Penn Comprehensive Neuroscience Center

Faculty Members
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Alice S. Chen-Plotkin, MD

Assistant Professor of Neurology
Attending Neurologist, Pennsylvania Hospital
Department: Neurology

Contact information
Hospital of the University of Pennsylvania
150 Johnson Pavilion
Philadelphia, PA 19104
Office: 215-573-7193
Lab: 215-746-8191
Graduate Group Affiliations
AB (English)
Harvard-Radcliffe College, 1996.
MSc (Biology)
University of Oxford, 1998.
Harvard Medical School, 2003.
Post-Graduate Training
Intern in Medicine, Brigham and Women's Hospital, Harvard Medical School, 2003-2004.
Resident in Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Partners Neurology, Harvard Medical School, 2004-2007.
Fellow in Movement Disorders, Pennsylvania Hospital, University of Pennsylvania School of Medicine, 2007-2008.
Postdoctoral Research in Neurodegenerative Disease, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 2007-2010.
American Board of Psychiatry and Neurology (Neurology), 2008.
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Description of Research Expertise

The over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes. Our general approach is to use unbiased genomic- or proteomic-scale screens to generate leads, which are then followed mechanistically in relevant systems. The rationale behind using genomic/proteomic-scale screens of genetic variation, mRNA expression, microRNA expression, or protein expression is that (1) they avoid bias generated by one’s preconceptions of what may be key disease genes or proteins and (2) they can give one a more global picture of pathophysiology, a picture that encompasses what is happening to an organism as a whole, or at least an organism’s genome/proteome as a whole, as these diseases progress. To conduct the type of research outlined here, we employ a combination of bench and computational methods.

We are part of the Neurology Department at the University of Pennsylvania School of Medicine. The lab is located in the Johnson Pavilion.

Description of Clinical Expertise

Movement disorders

Selected Publications

Chen-Plotkin Alice S, Hu William T, Siderowf Andrew, et al.: Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Annals of neurology 69(4): 655-63, Apr 2011.

Chen-Plotkin Alice S, Martinez-Lage Maria, Sleiman Patrick M A, et al.: Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of neurology 68(4): 488-97, Apr 2011 Notes: First and corresponding author.

Vass Ryan, Ashbridge Emily, Geser Felix, Hu William T, Grossman Murray, Clay-Falcone Dana, Elman Lauren, McCluskey Leo, Lee Virginia M Y, Van Deerlin Vivianna M, Trojanowski John Q, Chen-Plotkin Alice S: Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta neuropathologica 121(3): 373-80, Mar 2011.

Elden Andrew C*, Kim Hyung-Jun*, Hart Michael P*, Chen-Plotkin Alice S*, et al.: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature 466(7310): 1069-75, Aug 2010 Notes: Co-first author with equal contribution.

Chen-Plotkin AS, Lee VM, Trojanowski JQ: TAR DNA-binding protein 43 in neurodegenerative disease. Nature Reviews Neurology 6(4): 211-20, Apr 2010.

Van Deerlin VM,* Sleiman PM,* Martinez-Lage M,* Chen-Plotkin A,* et al. : Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics 42(3): 234-9, Mar 2010 Notes: Co-first author with equal contribution.

Chen-Plotkin, Alice S. Xiao, Jiping. Geser, Felix. Martinez-Lage, Maria. Grossman, Murray. Unger, Travis. Wood, Elisabeth M. Van Deerlin, Vivianna M. Trojanowski, John Q. Lee, Virginia M-Y.: Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathologica 119(1): 111-22, Jan 2010.

Hu W T, Chen-Plotkin A, Grossman M, Arnold S E, Clark C M, Shaw L M, McCluskey L, Elman L, Hurtig H I, Siderowf A, Lee V M-Y, Soares H, Trojanowski J Q: Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology 75(23): 2079-86, Dec 2010.

Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM-Y: Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Human molecular genetics 17(10): 1349-62, May 2008.

Chen-Plotkin AS, Yuan W, Anderson C, McCarty Wood E, Hurtig HI, Clark CM, Miller BL, Lee VM-Y, Trojanowski JQ, Grossman M, Van Deerlin VM: Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology 70(7): 521-7, Feb 2008.

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Last updated: 06/02/2014
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