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Faculty Members:
Donald M. O'Rourke Jr., MD
Associate Professor of Neurosurgery
Faculty
Faculty Member
Faculty
Founding Member
Director, Human Brain Tissue Bank
Associate Professor
Department: Neurosurgery
Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
Fax: 215-349-5534
Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D.
University of Pennsylvania, 1987.
M.A.
University of Pennsylvania (Arts), 2002.
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D.
University of Pennsylvania, 1987.
M.A.
University of Pennsylvania (Arts), 2002.
Post-Graduate Training
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., Ph.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., Ph.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.
Certifications
Diplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.
Permanent linkDiplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.
Selected Publications
Kapoor GS, Christie A, O'Rourke DM: EGFR inhibition in glioblastoma cells induces G2/M arrest and is independent of p53. Cancer Biology & Therapy 6: 571-579, 2007.AL-Okaili RN, Krejza J, Woo J, Wolf RL, O’Rourke DM, Judy KD, Poptani H, Melhem ER: Intra-axial brain masses: MR imaging-based diagnostic strategy-Initial experience. Radiology 243: 539-550, 2007.
Wang S, Wolf RL, Woo J, Wang J, O’Rourke DM, Roy S, Melhem E, Poptani H: : Actinomycotic Brain Abscess: Combined Findings of Diffusion, Perfusion and MR Spectroscopy. AJNR 48: 346-350, 2006.
Reddy CD, Guttapalli A, Adamson P, Vemuri MC, O’Rourke D, Sutton LN, Phillips PC: Anticancer effects of fenretinide in human medullblastoma. Cancer Letters 231: 262-269, 2006.
Wolf RL, Wang J, Wang S, Melhem ER, O’Rourke DM, Judy KD, Detre JA: Grading of CNS Neoplasms Using Continuous Arterial Spin Labeled Perfusion MR Imaging at 3 Tesla. JMRI 22: 475-482, 2005.
Boockvar JB, Schouten J, Royo N, Millard M, Spangler Z, Castelbuono D, Snyder EY, O'Rourke DM, McIntosh TK: Experimental traumatic brain injury modulates the survival, migration and terminal phenotype of transplanted EGFR activated neural stem cells. Neurosurgery 56: 163-171, 2005.
Zhan Y, O'Rourke DM: Shp2 participates in an ERK-dependent pathway that modulates phosphorylation of an activated EGFR oncoprotein and glioblastoma cell survival. Cancer Res 64: 8292-8298, 2004.
Pore N, Liu S, Shu H-K, Li B, Haas-Kogan D, Stokoe D, Milanini-Mongiat J, Pages G, O'Rourke DM, Bernhard E, Maity A: Sp1 is involved in Akt mediated induction of VEGF expression through a HIF-1 independent mechanism. Mol Biol Cell 15: 4841-4853, 2004.
Neznanov N, Neznanova L, Kondratov RV, O'Rourke DM, Ullrich A, Gudkov AV: The ability of protein tyrosine phosphatase SHP-1 to suppress NFkB can be inhibited by dominant negative mutant of SIRPalpha. DNA Cell Biol 23: 175-182, 2004.
Kapoor GS, Zhan Y, Johnson GR, O'Rourke DM: Distinct domains in the SHP2 phosphatase differentially regulate EGFR/NFkB activation through Gab1 in glioblastoma cells. Mol Cell Biol 24: 823-836, 2004.
