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Geoffrey Karl Aguirre, MD, PhD

Associate Professor of Neurology
Associate Director, Penn Center for Neuroscience and Society
Assistant Directory Neurology Residency, Department of Neurology
Department: Neurology

Contact information
Department of Neurology
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3390
Fax: 215-349-8260
Graduate Group Affiliations
BA (Politics)
Princeton University, 1992.
PhD (Neuroscience)
University of Pennsylvania, 2000.
University of Pennsylvania, 2001.
Post-Graduate Training
Internship in Medicine, Pennsylvania Hospital, 2001-2002.
Resident in Neurology, University of Pennsylvania, 2002-2004.
American Board of Neurology, 2005.
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Description of Research Expertise

I study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.

Description of Clinical Expertise

My sub-speciality in Behavioral Neurology, and I treat patients with a variety of disturbances of visual perception, thinking and memory.

Description of Other Expertise

Resident Education

I am an Associate Director of the Neurology Residency Program for the University of Pennsylvania. My focus is on the scholarly and research activities of the residents. I direct the "research firm" which is an ongoing educational program covering career development, research methodology, and the responsible conduct of research.

Selected Publications

Cideciyan Artur V, Aguirre Geoffrey K, Jacobson Samuel G, Butt Omar H, Schwartz Sharon B, Swider Malgorzata, Roman Alejandro J, Sadigh Sam, Hauswirth William W: Pseudo-fovea formation after gene therapy for RPE65-LCA. Investigative ophthalmology & visual science 56(1): 526-37, Jan 2015.

Butt Omar H, Benson Noah C, Datta Ritobrato, Aguirre Geoffrey K: Hierarchical and homotopic correlations of spontaneous neural activity within the visual cortex of the sighted and blind. Frontiers in human neuroscience 9: 25, 2015.

Persichetti Andrew S, Aguirre Geoffrey K, Thompson-Schill Sharon L: Value Is in the Eye of the Beholder: Early Visual Cortex Codes Monetary Value of Objects during a Diverted Attention Task. Journal of cognitive neuroscience Page: 1-9, Nov 2014.

Spitschan Manuel, Jain Sandeep, Brainard David H, Aguirre Geoffrey K: Opponent melanopsin and S-cone signals in the human pupillary light response. Proceedings of the National Academy of Sciences of the United States of America 111(43): 15568-72, Oct 2014.

Cucchiara Brett, Datta Ritobrato, Aguirre Geoffrey K, Idoko Kimberly E, Detre John: Measurement of visual sensitivity in migraine: Validation of two scales and correlation with visual cortex activation. Cephalalgia : an international journal of headache Sep 2014.

Benson Noah C, Butt Omar H, Brainard David H, Aguirre Geoffrey K: Correction of distortion in flattened representations of the cortical surface allows prediction of v1-v3 functional organization from anatomy. PLoS computational biology 10(3): e1003538, Mar 2014.

Datta Ritobrato, Aguirre Geoffrey K, Hu Siyuan, Detre John A, Cucchiara Brett: Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura. Cephalalgia 33(6): 365-74, Apr 2013.

Butt Omar H, Benson Noah C, Datta Ritobrato, Aguirre Geoffrey K: The fine-scale functional correlation of striate cortex in sighted and blind people. The Journal of Neuroscience 33(41): 16209-19, 2013.

Cucchiara Brett, Wolf Ronald L, Nagae Lidia, Zhang Quan, Kasner Scott, Datta Ritobrato, Aguirre Geoffrey K, Detre John A: Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study. PloS one 8(7): e71007, 2013.

Benson Noah C, Butt Omar H, Datta Ritobrato, Radoeva Petya D, Brainard David H, Aguirre Geoffrey K: The retinotopic organization of striate cortex is well predicted by surface topology. Current biology 22(21): 2081-5, Nov 2012.

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Last updated: 09/21/2015
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