DECEASED

Scott A. Mackler, MD, PhD, FACP

faculty photo
Department: Medicine

Contact information
67 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 573-5724
Education:
BA (Biology)
University of Pennsylvania, 1980.
BS (Physical Therapy)
University of Pennsylvania, 1980.
M.D.
University of Pennsylvania, 1986.
Ph.D. (Anatomy)
University of Pennsylvania, 1986.
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Description of Research Expertise

Dr. Mackler is a clinician/scientist in the area of addiction. He couples clinical practice in the area of general medical care to those with substance abuse problems with basic science research. Dr. Mackler has appointments in the Departments of Pharmacology and Psychiatry as well as the Institute for Neuroscience. Addiction to many classes of drugs is associated with alterations in the expression of multiple mRNAs in the mammalian CNS. His research is focused on identifying which mRNAs have their levels regulated by cocaine in order to better define the molecular basis of the self-administration of addictive drugs. Dr. Mackler has taught medical students, residents, post doctoral fellows, nurses and other Penn faculty in many different departments in the area of substance abuse. He is a Fellow of the American College of Physicians.

Selected Publications

Mackler SA, Homan YX, Korutla L, Conti AC, Blendy JA: The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1. Neuroscience 121(2): 355-61, 2003.

Wang PJ, Stromberg M, Replenski S, Snyder-Mackler A, Mackler SA: The relationship between cocaine-induced increases in NAC1 and behavioral sensitization. Pharmacol Biochem Behav. 75(1): 49-54, April 2003.

Korutla L, Neustadter JH, Fournier KM, Mackler SA: NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells. Neurosci Res 46(1): 33-9, May 2003.

Stromberg MF, Sengpiel T, Mackler SA, Volpicelli JR, O'Brien CP, Vogel WH: Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat. Alcohol 28(3): 169-79, November 2002.

Korutla L, Wang PJ, Lewis DM, Neustadter JH, Stromberg MF, Mackler SA: Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1. Neuroscience 110(3): 421-9, 2002.

Stromberg MF, Rukstalis MR, Mackler SA, Volpicelli JR, O'Brien CP: A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats. Pharmacol Biochem Behav 72(1-2): 483-90, May 2002.

Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP: Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. Alcohol 23(2): 109-16, February 2001.

Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP, Dewey SL: The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat. Pharmacol Biochem Behav 68(2): 291-9, February 2001.

Vorwerk CK, Naskar R, Schuettauf F, Quinto K, Zurakowski D, Gochenauer G, Robinson MB, Mackler SA, Dreyer EB: Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. Invest Ophthalmol Vis Sci. 41(11): 3615-21, October 2000.

Mackler SA, Korutla L, Cha XY, Koebbe MJ, Fournier KM, Bowers MS, Kalivas PW: NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat. J Neurosci. 20(16): 6210-7, August 2000.

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Last updated: 10/19/2012
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