Claire H. Mitchell, Ph.D.
Associate Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology
Graduate Group Affiliations
Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Email:
CHM@EXCHANGE.UPENN.EDU
CHM@EXCHANGE.UPENN.EDU
Publications
Education:
B.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Ion Channels of Ocular Epithelia)
Institute of Ophthalmology, University College London, U.K., 1994.
Permanent linkB.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Ion Channels of Ocular Epithelia)
Institute of Ophthalmology, University College London, U.K., 1994.
Description of Research Expertise
My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.Selected Publications
Guha Sonia, Baltazar Gabriel C, Tu Leigh-Anne, Liu Ji, Lim Jason C, Lu Wennan, Argall Arthur, Boesze-Battaglia Kathleen, Laties Alan M, Mitchell Claire H: Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. Journal of neurochemistry 122(4): 823-33, Aug 2012.Liu Ji, Lu Wennan, Guha Sonia, Baltazar Gabriel C, Coffey Erin E, Laties Alan M, Rubenstein Ronald C, Reenstra William W, Mitchell Claire H: Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells. American journal of physiology. Cell physiology 303(2): C160-9, Jul 2012.
Xia Jingsheng, Lim Jason C, Lu Wennan, Beckel Jonathan M, Macarak Edward J, Laties Alan M, Mitchell Claire H: Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. The Journal of physiology 590(Pt 10): 2285-304, May 2012.
Li Ang, Leung Chi Ting, Peterson-Yantorno Kim, Stamer W Daniel, Mitchell Claire H, Civan Mortimer M: Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. Journal of cellular physiology 227(1): 172-82, Jan 2012.
Lim, J.C., Mitchell, C.H. : Inflammation, pain, and pressure - Purinergic signaling in oral tissues Journal of Dental Research 91(12): 1103-1109, 2012.
Baltazar Gabriel C, Guha Sonia, Lu Wennan, Lim Jason, Boesze-Battaglia Kathleen, Laties Alan M, Tyagi Puneet, Kompella Uday B, Mitchell Claire H: Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells. PloS one 7(12): e49635, 2012.
Li Ang, Zhang Xiulan, Zheng Danying, Ge Jian, Laties Alan M, Mitchell Claire H: Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma. Experimental eye research 93(4): 528-33, Oct 2011.
Li, A., Leung, C. T., Peterson-Yantorno, K., Stamer, W. D., Mitchell, C. H., Civan, M. M.: Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. Journal of Cell Physiology doi: 10.1002/jcp.22715., 2011.
Li Ang, Leung Chi Ting, Peterson-Yantorno Kim, Mitchell Claire H, Civan Mortimer M: Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. American journal of physiology. Cell physiology 299(6): C1308-17, Dec 2010.
Zeiger Ulrike, Mitchell Claire H, Khurana Tejvir S: Superior calcium homeostasis of extraocular muscles. Experimental eye research 91(5): 613-22, Nov 2010.