Faculty

Stephen R. Thom, MD, PhD

Emeritus Professor of Emergency Medicine

Department: Emergency Medicine

Graduate Group Affiliations

Pharmacology

Contact information

University of Pennsylvania
Institute for Environmental Medicine
1 John Morgan Building
36th Street and Hamilton Walk
Philadelphia, PA 19104-6068

Email:
sthom@mail.med.upenn.edu

Education:
B.A. (Biology)
University of Rochester, Rochester, NY, 1975.
Ph.D. (Microbiology)
University of Rochester, Rochester, NY, 1981.
M.D.
University of Rochester, Rochester, NY, 1981.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Thom Stephen R, Yang Ming, Bhopale Veena M, Huang Shaohui, Milovanova Tatyana N: Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries. Journal of applied physiology (Bethesda, Md. : 1985) Oct 2010.

Thom Stephen R, Bhopale Veena M, Milovanova Tatyana M, Hardy Kevin R, Logue Christopher J, Lambert David S, Troxel Andrea B, Ballard Kerri, Eisinger Dominic: Plasma biomarkers in carbon monoxide poisoning. Clinical toxicology (Philadelphia, Pa.) 48(1): 47-56, Jan 2010.

Thom Stephen R: Oxidative stress is fundamental to hyperbaric oxygen therapy. Journal of applied physiology (Bethesda, Md. : 1985) 106(3): 988-95, Mar 2009.

Milovanova Tatyana N, Bhopale Veena M, Sorokina Elena M, Moore Jonni S, Hunt Thomas K, Hauer-Jensen Martin, Velazquez Omaida C, Thom Stephen R: Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. Journal of applied physiology (Bethesda, Md. : 1985) 106(2): 711-28, Feb 2009.

Milovanova Tatyana N, Bhopale Veena M, Sorokina Elena M, Moore Jonni S, Hunt Thomas K, Hauer-Jensen Martin, Velazquez Omaida C, Thom Stephen R: Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Molecular and cellular biology 28(20): 6248-61, Oct 2008.

Thom Stephen R, Bhopale Veena M, Mancini D Joshua, Milovanova Tatyana N: Actin S-nitrosylation inhibits neutrophil beta2 integrin function. The Journal of biological chemistry 283(16): 10822-34, Apr 2008.

TN Milovanova, JS Moore, TK Hunt, SR Thom: Stem cell mobilization and vasculogenesis stimulated by hyperoxia and lactate. Experimental Biology May 2007.

KA Gallagher, MD Goldstein, DG Buerk, A Nedeau, M Xaio, H Chen, SR Thom, ZL Liu, OC Valazquez: Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF. Clin Invest 117: 1249-1259, 2007.

ST Han, VM Bhopale, SR Thom: Xanthine oxidorecductase and neurological sequelae of carbon monoxide poisoning. Toxicol Lett 170: 115-115, 2007.

Thom, S.R., Bhopale, V.M., Velazquez, O.C., Goldstein, L.J., Thom, L.H., and Buerk, D.G. : Stem cell mobilization by hyperbaric oxygen. Experimental Biology April 2006.