAAC1). Journal of Neurochemistry Mar 2011.
Ross John R, Porter Brenda E, Buckley Peter T, Eberwine James H, Robinson Michael B: mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizure. Neurochemistry International 58(3): 366-75, Feb 2011.
X. ZHU, J. BLENDY, B.E PORTER: Effect of inducible repression of CREB on the development of epilepsy Society for Neuroscience 2011.
P. A. MCRAE, E. BARANOV1, S. ROGERS, L. WANDREY, B. PORTER; : Proteolytic destruction of the aggrecan component of the perineuronal net in the epileptic hippocampus Society for Neuroscience 2011.